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Primary cilia restrict autoinflammation by mediating PD-L1 expression

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Science Bulletin 2024年第16期69卷 2505-2508页

作者： Xiaoyu Tian Kaiyue Zhang renjie Hong Hanyu Wang Xifeng dong Jun Zhou Yunfan Yang Min Liu Center for Cell Structure and Function Shandong Provincial Key Laboratory of Animal Resistance BiologyHaihe Laboratory of Cell EcosystemCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Department of Hematology Tianjin Medical University General HospitalTianjin 300052China Department of Cell Biology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Tissue Homeostasis Haihe Laboratory of Cell EcosystemTianjin 300462China

Ciliopathies are multisystem disorders characterized by the dysfunction of motile and/or non-motile cilia,which are microtubule-based structures protruding from the cell surface and function in cell motility and *** clinical manifestations of ciliopathies include retinal degeneration,mental retardation,renal abnormality,obesity,and skeletal dysplasia[1,2].Fibrosis of vital organs,characterized by the extensive deposition of extracellular matrix components,represents another complication frequently observed in patients and animal models of ciliopathies[3].

关键词： inflammation organs degeneration

Microglial Calcium Homeostasis Modulator 2:Novel Anti-neuroinflammation Target for the Treatment of Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第4期40卷 553-556页

作者： Yuan dong Li Tang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Qingdao Institute of Measurement Technology Qingdao266000China

Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are the most common causes of *** drugs for such diseases can only provide temporary help with the symptoms,leaving the discovery of new drugs urgently in *** cells are the local immune cells in the nervous system and have been recognized as the key player in neuroinflammation that contributes to the process of neurodegeneration[1],raising the discussion of aiming microglia as the therapeutic target for clinical treatment of neurodegenerative diseases.

关键词： inflammation degenerative drugs

1500 V锂离子电池簇电场分布仿真及绝缘风险分析

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中国电机工程学报 2024年第1期44卷 377-384,I0031页

作者：牛腾腾黄人杰渠展展惠东杨颖清华大学电机工程与应用电子技术系北京市海淀区100084 中国电力科学研究院有限公司北京市海淀区100192

锂离子电池储能在辅助可再生能源并网、电网调频和调峰等方面发挥重要作用。提高锂离子电池储能系统直流侧电压等级,有利于储能系统的降本增效,却对电池系统绝缘性能产生了更高的要求。该文对锂离子电池簇在直流1500 V下场强分布进行了... 详细信息

锂离子电池储能在辅助可再生能源并网、电网调频和调峰等方面发挥重要作用。提高锂离子电池储能系统直流侧电压等级,有利于储能系统的降本增效,却对电池系统绝缘性能产生了更高的要求。该文对锂离子电池簇在直流1500 V下场强分布进行了仿真计算,并考虑了绝缘结构胶中不同规格气泡缺陷的影响。由于存在共模干扰的影响,该文对直流电压、共模电压叠加下电池簇场强分布进行了仿真计算,结果表明:1500 V直流电压下场强最大值出现在外绝缘膜和绝缘罩交界处,贯穿型气泡缺陷使局部场强最大值增大130.6%,考虑共模电压影响后一个周期内场强最大值增幅约为86%,且场强最大值点由外绝缘膜转移至空气中。该文构建的跨越4个数量级的大跨度几何尺寸(10^(1)~10^(-3)m)电池系统电场仿真模型首次建立了储能电池簇中各电池单体金属壳体表面的电场分布,首次将共模干扰引入电池单体电场分析,提出了通过降低电池系统对地寄生电容从而抑制共模干扰、增加单体电池边角处绝缘强度从而减小最大电场强度的方法,解决了高压电池系统在共模干扰下电场分布畸变、绝缘风险增大的问题,为高压电池系统绝缘设计提供理论支撑。

关键词：锂离子电池储能系统气泡缺陷直流1500 V 共模电压

Miniaturized, Shared Electric and Magnetic Dipole, Pattern Diversity IoT Antenna for Sub-6 GHz Applications

