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Evidence-based expert consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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chinese Journal of Cancer research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing Rongsheng Zhao the Steering committee,the Consensus Panel and the Evidence Synthesis Group Evidence-based Pharmacy Professional committee of chinese Pharmaceutical association(CPA) hospital Pharmacy Professional committee of chinese Pharmaceutical association(CPA) Division of Therapeutic Drug Monitoring of chinese Pharmacological Society(CPS) Expert committee on Lymphoma of chinese Society of Clinical Oncology(CSCO) Expert committee on Leukemia of chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of china Anti-Cancer association(CACA) chinese Society of Hematology of chinese medical association(CMA) hospital Pharmacy Professional committee of Cross-Straits Medicine Exchange association(SMEA) Department of Pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Department of Pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic expert consensus from a pharmacological perspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based expert consensus was formulated using an evidence-based approach and the Delphi *** Joanna Briggs Institute Critical Appraisal(JBI)tool and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary expert consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

Stress Echocardiography for Chronic Coronary Syndrome:Clinical Practice Guidelines(2023)

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Journal of Geriatric Cardiology 2024年第5期21卷 475-505页

作者： Peng-Fei ZHANG Jia-Wei TIAN Tian-Gang ZHU Jue-Fei WU Xiao-Ping LENG Yi WANG Meng-Meng LI Xin-Hao LI Qian-Qian WANG Xiao-Peng FENG Jia-Yan LV Li-Xue YIN Yun ZHANG Mei ZHANG chinese Society of Echocardiography,Superficial Tissue and Vascular Group of chinese Society of Ultrasound in Medicine,Ultrasound Professional committee of chinese Medicine Education association State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanChina The Second Affiliated hospital of Harbin medical University HaerbinChina Peking University People's hospital BeijingChina Sichuan Province People's hospital ChengduChina Nanfang hospital Southern Medical UniversityGuangzhouChina Peking Union medical College hospital Chinese Academy of Medical SciencesBeijingChina 不详

In the context of the People's Republic of china,coronary artery disease(CAD)presents a sig-nificant clinical challenge,with over 11.3 mil-lion patients ***,the diagnos-is of CAD has predominantly relied on invasive coronary angiography.[1]However,recent advances in clinical research have revealed a notable trend:a substantial 82% of patients subjected to such invas-ive diagnostics do not necessitate interventional therapy.

关键词： coronary clinical patients

中国ERCP致十二指肠穿孔并发症管理指南(2023版)

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中华消化外科杂志 2024年第1期23卷 1-9页

作者：中华医学会消化内镜学分会内镜外科学组中国医师协会外科医师分会内镜外科专家工作组中国医师协会胰腺病专业委员会李汛不详兰州大学第一医院普通外科兰州730030

ERCP目前已成为诊断和治疗胆胰疾病的重要手段之一。十二指肠穿孔是ERCP术后最严重的并发症,其处理棘手,病死率高。为规范ERCP临床管理,改善患者结局,中华医学会消化内镜学分会内镜外科学组、中国医师协会外科医师分会内镜外科专家工作... 详细信息

ERCP目前已成为诊断和治疗胆胰疾病的重要手段之一。十二指肠穿孔是ERCP术后最严重的并发症,其处理棘手,病死率高。为规范ERCP临床管理,改善患者结局,中华医学会消化内镜学分会内镜外科学组、中国医师协会外科医师分会内镜外科专家工作组、中国医师协会胰腺病专业委员会组织国内ERCP领域专家,基于最新循证医学证据,制订《中国ERCP致十二指肠穿孔并发症管理指南(2023版)》,就临床医师最关注的ERCP致十二指肠穿孔并发症管理的6个方面给出16条推荐意见,以期进一步规范我国ERCP致十二指肠穿孔的诊断与治疗流程,促进ERCP技术的安全推广。

