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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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经典电路网络中奇异束缚态的实验观察

Science Bulletin 2024年第14期69卷 2194-2204页

作者：邹德源陈天孟海瑜 yee Sin Ang 张向东李庆华 Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Department of Physics National University of SingaporeSingapore 117542Singapore Science Mathematics and Technology ClusterSingapore University of Technology and DesignSingapore 487372Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China

Exceptional bound(EB)states represent a unique new class of robust bound states protected by the defectiveness of non-Hermitian exceptional *** distinct from the more well-known topological states and non-Hermitian skin states,they were recently discovered as a novel source of negative entanglement entropy in the quantum entanglement ***,EB states have been physically elusive,being originally interpreted as negative probability eigenstates of the propagator of nonHermitian Fermi *** this work,we show that EB states are in fact far more ubiquitous,also arising robustly in broad classes of systems whether classical or *** hinges crucially on a newlydiscovered spectral flow that rigorously justifies the EB nature of small candidate lattice *** a highlight,we present their first experimental realization through an electrical circuit,where they manifest as prominent stable resonant voltage *** work brings a hitherto elusive but fundamentally distinctive quantum phenomenon into the realm of classical metamaterials,and provides a novel pathway for the engineering of robust modes in otherwise sensitive systems..

关键词： Exceptional bound states Classical circuit network Non-Hermitian Robustness Exceptional point

Sonication and grinding pre-treatments on Gelidium amansii seaweed for the extraction and characterization of Agarose

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Frontiers of Environmental Science & Engineering 2018年第4期12卷 17-23页

作者： Kit Wayne Chew Pau Loke Show yee Jiun yap Joon ching Juan Siew Moi Phang Tau Chuan Ling Jo-Shu Chang Department of Chemical and Environmental Engineering Faculty of Engineering University of Nottingham Malaysia Campus Jalan Broga 43500 Semenyih Selangor Darul Ehsan Malaysia Bioseparation Research Group Faculty of Engineering University of Nottingham Malaysia Campus Jalan Broga 43500 Semenyih Selangor Darul Ehsan Malaysia Department of Applied Mathematics Faculty of Engineering University of Nottingham Malaysia Campus Jalan Broga 43500 Semenyih Selangor Darul Ehsan Malaysia Nanotechnology & Catalysis Research Centre (NANOCAT) Institute of Postgraduate Studies University of Malaya 50603 Kuala Lumpur Malaysia Institute of Ocean and Earth Sciences University of Malaya 50603 Kuala Lumpur Malaysia Institute of Biological Sciences University of Malaya 50603 Kuala Lumpur Malaysia Department of Chemical Engineering National Cheng Kung University Tainan 701 Taiwan China

Various prctreatments methods including sonication and grinding were perfonned on red seaweed Gelidium amansii for the subsequent extraction ofagarose. The agarose products are usually extracted from agar powder products from seaweeds. In this study, the agarose was extracted using a direct polyethylene glycol （PEG） method without the need to first process the agar from seaweed. The agar extract was frozen then thawed and mixed directly with PEG solution to precipitate the agarose. The quality of agarose obtained was evaluated through physico-chemical properties analysis which includes spectral technique （FTIR）, melting and boiling point, gel strength and sulfate content. These properties were compared with a non-pretreated sample and it was found that the addition of pretreatment steps improved the quality of agarosc but gave a slightly lower yield. The gel strength of pretreated samples was much higher and the sulfate content was lower compared to non-pretreated samples. The best pretreatment method was sonication which gave gel strength of 742 gcm - and sulfate content of 0.63%. The extraction of agarose can be further improved with the use of different neutralizing agents. Pretreating the seaweed shows potential in improving the quality of agarosc from seaweed and can be applied for thture extraction of the agarose.

关键词： AgaroseGe lidium Pretreatment Seaweed Sonication

Artificial Intelligence Based MPPT Techniques for Solar Power System: A review

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1043-1059页

作者： Kah Yung yap Charles R.Sarimuthu Joanne Mun-yee Lim the Department of Electrical and Computer Systems Engineering(ECSE) School of EngineeringMonash UniversitySubang JayaMalaysia

In the last decade,artificial intelligence(AI)techniques have been extensively used for maximum power point tracking(MPPT)in the solar power *** is because conventional MPPT techniques are incapable of tracking the global maximum power point(GMPP)under partial shading condition(PSC).The output curve of the power versus voltage for a solar panel has only one GMPP and multiple local maximum power points(MPPs).The integration of AI in MPPT is crucial to guarantee the tracking of GMPP while increasing the overall efficiency and performance of *** selection of AI-based MPPT techniques is complicated because each technique has its own merits and *** general,all of the AI-based MPPT techniques exhibit fast convergence speed,less steady-state oscillation and high efficiency,compared with the conventional MPPT ***,the AI-based MPPT techniques are computationally intensive and costly to ***,the hybrid MPPT is favorable in terms of the balance between performance and complexity,and it combines the advantages of conventional and AI-based MPPT *** this paper,a detailed comparison of classification and performance between 6 major AI-based MPPT techniques have been made based on the review and MATLAB/Simulink simulation *** merits,open issues and technical implementations of AI-based MPPT techniques are *** intend to provide new insights into the choice of optimal AI-based MPPT techniques.

