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Protective Effects of Tetramethlpyrazine Preconditioning Mediated by Bradykinin on Isolated Rat Hearts

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Protective Effects of Tetramethlpyrazine Preconditioning Med...

Perinuclear calcium waves induced by activation of α1-adrenoceptors underlie autonomous nuclear calcium regulation in developing cardiomyocytes

第十五届国际药理学大会

作者： Laiyuan Zou Mng He Qiren Huang.Key Laboratory of Food Science of Ministry of Education Nanchang University Nanchang 330047 china. department of pharmacology Nanchang University School of Pharmaceutical Sciences Nanchang 330006 china.

＜正＞ Aim: To study the preconditioning effects and mechanisms of tetramethlpyrazine （TMPZ） on isolated rat heart subjected to anoxia- reoxygenation（ A/R） injury. Method: Isolated rat hearts were perfused in Langendorff mode,and with TMPZ 100, 200, 400 μmol L - 1 or with TMPZ 200μmol L - 1 concomitantly HOE140 1μmol L- 1 for 15 min, then subjected to A/R injury. Heart rate, coronary flow （CF）, left ventricular pressure and its first derivative were recorded. The activities of LDH,GSH-Px, SOD and the contents of MDA in CF solutions or myocardium, the area of myocardial infarction were measured. Results: TMPZ100, 200, 400μmol L- 1 preconditioning could make heart functions improved, moreover, the activities of LDH, contents of MDA and the area of myocardial infarction decreased, whereas, the activities of GSH- Px, SOD increased on the heart subjected to A/R injury, but after treating with HOE140, the protective effects of TMPZ were mainly cancelled. Conclusion: TMPZ can induce the cardioprotective effects of pharmacological ischemic preconditioning and the mechanisms may be relative with the enhancement of the activity of bradykinin system.

关键词： Tetramethlpyrazine Bradykmin Isolated rat heart

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Perinuclear calcium waves induced by activation of α1-adren...

Protective Effects of Octacosanol in MPTP-treated Mouse Model of Parkinson s Disease through differential Regulation of Activities of ERK,p38 and JNK Mitogen-activated Protein Kinases

The 15th World Congress of pharmacology

作者： Dali Luo Xiaomei Lan Kaitao Li Youyi Zhang Rui-Ping Xiao Qide Han Heping Cheng Institute of Cardiovascular Science at Health Science Center Peking University Beijing 100083 china. Institute of Molecular Medicine and College of Life Science Peking University Beijing 100871 china. department of pharmacology School of Chemical Biology & Pharmaceutical Sciences Capital University of Medical Sciences Beijing 100069 china.

＜正＞Dynamic nuclear Ca2+ signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca2+ regulatory mechanism that is mediated by perinuclear inositol 1,4,5-trisphosphate receptors （IP3Rs） in developing cardiac myocytes. Activation of IP3Rs by α1-adrenergic receptor （α1-AR） stimulation or by IP, application （in saponin-permeabilized cells） increases Ca2+ spark frequency preferentially in the perinuclear region in neonatal rat ventricular myocytes. Strikingly, we observed "perinuclear Ca2+ waves" that engulf the entire nucleus without spreading into the bulk cytosol. A perinuclear enrichment of IP3Rs supports the hyperexcitability of Ca2+-induced Ca2+ release in the layer of perinuclear sarcoplasmic reticulum （SR）. α1-AR stimulation enhances the formation of IP, and occurrence of perinuclear Ca2+ waves and confers them the ability to trigger cytosolic Ca2+ waves via IP3R-dependent pathways. This finding accounts for a profound frequency-dependent modulation of global Ca2+ oscillation during α1AR stimulation. Thus, IP3R Ca2+ waves traveling in the layer of perinuclear SR provide active, autonomous regulation of nuclear Ca2+ signaling, and serve as a pacemaker to drive global Ca2+ oscillation in the context of α1AR stimulation in developing cardiac myocytes.

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Protective Effects of Octacosanol in MPTP-treated Mouse Mode...

7th CIIE likely to prove solid growth platform for many companies

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Tao Wang1,Pingping Zuo2,Piu Chan1 (1 department of Neurobiology and Neurology,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Xuanwu Hospital of Capital Medical University,Beijing 100053,china. 2 department of pharmacology,Institute of Basic Medical Sciences,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100005,china.

Aim Parkinson s disease(PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),increasing evidence from human and animal studies suggested that oxidative stress is an important pathogenesis mediator in PD progress. This study examined the protective effects of octacosanol on 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice.

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china.Textile 2024年第4期 20-21页

作者： Editorial department of china.Daily

The robust demand of the Chinese market and the improving business environment in the country make china.a big growth opportunity for companies wishing to further expand their operations,said corporates that have registered to participate at this year's china.International Import *** 7th edition of the annual CIIE,to be held in Shanghai from Nov 5 to 10,started its 100-day countdown on Saturday.