关键词：经内镜逆行胰胆管造影术内镜外科十二指肠穿孔并发症指南

中国髓外浆细胞瘤诊断与治疗专家共识(2024年版)

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中华血液学杂志 2024年第1期45卷 8-17页

作者：中华医学会血液学分会浆细胞疾病学组中国医师协会多发性骨髓瘤专业委员会黄晓军吴德沛李娟不详国家血液系统疾病临床医学研究中心北京大学人民医院北京大学血液病研究所造血干细胞移植治疗血液病北京市重点实验室北京100044 国家血液系统疾病临床医学研究中心江苏省血液研究所苏州大学附属第一医院苏州215006 中山大学附属第一医院广州510080

髓外浆细胞瘤(extramedullary plasmacytoma,EMP)是恶性浆细胞病的一种特殊类型,表现复杂、异质性强。大部分EMP预后差,缺乏循证医学证据支持下的预后分层系统和理想的治疗策略,无法满足临床需求。为提高对这类疾病的认识,中华医学会血... 详细信息

髓外浆细胞瘤(extramedullary plasmacytoma,EMP)是恶性浆细胞病的一种特殊类型,表现复杂、异质性强。大部分EMP预后差,缺乏循证医学证据支持下的预后分层系统和理想的治疗策略,无法满足临床需求。为提高对这类疾病的认识,中华医学会血液学分会浆细胞疾病学组和中国医师协会多发性骨髓瘤专业委员会编写《中国髓外浆细胞瘤诊断与治疗专家共识》,旨在规范EMP的临床诊治,最终改善浆细胞瘤患者的总体生存。

关键词：浆细胞瘤诊断鉴别临床方案

颈侧方切口胸锁乳突肌肌间入路甲状腺手术中国专家共识(2024版)

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中华内分泌外科杂志（中英文） 2024年第2期18卷 149-155页

作者：中国医师协会外科医师分会甲状腺外科专家工作组中国研究型医院学会甲状腺疾病专业委员会中国医疗保健国际交流促进会普通外科学分会田文邬一军黄韬余济春钟江涛(绘图) 不详解放军总医院第一医学中心普通外科医学部甲状腺(疝)外科北京100853 浙江大学医学院附属第一医院甲状腺外科杭州310003 华中科技大学同济医学院附属协和医院南昌大学第二附属医院浙江大学医学院附属第一医院

颈侧方切口胸锁乳突肌肌间入路甲状腺手术采用颈侧区皮纹切口,通过胸锁乳突肌胸骨头与锁骨头间的天然间隙进入甲状腺术区,直视下分离并保护喉返神经、喉上神经、甲状旁腺,清扫中央区淋巴结,在安全切除病灶的同时,尽可能地保护了颈前区功... 详细信息

颈侧方切口胸锁乳突肌肌间入路甲状腺手术采用颈侧区皮纹切口,通过胸锁乳突肌胸骨头与锁骨头间的天然间隙进入甲状腺术区,直视下分离并保护喉返神经、喉上神经、甲状旁腺,清扫中央区淋巴结,在安全切除病灶的同时,尽可能地保护了颈前区功能,并具有较好的颈部外观,其临床效果在实践中得到了国内学者的广泛认可。为了更好地推动该术式的规范化实施,中国医师协会外科医师分会甲状腺外科专家组、中国研究型医院学会甲状腺疾病专业委员会和中国医疗保健国际交流促进会普通外科学分会结合最新相关文献和多个中心的临床经验,撰写此共识。

关键词：颈侧方切口胸锁乳突肌肌间入路颈前区功能甲状腺切除术甲状腺肿瘤

Expert Consensus on the Treat-to-Target Strategy for Psoriasis With Biological Agents in china(Simplified Edition)

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International Journal of Dermatology and Venereology 2024年第2期7卷 61-69页

