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The circadian clock in enamel development

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International Journal of Oral Science 2024年第3期16卷 371-380页

作者： Ke Wu Xiaochan li Yunyang Bai Boon chin Heng Xuehui Zhang Xuliang Deng Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina 4th Division Peking University School and Hospital of StomatologyBeijingChina Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration The First People’s Hospital of Jinzhong JinzhongChina

Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological *** circadian clock mechanisms in brain and peripheral tissues can oscillate independently or be synchronized/disrupted by external *** enamel is a type of mineralized tissue that forms the exterior surface of the tooth *** Retzius lines are readily observable microstructures of mature tooth enamel that indicate the regulation of amelogenesis by circadian *** enamel is formed by enamel-forming cells known as ameloblasts,which are regulated and orchestrated by the circadian clock during *** review will first examine the key roles of the circadian clock in regulating ameloblasts and *** physiological processes are involved,including gene expression,cell morphology,metabolic changes,matrix deposition,ion transportation,and ***,the potential detrimental effects of circadian rhythm disruption on enamel formation are *** rhythm disruption can directly lead to Enamel Hypoplasia,which might also be a potential causative mechanism of amelogenesis ***,future research trajectory in this field is *** is hoped that this review will inspire more intensive research efforts and provide relevant cues in formulating novel therapeutic strategies for preventing tooth enamel developmental abnormalities.

关键词： enamel crown exterior

Stable,intense supercontinuum light generation at 1 kHz by electric field assisted femtosecond laser filamentation in air

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light(Science & Applications) 2024年第2期13卷 354-365页

作者： Yaoxiang liu Fukang Yin Tie-Jun Wang Yuxin Leng Ruxin li Zhizhan Xu See Leang chin State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)light source has advanced ultrafast laser spectroscopy in condensed matter science,biology,physics,and *** to the frequently used photonic crystal fibers and bulk materials,femtosecond laser filamentation in gases is damage-immune for supercontinuum generation.A bottleneck problem is the strong jitters from filament induced self-heating at kHz repetition rate *** demonstrated stable kHz supercontinuum generation directly in air with multiple mJ level pulse *** was achieved by applying an external DC electric field to the air plasma *** pointing jitters of the 1 kHz air filament induced SC light were reduced by more than 2 *** stabilized high repetition rate laser filament offers the opportunity for stable intense SC generation and its applications in air.

关键词： intense repetition light

Provoking Buying Behaviors Amid Crises:Unfolding the Underlying Mechanisms of Psychological Impairments

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International Journal of Mental Health Promotion 2024年第4期26卷 279-292页

作者： Muhammad Waleed Ayub Ghouri Guofeng Wang Muhammad Ali Hussain Zhisheng li Tachia chin School of Management Zhejiang University of TechnologyHangzhou310023China School of Management and Economics University of Electronic Science and Technology of ChinaChengdu611731China Business School NingboTech UniversityNingbo315100China

Crises in the past have caused devastating,long-lasting impacts on the global *** after-effects always bring some dynamic and rigorous challenges for businesses and *** challenges have always been a point of discussion for *** recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological *** of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and *** address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online *** found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator ***,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.

关键词： Panic buying health belief model mental health competitive arousal theory intolerance of uncertainty cyberchondria

Biogeochemistry of sedimentary organic matter in the Yongjiang River estuary in the southern part of Hangzhou Bay,china,since the Late Pleistocene

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Journal of Oceanology and limnology 2024年第3期42卷 772-786页

作者： Dongqin HUANG Xiaolong li Zilong li Pei Sun LOH Jianxiong HU Jianfang CHEN Yuan-Pin CHANG chin-Wen YANG Qin GAO Institute of Marine Geology and Resources Ocean CollegeZhejiang UniversityZhoushan 316021China Ministry of Water Resources of the People’s Republic of china Beijing 100054China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Department of Oceanography Sun Yat-sen UniversityKaohsiung 80424China

A sediment core(YJK19-02)collected from the southern outlet of Hangzhou Bay near the Yongjiang River estuary in East china was analyzed for grain size,lignin,bulk elemental composition,stable carbon isotope,and rare earth elements(REEs)to determine the sources and diagenesis of sedimentary organic matter(OM)of the estuary and adjacent areas since the Late Pleistocene.δ^(13)C values(-24.80‰–-23.60‰),total organic carbon/total nitrogen(TOC/TN)molar ratios(8.00–12.14),and light rare earth element/heavy rare earth element ratios(LREE/HREE=8.34–8.91)revealed the predominance of terrestrial sources of OM,mainly from the Changjiang(Yangtze)*** lignin parameters of syringyl/vanillyl(S/V=0.20–0.73)and cinnamyl/vanillyl(C/V=0.03–0.19)ratios indicate the predominance of nonwoody angiosperms,and the vanillic acid/vanillin ratios[(Ad/Al)_(V)=0.32–1.57]indicate medium to high degrees of lignin *** increasing trend ofΛ(total lignin in mg/100-mg OC)values from ca.14500 a BP to ca.11000 a BP reflected the increase in temperature during the Late ***,a time lag effect of temperature on vegetation abundance was also *** relatively higher and stableΛvalues correspond to the higher temperature during the mid-Holocene from ca.8500 a BP to ca.4500 a BP.Λvalues decreased from ca.4000 a BP to the present,corresponding to historical temperature fluctuations during this *** results show that the vegetation abundance in the Yongjiang River Basin since the Late Pleistocene was related to the temperature fluctuation duo to climate change.

