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STING regulates BCR signaling in normal and malignant B cells

Cellular & Molecular Immunology 2021年第4期18卷 1016-1031页

作者： chih-hang anthony tang Avery C.Lee Shiun Chang Qin Xu Andong Shao Yun Lo Walker T.Spalek Javier A.Pinilla-lbarz Juan R.Del Valle chih-Chi Andrew Hu The Wistar Institute 3601 Spruce StreetPhiladelphiaPA 19104USA Department of Malignant Hematology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Department of Chemistry&Biochemistry University of Notre DameNotre DameIN 46556USA

STING is an endoplasmic reticulum(ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type Ⅰ interferons;however,the role of STING in B cell receptor(BCR)signaling remains *** generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM,Ig a and Igβ via SEL1L/HRD1-mediated ER-associated degradation(ERAD).B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated *** immunized with T-independent antigens,STING V154M mice produced significantly fewer antigen-specific plasma cells and antibodies than immunized wild-type(WT)*** further generated B cell-specific STING^(KO) mice and showed that STING^(KO) B cells indeed responded to activation by transducing stronger BCR signals than their STING-proficient *** B cell-specific STING^(KO) mice were T-independently immunized,they produced significantly more antigen-specific plasma cells and antibodies than immunized STIN^(WT)*** both human and m ouse IGHV-unmutated malignant chronic lymphocytic leukemia(CLL)cells downregulated the expression of STING,we explored whether STING downregulation could contribute to the well-established robust BCR signaling phenotype in malignant CLL *** generated a STING-deficient CLL mouse model and showed that STING-deficient CLL cells were indeed more responsive to BCR activation than their STING-proficient *** results revealed a novel B cell-intrinsic role of STING in negatively regulating BCR signaling in both normal and malignant B cells.

关键词： STING BCR ER-associated degradation CLL Plasma cells

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STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function

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Cellular & Molecular Immunology 2021年第3期18卷 632-643页

作者： Hee-Jin ChoiTaylor Ticer Yongxia Wu chih-hang anthony tang Corey Mealer David Bastian M.Hanief Sofi Linlu Tian Steven Schutt Hee-Jin Choi Taylor Ticer Mengmeng Zhang Xiaohui Sui Lei Huang Andrew L.Mellor chih-Chi Andrew Hu Xue-Zhong Yu Microbiology&Immunology Medical University of South CarolinaCharlestonSCUSA Immunology Microenvironment&Metastasis ProgramThe Wistar InstitutePhiladelphiaPAUSA Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle upon TyneUK Department of Medicine Medical University of South CarolinaCharlestonSCUSA Hollings Cancer Center Medical University of South CarolinaCharlestonSCUSA

Stimulator of interferon genes(STING)-mediated innate immune activation plays a key role in tumor-and self-DNA-elicited antitumor immunity and ***,STING can also suppress tumor immunity and *** signaling In host nonhematopoietic cells was reported to either protect against or promote graft-versus-host disease(GVHD),a major complication of allogeneic hematopoietic cell transplantation(allo-HCT).Host hematopoietic antigen-presenting cells(APCs)play key roles in donor T-cell priming during GVHD ***,how STING regulates host hematopoietic APCs after allo-HCT remains *** utilized murine models of allo-HCT to assess the role of STING in hematopoietic ***-deficient recipients developed more severe GVHD after major histocompatibility complex-mismatched *** bone marrow chimeras,we found that STING deficiency in host hematopoietic cells was primarily responsible for exacerbating the ***,STING on host CD11c+cells played a dominant role in suppressing allogeneic T-cell ***,STING deficiency resulted in increased survival,activation,and function of APCs,including macrophages and dendritic ***,constitutive activation of STING attenuated the survival,activation,and function of APCs isolated from STING V154M knock-in ***-deficient APCs augmented donor T-cell expansion,chemokine receptor expression,and migration into intestinal tissues,resulting in accelerated/exacerbated *** pharmacologic approaches,we demonstrated that systemic administration of a STING agonist(bis-(3'-5')-cyclic dimeric guanosine monophosphate)to recipient mice before transplantation significantly reduced GVHD *** conclusion,we revealed a novel role of STING in APC activity that dictates T-cell allogeneic responses and validated STING as a potential therapeutic target for controlling GVHD after allo-HCT.