作者： Ai-Jun Chen Da-Xing Cai Xiang Chen Yong Cui Yan Ding Heng Gu Xing-Hua Gao Chao Ji Xiao-Jing Kang Ye-Hong Kuang Cheng-Zhi Lyu Min Li Wei Li Xia Li Yu-Zhen Li Xiao-Yong Man Jian-Jun Qiao Juan Su Liang-Dan Sun Yu-Ling Shi Juan Tao Jian-Xin Xia Rong Xiao Bin Yang Wu Zhu Xue-Jun Zhang committee on Psoriasis Dermatology and Venereology Branch of the chinese medical association Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250100China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology China-Japan Friendship HospitalBeijing 100192China Department of Dermatology Hainan Provincial Hospital of Skin DiseaseHaikouHainan 570311China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uyghur Autonomous Region 830001China Department of Dermatology Dalian Dermatosis HospitalDalianLiaoning 116021China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhouJiangsu 215127China Department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610044China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200093China Department of Dermatology The Union Hospital of Tongji Medical CollegeHuazhong University of Science and Te

Psoriasis is a chronic,recurrent,inflammatory systemic disease that is not only characterized by skin manifestations but may also be accompanied by various comorbidities,imposing a heavy burden on patients’physical and mental health and affecting their quality of *** the continuous approval of various biological agents for clinical use has provided more effective treatment options to patients with psoriasis,no consensus on the evaluation of comprehensive treatment goals has yet been *** treat-to-target(T2T)strategy requires consideration of multiple dimensions of treatment outcomes,the development of long-term management goals,and regular assessments of treatment conditions,which are often used in the management of chronic ***,based on the latest consensuses and guidelines,research data,and clinical experience as well as the combination of survey results and expert group discussions,the present consensus focuses on 4 dimensions of short-and long-term integrated management goals for biological agents:alleviating skin lesions,improving quality of life,screening and managing psoriasis comorbidities,and ensuring drug *** implementation methods,evaluation time,treatment monitoring,and program adjustments are also herein described to achieve comprehensive management of psoriasis to the maximum *** consensus provides a reference for clinical practice.

关键词： psoriasis biological agents treat-to-target comorbidity consensus

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阿尔茨海默病中西医结合诊疗中国专家共识

中华行为医学与脑科学杂志 2024年第2期33卷 97-108页

作者：中国老年保健协会阿尔茨海默病分会中国中药协会脑病药物研究专业委员会杜怡峰解恒革田金洲唐诗徐向青丛琳不详山东第一医科大学附属省立医院济南250021 解放军总医院第二医学中心国家老年疾病临床医学中心北京100853 北京中医药大学东直门医院北京100700 山东中医药大学附属医院

阿尔茨海默病(Alzheimer''s disease,AD)是最常见的痴呆类型,严重危害中老年人身体健康。近年来AD现代诊治技术被不断探索并逐渐取得临床实效。中西医结合可充分结合中医和西医诊疗特点及优势,标本兼防兼治,进而取得积极的临床效果。因... 详细信息

阿尔茨海默病(Alzheimer''s disease,AD)是最常见的痴呆类型,严重危害中老年人身体健康。近年来AD现代诊治技术被不断探索并逐渐取得临床实效。中西医结合可充分结合中医和西医诊疗特点及优势,标本兼防兼治,进而取得积极的临床效果。因此,专家组在检索国内外AD临床试验文献和指南基础上,撰写AD中西医结合诊疗中国专家共识。基于循证医学证据,针对AD的中西医病因病理机制、诊断方法以及中西医防治等达成共识,旨在为AD的中西医结合诊疗提供指导方案。

关键词：阿尔茨海默病中西医结合诊疗专家共识

机器人手术系统辅助甲状腺和甲状旁腺手术临床实践指南(2024版)

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中华外科杂志 2024年第9期62卷 805-817页

作者：中国医师协会外科医师分会甲状腺外科专家工作组中国研究型医院学会甲状腺疾病专业委员会中国医疗保健国际交流促进会普通外科学分会田文贺青卿朱见李超王丹不详解放军总医院第一医学中心普通外科北京100853 联勤保障部队第九六○医院甲状腺乳腺外科济南250031 联勤保障部队第九六○医院济南250031 四川省肿瘤医院

