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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei-Na QUAN~1,Shuang LIANG~2,Tao ZHANG~2,Zhuo YANG~(1,*) 1 laboratory of Neurophysiology,Medical School,Nankai University,Tianjin 300071,china 2 laboratory of bioinformatics,Life Science Institude,Nankai University,Tianjin 300071,china

＜正＞Objective This study was designed to establish an animal model of depression,and using physiological, behavioral and electrophysiological methods to explore the pathogenesis of depression and to assess possible antidepressant effects of Memantine hydrochloride（HCL）,a selective N-methyl-D-aspartate（NMD A） antagonist,in this animal *** The animal model of depression was established in male Wistar rats by combining isolation rearing with chronic unpredictable mild stress（CUMS）.Memantine HCL（20 mg/kg） was administered intraperitoneally from the second day of establishing depression model,for 21 d,until the first day of water maze *** rats’ physiological status was observed by their weights and sucrose *** change was observed by water maze *** change was tested by recording long-term potentiation（LTP） from thalamus to prefrontal *** （1） Compared with normal group,rats’ weight increase and sucrose consumption was statistically lower in CUMS model group and Memantine HCL-treated group.（2） In the water maze test,the mean escape latency（EL） of the first period of Oriented Navigation Training（ONT） was significantly prolonged in CUMS model group and Memantine HCL-treated group as compared with that of normal *** of the second and third periods of ONT was significantly prolonged in Memantine HCL-treated group as compared with those of normal group and CUMS model group.（3） LTP test showed that excitatory postsynaptic potential（PSP） slopes were statistically different among three *** model group had the lowest slopes and normal group had the highest *** Animal model of depression can be established successfully by isolation rearing combined with chronic unpredicted mild *** a 21-d trial,Memantine in the dose of 20 mg/kg was not effective in the treatment of depression,but it could improve synaptic plasticity in prefrontal cortex in model rats.

关键词： depression Memantine HCL isolation rearing CUMS water maze LTP

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Zinc oxide nanoparticles affect neuroplasticity and spatial learning and memory ability in hippocampus of wistar rats

Zinc oxide nanoparticles affect neuroplasticity and spatial ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Da-Dong HAN~1 Jin-Xia ZHAO~2 Tao ZHANG~2 Guo-Gang REN~3 Zhuo YANG~(1 *) 1 laboratory of Neurophysiology Medical School Nankai University Tianjin 300071 china 2 laboratory of bioinformatics Life Science Institute Nankai University Tianjin 300071 china 3 University of Hertfordshire Hatfield Herts AL10 9AB UK

＜正＞Objective Zinc oxide nanoparticles（ZnO） are widely applied in toothpaste,beauty products,sunscreens, coating and textiles as base material or *** biological properties of the ZnO have been investigated in etiology,pathology,physiology and *** study focuses on the effects of ZnO nanoparticles on neuroplasticity and spatial learning and memory in hippocampus of Wistar *** underlined mechanism to interpret the interactive behaviour was studied *** Experimental methods involved using ZnO nanoparticles suspension （4mg/kg,0.4mg/mL,i.p.,b.i.w.） which was injected into 4-week-old male Wistar rats,for 8 weeks and subsequently long- term potentiation（LTP） and long-term depression（LTD） were evaluated and numerically *** water maze （MWM）,including place navigation test,spatial probe test and reversal acquisition phases,was also detected and ***’s and HE staining processes were employed in order to define pathological ***（1） It is shown that the LTP was significantly enhanced,including slope of field excitatory postsynaptic potential（fEPSP, 168.156±4.540） and amplitude of population spike（PS,286.872±16.587）,in rats treated by ZnO,compared to those of the control group（fEPSP,126.465±3.767;PS,175.773±10.042,P＜0.01,P＜0.01）.However,no change was found in the LTD and, neither the slope of fEPSP nor amplitude of the PS（P＞0.05） was shafted.（2） In the mentioned navigation test,the escape time was prolonged in rats treated by ZnO（18.355±2.956） compared with control group（10.838±2.346）.In spatial probe test, the ratio of time spent in the target quadrant（36.283±5.372） was reduced and the number of crossing the plate（2.8333+0.7923） was decreased in ZnO treated group compared with those of control group（6.667±0.803;55.817±3.051,P＜0.01,P＜0.01）.In reversal acquisition phase,the escape time was prolonged（18.384±4.404） in ZnO-treated group compared with that of control group（9.205±2.516,P＜0.01）.（3） Nissle’s staining

关键词： zinc oxide nanoparticles neuroplasticity LTP LTD spatial learning and memory Morris water Maze hippocampus

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The genome-wide analysis of intermediate-size ncRNAs in higher plants

The genome-wide analysis of intermediate-size ncRNAs in high...

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第十三届全国植物基因组学大会

作者： Danmeng Zhu~1,Tingting Liu~1,Xuncheng Wang~1,Wei Deng~2,Yuqiu Wang~1,Guangming He~1, Runsheng Chen~2,Xingwang Deng~(1,3*) 1 Peking-Yale Joint Research Center for Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences,Peking University,Beijing 100871,china. 2 bioinformatics laboratory,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,china 3 Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven, CT 06520-8104,USA.

