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Management of retroperitoneal high-grade serous carcinoma of unknown origin:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1190-1195页

作者： Wen-Lin hsieh Dah-ching Ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi UniversityHualien 970Taiwan Institute of Medical Sciences Tzu Chi UniversityHualien 970TaiwanTaiwan

BACKGROUND Retroperitoneal high-grade serous carcinoma(HGSC)of unknown origin is a sporadic tumor that can originate from ovarian ***,we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and *** SUMMARY A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U/mL upon a regular health *** tomography revealed retroperitoneal lymph node ***,positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the *** a result,she underwent laparoscopic lymph node resection,and pathology revealed metastatic adenocarcinoma with CK7(+),PAX8(+),WT1(+),PR(-),and p53 mutational loss of expression,indicating that the origin may be from the *** patient was admitted to our ward and underwent laparoscopic staging;however,the pathological results were *** the suspicion of retroperitoneal HGSC of unknown origin,chemotherapy and targeted therapy were *** marker levels decreased after *** We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy,staging surgery,chemotherapy,and targeted therapy.

关键词： High-grade serous carcinoma Retroperitoneum Origin Chemotherapy Lymph node Case report

Effect of Fe metal on the growth of silicon oxide nanowires

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 317-321页

作者： Wei-long Liu Shu-huei hsieh ching He Chen Wen-jauh Chen Department of Materials Science and Engineering Formosa University Yunlin 632 China Taipei Department of Materials Engineering Pingtung University of Science and Technology Pingtung 912 China Taipei Graduate School of Materials Science Yunlin University of Science and Technology Yunlin 632 China Taipei

Silicon oxide （SiOx） nanowires are generally grown on Si substrate under the catalysis of Au in N2 atmosphere at elevated temperatures. Because the price of Au metal is quite high, Fe metal is then used to replace a part of Au for catalyzing the growth of SiOx nanowires. The results show that the Fe film can be used as the diffusion barrier of Au. SiOx nanowires are grown on Au/Fe/Si substrate at 1030℃. Under the catalysis of Fe/Au, the efficiency for the growth of SiOx nanowires is promoted.

关键词： silicon oxide nanowires Au catalyst Fe substitution Si substrate

Hepatic immune tolerance induced by hepatic stellate cells

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World Journal of Gastroenterology 2015年第42期21卷 11887-11892页

作者： ching-Chuan hsieh Chien-Hui Hung Lina Lu Shiguang Qian Department of Surgery Chang Gung Memorial Hospital at Chiayi Graduate Institute of Clinical Medical Sciences Chang Gung University Department of Immunology Lerner Research Institute Transplantation Center Digestive Disease Institute Cleveland Clinic Department of General Surgery Transplantation Center Digestive Disease Institute Cleveland Clinic

The liver, which is a metabolic organ, plays a pivotal role in tolerance induction. Hepatic stellate cells(Hp SCs), which are unique non-parenchymal cells, exert potent immunoregulatory activity during cotransplantation with allogeneic islets effectively protecting the islet allografts from rejection. Multiple mechanisms participate in the immune tolerance induced by Hp SCs, including the marked expansion of myeloid-derived suppressor cells(MDSCs), attenuation of effector T cell functions and augmentation of regulatory T cells. Hp SC conditioned MDSC-based immunotherapy has been conducted in mice with autoimmune disease and the results show that this technique may be promising. This article demonstrates how Hp SCs orchestrate both innate immunity and adaptive immunity to build a negative network that leads to immune tolerance.

关键词： Hepatic stellate cells Myeloid-derived suppressor

Numerical study of the effects of check dams on erosion and sedimentation in the Pachang River

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International Journal of Sediment Research 2013年第3期28卷 304-315页

作者： Hui-ming hsieh ching-ruey LUO Jinn-chuang YANG Rou-fei CHEN Department of Computer Science and Multimedia Design Taiwan Shoufu University Department of Civil Engineering National Chi-Nan University Dept.of Civil Engineering National Chiayio Tung University Department of Geology Chinese Culture University

Scouring and deposition processes resulting from variable rainfall and typhoon occurrence in tropical climatic conditions induce significant changes in the riverbeds of *** the Pachang River of western Taiwan,severe damage occurs during typhoons due to large and sudden variations in discharge,erosion,sediment transport and *** order to simulate this process,the NETSTARS numerical modeling tool was used in the present *** influence of existing and planned check dam structures on flow control was also analyzed to determine their capacity to resist river erosion or to not be buried beneath *** only does the modeling tool allow calculation of the erosion-deposition behavior at the scale of the whole river,but it also provides local determination of the optimum location and characteristics such as foundation depth and lateral encroachment of future check *** results of a 10-year,long-term modeling simulation in terms of riverbed stability and scouring potential thus provide insights about unsafe future behavior at 4 *** numerical model provides a better general understanding and useful information for the optimal prevention of both the scouring damage and the burial related to sediment deposition with large changes in discharge and sediment transport.