关键词： Stimulator of interferon genes antigen-presenting cells allogeneic hematopoietic cell transplantation graft-versushost diseases hematopoietic stem-cell transplantation T cells

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Fault location of untransposed double-circuit transmission lines based on an improved Karrenbauer matrix and the QPSO algorithm

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Protection and Control of Modern Power Systems 2023年第3期8卷 139-152页

作者： Minan tang hang Lu Bin Li School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhouChina School of Electrical and Information Engineering Tianjin UniversityTianjinChina.

Some double-circuit transmission lines are untransposed,which results in complex coupling relations between the parameters of the transmission *** the traditional modal transformation matrix is directly used to decouple the parameters,it can lead to large errors in the decoupled modal parameter,errors which will be amplified in the fault location ***,it makes the fault location results of the untransposed double-circuit transmission lines less ***,a new modal transformation method is needed to decou-ple the parameter matrix of untransposed double-circuit transmission lines and realize the fault location according to the decoupled modal *** improving the basis of the Karrenbauer matrix,a modal transformation matrix suitable for decoupling parameters of untransposed double-circuit transmission lines is *** address the dif-ficulties in solving the fault location equation of untransposed double-circuit transmission lines,a new fault location method based on an improved Karrenbauer matrix and the quantum-behaved particle swarm optimization(QPSO)algorithm is ***,the line parameter matrix is decomposed into identical and inverse sequence compo-nents using the identical-inverse sequence component *** Karrenbauer matrix is then transformed to obtain the improved Karrenbauer matrix for untransposed double-circuit transmission lines and applied to identi-cal and inverse sequence components to solve the decoupled modal ***,based on the principle that voltage magnitudes at both ends are equal,the fault location equation is expressed using sequence compo-nents at each end,and the QPSO algorithm is introduced to solve the ***,the feasibility and accuracy of the proposed method are verified by PSCAD *** simulation results fully demonstrate that the innova-tive improvement on the basis of the traditional modal transformation matrix in this paper can realize the m

关键词： Fault location Untransposed double-circuit transmission lines Karrenbauer matrix Quantum particle

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Spin coating of TPB film on acrylic substrate and measurement of its wavelength shifting efficiency

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Nuclear Science and Techniques 2020年第3期31卷 57-65页

作者： hang Yang Zi-Feng Xu Jian tang Yi Zhang School of Physics Sun Yat-sen UniversityGuangzhou 510275China School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China

Scintillation light from a liquid noble gas during a neutrino or dark matter experiment lies typically within the vacuum ultraviolet region and might be strongly absorbed by surrounding materials such as light guides or *** butadiene(TPB)is a fluorescent material,acts as a wavelength shifter,and can turn UV light into visible light at a peak wavelength of approximately 425 nm,enabling the light signals to be easily detected during physics *** with a traditional TPB coating method using vapor deposition,we propose an alternative technique applying a spin-coating procedure to facilitate the development of neutrino and dark matter *** article introduces a method to fabricate a TPB film on an acrylic substrate by using a spincoating method,reports the measurements of the sample film thickness and roughness,demonstrates the reemission spectrum,and quantifies the wavelength shifting efficiency.

关键词： Wavelength shifter Tetraphenyl butadiene Spin-coating method

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NLRC3 alleviates hypoxia/reoxygenation induced inflammation in RAW264.7 cells by inhibiting K63-linked ubiquitination of TRAF6

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 455-460页

作者： Zhong-tang Li hang Liu Wan-Qiu Zhang Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Background:NOD-like receptor family CARD domain containing 3(NLRC3)plays an important role in both innate and adaptive *** study was to explore the function and related mechanisms of NLRC3 in a hypoxia/reoxygenation(H/R)-induced inflammatory response in RAW264.7 ***:Liver ischemia-reperfusion(I/R)model in mice and H/R model in RAW264.7 cells were *** blotting was used to determine the protein expression level of NLRC3 in liver tissue and NLRC3,TRAF6,p–p65,p65,IκB–α,and the K63-linked ubiquitination level of TRAF6 in *** immunofluorescence assay was performed to evaluate the nuclear level of the NF–κB(p65).ELISA was conducted to measure the content of IL–1βin serum and cell *** interaction between NLRC3 and TRAF6 in cells was analyzed by the Co-IP ***:The NLRC3 protein level in liver tissue was decreased with the prolongation of reperfusion time(P<0.05).The expression of NLRC3 and IκB–αprotein in RAW264.7 was decreased gradually,while the expression of p–p65 and TRAF6 proteins and K63-linked ubiquitination of TRAF6 were increased gradually with the prolongation of reoxgenation time(P<0.05).The Co-IP assay revealed that NLRC3 and TRAF6 can bind to each other ***,NLRC3 had no effect on the expression of TRAF6 *** ubiquitination test results showed that the K63-linked ubiquitination level of TRAF6 in H/R+Lv–NLRC3 group was significantly lower than that in the H/R+negative control(NC)group(P<0.05).Moreover,the activation of NF–κB in H/R+Lv–NLRC3 group was inhibited compared with that in the H/R+NC group,and the level of the inflammatory factor IL–1βin the cell culture supernatant was also decreased accordingly(P<0.05).Conclusions:NLRC3 might alleviate H/R-induced inflammation in RAW264.7 cells by inhibiting K63-linked ubiquitination of TRAF6.

