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Underground Space 2024年第2期15卷 298-311页

作者： Cungang Lin Junjie Zheng Yiwen Ye Farrokh Nadim Zhongqiang Liu chenyang Zhao Yu chen Zhi Ding Guangdong Research Center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou 510275China Guangdong Key Laboratory of Marine Civil Engineering School of Civil EngineeringSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory for Tunnel Engineering Ministry of EducationGuangzhou 510275China southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Civil Engineering Wuhan UniversityWuhan 430072China Guangdong Road and Bridge construction Development co. Ltd.Guangzhou 510660China Norwegian Geotechnical Institute Oslo 0806Norway Key Laboratory of Safe construction and Intelligent maintenance for Urban Shield Tunnels of Zhejiang Province Hangzhou 310015China

Soil-pipeline separation due to tunnelling has been certainly substantiated in previous model ***,this phenomenon has seldom been considered in current analytical *** study formulates a tensionless Winkler solution that could make allowance for gap formation in soil-pipeline interaction *** solution is validated by comparisons with existing experimental measurements and two recognized analytical ***,its advantage over an existing Winkler solution is *** parametric studies reveal that the effects of gap formation on the response of a pipeline rely largely on the tunnel volume loss and the pipeline’s bending stiffness and burial *** general,a pipeline’s bending moments and subgrade reaction forces are more susceptible than its deflections to the gap formation.

关键词： Soil-pipeline interaction Tunnelling Tensionless Winkler model ground settlement Analytical solution Gap formation

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan chen Ming chen department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China department of Oncology Maoming People’s HospitalMaoming 525000China department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival

Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei chen Xiao-Dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South china Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer

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Cancer communications 2024年第4期44卷 469-490页

作者： Jiayao Wang Jiehao Zhang Hao Liu Lingnan Meng Xianchun Gao Yihan Zhao chen Wang Xiaoliang Gao Ahui Fan Tianyu Cao Daiming Fan Xiaodi Zhao Yuanyuan Lu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxiP.R.China The Air Force Hospital of southern Theater command GuangzhouGuangdongP.R.China National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsGuangxi Medical UniversityNanningGuangxiP.R.China Second Clinical college Shaanxi University of Traditional Chinese MedicineXianyangShaanxiP.R.China college of Life Sciences Northwest UniversityXi’anShaanxiP.R.China

Background:Chemoresistance is a major cause of treatment failure in gas-tric cancer(GC).Heterogeneous nuclear ribonucleoprotein A2B1(hnRNPA2B1)is an N6-methyladenosine(m6A)-binding protein involved in a variety of ***,whether m6A modification and hnRNPA2B1 play a role in GC chemoresistance is largely *** this study,we aimed to investigate the role of hnRNPA2B1 and the downstream mechanism in GC ***:The expression of hnRNPA2B1 among public datasets were analyzed and validated by quantitative PCR(qPCR),Western blotting,immunoflu-orescence,and immunohistochemical *** biological functions of hnRNPA2B1 in GC chemoresistance were investigated both in vitro and in *** sequencing,methylated RNA immunoprecipitation,RNA immunoprecipi-tation,and RNA stability assay were performed to assess the association between hnRNPA2B1 and the binding *** role of hnRNPA2B1 in maintenance of GC stemness was evaluated by bioinformatic analysis,qPCR,Western blotting,immunofluorescence,and sphere formation *** expression patterns of hnRNPA2B1 and downstream regulators in GC specimens from patients who received adjuvant chemotherapy were analyzed by RNAscope and multiplex ***:Elevated expression of hnRNPA2B1 was found in GC cells and tis-sues,especially in multidrug-resistant(MDR)GC cell *** expression of hnRNPA2B1 was associated with poor outcomes of GC patients,especially in those who received 5-fluorouracil *** hnRNPA2B1 effectively sensitized GC cells to chemotherapy by inhibiting cell proliferation and induc-ing apoptosis both in vitro and in ***,hnRNPA2B1 interacted with and stabilized long noncoding RNA NEAT1 in an m6A-dependent ***,hnRNPA2B1 and NEAT1 worked together to enhance the stemness properties of GC cells via Wnt/β-catenin signaling *** clin-ical specimens from GC patients subjected to chemotherapy,the expression levels of hnRNPA2B1