关键词： Yongjiang River estuary sedimentary organic matter lignin environmental change Late Pleistocene

Electrical performance and reliability analysis of vertical gallium nitride Schottky barrier diodes with dual-ion implanted edge termination

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Chip 2024年第3期3卷 36-42页

作者： Bo li Jinpei lin linfei Gao Zhengweng Ma Huakai Yang Zhihao Wu Hsien-chin Chiu Hao-Chung Kuo Chunfu Zhang Zhihong liu Shuangwu Huang Wei He Xinke liu College of Materials Science and Engineering College of Electronics and Information EngineeringInstitute of Microelectronics(IME)Guangdong Research Center for Interfacial Engineering of Functional MaterialsState Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Department of Electronic Engineering Chang Gung UniversityTaoyuan 333TaiwanChina Department of Photonics and the Institute of Electro-Optical Engineering and with Foxconn Semiconductor Research InstituteNational Chiao Tung UniversityHsinchu 300TaiwanChina Xidian University School of MicroelectronicsXi’an710071China

In this study,a galliumnitride(GaN)substrate and its 15μmepitaxial layer were entirely grown by adopting the hydride vapor phase epitaxy(HVPE)*** enhance the breakdown voltage(VBR)of vertical GaN-on-GaN Schottky barrier diodes(SBDs),a dual ion coimplantation of carbon and heliumwas employed to create the edge *** resulting devices exhibited a low turn-on voltage of 0.55 V,a high Ion/Ioff ratio of approximately 109,and a lowspecific onresistance of 1.93 mU cm^(2).When the ion implantation edge was terminated,the maximumVBR of the devices reached 1575 V,with an average improvement of 126%.These devices demonstrated a high figure of merit(FOM)of 1.28 GW cm^(-2) and showed excellent reliability during pulse stress testing.

关键词： Vertical GaN SBD HVPE Dual ion co-implantation Leakage mechanism Device reliability

Outcomes of a non-randomised audit of single pigtail suture stents in urolithiasis management of Asian patients in Singapore

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Asian Journal of Urology 2024年第2期11卷 324-330页

作者： Ee Jean lim Zhen Wei Choo Reshma Mangat Pradeep Durai Sarvajit Biligere Yiquan Tan Loh Hin Yeung Marcus Nicole Andrea Seet li Ting chin Tiong Heng Stefania Ferreti Vineet Gauhar Urology Department Singapore General HospitalSingapore Urology Department Tan Tock Seng HospitalSingapore Urology Department Ng Teng Fong HospitalSingapore Urology Department Azienda Ospedaliera-Uiversitaria(Hospital and University of Parma)ParmaItaly

Objective:Double-J(DJ)ureteric stents are commonly placed perioperatively for semirigid or flexible ureteroscopic renal *** is believed that lesser stent material within the bladder mitigates stent-related *** study aimed to evaluate the J-Fil ureteral stent,a single pigtail suture stent compared with conventional DJ stent in relation to stent symptoms in an Asian population undergoing ureterorenal ***:Based on internal audit committee recommendation approval,the records of 50 patients retrieved,available data of 41 patients who were prospectively enrolled into two groups(Group 1[J-Fil stent group],n=21 and Group 2[DJ stent group],n=20)between August 2020 to January 2021,were *** compared were nature of procedure,stone location and size,ease of deployment or removal,and complications.A modified universal stent symptom questionnaire was used to assess morbidity of stent symptoms within 48 h of insertion and at ***:Both groups had similar median age,distribution in male to female ratio,and stone *** overall median universal stent symptom questionnaire score at insertion was similar for bladder pain,flank or loin pain,and quality of life between Group 1 and 2;however,at removal Group 1 fared significantly better than Group 2,especially for flank or loin pain and pain at *** groups had similar ease in insertion with no hospital ***:Our audit favoured the single pigtail suture stent in Asian ureters in mitigating stent-related *** showed a good safety profile with easy deployment and *** promises a new standard in stenting.