关键词： companies likely operations

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脑瘤消胶囊对荷S180肉瘤小鼠的抗肿瘤作用

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陕西肿瘤医学 2002年第1期10卷 6-7,18页

作者：曹舫赵保华廖子君孙波袁秉祥陕西省肿瘤医院西安710061 西安交通大学医学院西安710061

目的　观察脑瘤消胶囊对实验性荷S180肉瘤小鼠的抗肿瘤作用 ,探讨脑瘤消胶囊治疗颅内肿瘤的作用机制。方法　随机将小鼠分为 6组 :正常对照组、荷S180肉瘤模型组、模型 +环己亚硝脲组和模型 +脑瘤消小、中、大剂量组。小鼠皮下接种S180... 详细信息

目的　观察脑瘤消胶囊对实验性荷S180肉瘤小鼠的抗肿瘤作用 ,探讨脑瘤消胶囊治疗颅内肿瘤的作用机制。方法　随机将小鼠分为 6组 :正常对照组、荷S180肉瘤模型组、模型 +环己亚硝脲组和模型 +脑瘤消小、中、大剂量组。小鼠皮下接种S180肉瘤后开始灌胃给药 ,每天一次 ,连续 8天。停药后次日处死小鼠 ,称瘤重后计算瘤重抑制百分率 ,并对瘤组织进行病理学检查 ,实验共重复三次。结果　与模型组 (ig生理盐水 )比较 ,脑瘤消胶囊各剂量组小鼠肿瘤明显缩小 (P <0 .0 1)。结论　 0 .5～ 2 .0g/kg脑瘤消胶囊灌胃给药可明显抑制小鼠荷S180实体瘤的生长和浸润。

关键词：脑瘤消胶囊 S180肉瘤抗肿瘤作用动物实验

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Serving High-Level Opening up with "TaxExpress"

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Belt and Road Initiative Tax Journal 2024年第1期 97-105页

作者： International Taxation department, State Taxation Administration,the People's Republic of china International Taxation department State Taxation Administrationthe People's Republic of China

Over the past decade,the Chinese tax authorities have been actively supporting the development of the Belt and Road Initiative,by creating a unique cross-border tax and fee service model with Chinese characteristics,which has laid a solid foundation for the establishment of the "TaxExpress" cross-border service *** October 2023,the State Taxation Administration of china.STA) officially launched the "TaxExpress" brand,focusing on one service matrix,two service teams,three service mechanisms,and four knowledge *** brand aims to enhance cooperation between ministries and commissions,promote international exchanges,and establish a framework for effective cross-border tax and fee *** forward,the STA will continue to leverage existing resources to support high-level opening up,by enhancing brand value,improving measures for international tax and fee services,expanding cross-border tax and fee services,strengthening professional talent teams,so as to develop a cross-border tax and fee service system that combines Chinese characteristics with international best practices.

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Problem-based learning in pharmacology:a survey of department heads in Taiwan, china

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Acta Pharmacologica Sinica 2004年第9期 137-139页

作者： Ying-tung LAUdepartment of Physiology and pharmacology School of Medicine, Chang Cung University, Taoyuan, Taiwan, china

Problem-based learning (PEL) requires active student participation and the use of clinical cases as a trigger to learn within a given area. It has gained much attention as a pedagogic alternative in the course of reform in medical education due to information overload. From discipline-based consideration, it is interesting to understand the views of department heads of pharmacology about implementing PBL for their medical students. According to a

关键词： problem-based learning pharmacology medical education

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金融多措并举支持经济高质量发展

中国金融 2024年第19期 9-15页

作者：本刊编辑部不详

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让... 详细信息

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让公众感受到了金融支持经济高质量发展的力度,支持实体经济发展的深度和提升老百姓生活幸福感、满足感的温度。

关键词：金融监督管理金融支持经济实体经济发展中国证券监督管理委员会高质量发展多措并举生活幸福感新闻发布会

“有效降低全社会物流成本”研讨会专家观点综述

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中国流通经济 2024年第5期38卷 3-17页

作者：本刊编辑部《中国流通经济》编辑部

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处... 详细信息

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处联合主办了“有效降低全社会物流成本”研讨会。本次研讨会邀请我国流通物流领域的专家学者,围绕物流服务实体经济和人民群众、物流成本构成、交通运输体系改革、统一高效物流市场构建和现代商贸流通体系完善等问题,发表观点,为探索有效降低全社会物流成本可行路径,构建现代流通体系提供理论支持和实践指导。本刊编辑部对专家阐述的主要观点进行了归纳整理,以飨读者。

关键词：全社会社会物流成本新质生产力流通体系降本增效

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