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Health 2016年第8期8卷 764-771页

作者： Mayumi Watanabe chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

Body temperature is an important clinical indicator of health and illness. Many studies of human body temperature have been conducted;however, there are no studies that compare the body temperatures of humans and other homeothermic animals. Twenty-six homeothermic animal species, including humans, were selected and characteristics of their internal environment were studied based on previous reports. The studied species were divided into two groups based on habitat (eight aquatic and eighteen terrestrial species) and three groups based on diet (carnivores, herbivores, and omnivores). Body temperatures, erythrocyte counts, and lymphocyte percentages were compared between species and between groups. Our results showed that carnivores had lower body temperatures and erythrocyte numbers than herbivores, and lower lymphocyte ratios than both herbivores and omnivores. Aquatic mammals that experienced a second adaptation event during their evolutionary process had lower body temperatures and lymphocyte ratios than terrestrial animals. These results suggest that excessive adaptation induced by stress or a change in environment may result in relative hypothermia and lymphocytopenia, features that aquatic mammals with stressful evolutionary backgrounds share with human cancer patients. However, our study is based on analysis of previous observations and reports, and further research (e.g., larger-scale studies) is needed to support this hypothesis.

关键词： Body Temperature Erythrocyte Lymphocyte Carnivore Adaptation

Research on stress-induced apoptosis of natural killer cells and the alteration of their killing activity in mouse liver

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World Journal of Gastroenterology 2013年第37期19卷 6258-6264页

作者： Zhen Ma Yang Liu Xin Zhou Hai-Long Yu Ming-Qi Li chikako tomiyama-Miyaji Toru Abo Xue-Feng Bai Department of Colorectal Surgery Harbin Medical University Cancer Hospital Department of General Surgery the Second Affiliated Hospital of Harbin Medical University Department of Immunology Niigata University School of Medicine

AIM:To investigate the stress-induced apoptosis of natural killer(NK)cells and the changes in their killing activity in mouse ***:A restraint stress model was established in *** cytometry was employed to measure the percentage of NK cells and the changes in their absolute number in mouse *** cytotoxicity of hepatic and splenic NK cells was assessed against YAC-1 target cells via a 4 h 51Cr-release ***:The restraint stress stimulation induced the apoptosis of NK cells in the liver and the spleen,which decreased the cell *** number and percentage of NK cells in the spleen ***,the number of NK cells in the liver decreased,whereas the percentage of NK cells was significantly *** apoptosis of NK cells increased gradually with prolonged stress time,and the macrophage-1(Mac-1)+NK cells were more susceptible to apoptosis than Mac-1-NK *** numbers of Mac-1-NK cells in the liver,which are more resistant to stress-induced apoptosis,were observed than the Mac-1-NK cells in the *** stress stimulation diminished the killing activity of NK cells in the spleen was significantly decreased,but the retention of numerous Mac-1-NK cells in the liver maintained the killing ***:Significant stress-induced apoptosis was observed among Mac-1+NK cells,but not Mac-1-NK cells in the mouse *** stimulation markedly decreased the killing activity of NK cells in the spleen but remained unchanged in the liver.

关键词： Restraint stress Natural killer cells Cell apoptosis Killing activity

A Specific Pattern in the Basal Body Temperature Chart during the First Week of Pregnancy May Warn of a Miscarriage Crisis

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Health 2016年第8期8卷 723-729页

作者： Mayumi Watanabe Yoshinobu Nakamura chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Nakamura Seikotsuin Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

We studied the efficiency of acupuncture for patients who were unable to give birth though they had experienced conventional infertility treatment for more than 2 years by medical specialists. We then investigated characteristics of difficult pregnancy cases with measurement of body temperature and observation of basal body temperature (BBT) charts. Thirty-three patients had acupuncture every week for more than 2 years and 17 of them delivered. At the same time, their cutaneous body temperature was measured at five locations. Moreover, patients and acupuncturists had a weekly discussion of the patient’s BBT chart. The delivery group showed more balanced and higher cutaneous body temperatures than the miscarriage and no pregnancy groups. The delivery group showed a smooth increase in the BBT chart while the miscarriage group showed a specific pattern in shifting temperatures from low to high zones. Acupuncture might suppress excess sympathetic dominance, which induced hyperthermia as well as interruption of pregnancy. Additionally, weekly discussion and medical advice could help patients. However, further study of males, healthy women, or larger, comparative studies exploring the social and cultural background of other countries were needed to add support to these factors.

