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陕西中医 2019年第1期40卷 40-42页

作者：高咏莉郑州市第八人民医院精神科郑州453000

目的 :探讨分析疏肝活血养心方在抑郁症患者中的临床应用效果,及治疗方案的安全性分析。方法:将143例抑郁症患者纳为研究对象,所有患者符合抑郁症诊断标准且自愿参与研究,告知患者本次研究方案,依照其治疗意愿进行分组,对照组70例患者... 详细信息

目的 :探讨分析疏肝活血养心方在抑郁症患者中的临床应用效果,及治疗方案的安全性分析。方法:将143例抑郁症患者纳为研究对象,所有患者符合抑郁症诊断标准且自愿参与研究,告知患者本次研究方案,依照其治疗意愿进行分组,对照组70例患者采用常规西药治疗,观察组73例患者则给予疏肝活血养心方治疗,分析两组患者的临床疗效及治疗安全性,观察不同时段患者的汉密尔顿抑郁量表(HAMD)的变化情况。结果:经过2个月的治疗,两组患者均有改善,但观察组治疗效果明显优于对照组,且观察组不良反应的发生率更低,组间比较结果有统计学意义(P<0.05);治疗前与治疗后1月两组患者HAMD评分差异不明显,但治疗后2月组间评分差异较大,观察组明显低于对照组(P<0.05)。结论:常规西药治疗抑郁症有一定的疗效,但会发生较多不良反应,同时对于患者的抑郁改善效果并不稳定,中药方剂不但降低了不良反应的发生率,同时对于抑郁患者的症状改善更加显著,疏肝活血养心方治疗抑郁症安全有效。

关键词：疏肝活血养心方抑郁症安全性汉密尔顿抑郁量表疗效不良反应

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Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dys-kinesia in Chinese schizophrenic patients

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Acta Pharmacologica Sinica 2006年第3期27卷 328-332页

作者： Yan FU~(1,2) Chang-he FAN~2 He-huang DENG San-hong HU De-peng LV Li-hua LI Jun-jie WANG Xin-qiao LU Guangzhou psychiatry Hospital,Guangzhou 510370,china GuangzhoupsychiatryHospital Guangzhou510370China

Aim:To investigate the possible association of the CYP2D6 gene C100T poly-morphism and the CYP1A2 gene C163A polymorphism with tardive dyskinesia(TD)in Chinese patients with ***:The recruited schizo-phrenic patients were assessed with the Abnormal Involuntary Movement Scale(AIMS),and divided into groups with TD(n=91) and without TD(n=91)accord-ing to the AIMS *** of the CYP2D6 and CYP1A2 genes weredetermined by polymerase chain reaction(PCR)-restriction fragment length poly-morphism(RFLP).Results:No allele frequencies deviated from *** significant differences in genotypes frequencies of the CYP2D6C100T polymorphism were observed between patients with TD and without TD(X~2=4.078,P>0.05),but patients with TD had a significant excess of the T allelecompared with those without TD(X~2=4.28,P<0.05).Moreover,the frequency ofthe CYP1A2 C allele in patients with TD was significantly higher than that in thosewithout TD(x~2=6.38,P<0.05).An association between TD and the CYP2D6 100Tand CYP1A2 163C alleles was ***,there were no differences inthe mean AIMS scores among different genotypes in TD patients as a group or *** results of logistic regression analysis demonstrated that mean ageand duration of illness were risk factors for TD,but not sex,cumulative exposureto neuroleptic drugs in years,CYP2D6 or CYP1A2 ***:TheC100T polymorphism of the CYP2D6 gene and the C163A polymorphism of theCYP1A2 gene may be associated with neuroleptic drug-induced tardive dyskine-sia in Chinese patients with ***,genetic factors have a weakerassociation with susceptibility to TD compared with mean age and duration of illness.

关键词： tardive dyskinesia schizophrenia CYP2D6 gene CYP1A2 gene restriction fragment length polymorphism gene frequency genotype

A meta-analysis of oxidative stress markers in schizophrenia

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中国科学：生命科学英文版 2010年第1期53卷 112-124页

作者： ZHANG Ming1,2,ZHAO ZhongMing3,HE Lin1,2,4 & WAN ChunLing1,2 1 Bio-X Center,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200030,china 2 Institutes for Nutritional Sciences,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,china 3 departments of Biomedical Informatics,psychiatry,and Cancer Biology,Vanderbilt University Medical Center,Nashville,TN 37232,USA 4 Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,china 1. Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200030 China2. Institutes for Nutritional Sciences Shanghai Institute of Biological Sciences Chinese Academy of Sciences Shanghai 200031 China3. Departments of Biomedical Informatics Psychiatry and Cancer Biology Vanderbilt University Medical Center Nashville TN 37232 USA4. Institutes of Biomedical Sciences Fudan University Shanghai 200032 China

Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent *** evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy *** study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ *** significant effect size was found for the activities of GP and CAT in SCZ patients(P>0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 *** subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and *** result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia.

