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Advances in Applied Mathematics and Mechanics 2014年第5期6卷 637-662页

作者： Po-Wen hsieh Suh-Yuh Yang Cheng-Shu You Department of Applied Mathematics Chung Yuan Christian UniversityJhongli CityTaoyuan County 32023Taiwan Department of Mathematics National Central UniversityJhongli CityTaoyuan County 32001Taiwan

This paper is devoted to a new high-accuracy finite difference scheme for solving reaction-convection-diffusion problems with a small diffusivityε.With a novel treatment for the reaction term,we first derive a difference scheme of accuracy O(ε^(2)h+εh^(2)+h^(3))for the 1-D *** the alternating direction technique,we then extend the scheme to the 2-D case on a nine-point *** apply the high-accuracy finite difference scheme to solve the 2-D steady incompressible Navier-Stokes equations in the stream function-vorticity *** examples are given to illustrate the effectiveness of the proposed difference *** made with some high-order compact difference schemes show that the newly proposed scheme can achieve good accuracy with a better stability。

关键词： Reaction-convection-diffusion equation incompressible Navier-Stokes equations boundary layer interior layer finite difference scheme

Advection-Enhanced Gradient Vector Flow for Active-Contour Image Segmentation

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Communications in Computational Physics 2019年第6期26卷 206-232页

作者： Po-Wen hsieh Pei-Chiang Shao Suh-Yuh Yang Department of Applied Mathematics National Chung Hsing UniversitySouth DistrictTaichung City 40227Taiwan Department of Mathematics National Central UniversityJhongli DistrictTaoyuan City 32001Taiwan National Center for Theoretical Sciences National Taiwan UniversityDa’an DistrictTaipei City 10617Taiwan

In this paper,we propose a new gradient vector flow model with advection enhancement,called advection-enhanced gradient vector flow,for calculating the external force employed in the active-contour image *** proposed model is mainly inspired by the functional derivative of an adaptive total variation regularizer whose minimizer is expected to be able to effectively preserve the desired object *** specifically,by incorporating an additional advection term into the usual gradient vector flow model,the resulting external force can much better help the active contour to recover missing edges,to converge to a narrow and deep concavity,and to preserve weak *** experiments are performed to demonstrate the high performance of the newly proposed model.

关键词： Image segmentation active contour gradient vector flow external force

THE PHOTOCHEMICAL SYNTHESIS OF THE PYRIDINE ADDUCT OF TETRAPHENYLPORPHYRINATORHODIUM(Ⅱ)AND THE MECHANISM OF PHOTOCHEMICAL REACTION

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Chinese Chemical Letters 1991年第4期2卷 279-280页

作者： A.K.hsieh Department of Chemistry National University of Singapore

A new rhodium(Ⅱ)porphyrin complex was isolated by chromatography from the photochemical reac- tion of(μ—tetraphenylporphyrinato)bis[dicarbonylrhodium(Ⅰ)]with pyridine in benzene and has been charac- *** the result... 详细信息

关键词： TPP THE PHOTOCHEMICAL SYNTHESIS OF THE PYRIDINE ADDUCT OF TETRAPHENYLPORPHYRINATORHODIUM AND THE MECHANISM OF PHOTOCHEMICAL REACTION

Effect of Growth Hormone on Dawn Phenomenon in Healthy Adults

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Open Journal of Endocrine and Metabolic Diseases 2015年第6期5卷 55-63页

作者： Kuang-Chung Shih Sheng-Hwu hsieh Chii-Min Hwu ching-Fai Kwok Szu-Han Chiu Yu-ching Chou Low-Tone Ho Division of Endocrinology and Metabolism Department of Medicine Taipei-Veterans General Hospital Taipei Taiwan Division of Endocrinology and Metabolism Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Division of Endocrinology and Metabolism Chang Gung Memorial Hospital Chang Gung University College of Medicine Taoyuan Taiwan Faculty of Medicine School of Medicine National Yang-Ming University Taipei Taiwan Department of Internal Medicine National Military Taoyuan General Hospital Taoyuan Taiwan School of Public Health National Defense Medical Center Taipei Taiwan Department of Medical Research Taipei-Veterans General Hospital Taipei Taiwan