关键词： Basal Body Temperature (BBT) Chart Miscarriage Kyusaku Ogino Acupuncture Medical Advice

Internal environment for growth of cancer cells in mice: hypothermia, anemia and lymphocytopenia

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Health 2011年第4期3卷 238-244页

作者： Mayumi Watanabe Hiroaki Matsumoto chikako tomiyama Kohei Akazawa Toru Abo 不详

The internal environment in tumor-bearing mice was investigated in detail. When EL-4 lymphoma cells (5 × 106 cells/mouse) were intraperitoneally inoculated into C57BL/6 mice, approximately 70% of the mice died by day 24. In this regard, the internal environment was compared between control mice, surviving mice and tumor-bearing mice which died. The most prominent sign was hypothermia (<34?C from day 16) seen in tumor-bearing mice which died. Control mice and surviving mice did not show such hypothermia (around 38?C). Other changes, including anemia and lymphocytopenia, were also seen in tumor-bearing mice which died, but not in control mice and surviving mice. Immunological study revealed that NKT cells, which have been previously identified to be the major effector lymphocytes against EL-4 cells, almost disappeared, especially in the liver of tumor-bearing mice which died. These results suggest that a specific internal environment might be required for continuous tumor growth in vivo. Such internal environmental factors include hypothermia, ane- mia and severe immunosuppression.

关键词： Cancer Hypothermia Anemia Immunosuppression Glycolysis Mitochondria

Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin

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Advances in Infectious Diseases 2023年第3期13卷 478-497页

作者： Hideki Yamamoto chikako tomiyama Sho Yamasaki Shinobu Saijo Yoichiro Iwakura Kazuyoshi Kawakami Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Department of Molecular Immunology Research Institute for Microbial Diseases Osaka University Osaka Japan Laboratory of Molecular Immunology Immunology Frontier Research Center Osaka University Osaka Japan Project for Cytokine Research Division of Molecular Immunology Medical Mycology Research Center Chiba University Chiba Japan Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Chiba Japan Department of Medical Microbiology Mycology and Immunology Tohoku University Miyagi Japan Department of Internal Medicine Hirose Hospital Miyagi Japan

C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed analysis on the involvement of Dectin-2, a CLR that senses high mannose polysaccharide, in innate immune responses induced by influenza virus hemagglutinin (HA). Treatment of HA with periodate or PNGase F induced lower interleukin (IL)-12p40 secretion by conventional dendritic cells (DCs) compared with the untreated group. In contrast, treatment with O-glycosidase did not affect cytokine production. Green fluorescent protein expression in canonical Dectin-2-transducing cells was approximately 3% - 12% following HA stimulation, except with the A/H1N1pdm09 subtype HA. This expression was markedly reduced in cells possessing mutated amino acids in the carbohydrate recognition domain of Dectin-2, especially following stimulation with HA derived from the A/H3N2 subtype. Interferon (IFN)-α production from CD11c+Siglec-H+PDCA-1+ plasmacytoid DCs was significantly increased in Dectin-2 knockout mice compared with wild-type mice upon stimulation with HA except for the B/Yamagata lineage HA. These results suggested that Dectin-2 is involved in initiating inflammatory responses via mannose polysaccharide on HA. However, other mechanisms may function in the antiviral response, including the type I IFN axis.

关键词： C-Type Lectin Receptors Influenza Virus Innate Immunity Type I Interferon

Traditional Japanese Style Bathing May Contribute to Good Health and Longevity

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Health 2016年第8期8卷 756-763页

作者： Mayumi Watanabe Shigeharu Koboshi Hiroshi Yoshimoto Kazuhiro Kobayashi chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Hot Album Tansansen Tablet Inc. Hachiouji Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

The objective of this study was to determine how traditional Japanese style bathing could promote good health. Using healthy volunteers, we assessed body temperature (core and cutaneous), red blood cells, white blood cells (WBCs), venous blood gas parameters (PO2, SO2, PCO2, TCO2, HCO3, and pH), weight loss (which may indicate sweat volume), and the time until sweating before and after bathing. We simultaneously conducted a double-blind clinical trial using a bath additive group and a control group to investigate the effect of a bath additive on the same parameters. We found that bathing increased the core and cutaneous body temperature, as well as PO2, SO2, and blood pH. All of the subjects also showed increases in heart rate and weight loss (sweat volume). After bathing, the number and ratio of granulocytes increased while the number and ratio of lymphocytes decreased. These results tended to be emphasized in the bath additive group;however, significant between-group differences were not detected. Our results indicated that bathing improved blood circulation and had a modulatory effect on the autonomic nervous system. This suggested that traditional Japanese style bathing might contribute to good health and longevity;however, additional larger-scale studies were needed to confirm or refute this conclusion.

