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Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells

World Journal of Diabetes 2017年第4期8卷 143-153页

作者： Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti chloébelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar Institut des Maladies Métaboliques et Cardiovasculaires I2MCINSERM U1048Institut.National de la Santé et de la Recherche Médicale &Université Paul Sabatier Genmedica Therapeutics S.L. Esplugues de Llobregat Combinatorial Chemistry Unit Barcelona Science ParkUniversity of Barcelona CIBER-BBN Networking Centre on BioengineeringBiomaterials and Nanomedicine Departament de Bioquimica i Biomedicina Molecular Facultat de BiologiaUniversitat de Barcelona CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud Carlos Ⅲ Institute for Research in Biomedicine(IRB Barcelona) the Barcelona Institute of Science and Technology

AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating *** Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake *** In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance.

关键词： Adipocyte Lipolysis Amine oxidases Insulin resistance Obesity Hydrogen peroxide Vanadium Antidiabetics

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Advances in the engineering of the outer blood-retina barrier:From in-vitro modelling to cellular therapy

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Bioactive Materials 2024年第1期31卷 151-177页

作者： chloé Dujardin Walter Habeler Christelle Monville Didier Letourneur Teresa Simon-Yarza UniversitéParis Cité UniversitéSorbonne Paris NordLaboratory for Vascular Translational Science(LVTS)INSERM-U114875018 ParisFrance INSERM U861 I-StemAFMInstitute for Stem Cell Therapy and Exploration of Monogenic Diseases91100Corbeil-EssonnesFrance U861 I-StemAFMUniversitéParis-SaclayUniversitéD’Evry91100Corbeil-EssonnesFrance CECS Centre D’étude des Cellules Souches91100Corbeil-EssonnesFrance

The outer blood-retina barrier(oBRB),crucial for the survival and the proper functioning of the overlying retinal layers,is disrupted in numerous diseases affecting the retina,leading to the loss of the photoreceptors and ultimately of *** study the oBRB and/or its degeneration,many in vitro oBRB models have been developed,notably to investigate potential therapeutic strategies against retinal ***,to this day,most of these pathologies are untreatable,especially once the first signs of degeneration are *** cure those patients,a current strategy is to cultivate in vitro a mature oBRB epithelium on a custom membrane that is further implanted to replace the damaged native *** a description of the oBRB and the related diseases,this review presents an overview of the oBRB models,from the simplest to the most ***,we propose a discussion over the used cell types,for their relevance to study or treat the *** designed for in vitro applications are then examined,by paying particular attention to the design evolution in the last years,the development of pathological models and the benefits of co-culture models,including both the retinal pigment epithelium and the ***,this review focuses on the models developed for in vivo implantation,with special emphasis on the choice of the material,its processing and its characterization,before discussing the reported pre-clinical and clinical trials.

关键词： Outer-blood retina barrier Tissue engineering and cellular therapy In-vitro disease modelling 3D complex models

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Formidable females redux:male social integration into female networks and the value of dynamic multilayer networks

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Current Zoology 2021年第1期67卷 49-57页

作者： Tyler R.BONNELL chloéVILETTE Christopher YOUNG Stephanus Peter HENZI ouise BARRETT Department of Psychology University of Lethbridge4401 University DriveLethbridgeT1K 3M4Canada Applied Behavioural Ecology and Ecosystems Research Unit University of South AfricaFloridaGautengSouth Africa Endocrine Research Laboratory Mammal Research InstituteFaculty of Natural and Agricultural ScienceUniversity of PretoriaPretoriaSouth Africa

The development of multilayer network techniques is a boon for researchers who wish to understand how different interaction layers might influence each other,and how these in turn might influence group ***,we investigate how integration between male and female grooming and aggression interaction networks influences male power trajectories in vervet monkeys chlorocebus *** previous analyses of this phenomenon used a monolayer approach,and our aim here is to extend these analyses using a dynamic multilayer *** do so,we constructed a temporal series of male and female interaction *** then used a multivariate multilevel autoregression model to compare cross-lagged associations between a male's centrality in the female grooming layer and changes in male Elo *** results confirmed our original findings:changes in male centrality within the female grooming network were weakly but positively tied to changes in their Elo ***,the multilayer network approach offered additional insights into this social process,identifying how changes in a male's centrality cascade through the other network *** dynamic view indicates that the changes in Elo ratings are likely to be short-lived,but that male centrality within the female network had a much stronger impact throughout the multilayer network as a whole,especially on reducing intermale aggression(i.e.,aggression directed by males toward other males).We suggest that multilayer social network approaches can take advantage of increased amounts of social data that are more commonly collected these days,using a variety of *** data are inherently multilevel and multilayered,and thus offer the ability to quantify more precisely the dynamics of animal social behaviors.

