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Journal of Ocean University of china 2024年第2期23卷 427-437页

作者： kou Hailei HUANG Jiaming CHENG Yang College of Engineering Ocean University of ChinaQingdao 266100China Fourth Division Organization Department of the CPC Qingdao Municipal CommitteeQingdao 266100China

Structure-soil interface friction characteristics is of importance to investigate the interaction between engineering structures and soils,especially for offshore *** interface friction behavior between marine clay and structural materials with different roughness was studied in this paper by using 3D optical scanning tests,a modified direct shear device and numerical *** between the surface roughness of structures,water content and interface friction angle were presented by model *** increase of water contents decreased the interface friction *** interfaces with different roughness,the interface friction angles will be smaller than that of the soil when the water content exceeds a certain *** roughness of the interface and the water content of the soil are mutually coupled to influence the coefficient of friction(COF).This paper proposed a Finite Element Method(FEM)to simulate the interface direct shear tests of structures with different *** surface models with different roughness are established based on the structure data obtained by 3D *** Coupled Eulerian-Lagrangian(CEL)approach was employed to analyse soils sheared by irregular *** interface behavior for interfaces with different roughness under cyclic shear stresses was analyzed by FEM.

关键词： marine clay construction material interface friction behavior surface roughness Finite Element Method

A modified smoothed particle hydrodynamics method considering residual stress for simulating failure and its application in layered rock mass

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Journal of Mountain Science 2024年第6期21卷 2091-2112页

作者： XIA Chengzhi SHI Zhenming kou Huanjia department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China

Residual strength is an indispensable factor in evaluating rock fracture,yet the current Smoothed Particle Hydrodynamics(SPH)framework rarely considers its influence when simulating *** improved cracking strategy considering residual stress in the base bond SPH method was proposed to simulate failures in layered rocks and slopes and verified by experimental results and other simulation methods(i.e.,the discrete element method).Modified Mohr–Coulomb failure criterion was applied to distinguish the mixed failure of tensile and *** fracture markψwas introduced to improve the kernel function after tensile damage,and the calculation of residual stress after the damage was derived after shear *** simulations were carried out to evaluate its performance under different stress and scale conditions and to verify its effectiveness in realistically reproducing crack initiation and propagation and coalescence,even fracture and *** results indicate that the improved cracking strategy precisely captures the fracture and failure pattern in layered rocks and rock *** residual stress of brittle tock is correctly captured by the improved SPH *** improved SPH method that considers residual strength shows an approximately 13%improvement in accuracy for the safety factor of anti-dip layered slopes compared to the method that does not consider residual strength,as validated against analytical *** infer that the improved SPH method is effective and shows promise for applications to continuous and discontinuous rock masses.

关键词： Smoothed particle hydrodynamics Cracking strategy Residual stress Layered rock Crack propagation

考虑寒区隧道围岩冻结温度渐变的冻胀力解析解

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同济大学学报（自然科学版） 2024年第3期52卷 360-369页

作者：曹善鹏夏才初周舒威寇继生同济大学土木工程学院上海200092 宁波大学岩石力学研究所浙江宁波315211 绍兴文理学院土木工程学院浙江绍兴312000

为考虑寒区隧道围岩单向冻结和径向冻结温度渐变会引起的不同方向和不同冻结深度处的非均匀冻胀变形,通过引入冻胀围岩径向冻结温度T(r)和平行与垂直冻结方向的非均匀冻胀系数k反映围岩的非均匀冻胀性,理论推演建立了寒区隧道冻胀力解析... 详细信息

为考虑寒区隧道围岩单向冻结和径向冻结温度渐变会引起的不同方向和不同冻结深度处的非均匀冻胀变形,通过引入冻胀围岩径向冻结温度T(r)和平行与垂直冻结方向的非均匀冻胀系数k反映围岩的非均匀冻胀性,理论推演建立了寒区隧道冻胀力解析解,并进行了案例和影响因素分析。研究表明:忽略冻结温度渐变影响时冻胀力明显偏大,考虑冻结温度渐变可有效提高冻胀力计算的可靠性;考虑冻结温度渐变影响的冻胀力随着非均匀冻胀系数k的增大呈对数函数增大,随冻结与未冻围岩的弹性模量比EⅡ/EⅢ的增大而线性减小,且EⅡ/EⅢ越大时冻胀力产生所需围岩达到的临界k值也越大;隧道冻胀力随围岩冻结圈外径、未冻围岩弹性模量和原岩应力的增大而增大,但随衬砌内径、冻结围岩单位温度冻胀系数的增大而逐渐降低。