关键词： chemoresistance gastric cancer hnRNPA2B1 NEAT1 stemness

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益生菌冷冻干燥高活性保护机制研究进展

微生物学报 2024年第5期64卷 1402-1416页

作者：吴家琳李滢刘振杰陈谋通吴清平广东省科学院微生物研究所华南应用微生物国家重点实验室、广东省微生物安全与健康重点实验室、国家卫健委微生物食品营养与安全科技创新平台广东广州510070 华南农业大学食品学院广东广州510642

摄取足量益生菌有助于维持肠道微生物群落的稳态,对维持人体肠道健康具有重要意义。然而,在工业化应用中,益生菌抗逆能力较弱且对储存条件要求高,导致益生菌产品对运输和活性维持条件要求较高,这些产业需求对高活力益生菌的制备工艺提... 详细信息

摄取足量益生菌有助于维持肠道微生物群落的稳态,对维持人体肠道健康具有重要意义。然而,在工业化应用中,益生菌抗逆能力较弱且对储存条件要求高,导致益生菌产品对运输和活性维持条件要求较高,这些产业需求对高活力益生菌的制备工艺提出了挑战。干燥处理常应用于保持益生菌活性和稳定性,其中冷冻干燥技术应用最广泛,但冻干过程中益生菌会受到各类环境压力的刺激,引起细胞损伤甚至死亡。因此,可以显著提高益生菌存活率的冻干保护剂成为目前益生菌工业应用的研究热点。本文从益生菌常用及新发现的冻干保护剂种类及其作用机制进行了系统归纳,对菌株冻干后细胞存活率的影响因素进行全面综述,并对冻干保护剂研究方向进行了展望,旨在为高活力益生菌冻干菌粉的研制提供理论支持。

关键词：益生菌冷冻干燥冻干保护剂生理状态脂肪酸调控

柔直换流站柔性直流换流阀控制保护屏出口回路异常情况分析

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电工技术 2024年第7期 178-181,184页

作者：曾鸿陈海永李倩何海欢陈凯中国南方电网有限责任公司超高压输电公司广州局广东广州510000

通过对柔直换流站极2低端阀组站系统调试期间,极2低端A套阀控制保护带电跳闸试验时断路器操作箱三相出口不一致情况进行分析,对极2低端阀控跳闸出口逻辑、组控跳闸出口逻辑及断路器操作箱回路进行梳理,总结出阀控系统跳闸出口时,组控系... 详细信息

通过对柔直换流站极2低端阀组站系统调试期间,极2低端A套阀控制保护带电跳闸试验时断路器操作箱三相出口不一致情况进行分析,对极2低端阀控跳闸出口逻辑、组控跳闸出口逻辑及断路器操作箱回路进行梳理,总结出阀控系统跳闸出口时,组控系统手跳与远跳命令同时下发,STJ继电器与TJR继电器由于动作时序不一致,导致断路器操作箱出口跳闸信号灯三相不一致。通过对该回路进行改进,取消了阀控系统跳闸启动组控系统手跳回路的逻辑,通过逻辑优化确保现场调试及后期运维工作安全有序开展。该策略可在柔直换流站阀控、组控逻辑配置中推广使用。

关键词：阀控制保护跳闸组控系统出口 STJ TJR 逻辑优化

基于双层Winkler地基的盾构穿越管线挠曲与脱空分析

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岩石力学与工程学报 2024年第5期43卷 1270-1281页

作者：林存刚王忠杰郭成超王复明陈瑜赵辰洋丁智中山大学土木工程学院广东省地下空间开发工程技术研究中心广东广州510275 隧道工程灾变防控与智能建养全国重点实验室广东广州510275 南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 广东省海洋土木工程重点实验室广东广州510275 浙江省城市盾构隧道安全建造与智能养护重点实验室浙江杭州310015

盾构掘进诱发上覆管线的挠曲和脱空分析对其结构保护至关重要。基于双层Winkler地基并考虑管线上覆与下卧地基刚度差异,对盾构隧道开挖上覆管线挠曲和脱空进行理论与模型试验证实分析。基于荷载板试验对传统管线砂土地基承载理论加以修... 详细信息