关键词： schizophrenia oxidative stress meta-analysis lipid peroxidation nitric oxide antioxidant enzymes

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The Risk Factors’ of Alcohol Dependence Syndrome and the Reasons for Rapid Deterioration of the Alcohol-Related Mental Health Problem in Jinuo Nationality

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The Risk Factors’ of Alcohol Dependence Syndrome and the Re...

Effects of (-)-stepholidine on NMDA receptors:comparison with haloperidol and clozapine

第四届泛亚太地区心理卫生学术研讨会

作者： Zhao Xudong Xu Xiufeng Guo Wanjun etal. department of psychiatry The First Affiliated Hospital of Kunming Medical Colledge Kunming 650032 P.R.china

＜正＞Objective:To find the risk factors of Alcohol Dependence Syndrome of Jinuo Nationality and to discuss the reasons for the rapid deterioration of Alcohol-Related Mental Health Problem in Jinuo Nationality （ARMHPJ） in recent 20-years. Methods: Based on the epidemiological data which had been report in another paper（?）"Stratified random sampling 625 adults （16+ years old）, integrating epidemiological methods with anthropological methods, we used a questionnaire which had been proved available by reliability and validity to investigate the attitude to drinking of Jinuo villagers, and collected the

关键词： Alcohol Dependence Syndrome Jinuo Nationality Risk Factor

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Acta Pharmacologica Sinica 2007年第7期28卷 953-958页

作者： Wei-hua GU~2,Shen YANG~2,Wei-xing SHI~3,Xue-chu ZHEN~2,Guo-zhang JIN~(2,4)~2 department of Pharmacology,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes ofBiological Sciences,Graduate School of the Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 201203,china ~3 Neuropsychopharmacological Research Unit,department of psychiatry,Yale University School of Medicine,New Haven,Connecticut06511,USA department of Pharmacology State Key Laboratory of Drug Research ShanghaiInstitute of Materia Medica Shanghai Institutes of Biological Sciences Graduate School of theChinese Academy of Sciences Chinese Academy of Sciences Shanghai 201203 Chi

Aim:To examine whether （-）-stepholidine （SPD） has a direct effect on the N-methyl-D-aspartic acid receptors （NMDAR） containing the NMDA receptor sub-units NR2A or NR2B and to compare its effect with those of haloperidol （Hal） andclozapine （Cloz）.Methods:NMDAR was transiently expressed in human embry-onic kidney 293 （HEK293） *** in intracellular calcium concentration([Ca2+]i) induced by NMDAR activation were monitored with Fura-2 ratio ***:SPD had no significant effects on either subunit of NMDARat a concentration of less than 100 μmol/*** selectively inhibited NMDARcontaining the NR2B subunit,whereas Cloz inhibited both subunits of *** both Hal and Cloz inhibited NR1a/NR2B receptor-mediated Ca2+influx,their effects were *** was more potent and had a faster peak effect ***:Both Hal and Cloz inhibit NMDAR-mediated function,whereasSPD produced only a little inhibition at a high *** on our otherstudies,the modulation of SPD on NMDAR function may be via D1receptoraction underlying an indirect mechanism.

关键词： (-)-stepholidine haloperidol clozapine NMDA receptor calcium imaging neuroleptics

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综合医院2000例“神经症”的诊断分析

天津医药 1987年第12期 727-730页

作者：陈钟舜天津医学院精神医学教研室天津医学院附属医院精神卫生门诊

作者就综合医院各科门诊转入的2000名“神经症”患者,根据国际疾病分类及许—钟二氏拟定的神经症诊断标准,并采用心理诊断量表重新进行了诊断分类。结果发现,在这些患者中共包括有21种不同的疾病,其中,神经衰弱仅占15%。在讨论中,作者... 详细信息

作者就综合医院各科门诊转入的2000名“神经症”患者,根据国际疾病分类及许—钟二氏拟定的神经症诊断标准,并采用心理诊断量表重新进行了诊断分类。结果发现,在这些患者中共包括有21种不同的疾病,其中,神经衰弱仅占15%。在讨论中,作者着重指出,焦虑症、隐匿性抑郁症、特别是社交障碍、心身病以及早期分裂症的诊断问题。最后强调了在综合医院内开设精神卫生门诊的重要性。

关键词：神经症心身症患者门诊隐匿性抑郁症抑郁等位症焦虑症综合医院

Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of β-cells in Goto-Kakizaki rats

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World Journal of Gastroenterology 2010年第18期16卷 2244-2251页