关键词： NLRC3 TRAF6 K63-linked ubiquitination Liver ischemia-reperfusion injury

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Specific ion effect of H^(+) on variably charged soil colloid aggregation

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Pedosphere 2020年第6期30卷 844-852页

作者： Yekun Zhang Rui TIAN Jia tang hang LI Chongqing Key Laboratory of Soil Multi-Scale Interfacial Process College of Resources and EnvironmentSouthwest UniversityChongqing 400715China

Specific ion effects(Hofmeister effects)have recently attracted the attention of soil scientists,and it has been found that ionic non-classic polarization plays an important role in the specific ion effect in ***,this explanation cannot be applied to H+.The aim of this work was to characterize the specific ion effect of H+on variably charged soil(yellow soil)colloid *** total average aggregation(TAA)rate,critical coagulation concentration(CCC),activation energy,and zeta potential were used to characterize and compare the specific ion effects of H+,K+,and Na+.Results showed that strong specific ion effects of H+,K+,and Na+existed in variably charged soil colloid *** TAA rate,CCC,and activation energy were sensitive to H+,and the addition of a small amount of H+changed the TAA rate,CCC,and activation energy *** zeta potential results indicated that the specific ion effects of H+,K+,and Na+on soil colloid aggregation were caused by the specific ion effects of H+,K+,and Na+on the soil electric field *** addition,the origin of the specific ion effect for H+was its chemical adsorption onto surfaces,while those for alkali cations were non-classic *** study indicated that H+,which occurs naturally in variably charged soils,will dominate variably charged soil colloid aggregation.

关键词： activation energy chemical adsorption critical coagulation concentration dynamic light scattering Hofmeister effect total average aggregation rate zeta potential

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High pyrolysis temperature biochar reduced the transport of petroleum degradation bacteria Corynebacterium variabile HRJ4 in porous media

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Journal of Environmental Sciences 2021年第2期33卷 228-239页

作者： Saisai Guo Xiaomei Liu hang Zhao Lan Wang Jingchun tang College of Environmental Science and Engineering Nankai UniversityTianjin 300350China Key Laboratory of Pollution Processes and Environmental Criteria(Ministry of Education) Tianijin 300350China Tianjin Engineering Research Center of Enuironmental Diagnosis and Contamination Remediation Tianjin 300350China

Biochar has been widely applied for the remediation of petroleum-contaminated ***,the effect of biochar on the transport of petroleum degradation bacteria has not been studied.A typical Gram-positive petroleum degradation bacteria-Corynebacterium variabile HRJ4 was used to study the effect of different biochars on bacterial transport and *** indicated that the addition of biochar in sand was effective for reducing the transport of bacteria and poplar sawdust biochar(PSBC)had a stronger hinder effect than corn straw biochar(CSBC).The hindrance was more evident with pyrolysis temperature of biochar raised from 300℃ to 600℃,which was attributed to the increase of specific surface area(309 times).The hindrance effect also enhanced with higher application rate of ***,the reduction of HRJ4 transport was more obvious in higher(25 mmol/L)concentration of Na Cl solution owing to electrostatic attraction *** adsorption of biochar to HRJ4 was defined to contribute to the hindrance of HRJ4 transport *** the influence of feedstocks and pyrolysis temperature on HRJ4 transport,it suggested that specific surface area had the greatest effect on HRJ4 transport,and pore-filling,electrostatic force also contributed to HRJ4 retained in quartz sand *** last,phenol transportation experiment indicated that the restriction of biochar on HRJ4 enhanced the phenol removal rate in the *** study provides a theoretical basis for the interaction of biochar and bacteria,which is vital for the remediation of oil-contaminated soil and groundwater in the field.