关键词： multilayer networks multilevel multivariate autoregressive model primate social dynamics social networks sociality time-aggregated networks vervet monkeys

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Self-activation of Vγ9Vδ2 T cells by exogenous phosphoantigens involves TCR and butyrophilins

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Cellular & Molecular Immunology 2021年第8期18卷 1861-1870页

作者： chloéLaplagne Laetitia Ligat Juliet Foote Frederic Lopez Jean-Jacques Fournié Camille Laurent Salvatore Valitutti Mary Poupot Inserm UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouseFrance UniversitéToulouse III Paul-Sabatier ToulouseFrance ERL 5294 CNRS ToulouseFrance IUCT-O ToulouseFrance

The high cytotoxic activity of Vγ9Vδ2 T lymphocytes against tumor cells makes them useful candidates in anticancer ***,the molecular mechanism of their activation by phosphoantigens(PAgs)is not completely *** studies have depicted the mechanism of Vγ9Vδ2 T-cell activation by PAg-sensed accessory cells,such as immune presenting cells or tumor *** this study,we demonstrated that pure resting Vγ9Vδ2 T lymphocytes can self-activate through exogenous PAgs,involving their TCR and the butyrophilins BTN3A1 and *** is the first time that these three molecules,concurrently expressed at the plasma membrane of Vγ9Vδ2 T cells,have been shown to be involved together on the same and unique T cell during PAg ***,the use of probucol to stimulate the inhibition of this self-activation prompted us to propose that ABCA-1 could be implicated in the transfer of exogenous PAgs inside Vγ9Vδ2 T cells before activating them through membrane clusters formed byγ9TCR,BTN3A1 and *** self-activation of Vγ9Vδ2 T cells,which leads to self-killing,can therefore participate in the failure ofγδT cell-based therapies with exogenous PAgs and should be taken into account.

关键词： Vγ9Vδ2 T cells Phosphoantigen Butyrophilins T-cell receptor

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Printing accuracy tracking with 2D optical microscopy and super-resolution metamaterial-assisted 1D terahertz spectroscopy

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npj Flexible Electronics 2020年第1期4卷 178-184页

作者： Mariia Zhuldybina Xavier Ropagnol chloéBois Ricardo J.Zednik François Blanchard Département de génieélectrique École de technologie supérieure(ÉTS)MontréalQCCanada Institut national de la recherche scientifique Énergiematériaux et télécommunications(INRS-EMT)VarennesQCCanada Institut des Communications Graphiques et de l’imprimabilité MontréalQCCanada Collège Ahuntsic MontréalQCCanada Département de génie mécanique École de technologie supérieure(ÉTS)MontréalQCCanada

Printable electronics is a promising manufacturing technology for the potential production of low-cost flexible electronic devices,ranging from displays to active *** is known that rapid printing of conductive ink on a flexible substrate is vulnerable to several sources of variation during the manufacturing ***,this process is still not being subjected to a quality control method that is both non-invasive and in *** address this issue,we propose controlling the printing accuracy by monitoring the spatial distribution of the deposited ink using terahertz(THz)*** parameters studied are the printing speed of an industrial roll-to-roll press with flexography printing units and the pre-calibration compression,or expansion factor,for a pattern printed on a flexible plastic *** pattern,which is carefully selected,has Babinet’s electromagnetic transmission properties in the THz frequency *** validate our choice,we quantified the geometric variations of the printed pattern by visible microscopy and compared its accuracy using one-dimensional THz *** study shows a remarkable agreement between visible microscopic observation of the printing performance and the signature of the THz ***,under specific conditions,one-dimensional(1D)THz information from a resonant pattern can be more accurate than two-dimensional(2D)microscopy *** result paves the way for a simple strategy for non-invasive and contactless in situ monitoring of printable electronics production.

关键词： printing visible pattern

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Multi-scale approach to understanding climate effects on offspring size at birth and date of birth in a reptile

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Integrative Zoology 2010年第2期5卷 164-175页

作者： chloéD.CADBY Geoffrey M.WHILE Alistair J.HOBDAY Tobias ULLER Erik WAPSTRA School of Zoology University of Tasmania Climate Adaptation Flagship CSIRO Marine and Atmospheric ResearchHobartAustralia Edward Grey Institute Department of ZoologyUniversity of OxfordUK

Climate change is already impacting species around the *** most focus has been on the effect of temperature,changes in climatic variables other than temperature are also expected to drive biological *** models suggest that ectotherms,such as reptiles,will be strongly affected by climate change;however,data from natural populations are ***,we use extensive data from 2 populations of a viviparous lizard(Niveoscincus ocellatus Gray,1845)at the climatic extreme of the species *** examine the effects of climate at a local,a regional and a global scale(thus,integrating a suite of variables at different spatial and temporal scales)on 2 key life history traits:offspring date of birth and size at ***,our results show that across 9 years of study,local temperature had strong effects on the offspring date of birth but not on the size at ***,a rapid increase in local temperature throughout the species range(as predicted under global warming scenarios)is likely to affect phenological processes with potential concomitant effects on offspring fitness and survival.