关键词： Body Temperature Bathing Bath Additive Blood Gas Heart Rate Sweat

Does East Meet West?—The Association between Oriental Tongue Inspection and Western Clinical Assays of White Blood Cell Subsets

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Health 2015年第7期7卷 801-808页

作者： Mayumi Watanabe Eisuke Kainuma chikako tomiyama Zaigen Oh Joe Koshizawa Gouzou Nagano Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan The House of Kainuma Acupuncture & Moxibustion Oriental Medical Center Group (Kainuma Shinkyu-in) Murakami Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Section of Traditional Chinese Medicine Graduate School of Kansai University of Health Sciences Osaka Japan Nagano Clinic Tokyo Japan Nihon Jiritsushinkei Meneki Chiryo Kenkyu-kai Tokyo Japan

The autonomic nervous system (ANS) controls white blood cell (WBC) subsets;therefore, the status of ANS can be assessed by assaying WBCs. However, this requires invasive blood sampling, time, cost, and training. Therefore, this study focused on a traditional technique, tongue inspection, which is a simpler method. The purpose of this study was to investigate whether there is an association between the traditional method of tongue inspection and clinical assay of WBC subsets. Twenty-one female alopecia areata patients were divided into two age-matched groups: 1) alopecia areata totalis (AT);and 2) alopecia areata multiplex (AM). Images of patient tongues were captured by a digital camera and categorized before blood sampling. Finally, patients were divided into five groups (normal, Yin+, Yang–, Yin– and Yang+) based on the Eight Principles of traditional Chinese medicine (TCM). Concurrently, venous blood was obtained for WBC subsets. The absolute numbers of WBCs and granulocytes of the AT group were higher than those of the AM group. The AT group was Yin+ but not Yang+, whereas the AM group was Yang+ but not Yin+. Thus, the AT group showed more elements of “cold” (Yin > Yang) compared with the AM group with elements of “hot” (Yin < Yang). Tongue inspection suggested a possibility of consistence with those of WBCs although statistical significance was not obtained. Moreover, some Yin+ and Yang+ subjects showed some trend in similarities between tongue inspection and WBC subsets although this was not statistically significant. Therefore, traditional techniques (such as tongue inspection) acupuncture must be studied further to detect whether subtle effects are induced by acupuncture treatment. As this study is underpowered, a larger scale study including males is required in the future.

关键词： Alopecia Areata Totalis Alopecia Areata Multiplex Tongue Inspection White Blood Cell Subset Autonomic Nervous System Traditional Chinese Medicine (TCM)

Blood Pressure Balance as a Marker for Early Detection of Cerebral Infarction and a Criterion for Inclusion/Exclusion from Acupuncture Treatment

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Health 2021年第8期13卷 857-867页

作者： Mayumi Watanabe Yoshinobu Nakamura chikako tomiyama Nozomu Mandai Hanaa Yousef Bakir Tokimasa Takeda Faculty of Health Sciences Kansai University of Health Sciences Osaka Japan Faculty of Science and Engineering Chuo University Tokyo Japan Acupuncture Center Nakamura Seikotsuin Niigata Japan Niigata University of Health and Welfare Niigata Japan Graduate School of Health Sciences Niigata University Niigata Japan Center for Humanities and Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan Faculty of Medicine Assiut University Assiut Governorate Egypt Zinbunken Kyoto University Kyoto Japan

Background: Early detection of cerebral infarction (CI) by home acupuncturists might be helpful in reducing stroke mortality. We compared vital signs of patients who developed CI and those who did not to ascertain if blood pressure balance is a useful marker for the early detection of CI and for distinguishing cases with potentially effective/ineffective acupuncture treatment. Methods: In this retrospective study, vital signs such as body temperature, pulse, and blood pressure, were simultaneously obtained from the right and left arms of patients who received weekly acupuncture treatment. We focused on the differences between values obtained from the right and left arms (the balance) and compared the values of patients who developed CI [CI (+)] (n = 18) and those of age-/gender-matched patients who did not [CI (−)] (n = 18). Results: Left/right blood pressure was significantly more unbalanced in the CI (+) group than in the CI (−) group, especially immediately before the onset of CI. Moreover, all CIs occurred on the side with a lower blood pressure. Discussion and Conclusions: Blood pressure balance might aid in the early detection of CI and to determine whether treatment with traditional or modern medicine is more appropriate. Acupuncture may thus help maintain patients’ quality of life.