The purpose of this study was to investigate the involvement of growth hormone in the diurnal variation of insulin sensitivity in healthy adults. Afternoon (16:00 hr) or night (23:00 hr) pretreatment with a subcutaneous injection of normal saline, human growth hormone to mimic the normal nocturnal rise in growth hormone, or octreotide to inhibit endogenous growth hormone secretion to create a state of relative nocturnal growth hormone deficiency, was given 16 hours before undergoing the modified insulin suppression test in healthy subjects. The morning and evening experiments were separated by an interval of at least 3 days. Thus, each subject was tested on six separate occasions arranged in a random order. A higher value of the steady-state plasma glucose (SSPG) is indicative of lower insulin sensitivity. Plasma glucose, serum insulin, insulin-like growth factor-1, nonesterified fatty acids (NEFA), and metabolic clearance rate of insulin (MCRI) were measured. In the normal saline and human growth hormone groups, SSPG levels were lower in the morning than in the evening. Evening SSPG levels, MCRI, and NEFA concentrations were higher in the participants treated with normal saline and growth hormone than in the octreotide group. Differences in SSPG levels between the morning and evening values were higher in the participants pretreated with normal saline and growth hormone than in those treated with octreotide. A diurnal variation in insulin sensitivity existed in healthy subjects. These results provided direct evidence that the role of growth hormone in regulating insulin sensitivity might be related to changes in the MCRI and the metabolism of NEFA in healthy subjects.

关键词： Insulin Sensitivity Dawn Phenomenon Growth Hormone Octreotide Healthy Adult

Mitigating Illumination-,Leaf-,and View-Angle Dependencies in Hyperspectral Imaging Using Polarimetry

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Plant Phenomics 2024年第2期6卷 309-322页

作者： Daniel Krafft Clifton G.Scarboro William hsieh Colleen Doherty Peter Balint-Kurti Michael Kudenov Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNCUSA NC Plant Sciences Initiative North Carolina State UniversityRaleighNCUSA Department of Molecular and Structural Biochemistry North Carolina State UniversityRaleighNCUSA Department of Entomology and Plant Pathology North Carolina State UniversityBox 7616RaleighNC 27695USA Plant Science Research Unit USDA-ARSRaleighNC 27695USA

Automation of plant phenotyping using data from high-dimensional imaging sensors is on the forefront of agricultural research for its potential to improve seasonal yield by monitoring crop health and accelerating breeding programs.A common challenge when capturing images in the field relates to the spectral reflection of sunlight(glare)from crop leaves that,at certain solar incidences and sensor viewing angles,presents unwanted *** research presented here involves the convergence of 2 parallel projects to develop a facile algorithm that can use polarization data to decouple light reflected from the surface of the leaves and light scattered from the leaf's tissue.

关键词： imaging dependencies hyperspectral illumination- leaf- mitigating polarimetry using view-angle

Characterization of horseshoe vortex in a developing scour hole at a cylindrical bridge pier

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International Journal of Sediment Research 2019年第2期34卷 118-124页

作者： Dawei Guan Yee-Meng Chiew Maoxing Wei Shih-Chun hsieh College of Harbour Coastal and Offshore EngineeringHohai University School of Civil and Environmental Engineering Nanyang Technological University

Since local scour at bridge piers in rivers and estuaries is a major cause of bridge failure,estimation of the maximum local scour depth is of great importance to hydraulic and coastal *** numerous studies that focus on scour-depth prediction have been done and published,understanding of the flow and turbulence characteristics of the horseshoe vortex that drives the scour mechanism in a developing scour hole still is *** study aims to quantify the detailed turbulent flow field in a developing clear-water scour hole at a circular pier using Particle Image Velocimetry(PIV).The distributions of velocity fields,turbulence intensities,and Reynolds shear stresses of the horseshoe vortex that form in front of the pier at different scour stages(t = 0,0.5,1,12,24,and 48 h)are presented in this *** scour development,the horseshoe vortex system was found to evolve from one initially small vortex to three *** strength and size of the main vortex are found to increase with increasing scour *** regions of both the maximum turbulence intensity and Reynolds shear stress are found to form at a location upstream of the main vortex,where the large turbulent eddies have the highest possibility of *** from this study not only provide new insight into the complex flow-sediment interaction at bridge piers,but also provide valuable experimental databases for advanced numerical simulations.

关键词： Sediment transport Scour Bridge pier PIV Horseshoe vortex Turbulence Scour hole

Human-micromanipulator cooperation using a variable admittance controller

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Science China(Information Sciences) 2019年第5期62卷 14-16页

作者： hsieh-Yu LI Theshani NURADHA Sebaratnam Alex XAVIER U-Xuan TAN Pillar of Engineering Product Development Singapore University of Technology and Design Department of Electronic and Telecommunication Faculty of Engineering University of Moratuwa

Dear editor,Micro-scale operations, such as microsurgery [1]and micro-devices assembly [2], have been gaining importance among different industries. However,it is challenging to execute these operations owing to the accuracy requirements of the operation which are close to the limit of the human hand accuracy. For example, microsurgery is a diffi-