盾构掘进诱发上覆管线的挠曲和脱空分析对其结构保护至关重要。基于双层Winkler地基并考虑管线上覆与下卧地基刚度差异,对盾构隧道开挖上覆管线挠曲和脱空进行理论与模型试验证实分析。基于荷载板试验对传统管线砂土地基承载理论加以修正,提出适用于盾构穿越管土相互作用分析的砂土地基刚度和极限承载力取值建议。参数分析发现,管线脱空宽度随管线抗弯刚度和隧道开挖地层损失增大而变大,但变化速率递减;当地层损失或管线抗弯刚度较大时,管土线弹性相互作用理论和考虑界面脱空的单层地基计算方法均高估了管线挠曲和弯矩,而考虑界面脱空的双层Winkler地基计算方法可更准确地预估管线挠曲。

关键词：隧道工程双层Winkler地基盾构掘进管土相互作用界面脱空模型试验地基承载理论

基于SRF‑PLL的模糊自适应软件锁相方法研究

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武汉大学学报（工学版） 2024年第7期57卷 988-996页

作者：肖雄谭炳源姚栋方陈崇明吴瀛郭江中国南方电网有限责任公司超高压输电公司检修试验中心广东广州510700 武汉大学动力与机械学院湖北武汉430072

软件锁相法是电网基波测量中的一项重要工程技术。针对传统锁相环成本较高、结构复杂、动态性能不佳及鲁棒性差等问题,系统分析了三相同步锁相环(synchronous reference frame phase-locked loop,SRF-PLL)的基本原理,提出了一种基于SRF-... 详细信息

软件锁相法是电网基波测量中的一项重要工程技术。针对传统锁相环成本较高、结构复杂、动态性能不佳及鲁棒性差等问题,系统分析了三相同步锁相环(synchronous reference frame phase-locked loop,SRF-PLL)的基本原理,提出了一种基于SRF-PLL结构的模糊自适应软件锁相方法,并进行了仿真研究,给出了基于嵌入式微控制器的算法实现,进行了硬件联调试验。与传统SRF-PLL结构锁相环相比,该方法属于全软件算法,运行稳定,对非线性系统参数变化具有较好的适应性,且具有较好的动态性能和鲁棒性,其调节原理简单,易于模块化移植,在电能计量等工程领域有较好的应用前景。

关键词：基波测量软件锁相环三相同步坐标系模糊控制

门诊血液透析患者丙型肝炎病毒抗体假阳性情况调查与分析

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暨南大学学报（自然科学与医学版） 2024年第1期45卷 38-42,50页

作者：钟先阳李静张琼鹰陈建芸李文丹中国人民解放军南部战区总医院肾脏病科广东广州510010 中国人民解放军南部战区总医院检验科广东广州510010 中国人民解放军南部战区总医院输血医学科广东广州510010

目的:调查门诊血液透析患者丙型肝炎病毒抗体假阳性的发生率和发生原因,以便正确处理抗体检测报告和医患沟通困扰。方法:对中国人民解放军南部战区总医院2019年12月至2022年12月279名门诊血液透析患者的丙型肝炎病毒抗体和丙型肝炎病毒... 详细信息

目的:调查门诊血液透析患者丙型肝炎病毒抗体假阳性的发生率和发生原因,以便正确处理抗体检测报告和医患沟通困扰。方法:对中国人民解放军南部战区总医院2019年12月至2022年12月279名门诊血液透析患者的丙型肝炎病毒抗体和丙型肝炎病毒RNA检测结果进行整群抽样、横断面调查和回顾性研究。结果:调查发现共有81人丙型肝炎病毒抗体假阳性,占29.03%;其中S/co值介于1.0~5.0的占98.77%,介于5.0~10.0的占比为1.23%。全部病例经HCV-RNA复核3次,均为阴性。检验科与输血医学科采取不同的检测方法与报告程序,结果有显著性差异(Pco值处于灰区范围时多为假阳性,且与抗体检测策略和报告程序有关。

关键词：血液透析门诊患者丙型肝炎病毒抗体假阳性反应