关键词： Maximum power point tracking(MPPT) artificial intelligence(AI) fuzzy logic control(FLC) artificial neural network(ANN) genetic algorithm(GA) swarm intelligence(SI) machine learning(ML)

Development of a system configuration for a solar powered hydrogen facility using fuzzy logic control

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第11期14卷 822-834页

作者： Ying-tai LOONG Mahidzal DAHARI Hwa-jen yap Hue-yee CHONG Department of Mechanical Engineering Faculty of Engineering University MalayaKuala Lumpur 50603 Malaysia

Solar energy is a natural resource which can be harnessed to provide clean electricity for hydrogen production ***, this technology is not widely used because of control issues, particularly for hydrogen refuelling stations. At present,direct or DC-DC converter couplings are the most common system configurations for hydrogen refuelling stations. However, these system configurations are costly and suffer from gas shortage at hydrogen refuelling stations. Furthermore, the hydrogen produced by such system configurations varies considerably depending on the levels of solar radiation. In order to address these issues, a new system configuration is proposed, incorporating the feedback signal of the storage level in the control system. The photovoltaic(PV) system, electrolyzer, and storage tank are integrated with a fuzzy logic controller(FLC) to determine the backup current compensation for electrolyzer operation in order to obtain the minimum power required for hydrogen production. The proposed FLC is constructed with three input variables which are the PV current, hydrogen storage level, and the battery state of charge. The rules-based fuzzy inference process is based on the proposed configuration which combines the advantages of direct and DC-DC converter coupling configurations. The simulation results show that the proposed configuration offers better adaptability to variable radiation conditions compared to other methods. This gives a more promising option for ensuring the adequacy of hydrogen supply at hydrogen refuelling stations.

关键词： Hydrogen energy Solar energy Hydrogen refueling facility Fuzzy logic

Fuzzy-based risk prioritization for a hydrogen refueling facility in Malaysia

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 834-834页

作者： Hue-yee Chong Mahidzal Dahari Hwa-jen yap Ying-tai Loong Department of Mechanical Engineering Faculty of Engineering University Malaya

Hydrogen is starting to be mentioned as an alternative fuel to replace the fossil fuel in future transportation applications due to its characteristics of zero greenhouse gas emission and high energy efficiency. Before hydrogen fuel and its facilities can be introduced to the public, relevant safety issues and its hazards must be assessed in order to avoid any chance of injury or loss. While a traditional risk assessment has difficulty in prioritizing the risk of failure modes, this paper proposes a new fuzzy-based risk evaluation technique which uses fuzzy value to prioritize the risk of various scenarios. In this study, the final risk of each failure modes was prioritized by using the MATLAB fuzzy logic tool box with a combination of two assessments. The first assessment was concerned with the criteria which affected the actual probability of *** assessment considered the availability of the standard that was applied to prevent the likelihood of the scenario occurring. On the other hand, the second assessment was focused on evaluating the consequence of the failure by taking into account the availability of detection and the complexity of the failure rather than only the severity of the scenarios. A total of 87 failure scenarios were identified using failure modes and effect analysis(FMEA) procedures on hydrogen refueling station models. Fuzzy-based assessments were performed through risk prioritizing various failure scenarios with a fuzzy value(0 to 1) and risk level(low, medium, and high)while a traditional risk assessment approach presented the risks only in forms of level(low, medium, and/or high). Availability of the fuzzy value enabled further prioritizing on the risk results that fell in the same level of risk. This study concluded that fuzzy-based risk evaluation is able to further prioritize the decisions when compared with a traditional risk assessment method.

关键词：风险评估方法模糊值加氢站马来西亚设施优先级模糊逻辑工具箱故障模式

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Automatic analysis of deep-water remotely operated vehicle footage for estimation of Norway lobster abundance

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Frontiers of Information Technology & Electronic Engineering 2018年第8期19卷 1042-1055页

作者： ching Soon TAN Phooi yee LAU Paulo L.CORREIA Aida CAMPOS Centre for Computing and Intelligent Systems Universiti Tunku Abdul RahmanKampar 31900Malaysia lnstituto de Telecomunicaqoes Instituto Superior TecnicoAv.Rovisco Pais1Lisbon 1049-001Portugal Instituto Portugues do Mar e da Atmosfera(IPMA) Divisao de Modelacao e Gestao de Recursos da PescaLisbon 1749-077Portugal Centro de Ciencias do Mar(CCMAR)-Campus de Gambelas Faro 8005-139Portugal

Underwater imaging is being used increasingly by marine biologists as a means to assess the abundance of marine resources and their biodiversity. Previously, we developed the first automatic approach for estimating the abundance of Norway lobsters and counting their burrows in video sequences captured using a monochrome camera mounted on trawling gear. In this paper, an alternative framework is proposed and tested using deep-water video sequences acquired via a remotely operated vehicle. The proposed framework consists of four modules:(1) preprocessing,(2) object detection and classification,(3) object-tracking, and(4) quantification. Encouraging results were obtained from available test videos for the automatic video-based abundance estimation in comparison with manual counts by human experts(ground truth). For the available test set, the proposed system achieved 100%precision and recall for lobster counting, and around 83% precision and recall for burrow detection.

