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radiation medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of radiation Oncology china Anti-Cancer Association Branch of radiation Oncology Chinese medical Association Branch of radiation Oncology TreatmentPhysician Chinese medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui Wencheng Zhang 不详 Tianjin medical University Cancer Institute&Hospital Tianjin 300060China the Fourth Hospital of Hebei medical University Shijiazhuang 050011China National Cancer center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin medical University Cancer Hospital China

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of radiation Oncology,china Anti-Cancer Association,the Branch of radiation Oncology,Chinese medical Association,and the Branch of radiation Oncology Treatment Physician,Chinese medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

Structural and mechanical properties of amorphous carbon films deposited by the dual plasma technique

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Journal of University of Science and Technology beijing 2008年第5期15卷 622-626页

作者： Yaohui Wang,Xu Zhang,Xianying Wu,Huixing Zhang,and Xiaoji Zhang Key Laboratory of the ministry of Education of china for Beam Technology and material modification,Institution of Low Energy Nuclear Physics,beijing Normal University beijing radiation center,beijing 100875,china [a]Key Laboratory of the ministry of Education of china for Beam Technology material modification Institution of Low Energy Nuclear Physics Beijing Normal University beijing radiation center Beijing 100875 China

Direct current metal filtered cathodic vacuum arc （FCVA） and acetylene gas （C2H2） were wielded to synthesize Ti-containing amorphous carbon films on Si （100）. The influence of substrate bias voltage and acetylene gas on the microstructure and mechanical properties of the films were investigated. The results show that the phase of TiC in the （111） preferential crystallographic orientation exists in the film,and the main existing pattern of carbon is sp2. With increasing the acetylene flow rate,the contents of Ti and TiC phase of the film gradually reduce; however,the thickness of the film increases. When the substrate bias voltage reaches -600 V,the internal stress of the film reaches 1.6 GPa. The micro-hardness and elastic modulus of the film can reach 33.9 and 237.6 GPa,respectively,and the friction coefficient of the film is 0.25.

关键词： metal containing amorphous carbon amorphous carbon films filtered arc acetylene flow rate bias voltage structure and properties

An integrated view of the correlations between genomic and phenomic variables

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Journal of Genetics and Genomics 2009年第11期36卷 645-651页

作者： Dong Yang,Ying Jiang,Fuchu He State Key Laboratory of Proteomics,beijing Proteome Research center,beijing Institute of radiation medicine,beijing 102206,china [a]State Key Laboratory of Proteomics Beijing Proteome Research Center Beijing Institute of Radiation Medicine Beijing 102206 China

Genome sequencing opened the flood gate of ＂-omics＂ studies, among which the research about correlations between genomic and phenomic variables is an important part. With the development of functional genomics and systems biology, genome-wide investigation of the correlations between many genomic and phenomic variables became possible. In this review, five genomic variables, such as evolution rate （or ＂age＂ of the gene）, the length of intron and ORF （protein length） in one gene, the biases of amino acid composition and codon usage, along with the phenomic variables related to expression patterns （level and breadth） are focused on. In most cases, genes with higher mRNA/protein expression level tend to evolve slowly, have less intronic DNA, code for smaller proteins, and have higher biases of amino acid composition and codon usage. In addition, broadly expressed proteins evolve more slowly and are shorter than tissue-specific proteins. Studies in this field are helpful for deeper understanding the signatures of selection mediated by the features of gene expression and are of great significance to enrich the evolution theory.