关键词： Gram-positive bacteria Feedstocks HRJ4 Transport Retention

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Design of multilayer cellular neural network based on memristor crossbar and its application to edge detection

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Journal of Systems Engineering and Electronics 2023年第3期34卷 641-649页

作者： YU Yongbin tang Haowen FENG Xiao WANG Xiangxiang HUANG hang School of Information and software Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

Memristor with memory properties can be applied to connection points(synapses)between cells in a cellular neural network(CNN).This paper highlights memristor crossbar-based multilayer CNN(MCM-CNN)and its application to edge *** MCM-CNN is designed by adopting a memristor crossbar composed of a pair of ***-CNN based on the memristor crossbar with changeable weight is suitable for edge detection of a binary image and a color image considering its characteristics of programmablization and *** of merit(FOM)is introduced to evaluate the proposed structure and several traditional edge detection operators for edge detection *** results show that the FOM of MCM-CNN is three times more than that of the traditional edge detection operators.

关键词： edge detection figure of merit(FOM) memristor crossbar synaptic circuit memristor crossbar-based cellular neural network(MCM-CNN)

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Unraveling the size distributions of surface properties for purple soil and yellow soil

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Journal of Environmental Sciences 2015年第6期27卷 81-89页

作者： Ying tang hang Li Xinmin Liu Hualing Zhu Rui Tian Chongqing Key Laboratory of Soil Multi-Scale Interfacial Process College of Resources and Environment Southwest University Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Soils contain diverse colloidal particles whose properties are pertinent to ecological and human health, whereas few investigations systematically analyze the surface properties of these particles. The objective of this study was to elucidate the surface properties of particles within targeted size ranges（i.e. 〉 10, 1-10, 0.5-1, 0.2-0.5 and 〈 0.2 μm） for a purple soil（Entisol） and a yellow soil（Ultisol） using the combined determination method. The mineralogy of corresponding particle-size fractions was determined by X-ray *** found that up to 80% of the specific surface area and 85% of the surface charge of the entire soil came from colloidal-sized particles（〈 1 μm）, and almost half of the specific surface area and surface charge came from the smallest particles（〈 0.2 μm）. Vermiculite,illite, montmorillonite and mica dominated in the colloidal-sized particles, of which the smallest particles had the highest proportion of vermiculite and montmorillonite. For a given size fraction, the purple soil had a larger specific surface area, stronger electrostatic field, and higher surface charge than the yellow soil due to differences in ***, the differences in surface properties among the various particle-size fractions can also be ascribed to mineralogy. Our results indicated that soil surface properties were essentially determined by the colloidal-sized particles, and the 〈 0.2 μm nanoparticles made the largest contribution to soil properties. The composition of clay minerals within the diverse particle-size fractions could fully explain the size distributions of surface properties.

关键词： Particle size distribution Soil colloids Surface charge number Specific surface area Clay minerals

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A revised jump-diffusion and rotation-diffusion model

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Chinese Physics B 2019年第5期28卷 216-221页

作者： Hua Li Yu-hang Chen Bin-Ze tang Department of Physics Jinan University

Quasi-elastic neutron scattering(QENS) has many applications that are directly related to the development of highperformance functional materials and biological macromolecules, especially those containing some water. The analysis method of QENS spectra data is important to obtain parameters that can explain the structure of materials and the dynamics of water. In this paper, we present a revised jump-diffusion and rotation-diffusion model(rJRM) used for QENS spectra data analysis. By the rJRM, the QENS spectra from a pure magnesium-silicate-hydrate(MSH) sample are fitted well for the Q range from 0.3 ^(-1) to 1.9 ^(-1) and temperatures from 210 K up to 280 K. The fitted parameters can be divided into two kinds. The first kind describes the structure of the MSH sample, including the ratio of immobile water(or bound water) C and the confining radius of mobile water a_0. The second kind describes the dynamics of confined water in pores contained in the MSH sample, including the translational diffusion coefficient Dt, the average translational residence timeτ0, the rotational diffusion coefficient D_r, and the mean squared displacement(MSD) u^2. The r JRM is a new practical method suitable to fit QENS spectra from porous materials, where hydrogen atoms appear in both solid and liquid phases.

关键词： revised jump-diffusion and rotation-diffusion model (rJRM) data analysis of quasi-elastic neutron scattering (QENS) spectra dynamics of water magnesium-silicate-hydrate (MSH) samples

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