关键词： Object detection Object tracking Feature extraction Remotely operated vehicle(ROV)

Skin Impedance at Acupuncture Point Dingchuan in Subjects with and without Asthma

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中国康复医学杂志 2009年第6期24卷 481-484页

作者： Ngai Shirley Pui-ching Jones Alice yee-men Department of Rehabilitation Sciences The Hong Kong Polytech- nic University Hong Kong

Objective:Asthma can be a disabling disease and despite advances in pharmacology,the prevalence of this condition globally remains high and accounts for a significant proportion of public health care *** pharmacology is the mainstay of asthma management,drug side effects have promoted alternative therapeutic interventions,such as *** points have a lower skin impedance compared to non-acupuncture *** impairment is associated with changes in skin impedance at system-specific acupuncture *** of skin impedance changes may assist in the early diagnosis of asthma and monitoring the effectiveness of therapeutic interventions for this ***:This study compared skin impedance at acupuncture point Dingchuan(EX-B1),in 92 subjects with normal health(47 subjects,age 32.6 ±1.67yr) and those diagnosed with asthma(45 subjects,age 42.4 ±1.80 yr).Skin impedance was measured using a 2-electrode impedance meter bilaterally at EX-B1,0.5 "cun" lateral to the lower border of 7th cervical ***:The study showed that skin impedance was significantly higher at acupuncture point EX-B1 in subjects with asthma(29.4 ± 21 kΩ) compared to subjects with normal health(13.8±7.9 kΩ)(P=0.013).Skin impedance was negatively correlated to forced expiratory volume in 1 second(FEV1,r=-0.59,P=0.012 in females;and r=-0.68,P=0.015 in males).A receiver operator characteristic(ROC) curve revealed an optimum cut-off point of 35 kΩ for male and 10 kΩ for female ***:We conclude that EX-B1 skin impedance is higher in patients with asthma and skin impedance might be a possible adjunctive parameter for assisting diagnosis and monitoring asthmatic status.

关键词：哮喘治疗方法临床分析诊断方法

INTERPRETATION OF COPPER AND ZINC CONTAMINATION IN THE AQUATIC ENVIRONMENT OF PENINSULAR MALAYSIA WITH SPECIAL REFERENCE TO A POLLUTED RIVER,SEPANG RIVER

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湿地科学 2007年第4期5卷 311-321页

作者： Chee Kong yap Ahmad Ismail ching How Low Soon Guan Tan Department of Biology Faculty of ScienceUniversity Putra MalaysiaUPM 43400SerdangSelangorMalaysia

Three different aquatic ecosystems(an urban pond,Kelana Jaya Pond;a polluted river,Sepang River;and the intertidal and offshore areas of the west coast of Peninsular Malaysia)with different sets of ecological backgrounds and human activities were reviewed and assessed for the levels of Cu and Zn contamination with special reference to those found in polluted sediments collected from the Sepang *** discussion on the contamination levels of Cu and Zn in the aquatic environment of Peninsular Malaysia was based on a comparison of the metal contamination of 4 kinds of aquatic *** comparison of 4 different areas was based on ① total concentrations of 2 metals;② the concentrations and percentages of the nonresistant(EFLE,acid-reducible and oxidisable-organic)and resistant geochemical fractions;and ③ correlation coefficients(R-values)based on data of 4 areas separately and a combination of 4 *** Sepang River recorded nonresistant fractions of 63.1% for Zn and 55.8% for Cu in addition to slightly lower metal concentrations when compared to those(60%-70%)reported before the shutting down of the piggery activities in that *** nonresistant metal percentages(55%-63%)indicated that the metal concentrations were still dominated by anthropogenic sources since nonresistant fraction of metals were mostly contributed by anthropogenic *** positive results from the four different aquatic environments assessed here provided strong evidence to show that Malaysia's aquatic environment had received anthropogenic Cu and *** present study also showed that the percentage of the nonresistant fraction and the R-values based on correlation analysis of Cu and Zn could be used as indicators of Cu and Zn pollution in the Malaysian aquatic *** on the present data,the correlation coefficients(R-values)are potential indicators of EFLE Cu and acid-reducible Cu of the *** use of R-values as indicators of metal pollution is suggested and it

关键词：铜污染锌污染水生环境环境污染马来群岛沉积物