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子宫内膜异位症患者异位及在位内膜的L-plastin与雌激素受体的表达及相关性研究

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现代肿瘤医学 2013年第6期21卷 1313-1316页

作者：张弛远赵皤王丹波中国医科大学附属盛京医院妇产科辽宁沈阳110004 天津市中心妇产科医院妇产科天津300100

目的:探讨子宫内膜异位症(内异症)患者L-plastin与雌激素受体的表达及二者的相关性在内异症发生、发展中的意义。方法:采用RT-PCR方法及免疫组化S-P法检测L-plastin及雌激素受体在内异症患者的在位和异位内膜及正常子宫内膜中的表达,并... 详细信息

目的:探讨子宫内膜异位症(内异症)患者L-plastin与雌激素受体的表达及二者的相关性在内异症发生、发展中的意义。方法:采用RT-PCR方法及免疫组化S-P法检测L-plastin及雌激素受体在内异症患者的在位和异位内膜及正常子宫内膜中的表达,并对二者表达的相关性进行分析。结果:L-plastin在内异症患者在位及异位内膜中的表达水平均高于正常子宫内膜(P<0.05),且其在异位内膜中的表达水平高于在位内膜(P<0.05);雌激素受体在内异症患者在位及异位子宫内膜中的表达强于正常子宫内膜(P<0.05),且其在在位内膜中的表达强于异位内膜(P<0.05)。结论:L-plastin和雌激素受体在子宫内膜异位症患者在位及异位内膜中均表达增高,且呈正相关。L-plastin可能通过与ER结合在子宫内膜异位症发生、发展中发挥作用。L-plastin可能是与雌激素代谢相关的子宫内膜异位症特异性靶基因。

关键词：子宫内膜异位症 L-plastin 雌激素受体 RT-PCR 免疫组织化学

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新型口服抗凝药物拮抗剂的研究进展

心血管病学进展 2016年第2期37卷 156-159页

作者：张驰原吴智鸿李旭平刘启明中南大学湘雅二医院心血管内科湖南长沙410011

华法林曾作为唯一的口服抗凝剂在临床应用上已逾60年。近年来,一批新型口服抗凝药物有取代华法林用于血栓栓塞性疾病和非瓣膜性心房颤动脑卒中预防和治疗的趋势,新型口服抗凝药物较华法林的优势在其药代动力学的可预测性,较少的食物与... 详细信息

华法林曾作为唯一的口服抗凝剂在临床应用上已逾60年。近年来,一批新型口服抗凝药物有取代华法林用于血栓栓塞性疾病和非瓣膜性心房颤动脑卒中预防和治疗的趋势,新型口服抗凝药物较华法林的优势在其药代动力学的可预测性,较少的食物与药物相互作用以及无需常规监测凝血指标等。虽然新型口服抗凝药物半衰期较短,多数情况下无需特异性拮抗剂,但在大出血或紧急手术时,缺乏拮抗剂使处理更为困难。目前,一些关于新型口服抗凝药物潜在特异性拮抗剂已在早期临床试验中表现出良好的疗效和安全性,现就其研究进展做简要综述。

关键词：新型口服抗凝药拮抗剂 Idarucizumab Andexanetalfa Aripazine

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房颤相关差异性表达蛋白质研究进展

临床与病理杂志 2015年第9期35卷 1706-1711页

作者：张驰原胡恒境吴智鸿李旭平刘启明中南大学湘雅二医院心血管内科长沙410011

房颤(atrial fibrillation,AF)是临床最常见的持续性心律失常,与心房结构重构、电重构及代谢重构等密切相关。蛋白质作为细胞功能的最终执行者,在AF的发生发展中起着决定性作用。针对差异表达蛋白质的研究,为AF发生发展机制的阐明及治... 详细信息

房颤(atrial fibrillation,AF)是临床最常见的持续性心律失常,与心房结构重构、电重构及代谢重构等密切相关。蛋白质作为细胞功能的最终执行者,在AF的发生发展中起着决定性作用。针对差异表达蛋白质的研究,为AF发生发展机制的阐明及治疗靶点的选择提供了广阔的空间。研究表明,在AF的多个发生机制中均存在大量差异表达蛋白质。现就AF相关差异性表达蛋白质研究进展作简要综述。

关键词：房颤结构重构电重构炎症氧化应激能量代谢

Mechanical properties and damage evolution characteristics of waste tire steel fiber-modified cemented paste backfill

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International Journal of Mining Science and Technology 2024年第7期34卷 909-924页