作者： Zhen Li,Dong-Fei Li,Jing-Xing Dai,Yu Bai,Lin Yuan,Southern Medical University,Institute of Basic Medical Anatomy National Key Disciplines,Guangzhou 510515,Guangdong Province,china Hong-Ya Zhang,Lu-Xian Lv,Wen-Qiang Li,Second Affiliated Hospital,Xinxiang Medical College,Henan Province Key Laboratory of Biological psychiatry,Xinxiang 453002,Henan Province,china Ou Sha,department of Anatomy,Faculty of Medicine,Shenzhen University,Shenzhen 518060,Guangdong Province,china Southern Medical University Institute of Basic Medical Anatomy National Key Disciplines Guangzhou 510515 Guangdong Province China. lizhen3829@***

AIM:To study the effects of Roux-en-Y gastric bypass(RYGB) on the expression of pancreatic duodenal homeobox-1(PDX-1) and pancreatic β-cell regeneration/neogenesis,and their possible mechanisms in ***:Three groups of randomly selected nonobese diabetic Goto-Kakizaki(GK) rats were subjected to RYGB,sham-RYGB and sham-operation(sham-op) surgery,*** rats were euthanized at postoperative 1,2,4 and 12 *** pancreases were resected and analyzed using reverse transcription polymerase chain reaction to detect the mRNA of ***-PDX-1 immunohistochemical(IHC) staining and Western blotting were used to detect the protein of *** IHC staining of anti-Brdu and-insulin was performed to detect regenerated β-*** index of double Brdu and insulin positive cells was ***:In comparison with sham-RYGB and sham-op groups,a significant increase in the expressions of PDX-1 mRNA in RYGB group was observed at all experimental time points(1 wk:0.378 ± 0.013 vs 0.120 ± 0.010,0.100 ± 0.010,F = 727.717,P < 0.001;2 wk:0.318 ± 0.013 vs 0.110 ± 0.010,0.143 ± 0.015,F = 301.509,P < 0.001;4 wk:0.172 ± 0.011 vs 0.107 ± 0.012,0.090 ± 0.010,F = 64.297,P < 0.001;12 wk:0.140 ± 0.007 vs 0.120 ± 0.010,0.097 ± 0.015,F = 16.392,P < 0.001);PDX-1 protein in RYGB group was also increased significantly(1 wk:0.61 ± 0.01 vs 0.21 ± 0.01,0.15 ± 0.01,F = 3031.127,P < 0.001;2 wk:0.55 ± 0.00 vs 0.15 ± 0.01,0.17 ± 0.01,F = 3426.455,P < 0.001;4 wk:0.39 ± 0.01 vs 0.18 ± 0.01,0.22 ± 0.01,F = 882.909,P < 0.001;12 wk:0.41 ± 0.01 vs 0.20 ± 0.01,0.18 ± 0.01,F = 515.833,P < 0.001).PDX-1 mRNA and PDX-1 protein production showed no statistical significance between the two sham *** PDX-1 positive cells could be found in the pancreatic islets of the rats in RYGB group at all time *** addition,the percentage of Brdu-insulin double staining positive cells was higher in RYGB group than in the other two groups(1 wk:0.22 ± 0.13 vs 0.03 ± 0.06,0.03 ± 0.06,P < 0.0

关键词： Gastric bypass Diabetes mellitus Regene-ration β-Cells Animals Pancreatic duodenal homeobox-1

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大脑半球损害与木块图案测验

西安交通大学学报(医学版) 1981年第3期 336-339页

作者：陈佩璋西安医学院精神病学教研室

大脑两半球各有不同的优势,左侧大脑半球的语词性优势,早巳为大家所熟悉,割裂脑病人的研究更证明右侧大脑半球对进行非语词的、空间的信息具有特殊的作用。Johnstone(1979)的研究发现当说话或进行木块图案操作时在脑电图描记上R/L比

关键词：大脑半球木块左半球左利手定侧图案右利手成套测验

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成都市105名正常老年人智力调查

四川医学院学报 1985年第1期16卷 74-77页

作者：朱昌明杨昌芬马渝根四川医学院精神病学研究室

采用目前我国修订的韦氏成人智力量表对成都市105名正常老年人进行智力测查。发现男、女两组的言语量表分、作业量表分及全量表分的均数有显著性差异。各量表分均数有随年龄增长而下降的趋势。此结果与Eisderfer的资料一致。退化商数的... 详细信息

采用目前我国修订的韦氏成人智力量表对成都市105名正常老年人进行智力测查。发现男、女两组的言语量表分、作业量表分及全量表分的均数有显著性差异。各量表分均数有随年龄增长而下降的趋势。此结果与Eisderfer的资料一致。退化商数的测定,其“可能退化”及“肯定退化”占53.4％,是否说明这些老年人可能有大脑潜在病损,尚待追踪测试。

关键词：我国修订的韦氏成人智力量表正常老年人成都退化商数