关键词： Stent Ureteroscopy Pigtail suture stent Asianpatient Flexible ureteroscopic renal surgery

Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

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Genes & Diseases 2024年第3期11卷 144-147页

作者： Hongjia Zhang Xueqian Sun Zhanming li Tingting liu Fang Zhang Xinyu Meng Kaimi li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.chin Binhua P.Zhou Ping Jiang lishun Wang Jiong Deng Key Laboratory of Cell Differentiation and Apoptosis of chinese Minister of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology Kunming Medical UniversityKunmingYunnan 650500China Medical Research Center Binzhou Medical University HospitalBinzhouShandong 256600China Center for Traditional chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghai 201100China Department of Radiation Oncology Yantai Affiliated Hospital of Binzhou Medical UniversityYantaiShandong 264100China Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Laboratory Medicine Shanghai Pulmonary Hospital Affiliated Tongji UniversityShanghai 200080China Department of Physiology School of Basic Medical SciencesWeifang Medical UniversityWeifangShandong 261021China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Molecular and Celular Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40506USA Department of Respiratory Medicine The Second Affiliated HospitalDalian Medical UniversityDalianLiaoning116023China Peninsular Cancer Center Binzhou Medical UniversityYantaiShandong 264003China

Alcohol consumption contributes to global mortality and cancer ***(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA *** can be detoxified to acetate by acetaldehyde dehydrogenase... 详细信息

关键词： mortality damage ALDH2

lightning in a Forest (Wild) Fire: Mechanism at the Molecular Level

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Atmospheric and Climate Sciences 2024年第1期14卷 128-135页

作者： See Leang chin Xueliang Guo Harmut Schroeder Huanbin Xu Tie-Jun Wang Ruxin li Weiwei liu Department of Physics and Center for Optics Photonics and Lasers (COPL) Laval University Quebec Canada Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Max Planck Institute of Quantum Optics Garching Germany State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai China Institute of Modern Optics Nankai University Tianjin China

The mechanism of lightning that ignites a forest fire and the lightning that occurs above a forest fire are explained at the molecular level. It is based on two phenomena, namely, internal charge separation inside the atmospheric cloud particles and the existence of a layer of positively charged hydrogen atoms sticking out of the surface of the liquid layer of water on the surface of rimers. Strong turbulence-driven collisions of the ice particles and water droplets with the rimers give rise to breakups of the ice particles and water droplets into positively and negatively charged fragments leading to charge separation. Hot weather in a forest contributes to the updraft of hot and humid air, which follows the same physical/chemical processes of normal lightning proposed and explained recently[1]. lightning would have a high probability of lighting up and burning the dry biological materials in the ground of the forest, leading to a forest (wild) fire. The burning of trees and other plants would release a lot of heat and moisture together with a lot of smoke particles (aerosols) becoming a strong updraft. The condition for creating lightning is again satisfied which would result in further lightning high above the forest wild fire.

关键词： Forest Wild Fire lightning Molecular Level

短指软珊瑚(Sinularia acuta)热休克蛋白HSP70家族特征及进化分析

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热带海洋学报 2024年第4期43卷 123-136页

作者：李子若罗晏杰曹政 chin yaoxian 王沛政海南热带海洋学院崖州湾创新研究院海南三亚572022 海南南沙珊瑚礁生态系统国家野外科学观测研究站广东广州510300 海南热带海洋学院生态环境学院海南三亚572022 三亚海昌梦幻海洋不夜城海南三亚572022 海南省现代化海洋牧场工程研究中心海南三亚572022 海南省近岸海洋生态环境过程与碳汇重点实验室海南三亚572022

热休克蛋白70(heat shock protein 70, HSP70)在生物细胞或组织免受热或氧化应激等方面起着关键作用,是已知高度保守的蛋白质之一。由于全球环境持续升温,珊瑚大面积白化、死亡,珊瑚如何应对持续升温的抗逆机制是科学研究热点。本研究... 详细信息

热休克蛋白70(heat shock protein 70, HSP70)在生物细胞或组织免受热或氧化应激等方面起着关键作用,是已知高度保守的蛋白质之一。由于全球环境持续升温,珊瑚大面积白化、死亡,珊瑚如何应对持续升温的抗逆机制是科学研究热点。本研究从高温胁迫短指软珊瑚测序蛋白序列数据库分析鉴定出了28个HSP70蛋白家族成员,均为酸性亲水蛋白,大部分蛋白质结构较为稳定。亚细胞定位表明HSP70蛋白主要分布在珊瑚细胞核、细胞质中,在线粒体、内质网上也有少量分布。信号肽预测表明, 28个HSP70蛋白成员中26个没有信号肽,大部分不属于分泌蛋白,不存在跨膜结构。系统进化树结果表明短指软珊瑚HSP70蛋白家族成员聚成5大类。短指软珊瑚HSP70蛋白家族结构和保守基序分析中预测到了10条保守基序motif分为5个亚族。短指软珊瑚HSP70蛋白家族二级结构主要以α-螺旋和无规则卷曲为主,α-螺旋的含量占比大。28个HSP70家族蛋白中有25个预测到了N-糖基化位点,且位点个数在1~9范围内。28个HSP70家族蛋白均预测到磷酸化位点和O-糖基化位点,总个数分别在41~96和1~23范围内。本研究HSP70家族蛋白结果为今后珊瑚在应对全球升温胁迫中的适应机制等方面研究奠定了基础。

关键词：短指软珊瑚热休克蛋白 HSP70家族进化