关键词： Acupuncture Aged Blood Pressure Balance Cerebral Infarction Preventative Medicine

The Association between Self-Monitored Reproductive Parameters, Pregnancy Outcomes and Acupuncture Treatment

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Health 2016年第8期8卷 730-736页

作者： Mayumi Watanabe Yoshinobu Nakamura chikako tomiyama Haiyan Fu Minako Shimaya Yiwei Ling Toru Abo Departmentof Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Nakamura Seikotsuin Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Medical Record Room Fourth Hospital of Hebei Medical University Shijiazhuang China Department of Bioinformatics Niigata University Medical and Dental Hospital Niigata Japan Toru Abo Research Centre Niigata Japan

Many women track their daily basal body temperature (BBT), an important factor in reproductive status, as a part of fertility self-management. This study involved 135 patients who had undergone conventional infertility treatment;they had weekly acupuncture treatment and we assessed BBT, menstrual cycle, menstrual period and menstrual bleeding amount pre- and post-treatment. We also analyzed the rate of insufficient description of reproductive parameters, comparing patients who had delivered a baby with those who had a miscarriage and those who did not become pregnant. Menstrual cycle and period did not show notable changes pre- and post-acupuncture treatment in all groups. Menstrual bleeding amount decreased in the no-pregnancy group. There was a suggestion that acupuncture decreased very long menstrual cycle (e.g. bimonthly) to monthly. The insufficient description rate of menstrual bleeding amount was high in all groups. Weekly discussion about monitoring reproductive parameters could improve patients’ awareness in self-management. To prevent miscarriage patients needed psychological and medical advice for careful self-management in pregnancy and menstrual cycle.

关键词： Basal Body Temperature Chart Pregnancy Miscarriage Menstrual Cycle Insufficient

A Study of Hie and LBP: The First Step to Improve Subjective Well-Being

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Health 2023年第10期15卷 1013-1023页

作者： Mayumi Watanabe chikako tomiyama Takuya Nikaido Masae Ryufuku Nozom Mandai Tokimasa Takeda Tsutomu Komine Faculty of Science and Engineering Chuo University Tokyo Japan Faculty of Health Sciences Kansai University of Health Sciences Osaka Japan Graduate School of Health Sciences Niigata University Niigata Japan Department of Orthopaedic Surgery School of Medicine Fukushima Medical University Fukushima Japan Translational Research Center Fukushima Medical University Fukushima Japan Faculty of Nursing Science Tsuruga Nursing University Tsuruga Japan Zinbunken Kyoto University Kyoto Japan

Backgrounds: Health does not only physical health, therefore, we need to study it from various viewpoints. Many Japanese female complain of a Hie or a low back pain (LBP), which they reduce their subjective well-being. We analyze. Those patients often have acupuncture therapy. In this study, we analyze the characteristics of Hie and LBP, the satisfaction level of alternative therapy and we pursue a tip to improve subjective well-being. Methods: Of 1000 women, Hie (+)/Hie (−) or LBP (+)/LBP (−), we compared their body temperature (BT) (axilla) and body mass index (BMI). Furthermore, the Chi test identified ten factors of “body” and seven “mind” information. Results: In the result of BT (axilla) while LBP indicated a significant difference. Both Hie and LBP showed difference in the opposite direction. Hie did now show such clear differences in “body” information. However, interestingly, all seven questions in the “mind” information showed statistical difference. Discussion and conclusion: One reason why those patients have acupuncture therapy may acupuncture therapy traditionally has not separate “mind” and “body” and it has the concept of “mind-body unity”. To improve subjective well-being, first we need to focus on “Mind” as well as “mind-body unity”. Mental-health support is important for patients with Hie or LBP to reduce physiological stress.

关键词： Hie Low Back Pain (LBP) Subjective Well-Being Body Temperature (BT)