Recent large-scale analytical efforts have revealed various aspects of the functional sequence elements in several model organisms,and thereby contributed to the understanding of the non-protein coding parts of ***,the cellular RNA species with size range of 70～300nt have seldom been systematically annotated or extensively ***,we document a comparative genome-wide

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The genome-wide analysis of intermediate-size ncRNAs in higher plants

The genome-wide analysis of intermediate-size ncRNAs in high...

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2011全国植物生物学研讨会

作者： Danmeng Zhu1,Ting-Ting Liu~1,Wei Deng~2,Yuqiu Wang~1,Guangming He~1, Runsheng Chen~2 and Xing Wang Deng~(1,3),~* 1 Peking-Yale Joint Research Center for Plant Molecular Genetics and Agrobiotechnology,College of Life Sciences,Peking University,Beijing 100871,china 2 bioinformatics laboratory,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101, china 3 Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,CT 06520-8104,USA

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Interaction of cellular-localized signature modules in response to prostate cancer

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Progress in Natural Science:Materials International 2007年第11期17卷 1368-1375页

作者： Zhu Jing1, Guo Zheng1,2, Zhang Min2, Yang Da2, Wang Jing2 and Wang Chenguang2(1. School of Life Science and bioinformatics Centre, University of Electronic Science and Technology of china, Chengdu 610054, china 2. Department of bioinformatics, Bio-Pharmaceutical Key laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, china) School of Life Science and bioinformatics Centre University of Electronic Science and Technology of China Chengdu 610054 China Bio-Pharmaceutical Key laboratory of Heilongjiang Province Department of Bioinformatics Harbin Medical University Harbin 150081 China

Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge makes it promising for systematic understanding of complex human diseases at the functional modules level. Current modular categorizations can be defined and selected more specifically and precisely in terms of both biological processes and cellular locations, aiming at uncovering the modular molecular networks highly relevant to cancers. Based on Gene Ontology, we identifed the functional modules enriched with differentially expressed genes and characterized by biological processes and specific cellular locations. Then, according to the ranking of the disease discriminating abilities of the pre-selected functional modules, we further defined and filtered signature modules which have higher relevance to the cancer under study. Applications of the proposed method to the analysis of a prostate cancer dataset revealed insightful biological modules.

关键词： microarray analysis Gene Ontology classification analysis cellular location functional module

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Complicated evolutionary patterns of microRNAs in vertebrates

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Science china(Life Sciences) 2008年第6期51卷 552-559页

作者： WANG XiaoWo, ZHANG XueGong & LI YanDa MOE Key laboratory of bioinformatics and bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, china MOE Key laboratory of bioinformatics and bioinformatics Division TNLIST / Department of Automation Tsinghua University Beijing China

MicroRNAs (miRNAs) are a class of ～22 nt long endogenous non-coding RNAs that play important regulatory roles in diverse organisms. Up to now, little is known about the evolutionary properties of these crucial regulators. Most miRNAs were thought to be phylogenetically conserved, but recently, a number of poorly-conserved miRNAs have been reported and miRNA innovation is shown to be an ongoing process. In this work, through the characterization of an miRNA super family, we studied the evolutionary patterns of miRNAs in vertebrates. Recently generated miRNAs seem to evolve rapidly during a certain period following their emergence. Multiple lineage-specific expansions were observed. Homolgous premiRNAs may produce mature products from the opposite stem arms following tandem duplications, which may have important contribution to miRNA innovation. Our observations of miRNAs' complicated evolutionary patterns support the notion that these key regulatory molecules may play very active roles in evolution.

关键词： microRNA evolution miRNA:miRNA* interconversion lineage specific duplication

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Biological networks to the analysis of microarray data

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Progress in Natural Science:Materials International 2006年第12期16卷 1242-1251页

作者： FANG Zhuo~1, LUO Qingming~1**, ZHANG Guoqing~1 and LI Yixue~2**(1. Hubei bioinformatics and Molecular Imaging Key laboratory,Huazhong University of Science and Technology, Wuhan 430074, china 2. Shanghai Center for Bioinformation and Technology, Shanghai 200235, china) Hubei bioinformatics and Molecular Imaging Key laboratory Huazhong University of Science and Technology Wuhan 430074 China Shanghai Center for Bioinformation and Technology Shanghai 200235 China

Microarray technology, which permits rapid and large-scale screening for patterns of gene expressions, usually generates a large amount of data. How to mine the biological meanings under these data is one of the main challenges in bioinformatics. Compared to the pure mathematical techniques, those methods incorporated with some prior biological knowledge generally bring better interpretations. Recently, a new analysis, in which the knowledge of biological networks such as metabolic network and protein interaction network is introduced, is widely applied to microarray data analysis. The microarray data analysis based on biological networks contains two main research aspects: identification of active components in biological networks and assessment of gene sets significance. In this paper, we briefly review the progress of these two categories of analyses, especially some representative methods.

关键词： biological networks microarray data analysis subnetwork gene set.