关键词： genomic variable phenomic variable expression pattern evolution selection

Refraction of light in media

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Science china(Physics,mechanics & Astronomy) 2007年第5期50卷 591-600页

作者： ZHANG Tao Key Laboratory of Beam Technology and material modification of ministry of Education, Institute of Low Energy Nuclear Physics, beijing Normal University, beijing 100875, china beijing radiation center, beijing 100875, china Key Laboratory of Beam Technology material modification of ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China beijing radiation center Beijing 100875 China

The roles of the magnetic field and electric field of the light are investigated when the light is refracted in the medium. The model of the electron cloud conductor is presented. Electron cloud in a molecule is treated as a conductor and the Faraday’s Law is applied to this conductor that is in the alternating magnetic field of the light. dBm/dt of the light gives rise to an alternating induced current on the electron cloud conductor, and the light exchanges energy, i.e. the refractive energy, with the elec- tron cloud conductor. Formulas of refractive index, which is the ratio of light speed in vacuum to that in the medium, are derived with this model. These formulas are tested with several mediums and Langevin’s diamagnetic susceptibility of helium gas, and the results are in good agreement with the measured data. The anisotropy and the nonlinearity of the refractive index are explained with the theory described in this work.

关键词： refractive index, light, speed, medium, propagation

Protein Product Encoded by a Human Novel Gene E9730 Enhances AP-1 Activity through Interacting with Jab1

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 11-15页

作者： Zhao-Qing WANG, Han-Dong WEI, and Fu-Chu HE(Department of System Biology, beijing Institute of radiation medicine, Chinese Human National center at beijing, beijing 100850, china) Department of System Biology Beijing Institute of Radiation Medicine Chinese Human National Center at Beijing Beijing 100850 China

A novel human gene, named E9730 (a clone number of fetal liver cDNA library), has been identified from more than 14,000 expressed sequence tags (ESTs) based on our large scale sequencing of human fetal liver cDNA libraries. Although sequencing of this novel human gene indicates that it is a leucine zipper protein, the function of E9730 and its homologous genes among species is unknown yet. To find out physiological functional clue of E9730, the yeast two-hybrid system was used to screen the E9730-interac-ting protein(s), and one clone containing a cDNA insert with almost the entire coding sequence (amino acids 39-335) of human Jabl (Jun-activating domain binding protein 1) that interacted specifically with E9730 was identified. A specific association between Jabl and E9730 was shown by co-immunoprecipitation and co-localization experiments. Furthermore, E9730 appeared to enhance Jab 1 -induced AP-1 activity in a concentration-dependent manner and Jabl may be involved in the intracellular signaling trans

关键词： human E9730 gene CSN5/Jabl protein-protein interaction signaling transduction

Effect of wortmannin and 3-AB on G_2 phase arrest and transient failure to activate mPF induced by ionizing irradiation

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Chinese Science Bulletin 1998年第18期43卷 1550-1555页

作者： mENG Xiangbing and SUN Zhixian beijing Institute of radiation medicine, beijing 100850, china beijing Institute of radiation medicine Beijing China

Active mitosis promoting factor (mPF) composed of p34 cdc2 with cyclin B1 is required for the cell cycle transition from G 2 to m phase. Recent studies have demonstrated that ionizing radiation (IR) exposures associated with inhibition of p34 cdc2 activity was the mechanism of G 2 arrest. At low dose, IR causes transient failure to dephosphorylate p34 cdc2 instead of suppression of cyclin B or mPF formation of cyclin B with p34 cdc2 complex. But the signaling events that regulate p34 cdc2 in irradiated cells remain unclear. This note demonstrates that PI3 kinase family inhibitor wortmannin (wort) and PARP specific inhibitor 3_AB can reduce the G 2 arrest induced by 2Gy γ_ray. Immunoprecipitation studies demonstrate that wort and 3_AB can facilitate dephosphorylation of p34 cdc2 in G 2 phase arrest induced by radiation. These findings suggest that wort sensitive pathway and PARP may be involved in initiating the signal transduction of G 2 phase arrest caused by IR.

关键词： G 2 phase arrest ionizing radiation mPF wortmannin 3_AB.

