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Mass spectrometry analysis of melanoma related O-glycans in sera

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Science china Chemistry 2010年第4期53卷 807-811页

作者： BAI Chen1,4, WU Gang1 & ZHAO Liang2,3 1Department of Life Science, Fudan University, Shanghai 200433, china 2Department of Chemistry, Fudan University, Shanghai 200433, china 3Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, china 4Department of Food Science, Shanghai Business School, Shanghai 200235, china 1. Department of Life Science Fudan University Shanghai 200433 China4. Department of Food Science Shanghai Business School Shanghai 200235 China2. Department of Chemistry Fudan University Shanghai 200433 China3. Institutes of Biomedical Sciences Fudan University Shanghai 200433 China

Glycomics comparison was carried out by screening melanoma serum biomarkers between C57 mice with and without B16 implanted. O-glycans were released from 10 μL sera by β-elimination, purified by Graphitized Carbon Cartridge Solid Phase Extraction (GCC-SPE) and analyzed by MALDI-QIT-TOF-MS. MS raw data were acquired and exported by Launchpad software. MATLAB was then applied for further data analysis. 10 Glycans were considered to have stable changes after B16 implantation and 5 of them were under structural analysis via MS/MS.

关键词： mass spectrometry glycomics melanoma biomarkers

Global Existence of Classical Solutions for Some Oldroyd-B Model via the Incompressible Limit

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Chinese Annals of Mathematics,Series B 2006年第5期27卷 565-580页

作者： Zhen LEI School of Mathematical Sciences, Fudan University, Shanghai 200433, china School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, china. School of Mathematical Sciences Fudan University Shanghai 200433 China School of Mathematics Statistics Northeast Normal University Changchun 130024 China

In this paper, we prove local and global existence of classical solutions for a system of equations concerning an incompressible viscoelastic fluid of Oldroyd-B type via the incompressible limit when the initial data ... 详细信息

关键词： Incompressible limit Global existence Oldroyd model

Recent developments of nanoparticle-based enrichment methods for mass spectrometric analysis in proteomics

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Science china Chemistry 2010年第4期53卷 695-703页

作者： ZHANG LiJuan, LU HaoJie & YANG PengYuan Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, china 1. Department of Chemistry and Institutes of Biomedical Sciences Fudan University Shanghai 200433 China

In proteome research, rapid and effective separation strategies are essential for successful protein identification due to the broad dynamic range of proteins in biological samples. Some important proteins are often expressed in ultra low abundance, thus making the pre-concentration procedure before mass spectrometric analysis prerequisite. The main purpose of enrichment is to isolate target molecules from complex mixtures to reduce sample complexity and facilitate the subsequent analyzing steps. The introduction of nanoparticles into this field has accelerated the development of enrichment methods. In this review, we mainly focus on recent developments of using different nanomaterials for pre-concentration of low-abundance peptides/ proteins, including those containing post-translational modifications, such as phosphorylation and glycosylation, prior to mass spectrometric analysis.

关键词： enrichment nanoparticles mass spectrometry proteomics phosphorylation glycosylation

Cocycle deformations, braided monoidal categories and quasitriangularity

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Chinese Science Bulletin 1999年第6期44卷 510-513页

作者： CHEN HuixiangDepartment of Mathematics, Yangzhou University, Yangzhou 225002, china Institute of Mathematics, Fudan University, Shanghai 200433, china Depnrtment of Mathematics Yangzhou University Yangzhou China Institute of Mathematics Fudan University Shanghai China

Let A be a bialgebra, R ∈ A A be a strong “cocycle”. It will be shown that the monoidal category _Auhas a braided monoidal subcategory and several equivalent conditions for (A, R ) to be a quasitriangular bialgebra will be given. Furthermore, it will be shown that A contains a finite dimensional subbialgebra which is a quasitriangular Hopf algebra if R is a YB-operator.

关键词： strong cocycle Yang-Baxter operator braided monoidal category quasitriangular bialgebra.

ON WALL SHEAR STRESS OF ARTERY

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Journal of Hydrodynamics 2003年第3期15卷 1-9页

作者： Liu Zhao-rong, Liu Bao-yu, Qin Kai-rong Biomechanics Laboratory, Fudan University, Shanghai 200433, china, Biomechanics Laboratory Fudan University Shanghai 200433 China

In this paper, a method was proposed that the wall shear stress of arterycould be determined by measuring the centerline axial velocity and radial motion of arterial wallsimultaneously. The method is simple in application and can get higher precision when it is used todetermine the shear stress of arterial wall in vivo. As an example, the shear stress distribution inperiodic oscillatory flow of human carotid was calculated and discussed. The computed results showthat the shear stress distribution at any given instant is almost uniform and will be zero at thecenterline and tends to maximum at the vessel wall.