作者： Shenggen Cao chiyuan Che Yun zhang Changhao Shan Yang Liu Changzheng Zhao Shuyu Du State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources School of MinesChina University of Mining and TechnologyXuzhou 221116China College of Energy Engineering Xi’an University of Science&TechnologyXi’an 710054China

During the process of constructional backfill mining,the cemented paste backfill(CPB)typically exhibits a high degree of brittleness and limited resistance to *** this study,the mechanical and damage evolution characteristics of waste tire steel fiber(WTSF)-modified CPB were studied through uniaxial compression tests,acoustic emission(AE)tests,and scanning electron microscopy(SEM).The results showed that the uniaxial compressive strength(UCS)decreased when the WTSF content was 0.5%,1%,and 1.5%.When the WTSF content reached 1%,the UCS of the modified CPB exhibited a minimal decrease(0.37 MPa)compared to that without *** the WTSF content was 0.5%,1%,and 1.5%,peak strain of the WTSF-modified CPB increased by 18%,31.33%,and 81.33%,while the elastic modulus decreased by 21.31%,26.21%,and 45.42%,*** addition of WTSF enhances the activity of AE events in the modified CPB,resulting in a slower progression of the entire failure *** the failure,the modified CPB retained a certain level of load-bearing ***,the failure of the CPB was dominated by tensile *** the addition of WTSF,a gradual increase in the proportion of tensile cracks was observed upon loading the modified CPB sample to the pore compaction *** three-dimensional localization of AE events showed that the WTSF-modified CPB underwent progressive damage during the loading,and the samples still showed good integrity after ***,the response relationship between energy evolution and damage development of WTSF-modified CPB during uniaxial compression was analyzed,and the damage constitutive model of CPB samples with different WTSF contents was *** study provides a theoretical basis for the enhancement of CPB modified by adding WTSF,serving as a valuable reference for the design of CPB constructional backfill.

关键词： Constructional backfill Cemented paste backfill Waste tire steel fiber Acoustic emission Damage characteristics

Is the runoff coefficient increasing or decreasing after ecological restoration on China’s Loess Plateau?

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International Soil and Water Conservation Research 2021年第3期9卷 333-343页

作者： Haiyan Zheng chiyuan Miao Guanghui zhang Xiaoyan Li Shuai Wang Jingwen Wu Jiaojiao Gou State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing100875China

The“Grain for Green”project(GGP)was launched in 1999 on China’s Loess Plateau to reduce soil erosion,which had far-reaching impacts on the local eco-hydrological *** this study,we use monthly runoff depth and precipitation datasets spanning 1961 to 2015 for 16 primary basins of the plateau to reveal changes in runoff generation capacity before and after the *** use a Budyko-based elasticity method to calculate the runoff depth(R_(1))and runoff coefficient(C_(1))exclusively attributable to land use/cover *** indicate that the mean annual runoff coefficients(Co)decline by 26%—76%from the periods 1961—1999 to 2000—*** annual observed runoff depth(Ro)and C_(0)for 75%of basins show significant downward trends during 1961—1999;after the implementation of the GGP,both annual Ro and annual Co for over 50%of basins show upward *** study further finds that the increase of erosive rainfall during the period 2000-2015,whose mean increasing rate reaches 4.6 mm/year,is the main reason for the upward trends of Ro and *** removing the effect of precipitation variation during this period,we find that 11 out of 16 basins show decreased trends for Cj,with the downward rate between 2.4%and 6.0%per *** reduction rate in semi-arid areas is about four times the rate in semi-humid *** results remind us to consider the carrying capacity of local water resources when implementing soil and water conservation measures across the Loess Plateau.

关键词： Loess Plateau Precipitation Runoff coefficient Budyko-based elasticity method Land use/cover change

Development of mouse preimplantation embryos in space

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National Science Review 2020年第9期7卷 1437-1446页

作者： Xiaohua Lei Yujing Cao Baohua Ma Yunfang zhang Lina Ning Jingjing Qian Liwen zhang Yongcun Qu Tao zhang Dehong Li Qi Chen Junchao Shi Xudong zhang chiyuan Ma Ying zhang Enkui Duan State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Institute of Technical Physics Chinese Academy of Sciences Division of Ionizing Radiation National Institute of Metrology College of Veterinary Medicine Northwest A&F University/Key Laboratory of Animal BiotechnologyMinistry of Agriculture

The development of life beyond planet Earth is a long-standing quest of the human race, but whether normal mammalian embryonic development can occur in space is still unclear. Here, we show unequivocally that preimplantation mouse embryos can develop in space, but the rate of blastocyst formation and blastocyst quality are compromised. Additionally, the cells in the embryo contain severe DNA damage, while the genome of the blastocysts developed in space is globally hypomethylated with a unique set of differentially methylated regions. The developmental defects, DNA damage and epigenetic abnormalities can be largely mimicked by the treatment with ground-based low-dose radiation. However,the exposure to simulated microgravity alone does not cause major disruptions of embryonic development,indicating that radiation is the main cause for the developmental defects. This work advances the understanding of embryonic development in space and reveals long-term extreme low-dose radiation as a hazardous factor for mammalian reproduction.

