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Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea

World Journal of Gastroenterology 2011年第37期17卷 4218-4224页

作者： chien-Chang Chen Chee-Jen Chang Tzou-Yien Lin ming-Wei Lai Hsun-Chin Chao Man-Shan Kong Division of Gastroenterology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan 333 Taiwan China Department of Medicine Chang Gung University College of Medicine Taoyuan 333 Taiwan China Graduate Institute of Clinical Medical Sciences Clinical Informatics and Medical Statistics Research Center Chang Gung Memorial Hospital Taoyuan 333 Taiwan China

AIM:To explore the value of fecal lactoferrin in predicting and monitoring the clinical severity of infectious ***:Patients with acute infectious diarrhea ranging from 3 mo to 10 years in age were enrolled,and one to three stool samples from each subject were *** parameters,including white blood cells /differential count,C-reactive protein,fecal mucus,fecal pus cells,duration of fever,vomiting,diarrhea and severity(indicated by Clark and Vesikari scores),were recorded and *** lactoferrin was determined by enzyme-linked immunosorbent assay and compared in different pathogen and disease *** estimating equations(GEE) were also used for ***:Data included 226 evaluations for 117 individuals across three different time *** lactoferrin was higher in patients with Salmonella(11.17 μg/g ± 2.73 μg/g) or Campylobacter(10.32 μg/g ± 2.94 μg/g) infections and lower in patients with rotavirus(2.82 μg/g ± 1.27 μg/g) or norovirus(3.16 μg/g ± 1.18 μg/g) *** of fecal lactoferrin were significantly elevated in patients with severe(11.32 μg/g ± 3.29 μg/g) or moderate(3.77 μg/g ± 2.08 μg/g) disease activity compared with subjects with mild(1.51 μg/g ± 1.36 μg/g) disease activity(P < 0.05).GEE analysis suggests that this marker could be used to monitor the severity and course of gastrointestinal infections and may provide information for disease ***:Fecal lactoferrin increased during bacterial infection and with greater disease severity and may be a good marker for predicting and monitoring intestinal inflammation in children with infectious diarrhea.

关键词： Lactoferrin Diarrhea Generalized estimating equations Vesikari scores Clark scores

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Primary retroperitoneal mucinous cystadenoma:Report of a case and review of the literature

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World Journal of Gastroenterology 2008年第37期14卷 5769-5772页

作者： Sheng-Lei Yan Ho Lin chien-Long Kuo Hurng-Sheng Wu ming-Ho Huang Yueh-Tsung Lee Division of Gastroenterology Departmentof Internal Medicine Chang Bing Show Chwan MemorialHospital Changhua County 505 Taiwan China Department of Life Sciences NationalChun~ Hsing University. Taichung City 402. Taiwan. China Department of Pathology Show ChwanMemorial Hospital Changhua City 500 Taiwan China Division of GeneralSurgery Department of Surgery Show Chwan MemorialHospital Changhua City500 Taiwan China Division of General Surgery Departmentof Surgery Chang Bing Show Chwan Memorial HospitalChanghua County 505 Taiwan China

Primary retroperitoneal mucinous cystadenomas (RMCs) are very rare and their biological behavior and histogenesis remain speculative. An accurate preoperative diagnosis of these tumors is difficult because no effective diagnostic measures have been established. We describe a 29-year-old woman with abdominal pain and a palpable mass. Computed tomography (CT) of the abdomen revealed a retroperi-toneal cystic mass which was resected successfully at laparotomy. Histopathological examination of the resected mass confirmed the diagnosis of RMC. There was no evidence of disease 2 years after surgery.