关键词： NETSTARS model River bed erosion Check dam Pachang River

Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

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World Journal of Gastroenterology 2016年第12期22卷 3372-3380页

作者： ching-Yu Lai Ling-Ling hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh Chih-ching Yeh School of Public Health College of Public Health and Nutrition Taipei Medical University Taipei 11031 Taiwan Department of Public Health Chang Gung University Taoyuan 333 Taiwan Colorectal Section Chang Gung Memorial Hospital Taoyuan 333 Taiwan Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York NY 10032 United States Department of Public Health College of Public Health China Medical University Taichung 404 Taiwan

AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) ***: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were ***: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population.

关键词： APE1 OGG1 Taiwan Colorectal cancer Polymorphisms

Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan

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World Journal of Gastroenterology 2005年第10期11卷 1473-1480页

作者： Chih-ching Yeh Ling-Ling hsieh Reiping Tang Chung Rong Chang-Chieh Fung-Chang Sung Institute of Environmental Health Department of Public Health Colorectal Section

AIM: To investigate the colorectal cancer risk associated with polymorphic GSTM1, GSTT1 and GSTP1 and the effect of diet and ***: With consents, genotypes of the genes were determined using PCR methods for 727 cases and 736sex and age-matched healthy controls recruited at a medical center in the Northern Taiwan. Nurses who were blind to the study hypothesis conducted interviews with study participants for the information of socio-demographic variables, diet and ***: There was no significant association between GSTM1 genotypes and the disease. Men, not women, with GSTT1 null genotype were at significant risk of colorectal cancer, but limited to rectal tumor, and in men aged 60 years and less. The corresponding association with the GSTP1 with G allele compared to GSTP1 A/A genotype was at borderline significance. Compared to men with GSTT1 present and GSTP1 A/A combined, men with both GSTT1 null and GSTP1 with G allele genotypes were at significant risk (odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.21-3.02), also limited to the rectal tumor and younger men. The beneficial effects of vegetable/fruit intake on colorectal cancer were much higher for men with GSTT1 present (OR = 0.32, 95%CI = 0.20-0.50) or GSTP1 A/A genotypes (OR = 0.40, 95%CI = 0.25-0.64).These effects remained significant for women. But, the greatest protective effect from vegetable/fruit intake for women was observed in those with GSTT1 null or GSTP1 with G allele genotypes. In addition, non-smoking men benefitted significantly from combined effect of higher vegetable/fruit intake and GSTT1 present or GSTP1 A/A genotypes with OR = 0.17 and 0.21 ***: This study suggests that the GSTT1 gene can modulate the colorectal cancer risk and vegetable/fruit-related colorectal cancer risk, particularly in men of no smoking history.

关键词： Colorectal cancer Glutathione S-transferase Polymorphisms Vegetables Smoking

Delayed ischemic gangrene change of distal limb despite optimal decompressed colostomy constructed in obstructedsigmoid colon cancer:A case report

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World Journal of Gastroenterology 2006年第6期12卷 993-995页

作者： Wen-Shih Huang Kuang-Wen Liu Paul Y Lin ching-Chuan hsieh Jeng-Yi Wang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial Hospital ChiayiTaiwan Graduate Institute of Clinical Medicine Chang Gung UniversityTaoyuanTaiwanChina Department of Surgery E-Da Hospital/Ⅰ-Shou University KaohsiungTaiwanChina Division of Anatomical Pathology Department of Pathology Chang Gung Memorial HospitalChiayiTaiwanChina Division of General Surgery Department of Surgery Chang Gung Memorial HospitalChiayiTaiwanChina Division of Colon and Rectal Surgery Department of Surgery Chang Gung Memorial HospitalChiayiTaiwanChina