关键词： space-flight radiation microgravity preimplantation development DNA damage DNA methylation

Demands and technical developments of clinical flow cytometry with emphasis in quantitative,spectral,and imaging capabilities

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Nanotechnology and Precision Engineering 2022年第4期5卷 46-55页

作者： Ting zhang Mengge Gao Xiao Chen chiyuan Gao Shilun Feng Deyong Chen Junbo Wang Xiaosu Zhao Jian Chen State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044People’s Republic of China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049People’s Republic of China

As the gold-standard method for single-cell analysis,flow cytometry enables high-throughput and multiple-parameter characterization of individual biological *** review highlights the demands for clinical flow cytometry in laboratory hematology(e.g.,diagnoses of minimal residual disease and various types of leukemia),summarizes state-of-the-art clinical flow cytometers(e.g.,FACSLyricTMby Becton Dickinson,DxFLEX by Beckman Coulter),then considers innovative technical improvements in flow cytometry(including quantitative,spectral,and imaging approaches)to address the limitations of clinical flow cytometry in hematology ***,driven by these clinical demands,future developments in clinical flow cytometry are suggested.

关键词： Clinical demand Clinical flow cytometry Quantitative flow cytometry Spectral flow cytometry Imaging flow cytometry

A comprehensive review on coupled processes and mechanisms of soil-vegetation-hydrology, and recent research advances

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Science China Earth Sciences 2022年第11期65卷 2083-2114页

作者： Zhongkai LI Xiaoyan LI Sha ZHOU Xiaofan YANG Yongshuo FU chiyuan MIAO Shuai WANG Guanghui zhang Xiuchen WU Chao YANG Yuanhong DENG State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of Natural Resources Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXining 810016China School of Geographical Sciences Qinghai Normal UniversityXining 810016China College of Water Sciences Beijing Normal UniversityBeijing 100875China

Research on the coupling of soil,vegetation,and hydrological processes is not only a research hotspot in disciplines such as pedology,ecohydrology and Earth system science but also important for achieving sustainable ***,scientists from different disciplines usually study the coupling mechanism of soil-vegetation-hydrological processes at very different space and time scales,and the mechanistic connections between different scales are quite *** article reviewed research advances in coupled soil-vegetation-hydrological processes at different spatial scales—from leaf stomata to watershed and regional scales—and summarized the spatial upscaling methods and modeling approaches of coupled soil-vegetationhydrological *** identify and summarize the following coupling processes:(1)carbon-water exchange in leaf stomata and root-soil interface;(2)changes in soil aggregates and profile hydraulic properties caused by plant roots and water movement;(3)precipitation and soil moisture redistribution by plant canopy and root;(4)interactions between vegetation patches and local hydrological process;(5)links between plant community succession and soil development;and(6)links between watershed/regional water budget and vegetation phenology and ***,the limitations and knowledge gaps in the observations,mechanisms,scaling methods,and modeling approaches of coupled soil-vegetation-hydrological processes were *** achieve a deep integration of various coupling processes across different spatiotemporal scales,future work should strengthen multiscale,multifactor and multiprocess soil-vegetation-hydrology coupling observations and mechanism studies,develop new scaling methods,identify different feedback pathways,and take time-variable plant behavior and soil hydraulic properties into account during modeling.

关键词： Ecohydrological process Soil process Plant-soil feedback Modeling approaches Scaling method

Founding of the TAR As I Recorded

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China's Tibet 2005年第5期16卷 7-8页

作者： JIN chiyuan

In the early spring of 1965, the Nationalities Pictorial Press learned from the Central People＇s Government representative in Tibet, zhang Jingwu, that a picture album was to be published to mark the founding of the Tibet Autonomous Region, and Chairman Mao Zedong was invited to write its title, ＂Collected Paintings on the Tibet Autonomous Region＂. The press sent zhang Guanrong, Zhaxi Nyima and I to Tibet for gathering the pictures and for interviews.

关键词：西藏政治运动自治体制历史发展政权组织