关键词： Retroperitoneal Mucinous cystadenoma Cystic mass Clinical features

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GIS-based Evaluation on the Fault Motion-Induced Coseismic Landslides

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Journal of Mountain Science 2012年第5期9卷 601-612页

作者： ming-Wey HUANG chien-Yuan CHEN Tzu-Hsiu WU Chi-Ling CHANG Sheu-Yien LIU Ching-Yun KAO Taiwan Science & Technology Center for Disaster Reduction Sindian City Taipei County 231 Chinese Taipei Taiwan Chiayi University Department of Civil & Water Resources Engineering Chiayi City 60004 Chinese Taipei Chia Nan University of Pharmacy and Science Institute of Industrial Safety & Disaster Prevention Tainan City 71710 Chinese Taipei

Earthquake-induced potential landslides are commonly estimated using landslide susceptibility maps. Nevertheless, the fault location is not identified and the ground motion caused by it is unavailable in the map. Thus, potential coseismic landslides for a specific fault motion-induced earthquake could not be predicted using the map. It is meaningful to incorporate the fault location and ground motion characteristics into the landslide predication model. A new method for a specific fault motion-induced coseismic landslide prediction model using GIS （Geographic Information System） is proposed herein. Location of mountain ridges, slope gradients over 45~, PVGA （Peak Vertical Ground Accelerations） exceeded o.15 g, and PHGA （Peak Horizontal Ground Accelerations） exceeded o.25 g of slope units were representing locations that initiated landslides during the 1999 Chi-Chi earthquake in Taiwan. These coseismic landslide characteristics were used to identify areas where landslides occurred during Meishan fault motion-induced strong ground motions in Chiayi County in Taiwan. The strong ground motion （over 8 Gal in the database, 1 Gal = 0.0l m/s2, and 1 g = 981 GaD characteristics were evaluated by the fault length, site distance to the fault, and topography, and their attenuation relations are presented in GIS. The results of the analysis show that coseismic landslide areas could be identified promptly using GIS. The earthquake intensity and focus depthhave visible effects on ground motion. The shallower the focus depth, the larger the magnitude increase of the landslides. The GIS-based landslide predication method is valuable combining the geomorphic characteristics and ground motion attenuation relationships for a potential region landslide hazard assessment and in disaster mitigation planning.

关键词： Coseismic landslide GIS Chi-Chiearthquake

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Future temperature changes over the critical Belt and Road region based on CMIP5 models

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Advances in Climate Change Research 2018年第1期9卷 57-65页

作者： DONG Tian-Yun DONG Wen-Jie GUO Yan chou Jie-ming YANG Shi-Li TIAN Di YAN Dong-Dong State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China School of Atmospheric Sciences Sun Yat-Sen UniversityGuangzhou 510275China Zhuhai Joint Innovative Center for Climate-Environment-Ecosystem Future Earth Research InstituteBeijing Normal UniversityZhuhai 519087China Business School Beijing Normal UniversityBeijing 100875China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyHangzhou310012China

Based on data of 22 models from the Coupled Model Inter-comparison Project Phase 5(CMIP5),the performance of climate simulation is assessed and future changes under RCP2.6,RCP4.5 and RCP8.5 are projected over critical Belt and Road *** with observations,the CMIP5 models simulate the linear trend and spatial distribution of the annual mean surface air temperature(SAT)better in the north(NBR)and south(SBR)of the Belt and Road *** trend of the 22-model ensemble mean(CMIP5 MME)is 0.70/0.50 C per 100 years from 1901 to 2005,and the observed trend is 1.11/0.77 C per 100 years in the NBR/SBR *** 1971,the relative error between CMIP5 MME and observations is 22%/15%in the NBR/SBR ***/nine models are selected in the NBR/SBR to project future SAT changes under three RCP *** 2081e2100,warming in the NBR/SBR is projected to be(1.16±0.29)/(0.72±0.32)C,(2.41±0.54)/(1.55±0.44)C,and(5.23±1.02)/(3.33±0.65)C for RCP2.6,RCP4.5,and RCP8.5,*** the RCP scenarios,the NBR region shows greater warming than the SBR *** most significant warming is expected in Kazakhstan and the northern part of the *** associated uncertainty generally increases with time under the three RCP ***,increases in warming over the Belt and Road region are more remarkable under higher-emission scenarios than lower-emission ones.