Creating blow-hole colostomy for decompression could provide a time-saving and efficient surgical procedure for a severely debilitated case with a completely obstructed colorectal cancer. Complications are reported as prolapse, retraction, and paracolostomal abscess. However, complication with an ischemic distal limb has not been reported. We report a case of critical intra-abdominal disease after decompressed colostomy for relieving malignant sigmoid colon obstruction; a potential fatal condition should be alerted. A 76-year-old male visited our emergency department for symptoms related to obstructed sigmoid colon tumor with foul-odor vomitus containing fecal-like materials. An emergent blow-hole colostomy proximal to an obstructed sigmoid lesion was created, and resolution of complete colon obstruction was pursued. Unfortunately, extensive abdominal painful distention with board-like abdomen and sudden onset of high fever with leukocytopenia developed subsequently. Such surgical abdomen rendered a secondary laparotomy with resection of the sigmoid tumor along with an ischemic colon segment located proximally up to the previously created colostomy. Eventually, the patient had an uneventful postoperative hospital stay. In the present article, we have described an emergent condition of sudden onset of distal limb ischemia after blow-hole colostomy and concluded that despite the decompressed colostomy would resolve acute malignant colon obstruction efficiently; impending ischemic bowel may progress with a possible irreversible peritonitis. Any patient, who undergoes a decompressed colostomy without resection of the obstructed lesion, should be monitored with leukocyte count and abdominal condition survey frequently.

关键词： Colorectal cancer obstruction Colostomy IschemJc colitis Laparotomy

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

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World Journal of Stem Cells 2022年第1期14卷 76-91页

作者： Hsi-Lung hsieh Ming-Chin Yu Li-ching Cheng Ta-Sen Yeh Ming-Ming Tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial Hospital at LinkouTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Gastric cancer(GC)is a primary cause of cancer-related mortality worldwide,and even after therapeutic gastrectomy,survival rates remain *** presence of gastric cancer stem cells(GCSCs)is thought to be the major reason for resistance to anticancer treatment(chemotherapy or radiotherapy),and for the development of tumor recurrence,epithelial–mesenchymal transition,and ***,GCSCs have the capacity for self-renewal,differentiation,and tumor *** also synthesize antiapoptotic factors,demonstrate higher performance of drug efflux pumps,and display cell plasticity ***,the tumor microenvironment(TME;tumor niche)that surrounds GCSCs contains secreted growth factors and supports angiogenesis and is thus responsible for the maintenance of the growing ***,the genesis of GCSCs is unclear and exploration of the source of GCSCs is *** this review,we provide up-todate information about GCSC-surface/intracellular markers and GCSC-mediated pathways and their role in tumor *** information will support improved diagnosis,novel therapeutic approaches,and better prognosis using GCSC-targeting agents as a potentially effective treatment choice following surgical resection or in combination with chemotherapy and *** date,most anti-GCSC blockers when used alone have been reported as unsatisfactory anticancer ***,when used in combination with adjuvant therapy,treatment can *** providing insights into the molecular mechanisms of GCSCs associated with tumors in GC,the aim is to optimize anti-GCSCs molecular approaches for GC therapy in combination with chemotherapy,radiotherapy,or other adjuvant treatment.

关键词： Gastric cancer stem cells Stem cell-surface markers Tumor niche Tumor microenvironment

A Program of Art Education Exploring Life Issues --By Two Nudity Artworks

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Journal of Literature and Art Studies 2013年第11期3卷 708-717页

作者： Yu-ching hsieh National Chin-Yi University of Technology Taichung Taiwan

The purpose of this essay is to design an art education program based on post-modernist concepts to lead students to contemplate the meaning of life and build their insight about visual imagery of artworks, by looking at two nudity artworks--Edward Munch＇s ＂Puberty＂ and Frida Kahlo＇s ＂The Broken Column＂. The program will look at metaphors and the significance of life in these two artworks. Over and above exploring relative philosophical, aesthetic, historical, hermeneutic, and semiotic domains, the program will be designed in such a way that the intrinsic quality of art will be emphasized. The research method is a visual narrative approach, including image interpretation. Its purpose is to encourage students to consider how they experience life, the emotional elements of life, as well as the spiritual progression, physiological development, anxiety and suffering of life, etc.. The program will also provide students with diverse information and potential ways of thinking about and discussing the issues of life and art by using questions in a learning list. This program will be employed and executed over two hours of class time. It could become the general education teaching material or art curriculum.

关键词： interpretation art curriculum life issue metaphor narrative