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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： hui-Yi Hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Effects of large-amplitude internal solitary waves on ROV operation--A numerical study

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Science china Earth Sciences 2016年第5期59卷 1074-1080页

作者： shen hui HOU YiJun Nanjing University of Information Science and Technology Naniine 210044 China Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China

Remotely operated vehicles(ROVs) are unique tools for underwater industrial exploration and scientific research of offshore areas and the deep ocean. With broadening application of ROVs, the study of factors that affect their safe operation is important. Besides the technical skills to control ROV movement, the dynamical ocean environment may also play a vital role in the safe operation of ROVs. In this paper, we investigate the influence of large-amplitude internal solitary waves(ISWs), focusing on the forces exerted on ROVs by ISWs. We present a methodology for modeling ISW-induced currents based on Kd V model and calculate the ISW forces using the Morrison equation. Our results show that an extremely considerable load is exerted by the ISW on the ROV, resulting in a strong disturbance of the vehicle's stability, affecting the ROV control. The numerical results of this work emphasize the importance of considering dynamical conditions when operating underwater vessels, such as ROV. Further laboratory and field investigation are suggested to gain more understanding of this subject.

关键词： Remotely operated vehicle Internal solitary waves Morrison equation

BUCKLING AND POSTBUCKLING OF LAMINATED THIN CYLINDRICAL SHELLS UNDER HYGROTHERMAL ENVIRONMENTS

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Applied Mathematics and Mechanics(English Edition) 2001年第3期22卷 270-281页

作者： shen hui-shen(沈惠申) School of Civil Engineering and Mechanics Shanghai Jiaotong University Shanghai 200030 P R China

The influence of hygrothermal effects on the buckling and postbuckling of composite laminated cylindrical shells subjected to axial compression is investigated using a micro-to-macro-mechanical analytical model. The material properties of the composite are affected hy the variation of temperature and moisture, and are hosed on a micromechanical model of a laminate. The governing equations are based on the classical laminated shell theory, and including hygrothermal effects. The nonlinear prebuckling deformations and initial geometric imperfections of the shell were both taken into account. A boundary layer theory of shell buckling was extended to the case of laminated cylindrical shells under hygrothermal environments, and a singular peturbation technique was employed to determine buckling loads and postbuckling equilibrium paths. The numerical illustrations concern the postbuckling behavior of perfect and imperfect, cross-ply laminated cylindrical shells under different sets of environmental conditions. The influences played by temperature rise, the degree of moisture concentration, fiber volume fraction, shell geometric parameter, total number of plies, stacking sequences and initial geometric imperfections are studied.

关键词： structural stability postbuckling hygrothermal environments composite laminated cylindrical shell a boundary layer theory of shell buckling singular perturbation technique

新会陈皮中4株糖苷酶高产菌的分离鉴定、益生特性及发酵效果分析

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食品工业科技 2025年第1期46卷 171-180页

作者：沈飞王庭雨孙辉吴振强华南理工大学生物科学与工程学院广东广州510006 江门市泛亚生物工程与健康研究院广东江门529000 江门市泛亚生物工程与健康产业有限公司广东江门529000 仲恺农业工程学院农业与生物学院广东广州510006

为扩充促进新会陈皮发酵陈化的益生菌种质资源,本研究从新会陈皮中分离鉴定出4株细菌,并对其产酶能力、益生特性、安全性以及发酵新会陈皮的效果进行了评价。4株细菌均属于芽孢杆菌属,其中菌株L7具有最高的产滤纸酶、羧甲基纤维素酶、β... 详细信息

为扩充促进新会陈皮发酵陈化的益生菌种质资源,本研究从新会陈皮中分离鉴定出4株细菌,并对其产酶能力、益生特性、安全性以及发酵新会陈皮的效果进行了评价。4株细菌均属于芽孢杆菌属,其中菌株L7具有最高的产滤纸酶、羧甲基纤维素酶、β-葡萄糖苷酶和果胶酶能力,酶活分别达到1.84、0.79、1.6和1.24 U/mL。所有菌株均能在胃肠道环境下良好的存活,具有较强的抑菌性和共聚集性,无溶血性,且对多种抗生素敏感,表现出良好的益生特性和安全性。L7发酵新会陈皮效果最佳。经L7发酵后,新会陈皮结合态黄酮组分被有效地转化成游离态形式释放,特别是橙皮苷、川陈皮素和桔皮素,较未发酵新会陈皮分别提高了34.8%、93.7%以及102.7%。此外,L7发酵后的新会陈皮表现出更强的抗氧化活性,这与其具有更高的柚皮素和橙皮素含量密切相关。本研究结果为新会陈皮健康产品的开发和加速陈化技术的建立提供了参考。

关键词：新会陈皮芽孢杆菌糖苷酶益生特性发酵效果

Tritium concentration in soybean plants exposed to atmospheric HTO during nighttime and daytime

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Nuclear Science and Techniques 2016年第2期27卷 44-51页

作者： hui-Fang shen Wei Liu College of Arts and Sciences Shanxi Agricultural University Shanghai Institute of Applied Physics Chinese Academy of Sciences

Potted soybean plants were exposed to evaporate HTO for 1 h inside an exposure box at two different growth stage(flowering and podding stage, filling stage)during nighttime and daytime. The concentration of tissuefree water tritium(TFWT) and organically bound tritium(OBT) in leaves and beans was measured at the end of the exposure. The results indicated that the quasi-equilibrium between the TFWT concentrations in the soybean leaves and the HTO concentration of the ambient air moisture required more than 1 h to be reached. The relative TFWT concentrations in the nighttime represent about 1/2 to 2/3of the concentrations obtained in the day in the leaves compared to about 1/2 to 4/3 in the beans. The relative OBT concentrations under night conditions were about 2/5 to 1/2 of those under day conditions in the leaves, contrary to 1/2–7/10 for the beans. By developing tritium concentration assessment model with a short-term release of atmospheric HTO, we comprehensively considered the plant growth stage and the environmental conditions.