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Chinese Journal of Electronics 2024年第5期33卷 1224-1233页

作者： Zhan WANG Yuandan dong University of Electronic Science and Technology of china

By using a novel meta-resonator structure, a miniaturized, surface mountable, shared aperture, and hybrid electric/magnetic dipole pattern diversity antenna is proposed for Internet of things（IoT） applications. By exploring the shared electric（E-dipole） and magnetic dipole（M-dipole） structures, a novel T-shaped split-ring resonator（SRR） with even and odd modes is presented and studied by current distributions and equivalent *** and omnidirectional（monopole-like） patterns are achieved by exciting the M-dipole and E-dipole modes of the T-shaped SRR, respectively. To validate the proposed design, this shared aperture metamaterial-inspired pattern diversity antenna with a small size of 0.295λ0× 0.0065λ0× 0.115λ0is fabricated and measured. The measured overlapped-10 dB bandwidth is from 3.40 GHz to 3.63 GHz（7.0%, covering the LTE B42 band） and the port isolation is greater than 23 dB. Both two modes achieve a good radiation efficiency better than-0.79 d B（>83.0%）.

关键词： Antenna measurements Dipole antennas Surface mount technology Switches Size measurement Aperture antennas Internet of Things Electric/magnetic dipoles Internet of things (IoT) Metamaterial-based/inspired antenna LOW-PROFILE PATCH ANTENNA RECONFIGURABLE ANTENNA MICROSTRIP ANTENNA RADIATION-PATTERN HIGH-GAIN FREQUENCY ARRAY

GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

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china Foundry 2024年第3期21卷 265-275页

作者： Xiao-hong Wang Yu-lei Deng Qiao-yu Li Zhi-xin Xu Teng-fei Ma Xing Yang Duo dong dong-dong Zhu Xiao-hong Yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of Materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

Wideband Millimeter Wave Antenna with Cavity Backed Slotted Patch and Magneto-Electric Dipole

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Chinese Journal of Electronics 2024年第5期33卷 1234-1244页

作者： Yang CHENG Yuandan dong School of Electronic Science and Engineering University of Electronic Science and Technology of China

This paper proposes a wideband cavity-backed slotted patch antenna, loaded with a magneto-electric（ME）-dipole and fed by a microstrip line, for millimeter wave（mm-Wave） applications. The coupled-feed cavitybacked slotted patch antenna is loaded with the ME-dipole. The slotted patch antenna serves as both a radiator and a ground for the ME-dipole. The combination of the ME-dipole antenna and the slotted patch antenna realizes a –10 dB impedance bandwidth covering over 22.86–44.35 GHz（63.9%）. The pattern of the antenna element remains stable throughout this bandwidth. The proposed broadband antenna unit not only realizes single linearly polarized（LP）radiation but also can be designed for dual-LP radiation. The dual-polarized radiation can be achieved by changing the slot of the patch antenna to a crossed slot and altering the ME-dipole antenna to a dual-polarization form. A 2 × 2 dual-polarized array has been designed, fabricated, and tested. A novel dual-polarized feeding network is *** achieve higher isolation, broadband in-phase feed and differential feed are adopted, respectively. A low-loss single to the differential structure is proposed for differential feeding. The simulated isolation of the array is higher than 40 d *** results show that the dual-polarized 2 × 2 array has an overlapping bandwidth of 52.3%(|S11| < –10 dB and |S21| < –30 dB) with a peak gain of 14 dBi. The proposed antenna, featuring a wide overall bandwidth, low cost,and good radiation performance, is well suited for mm-Wave applications.