关键词：寒区隧道冻胀力非均匀冻胀冻结温度渐变

A novel multi-state bogie system reliability evaluation approach by extended d-MC model for high-speed trains

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Transportation Safety and Environment 2024年第3期6卷 35-46页

作者： Yong Fu Ruoqu Liu jisheng Dai Wenlong Zhu Xin Liu Yong Qin Zhuzhou CRRC Times Electric Co. Ltd.Times RoadShifeng DistrictZhuzhouHunan 412001China department of Statistics University of WarwickCoventry CV47ALUnited Kingdom State Key Lab of Rail Traffic Control&Safety Beijing Jiaotong UniversityHaidian DistrictBeijing 100044China

Bogie is a pivotal system and plays a critical part in the safety and reliability management of high-speed ***,the available bogie system reliability analysis methods lack the consideration of multi-state characteristics,and the common multi-state reliability analysis methods,being an NP-hard problem,lead to low *** order to overcome these drawbacks,this paper proposes a novel multi-state rail train bogie system reliability analysis approach based on the extended d-MC *** different function interactions within the bogie system are considered to build the multi-state bogie system flow network ***,an extended d-MC model is established to remove unnecessary d-MC candidates and duplicates,which greatly enhances the computing *** bogie system reliability is calculated,and examples are *** experiments are carried out for the different operational conditions of the bogie system and are used to test the practicability of the method proposed in this article;it is found that this method outperforms a newly developed method in solving multi-state reliability problems.

关键词： multi-state system reliability bogie flow network extended d-MC model

Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment

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Chinese Chemical Letters 2024年第9期35卷 303-308页

作者： jisheng Liu Junli Chen Xifeng Zhang Yin Wu Xin Qi Jie Wang Xiang Gao department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041China West china School of Basic Medical Sciences&Forensic Medicine Sichuan UniversityChengdu 610041China department of Hematology West China HospitalSichuan UniversityChengdu 610041China

FMS-like tyrosine kinase 3(FLT3)is a viable and important therapeutic target for acute myeloid leukemia(AML).FLT3 internal tandem duplication(FLT3-ITD)mutations have been identified in approximately 30%of AML patients,and are associated with unfavorable prognosis,higher risk of relapse,drug resistance,and poor clinical *** FLT3 inhibitors have demonstrated promising efficacy,they cannot cure AML or even significantly extend the lives of patients with FLT3-ITD *** is partly because of poor water solubility,insufficient membrane penetration and short half-life of small molecule ***,the presence of enzymes like CYP3A4 in bone marrow accelerate the elimination and metabolism of FLT3 inhibitors,resulting in low plasma concentrations and side *** we report the erythrocyte membrane-camouflaged FLT3 inhibitor nanoparticles to enhance FLT3-ITD AML ***,we physically coextruded red blood cell(RBC)membrane vesicles with nanoparticles derived from FLT3 inhibitor F30 to obtain F30@RBC-M,which exhibited comparable potent FLT3-ITD inhibitory effects compared to free F30 in vitro,while displaying a higher potent antitumor efficacy in xenograft models due to the prolonged circulation ***,administration of F30@RBC-M significantly extended the survival of mice in a transplanted mouse model than F30 free *** findings suggest that RBC membrane-coated nanoparticles derived from FLT3 inhibitors hold promise as a tool to enhance the therapeutic efficacy to treat FLT3-ITD AML.