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Discovery of immune related factors in Fenneropenaeus chinensis by annotation of ESTs

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Progress in Natural Science:Materials International 2004年第1期14卷 48-55页

作者： SHEN Yaoqing 1,2 , XIANG Jianhai 1*, WANG Bing 1,2 , LI Fuhua 1 and TONG Wei 3(1. Experimental Marine Biology laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071,china 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, china 3. Genomics & bioinformatics Institute, Chinese Academy of Sciences, Beijing 101300, china) Chinese Acad Sci Inst Oceanol Expt Marine Biol Lab Qingdao 266071 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China Chinese Acad Sci Geonom & Bioinformat Inst Beijing 101300 Peoples R China

A total of 10446 expressed sequence tags (ESTs) are obtained by a large scale sequencing of a cDNA library from cephalothorax of adult Fenneropenaeus chinensis . An EST analysis platform was built up based on local computers and bioinformatic techniques were used to annotate these ESTs in order to promptly find possible functional genes, especially for immune related factors. About 4% of the ESTs show similarity to the coding sequences of such factors, including lectin, serine protease, serpin, lysozyme, etc. These ESTs provide a partial profile of the immune system in F. chinensis and useful information for further study on these genes.

关键词： Fenneropenaeus chinensis bioinformatics ESTs immune factors

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Bioinformatic analysis of expressed sequence tags from sporophyte of Porphyra yezoensis (Bagiaceae, Rhodophyta)

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Progress in Natural Science:Materials International 2006年第1期16卷 39-49页

作者： XU Minjun1, MAO Yunxiang1,ZHANG Xuecheng1, ZHOU Xiaojun1, SUI Zhenghong1, ZHOU Hailin2 and LI Jinhong 2(1.laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of china, Qingdao 266003, china 2.James D Watson Institute of Genome Sciences, Zhejtang University / Key laboratory of Genomic bioinformatics of Zhejiang Province, Hangzhou Genomics Institute, Hangzhou 310008, china) laboratory of Marine Genetics and Breeding College of Marine Life Sciences Ocean University of China Qingdao 266003 China James D Watson Institute of Genome Sciences Zhejiang University/Key Laboratory of Genomic Bioinformatics of Zhejiang Province Hangzhou Genomics Institute Hangzhou 310008 China

A total of 719 expressed sequence tags （EST） clustered into 329 non-redundant EST groups are obtained from the sporophyte cDNA library of red algae, Porphyra yezoensis. Gene Ontology （GO） analysis is employed in characterizing 60 strictest annotated unique genes out of the 329 EST groups and some domains such as COX1, SodFeC, GST-N, SHMT, and RNase-PH related to the enzymes and proteins functioning in cells have been identified by HMMPFAM search. As its leafy gametophyte, the similar codon usage with strong bias is found in P. yezoensis filamentous sporophyte, regardless of some differences found in given amino acids. The average GC content of the 329 unique genes is 53. 0 % . In contrast, the third nucleotide of codon exhibits a higher GC content （ 72 % ） than that of the first （58%） and the second （42%） nucleotides. Similarity search of the present study shows a novel EST ratio of 60.2%, which is against the Porphyra ESTs database, suggesting further investigations towards elucidating the characteristics of Porphyra functional genome.

关键词： Porphyra yezoensis expressed sequence tags (EST) bionformatic analysis.

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Calculation of maximum ground movement and deformation caused by mining

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中国有色金属学会会刊：英文版 2011年第S3期21卷 562-569页

作者： LI Pei-xian1, 2, TAN Zhi-xiang1, 2, DENG Ka-zhong1, 2 1. Key laboratory for Land Environment and Disaster Monitoring of State Bureau of Surveying and Mapping, china University of Mining and Technology, Xuzhou 221116, china 2. Jiangsu Key laboratory of Resources and Environmental Information Engineering, china University of Mining and Technology, Xuzhou 221116, china Key laboratory for Land Environment and Disaster Monitoring of State Bureau of Surveying and Mapping China University of Mining and Technology Xuzhou 221116 China Jiangsu Key laboratory of Resources and Environmental Information Engineering China University of Mining and Technology Xuzhou 221116 China

In order to know the maximum mining ground deformation of arbitrary surface point, directions of the maximum surface tilt, curvature,horizontal displacement and horizontal deformation caused by multi-working faces were deduced based on probability integral method. The distribution forms of surface deformations in all direction φ∈[0, 2π] were obtained and also equations of maximum deformations were given based on calculation of mining ground deformation in direction φ. A mining subsidence analysis system was developed with VB6.0. The system implements the probability integral mining subsidence prediction with direct integration method, and it can avoid errors of arbitrary shaped working face subdivision of traditional method, and accuracy of mining subsidence prediction can be improved with the direct integral method. The system implements the contour chart and profile chart and also data analysis automation by manipulation of the SURFER kernel function and it complements the defect of existing subsidence prediction software. Calculation of maximum deformations caused by multi-working faces mining in a coal mine of Xuzhou, china was shown as application example. Engineering application indicates that maximum deformation of mining ground surface can be calculated and analyzed by the system. The research provides a theoretical basis and calculation tool for mining subsidence prediction and analysis.

关键词： mining subsidence probability integral method movement and deformation system development

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