关键词： Slot antennas Costs Dipole antennas Patch antennas Magnetoelectric effects Broadband communication Broadband antennas Array antenna Dual-polarized antenna Feeding network Magneto-electric dipole Millimeter-wave (mm-Wave) Patch BROAD-BAND POLARIZED ANTENNA ARRAY PLANAR BALUN

Real-time model correction using Kalman filter for Raman-controlled cell culture processes

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Chinese Journal of Chemical Engineering 2024年第6期70卷 251-260页

作者： Xiaoxiao dong Zhuohong He Xu Yan dong Gao Jingyu Jiao Yan Sun Haibin Wang Haibin Qu Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hisun Biopharmaceutical Co.Ltd. Hangzhou 311404China

Raman spectroscopy has found extensive use in monitoring and controlling cell culture *** this context,the prediction accuracy of Raman-based models is of paramount ***,models established with data from manually fed-batch cultures often exhibit poor performance in Raman-controlled ***,there is a need for effective methods to rectify these *** objective of this paper is to investigate the efficacy of Kalman filter(KF)algorithm in correcting Raman-based models during cell ***,partial least squares(PLS)models for different components were constructed using data from manually fed-batch cultures,and the predictive performance of these models was ***,various correction methods including the PLS-KF-KF method proposed in this study were employed to refine the PLS ***,a case study involving the auto-control of glucose concentration demonstrated the application of optimal model correction *** results indicated that the original PLS models exhibited differential performance between manually fed-batch cultures and Raman-controlled *** glucose,the root mean square error of prediction(RMSEP)of manually fed-batch culture and Raman-controlled culture was 0.23 and 0.40 g·L^(-1).With the implementation of model correction methods,there was a significant improvement in model performance within Raman-controlled *** RMSEP for glucose from updating-PLS,KF-PLS,and PLS-KF-KF was 0.38,0.36 and 0.17 g·L^(-1),***,the proposed PLS-KF-KF model correction method was found to be more effective and stable,playing a vital role in the automated nutrient feeding of cell cultures.

关键词： Raman spectroscopy Model correction Algorithm Model-predictive control Bioprocess

High-Efficiency Wideband Transmitarray Antenna Using Polarization-Rotating Elements with Parasitic Stubs

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Chinese Journal of Electronics 2024年第2期33卷 496-503页

作者： Xi WANG Yuandan dong University of Electronic Science and Technology of china

A high-efficiency polarization-rotating transmitarray antenna(TA) using wideband elements is proposed for millimeter-wave applications. The polarization-rotating element consists of three metallic layers and two substrates. Orthogonal polarizers are employed on the top and bottom of the element. And the split ring with a parasitic stub on the middle layer is symmetric about the diagonal, performing the polarization rotation and phase compensation simultaneously. A parasitic stub is designed to decrease transmission loss and broaden the bandwidth. The periodicity of the element is only 1/4 wavelength at 30 GHz. A prototype TA with 28 × 28 elements is designed, fabricated, and measured. The measured peak gain reaches 27.5 d Bi at 37.8 GHz. The 1-d B gain drop bandwidth is 30.8–40 GHz(26.0%).The aperture efficiency reaches as high as 71% at 31.5 GHz. Within the bandwidth of 26.5–38.8 GHz(37.7%), the aperture efficiency is higher than 50%. The proposed polarization-rotating TA features wide bandwidth and high efficiency, demonstrating great application potential for 5G millimeter-wave communication.

关键词： Wavelength measurement Transmitting antennas Prototypes Apertures Gain measurement Propagation losses Broadband antennas

Biomimetic MXene membranes with negatively thermo-responsive switchable 2D nanochannels for graded molecular sieving

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Green Energy & Environment 2024年第6期9卷 1058-1067页

作者： Yi Wang Yangyang Wang Chang Liu dongjian Shi Weifu dong Baoliang Peng Liangliang dong Mingqing Chen The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China International Research Center for Photo-responsive Molecules and Materials Jiangnan UniversityWuxiJiangsu214122China Research Institute of Petroleum Exploration&Development(RIPED) PetroChina/Key Laboratory of Oilfield ChemistryCNPCBeijing100083China

Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation ***,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature ***,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene *** uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different *** expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D ***,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary *** strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.

关键词： Thermo-responsive 2D membrane MXene nanosheets PNIPAm Temperature-tunable 2D nanochannels Graded molecular sieving