关键词： Human-micromanipulator cooperation using a variable admittance controller

Automated and miniaturized screening of antibiotic combinations via robotic-printed combinatorial droplet platform

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1801-1813页

作者： Fangchi Shao Hui Li Kuangwen hsieh Pengfei Zhang Sixuan Li Tza-Huei Wang Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Department of Mechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA

Antimicrobial resistance(AMR)has become a global health crisis in need of novel *** this end,antibiotic combination therapies,which combine multiple antibiotics for treatment,have at-tracted significant attention as a potential approach for combating *** facilitate advances in anti-biotic combination therapies,most notably in investigating antibiotic interactions and identifying synergistic antibiotic combinations however,there remains a need for automated high-throughput plat-forms that can create and examine antibiotic combinations on-demand,at scale,and with minimal reagent *** address these challenges,we have developed a Robotic-Printed Combinatorial Droplet(RoboDrop)platform by integrating a programmable droplet microfuidic device that generates antibiotic combinations in nanoliter droplets in automation,a robotic arm that arranges the droplets in an array,and a camera that images the array of thousands of droplets in *** further implement a resazurin-based bacterial viability assay to accelerate our antibiotic combination *** a demonstration,we use RoboDrop to corroborate two pairs of antibiotics with known interactions and subsequently identify a new synergistic combination of cefsulodin,penicillin,and oxacillin against a model *** *** therefore envision RoboDrop becoming a useful tool to efficiently identify new synergistic antibiotic combinations toward combating AMR.

关键词： Droplet microfluidics Antimicrobial resistance Antibiotic combinatorial screening Contact printing Robotics Pharmaceutical analysis High-throughput Antibiotic interactions

Roux-en-Y reconstruction does not require gastric decompression after radical distal gastrectomy

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World Journal of Gastroenterology 2012年第3期18卷 251-256页

作者： Cheng-Jueng Chen Tsang-Pai Liu Jyh-Cherng Yu Sheng-Der Hsua Tsai-Yuan hsieh Heng-Cheng Chu Chung-Bao hsieh Teng-Wei Chen, De-Chuan Chan Division of General Surgery Tri-Service General Hospital National Defense Medical Center 11490 Taipei Taiwan China Department of Surgery Mackay Memorial Hospital Mackay Medicine Nursing and Management College Peitou 10449 Taipei Taiwan China Division of Gastroenterology Tri-Service General Hospital National Defense Medical Center 11490 Taipei Taiwan China

AIM: To determine whether routine nasogastric (NG) decompression benefitted patients undergoing radical gastric surgery. METHODS: Between January 1998 and December 2008, 519 patients who underwent distal gastrectomy for gastric cancer were retrospectively divided into 2 time-period cohorts; those treated with Billroth Ⅱ (BⅡ) reconstruction in the first 6 years and those with Roux-en-Y (RY) reconstruction in the last 5 years. In the latter group, the patients were further divided into 2 subgroups; with and without nasogastric ***: Postoperatively, there were no significant differences in the number of anastomotic leaks between the 3 groups. In the tubeless RY group, time to semiliquid diet was significantly shorter than in the other 2 groups (4.4 d ± 1.4 d vs 7.2 d ± 1.3 d and 5.9 d ± 1.2 d, P = 0.005). The length of postoperative stay was significantly increased in patients with BⅡ reconstruction compared with patients with RY reconstruction with/without NG decompression (15.4 d ± 4.3 d in BⅡ group vs 12.6 d ± 3.1 d in decompressed RY and 11.4 d ± 3.4 d in the tubeless RY group, P = 0.035). The postoperative pneumonia rate was lowest in the tubeless group and highest in the BⅡ group (1.4% vs 4.6%, P = 0.01). Severe sore throat was noted in 59 (20.7%) members of the BⅡ group, 18 (17.4%) members of the decompressed RY group and 6 (4.2%) members of the tubeless RY group. Fewer patients in the tubeless group complained of severe sore throat (P = 0.001). CONCLUSION: This study provides support for abandoning routine NG decompression in patients undergoing subtotal gastrectomy with Roux-en-Y gastrojejunostomy.

关键词： Nasogastric decompression Billroth Ⅱ gas- trojejunostomy Roux-en-Y gastrojejunostomy Radical distal gastrectomy Gastric cancer

Relationship of Brazing Microstructure and Ti-Cu-Ni Phase Diagram

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材料科学与工程（中英文B版） 2017年第4期7卷 142-148页

作者： Ming-Chi Ho Pei Jen Lo Wei-liang Liu Ker-Chang hsieh Department of Materials and Optoelectronic Science National Sun Yat-Sen University Kaohsiung 804 Taiwan Metal Industries Research & Development Center Kaohsiung 804 Taiwan