关键词：大豆叶片氚浓度植物大气白天高浓度条件游离水评价模型

Improved CS Algorithm and its Application in Parking Space Prediction

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Journal of Bionic Engineering 2020年第5期17卷 1075-1083页

作者： Rui Guo Xuanjing shen hui Kang College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchun 130012China

This paper simulates the cuckoo incubation process and flight path to optimize the Wavelet Neural Network(WNN)model,and proposes a parking prediction algorithm based on WNN and improved Cuckoo Search(CS)***,the initialization parameters are provided to optimize the WNN using the improved *** traditional CS algorithm adopts the strategy of overall update and evaluation,but does not consider its own information,so the convergence speed is very *** proposed algorithm employs the evaluation strategy of group update,which not only retains the advantage of fast convergence of the dimension-by-dimension update evaluation strategy,but also increases the mutual relationship between the nests and reduces the overall running ***,we use the WNN model to predict parking *** proposed algorithm is compared with six different heuristic algorithms in five *** experimental results show that the proposed algorithm is superior to other algorithms in terms of running time and accuracy.

关键词： wavelet neural network cuckoo search algorithm available parking spaces prediction bionic

Dynamic thermo-mechanical behaviors of SME TiNi alloys subjected to shock loading

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Acta Mechanica Sinica 2020年第6期36卷 1336-1349,I0004页

作者： Lingyan shen Yonggui Liu Mengmeng hui School of Civil Engineering Henan Polytechnic UniversityJiaozuo454000China CAS Key Laboratory for Mechanical Behavior and Design of Materials University of Science and Technology of ChinaHefei230027China

Dynamic thermo-mechanical coupling behaviors of shape memory TiNi alloy in the strain rate ranging from 300 s^−1 to 2000 s^−1 are investigated by the split Hopkinson pressure bar(SHPB)device with an infrared(IR)detection *** stress–strain space,dynamic response shows a strong strain hardening property,however,in stress–temperature space,transformation path is particularly sensitive to the strain *** corresponding temperature evolution measured synchronously shows that local temperature increased associated with the forward phase transition,and it would keep the loading maximum value unchanged or decreased for unloading,depending on the strain ***,local temperature evolution was consistent with the transformation stress and its values at different points are the *** evolution and transformation deformation mechanism is then analyzed by a simple one-dimensional *** results show that latent heat and dissipated energy are responsible for temperature ***,the temperature evolution with strain rate reveals that with the increase of strain rate,the phase transformation deformation mechanism undergoes a transformation from phase transition fronts propagation during lower strain rates to combination of local nucleation and front propagation during middle strain rate and to uniform nucleations during higher strain *** results are helpful for a passive shape memory alloy(SMA)micro-valve design.

关键词： Thermal-mechanical coupling Temperature evolution Strain rate effect Phase transformation path

Ubiquitin phosphorylation in Parkinson’s disease:Implications for pathogenesis and treatment

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Translational Neurodegeneration 2016年第1期5卷 1-8页

作者： Lih-shen chin Lian Li Department of Pharmacology and Center for Neurodegenerative Disease Emory University School of MedicineAtlantaGA 30322USA

Parkinson’s disease(PD)is the most common neurodegenerative movement disorder,characterized primarily by the loss of dopaminergic neurons in substantia *** pathogenic mechanisms of PD remain unclear,and no effective therapy currently exists to stop neurodegeneration in this debilitating *** identification of mutations in mitochondrial serine/threonine kinase PINK1 or E3 ubiquitin-protein ligase parkin as the cause of autosomal recessive PD opens up new avenues for uncovering neuroprotective pathways and PD pathogenic *** studies reveal that PINK1 translocates to the outer mitochondrial membrane in response to mitochondrial depolarization and phosphorylates ubiquitin at the residue *** phosphorylated ubiquitin serves as a signal for activating parkin and recruiting autophagy receptors to promote clearance of damaged mitochondria via *** evidence has begun to indicate a link between impaired ubiquitin phosphorylation-dependent mitophagy and PD pathogenesis and supports the potential of Ser65-phosphorylated ubiquitin as a biomarker for *** new mechanistic insights and phenotypic screens have identified multiple potential therapeutic targets for PD drug *** review highlights recent advances in understanding ubiquitin phosphorylation in mitochondrial quality control and PD pathogenesis and discusses how these findings can be translated into novel approaches for PD diagnostic and therapeutic development.

关键词： Mitophagy Parkinson’s disease PINK1 Parkin Ubiquitin-protein ligase Ubiquitin phosphorylation Mitochondrial quality control Mitophagy