关键词： endothelial cells oscillatory flow shear stress vascular remodeling carotid

Limit theorem and uniqueness theorem of backward stochastic differential equations

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Science china Mathematics 2006年第10期49卷 1353-1362页

作者： JIANG Long Department of Mathematics, china University of Mining and Technology, Xuzhou 221008, china Institute of Mathematics, Fudan University, Shanghai 200433, china School of Mathematics and System Sciences, Shandong University, Jinan 250100, china 1. Department of Mathematics China University of Mining and Technology Xuzhou 221008 China 2. Institute of Mathematics Fudan University Shanghai 200433 China 3. School of Mathematics and System Sciences Shandong University Jinan 250100 China

This paper establishes a limit theorem for solutions of backward stochastic differential equations (BSDEs). By this limit theorem, this paper proves that, under the standard assumption g(t,y,0) = 0, the generator g of a BSDE can be uniquely determined by the corresponding g-expectationεg;this paper also proves that if a filtration consistent expectation S can be represented as a g-expectationεg, then the corresponding generator g must be unique.

关键词： backward stochastic differential equation, g-expectation, generator.

Essentially normal Hilbert modules and K-homology Ⅲ:Homogenous quotient modules of Hardy modules on the bidisk

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Science china Mathematics 2007年第3期50卷 387-411页

作者： Kun-yu GUO & Peng-hui WANG School of Mathematics, Pudan University, Shanghai 200433, china School of Mathematics Fudan University Shanghai 200433 China

In this paper, we study the homogenous quotient modules of the Hardy module on the bidisk. The essential normality of the homogenous quotient modules is completely characterized. We also describe the essential spectrum for a general quotient module. The paper also considers K-homology invariant defined in the case of the homogenous quotient modules on the bidisk.

关键词： Hardy modules bidisk essential normality K-homology.

Parametric estimation of discretely sampled Gamma-OU processes

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Science china Mathematics 2006年第9期49卷 1231-1257页

作者： ZHANG Shibin,ZHANG Xinsheng & SUN Shuguang School of Management, Fudan University, Shanghai 200433, china Department of Mathematics, Shanghai Maritime University, Shanghai 200135, china School of Management Fudan University Shanghai 200433 China Department of Mathematics Shanghai Maritime University Shanghai 200135 China

The stationary Gamma-OU processes are recommended to be the volatility of the financial assets. A parametric estimation for the Gamma-OU processes based on the discrete observations is considered in this paper. The estimator of an intensity parameter A and its convergence result are given, and the simulations show that the estimation is quite accurate. Assuming that the parameter A is estimated, the maximum likelihood estimation of shape parameter c and scale parameter a, whose likelihood function is not explicitly computable, is considered. By means of the Gaver-Stehfest algorithm, we construct an explicit sequence of approximations to the likelihood function and show that it converges the true (but unkown) one. Maximizing the sequence results in an estimator that converges to the true maximum likelihood estimator and the approximation shares the asymptotic properties of the true maximum likelihood estimator. Some simulation experiments reveal that this method is still quite accurate in most of rational situations for the background of volatility.

关键词： Gamma-OU process transition function Lévy process Lévy density stochastic volatility background driving Lévy process Laplace transformation maximum likelihood estimation

SIMULATION OF FLUID-SOLID INTERACTION ON WATER DITCHING OF AN AIRPLANE BY ALE METHOD

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Journal of Hydrodynamics 2011年第5期23卷 637-642页

作者： HUA Cheng FANG Chao CHENG Jin Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China School of Mathematical Sciences Fudan University Shanghai 200433 China

Ditching is considered as one of the important aspects of safety performances of airplanes. It is related primarily with the fluid-solid interaction, whose studies mainly depend on experiments at the present time. Numerical and analytical methods for fluid-solid interaction by using 3-D full scale airplane＇s model will reduce the dependence on the expensive model tests. Numerical studies can be used to estimate the safety of ditching and provide a reference for the crashworthiness design. This article proposes a 3-D dynamical structural model after the real shape of an airplane and an Arbitrary Lagrange-Euler （ALE） fluid-field model, to simulate the fluid-solid interactions caused by low speed ditching. The simulation is based on interaction computational methods, within LS-DYNA nonlinear finite-element code. The results of pressure distributions and accelerating time histories of the airplane＇s subfloor are discussed in the context of the safety of ditching, and the simulation results and the analytical methods are verified.

关键词： ditching fluid structure interaction Arbitrary Lagrange-Euler (ALE) finite element method