关键词： atmospheric index climate change lizard phenology sea surface temperature

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Waterbird use of farm dams in south-eastern Australia:abundance and influence of biophysical and landscape characteristics

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Chinese Birds 2017年第1期8卷 12-24页

作者： Andrew J.Hamilton chloéConort Aurore Bueno Christopher G.Murray James R.Grove Faculty of Veterinary and Agricultural Sciences The University of MelbourneDookie CampusCurrawaVIC 3647Australia Office of the Deputy Vice-Chancellor(Research and Innovation) Federation University AustraliaBallaratVIC 3353Australia Department of Rural Health Melbourne Medical School49 Graham StreetPO Box 6500SheppartonVIC 3632Australia École Nationale Supérieure Agronomique de Toulouse 31326 Castanet TolosanFrance Faculty of Science The University of MelbourneParkvilleVIC 3010Australia Faculty of Science Department of GeographyThe University of MelbourneParkvilleVIC 3010Australia

Background: While agriculture has taken much environmental water in Australia's Murray-Darling Basin, agricultural expansion has resulted in a vast number of farm dams, almost three-quarters of a million in the Murray-Darling Basin ***: Over a summer we studied(1) waterbird abundance and species richness and(2) the influence of biophysical and landscape characteristics across 49 farm dams at a large mixed-enterprise farm in northern Victoria on the southern reach of the Murray-Darling ***: On average, dams were found to host 27.1 ± 71.1 individuals/ha and 1.8 ± 2.9 species per pond. Such densities are comparable to those on natural wetlands. Dam surface area and perimeter and amount of vegetation were positively and strongly correlated with the Rallidae density(birds/ha), but no other parameters were strongly correlated with any other functional group. The landscape in which the dams were embedded had a highly significant effect(p < 0.001) on the number of birds found on a ***: Our research needs to be complemented with further studies in other parts of the Basin and on other taxa, but given at our site they supported similar densities of individuals and species to natural wetlands, and given the fact that there are 710,539 farm dams in the Murray-Darling Basin, which hosts much of Australia's waterbird fauna, it is reasonable to suggest that farm dams are overlooked, and possibly very important, avian biodiversity hotspots. It also highlights the importance of a landscape setting, in which dams are situated, on the number of birds using the dams.

关键词： Farm ponds Waterbirds Waterfowl Zooplankton

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Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders

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World Journal of Gastroenterology 2017年第11期23卷 2029-2036页

作者： Clémence Bildstein chloéMelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin Anne-Marie Leroi INSERM U1073 Service de Physiologie DigestiveCHU Rouen INSERM U1073 Service de Chirurgie DigestiveCHU Rouen EA 3830 Pole 3RCHU RouenGroupe de Recherche sur le Handicap Ventilatoire INSERM CIC 0204

AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for *** The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of *** Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI.

关键词： Neurogenic bowel dysfunction Fecal incontinence Constipation Obstructed defecation Transanal irrigation

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Time-lapse videography reveals different morphokinetic profiles of human embryos displaying direct or reverse cleavage at different stages of development: A retrospective sibling embryo study

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Asian pacific Journal of Reproduction 2020年第6期9卷 261-266页

作者： chloé Brits Katie Feenan Vince Chapple Phillip L.Matson Yan-he Liu School of Medical and Health Science Edith Cowan UniversityJoondalupWestern AustraliaAustralia Fertility Specialists of Western Australia ClaremontWestern AustraliaAustralia Fertility North Joondalup Private HospitalJoondalupWestern AustraliaAustralia School of Human Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia Monash IVF Group SouthportQueenslandAustralia

Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(35.0±4.6)years]were included for reverse cleavage analysis,and a total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(33.8±4.3)years]were included for direct cleavage analysis in this *** a sibling-embryo design,morphokinetic profiles(both before and after the onset of abnormal event)of embryos displaying reverse cleavage(n=241)or direct cleavage(n=244)were compared with their unaffected siblings(the controls)in the first,second and third cell cycles(n=32,n=142,n=562;n=195,n=412,n=205,respectively),at different developmental stages up to day ***:Direct cleavage embryos demonstrated significantly delayed cleavage rates prior to the event regardless of developmental stage of the occurrence,while reverse cleavage embryos showed similar cleavage rates to their unaffected *** event,direct cleavage embryos sped up cleavage rates while reverse cleavage embryos slowed ***:Altered morphokinetic profiles are displayed by direct cleavage embryos both before and after their occurrence and reverse cleavage embryos after the occurrence,which could potentially confound morphokinetic comparisons if not separated from their unaffected sibling *** study is warranted in order to fully understand the biological mechanisms of such events.

关键词： Time-lapse Direct cleavage Reverse cleavage Morphokinetics Cleavage abnormality

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Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 295-309页

作者： chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari Department of Digestive Surgery and Liver Transplantation Toulouse-Rangueil University Hospital Department of Pathology Toulouse University Hospital Department of Radiology Toulouse-Rangueil University Hospital Department of Oncology Toulouse-Rangueil University Hospital The Toulouse Research Methodology Support Unit Toulouse University Hospital

BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological *** recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor *** To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after *** January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt *** on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were *** Seventy-four patients were classified as responders and 76 as *** postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological *** were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 *** factors contributing to a poor prognosis for disease-free survi

关键词： Colorectal liver metastasis Tumor regression grade Neoadjuvant chemotherapy Liver surgery Histological response Hepatectomy

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