Collision dynamics of He@C_(60)+He@C_(60) at low energies

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Science china(Physics,mechanics & Astronomy) 2008年第7期51卷 765-772页

作者： ZHAO Qiang1,2, ZHANG FengShou1,2,3 & ZHOU HongYu1,2 1 Key Laboratory of Beam Technology and material modification of ministry of Education, Institute of Low Energy Nuclear Physics, beijing Normal University, beijing 100875, china 2 beijing radiation center, beijing 100875, china 3 center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, china 1. Key Laboratory of Beam Technology and material modification of ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China 2. beijing radiation center Beijing 100875 China 3. center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 China

A semi-empirical molecular dynamics model is developed. The central collisions of C60+C60 and He@C60+He@C60 at different incident energies are investigated based on this model. It is found that the dimer structures have been produced at proper incident energies and these fullerene dimers could be formed by a self-assembly of C60 fullerene and He@C60. The He atom has a significant effect at higher incident energy and this embedded He atom can enhance the stability of the dimer structure.

关键词： C60 He@C60 collision molecular dynamics

STUDY OF Ag DIFFUSION INTO Cu SINGLE CRYSTALS BY RUTHERFORD BACKSCATTERING SPECTROmETRY

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Acta metallurgica Sinica(English Letters) 2003年第5期16卷 332-334页

作者： R.Wang 1) Key Laboratory of Beam Technology and materials modification, ministry of Education, beijing 100875, china2) Institute of Low Energy Nuclear Physics, beijing Normal University, beijing 100875, china3) beijing radiation center, beijing 100875, china Key Laboratory of Beam Technology and materials modification Ministry of Education Beijing 100875China Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China beijing radiation center Beijing 100875 China

4.0me V 7Li++ RBS was used for investigations of thermal diffusion of Ag in Cu single crystals. The annealing of samples was carried out in vacuum in the temperature range from 498K to 613K. The element depth concentration profiles transformed from RBS spectra indicate that the diffusion of Ag into Cu is a typical volume diffusion. The Arrhenius parameters corresponding to the diffusion were obtained.

关键词： Ag diffusion single crystal

Anomalous magnetotransport in Lamn_(1-x)Te_xO_3

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Science china(Physics,mechanics & Astronomy) 2009年第7期52卷 987-992页

作者： TAN GuoTai1,2, CHEN ZhengHao3 & ZHANG XiaoZhong4,5 1 Key Laboratory of Beam Technology & materials modification of the ministry of Education, Institute of Low Energy Nuclear Physics, beijing Normal University, beijing 100875, china 2 beijing radiation center, beijing 100875, china 3 Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, beijing 100080, china 4 Key Laboratory of Advanced materials of the ministry of Education, Department of materials Science and Engineering, Tsinghua University, beijing 100084, china 5 beijing National center for Electron microscopy, Tsinghua University, beijing 100084, china 1. Key Laboratory of Beam Technology & materials modification of the ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing 100875 China 2. beijing radiation center Beijing 100875 China 3. Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China 4. Key Laboratory of Advanced materials of the ministry of Education Department of Materials Science and Engineering Tsinghua University Beijing 100084 China 5. beijing National center for Electron microscopy Tsinghua University Beijing 100084 China

The Lamn1-xTexO3+δ (x=0.1, 0.2, 0.3) were synthesized using solid-state reaction method for the first time. X-ray photoemission spectrum (XPS) shows that in the samples the Te ions have a valence of Te4+, and mn3+ ions are partly converted into mn2+ and mn4+ due to the excess oxygen and Te doping. The magnetotransport associated with mn2+, mn3+ and mn4+ was investigated. The experimental results show that the samples are insulator at 0 T when the amount of mn3+ is much larger or less than the sum of mn2+ and mn4+; by contrast, the samples display metal to insulator transition with increasing temperature when the amount of mn3+ is close to the sum of mn2+ and mn4+. These anomalous magnetotransport behaviors were analyzed in the frame of the double-exchange (DE) mechanism.

关键词： colossal magnetoresistance La-Te-mn-O magnetotransport