关键词： FLT3-ITD Acute myeloid leukemia AML Red blood cell membrane Biomimetics

Building a More Sustainable Chinese Loess Plateau

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Journal of Earth Science 2024年第1期35卷 283-287页

作者： Peiyue Li Xiaomei kou Yong Wang Le Niu School of Water and Environment Chang'an UniversityXi'an 710054China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of the Ministry of Education Chang'an UniversityXi'an 710054China Key Laboratory of Eco-Hydrology and Water Security in Arid and Semi-Arid Regions of the Ministry of Water Resources Chang'an UniversityXi'an 710054China Powerchina Northwest Engineering Corporation Limited Xi'an 710065China Powerchina Sinohydro Bureau 3 Co. LTD.Xi'an 710024China

The Chinese Loess Plateau,a region of remarkable ecological and economic value,grapples with significant water management challenges due to its distinctive geology and *** perspective offers a short review of the eco-environmental protection measures undertaken in the Loess Plateau,underscoring the transformative impacts of initiatives such as the“Grain for Green”***,it also highlights the enduring challenges,including land degradation,water resources issues,socio-economic inequities,and the implications of climate ***,water management emerges as a pivotal issue with far-reaching repercussions for soil conservation,biodiversity,and human *** paper concludes by proposing future actions,emphasizing the necessity for policy modifications,novel initiatives,and research to tackle these challenges and foster sustainable development in the Loess *** insights gained from this region could offer invaluable lessons for other regions confronted with similar challenges,thereby contributing to global efforts to mitigate desertification and champion sustainable development.

关键词： Loess Plateau eco-environmental protection water management sustainable development climate change

Recent advances in targeted fungicides and immune elicitors for rice blast management

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Plant Communications 2024年第9期5卷 5-7页

作者： Huanbin Shi Naweed I.Naqvi Yanjun kou State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Temasek Life Sciences Laboratory and department of Biological Sciences Research LinkNational University of SingaporeSingapore 117604Singapore

Blast disease,caused by the fungus Magnaporthe oryzae,wreaks havoc on crops worldwide,resulting in an approximate loss of 20%-30%of the annual rice yield(He et al.,2020;Liu et al.,2024).*** heads the top 10 list of the most devastating phytopathogens and serves as a model system for investigating fungal diseases in plants,thus offering insights relevant to disease control in important agricultural crops.

关键词： crops offering insight

Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

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Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo kou Shouqiang Zhang Tianqi Cao Hanqing Wu Jing Zhou department of Chemistry Capital Normal UniversityBejing100048China College of Teacher Education Capital Normal University Beijing100048China

The tumor microenvironment(TME)differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials(NaLuF_(4):Yb,Er)with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network(MPN)*** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy(CT)drug EGCG,which can cause apoptosis,Cu_(x)S_(y)is generated by combining Cu^(2+)with H_2S overexpressed in human colorectal cancer cells and can be used for photothermal therapy(PTT).Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Tumor microenvironment Metal-polyphenol networks Synergistic therapy Rare earths Nanomaterials

Electricity resonance-induced phase transition of water confined in nanochannels

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Communications in Theoretical Physics 2024年第5期76卷 159-165页

作者： Yunqiu Ma Zhigao Zhao Shaoqian Hao Jianlong kou Jiang-Xing Chen Institute of Condensed Matter Physics Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light SourceZhejiang Normal UniversityJinhua 321004China department of Physics Inner Mongolia UniversityHohhot 010021China department of Physics Hangzhou Normal UniversityHangzhou 311121China

The phase transition of water molecules in nanochannels under varying external electric fields is studied by molecular dynamics *** is found that the phase transition of water molecules in nanochannels occurs by changing the frequency of the varying electric *** molecules maintain the ice phase when the frequency of the varying electric field is less than 16 THz or greater than 30 THz,and they completely melt when the frequency of the varying electric field is 24 *** phenomenon is attributed to the breaking of hydrogen bonds when the frequency of the varying electric field is close to their inherent resonant ***,the study demonstrates that the critical frequency varies with the confinement *** new mechanism of regulating the phase transition of water molecules in nanochannels revealed in this study provides a perspective for further understanding of the phase transition of water molecules in nanochannels,and has great application potential in preventing icing and deicing.

关键词： electricity resonance phase transition water molecules molecular dynamics simulations