机器人外科是智能精准微创外科发展的成果,应用于甲状腺外科领域,取得了良好临床效果。我国《机器人手术系统辅助甲状腺和甲状旁腺手术专家共识(2016版)》的发布对机器人辅助甲状腺和甲状旁腺手术的规范化开展与临床推广起到了重要作用... 详细信息

机器人外科是智能精准微创外科发展的成果,应用于甲状腺外科领域,取得了良好临床效果。我国《机器人手术系统辅助甲状腺和甲状旁腺手术专家共识(2016版)》的发布对机器人辅助甲状腺和甲状旁腺手术的规范化开展与临床推广起到了重要作用。随着临床实践的深入、微创理念的更新、机器人平台更新换代和技术不断改进,机器人甲状腺和甲状旁腺外科得到了进一步发展,尤其在适应证拓展、机器人外科医师培训和团队建设方面有了较大进步。在2016版专家共识的基础上,结合近年发表的相关论著及临床研究,专家组撰写了《机器人手术系统辅助甲状腺和甲状旁腺手术临床实践指南(2024版)》,从手术团队培养、手术适应证、术前评估、患者体位和空间建立、甲状腺腺叶切除步骤、颈部淋巴结清扫技巧等方面进行了总结推荐,并对再次手术、甲状旁腺手术及术后并发症的防治等方面提出了合理建议,以期更好地指导临床实践。

关键词：甲状腺疾病甲状旁腺疾病机器人甲状腺手术机器人甲状旁腺手术双侧腋窝乳晕入路机器人外科医师智能精准微创外科指南

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体外膜氧合患者脑监测中国专家共识

中华医学杂志 2024年第9期104卷 662-673页

作者：中国医师协会体外生命支持专业委员会钱招昕侯晓彤不详国家老年疾病临床医学研究中心(湘雅)湖南省重症医学临床研究中心中南大学湘雅医院重症医学科长沙410008 首都医科大学附属北京安贞医院心脏外科危重症中心北京100029

近年来,随着体外膜氧合在严重呼吸衰竭、心源性休克和心肺复苏患者中的使用显著增加,体外膜氧合相关并发症越来越受重视,而脑损伤是体外膜氧合治疗期间最严重并发症之一,是影响体外膜氧合患者住院死亡率及远期生存质量的重要因素。由于... 详细信息

近年来,随着体外膜氧合在严重呼吸衰竭、心源性休克和心肺复苏患者中的使用显著增加,体外膜氧合相关并发症越来越受重视,而脑损伤是体外膜氧合治疗期间最严重并发症之一,是影响体外膜氧合患者住院死亡率及远期生存质量的重要因素。由于镇痛、镇静及肌松药的应用干扰神经系统体格检查结果,使得体外膜氧合治疗期间发生的脑损伤不容易被及时发现。因此床旁脑监测对于发现体外膜氧合患者脑损伤并提供早期干预指导具有重要价值。由此,中国医师协会体外生命支持专业委员会组织全国相关专家制订了《体外膜氧合患者脑监测中国专家共识》,本共识以体外膜氧合患者脑损伤的病理生理学机制为基础,以神经系统体格检查、血浆脑损伤生物标记物、颅脑影像、颅内压、脑血流、脑氧、脑电图、体感诱发电位等脑监测技术应用现状为依据,结合体外膜氧合的特殊临床应用场景,整合国内外最新循证医学证据,形成可供重症医学、神经病学、心血管病学、呼吸与危重病学、急诊医学等专业人员参考的15条体外膜氧合患者脑监测专家共识推荐意见。鉴于重症患者的特殊性、复杂性及个体差异,本专家共识推荐意见需结合患者个体情况而定。

关键词：体外膜氧合作用脑损伤脑监测专家共识