关键词： CMIP5 models The Belt and Road region Temperature projection RCPs

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Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer

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World Journal of Gastroenterology 2006年第1期12卷 123-126页

作者： Yau-Tong You Chung-Rong Chang chien Jeng-Yi Wang Koon-Kwan Ng Jinn-Shiun Chen Reiping Tang Jy-ming Chiang chien-Yuh Yeh Pao-Shiu Hsieh Division of Colon and Rectal Surgery Chang Gung Memorial HospitalLin-KouTaiwanChina Division of Colon and Rectal Surgery Chang Gung Memorial HospitalJia-YiTaiwanChina Department of Radiology Chang Gung Memorial HospitalKee-LungTaiwanChina

AIM： TO evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS： From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for a period ranging from 20 to 55 mo. Eighty of the four hundred and thirty-four patients showing strong clinical evidence for recurring colorectal cancer during the last followup were enrolled in this study. Each patient underwent contrast-enhanced computed tomographic colonography and colonoscopy on the same day. Any lesions, biopsies, identified during the colonoscopic examination, immediate complications and the duration of the procedure were recorded. The results of contrast-enhanced computed tomographic colonography were evaluated by comparing to those of colonoscopy, surgical finding, and clinical follow-up. RESULTS： Contrast-enhanced computed tomographic colonography had a sensitivity of 100%, a specificity of 83% and an overall accuracy of 94% in detecting local recurrent colorectal cancer. CONCLUSION： Conventional colonoscopy and contrastenhanced tomographic colonography can complement each other in detecting local recurrence of colorectal cancer.

关键词： Computed tomographic colonography Recurrent colorectal cancer

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Synthesis and characterization of Cu-Pt/MWCNTs for use in electrocatalytic applications

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Particuology 2011年第5期9卷 522-527页

作者： Yuh-Jing Chiou Hang-Jui Hsu Hong-ming Lin Wei-Jen Liou Huey-Wen Liou She-Huang Wu Shu-Hua chien Department of Materials Engineering Tatung University 40 Chungshan N. Rd. 3rd Sec 104 Taipei Taiwan China Institute of Chemistry Academia Sinica 128Academia Road Sec. 2 Nankang 115 Taipei Taiwan China

Improving catalyst performance by studying the preparation parameters, material structures and analysis methods is important work for catalyst researchers. In this study, Cu-Pt nanocomposites with different metal ratios were synthesized on MWCNTs using a polyol method. The structures and morphologies of the nano hybrid catalysts were analyzed by XRD and TEM. The XRD results indicate that Pt and Cu formed a bimetallic solid solution. The average diameters of the Pt and Cu-Pt nanoparticles on MWCNTs were between 3-10 nm and 5-15 nm, respectively. The electrocatalytic behavior of methanol oxidation reactions was investigated by cyclic voltammery （CV）. Cu（20%）/[Pt/MWCNTs（1：4）], which contained an optimal degree of solid solution, enhanced the methanol oxidation to the greatest degree.

关键词： Electrocatalysis Methanol Multi-walled carbon nanotubes NanoparticlesPlatinumCopper

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Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-Yu Lai Pei-Hsuan Hu Je-ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-Ching Lin Yu-Ching chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

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Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess:A case report

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World Journal of Gastroenterology 2021年第5期27卷 442-448页

作者： Heng Yeh Chia-Jung Kuo Ren-Chin Wu chien-ming Chen Wen-Sy Tsai ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le School of Medicine Chang Gung UniversityTaoyuan City 333323Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Taiwan Association of the Study of Small Intestine Disease Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Colon and Rectal Surgery Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Gastroenterology and Hepatology New Taipei City Municipal Tucheng HospitalNew Taipei City 236017Taiwan Liver Research Center Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan

BACKGROUND Fistula and intraabdominal abscess are common complications of Crohn’s disease(CD),but complex rectal fistula with abscess formation is *** necrosis factor antagonists combined with percutaneous drainage or surgical intervention is optimal treatment for fistulizing CD with intraabdominal *** is no study showing the efficacy of vedolizumab in such complicated *** SUMMARY A 47-year-old man has decompensated liver cirrhosis,Child *** suffered from abdominal pain,bloody diarrhea,fever,and body weight *** with rectoprostatic fistula,rectopresacral fistula,presacral abscess and cytomegalovirus(CMV)infection were *** received antibiotics,anti-viral therapy,transverse colostomy and vedolizumab *** months later,he had deep remission and complete fistula tracts *** Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.

关键词： Vedolizumab Crohn's disease Rectoprostatic fistula Rectal presacral fistula Presacral abscess Case report

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Rehabilitation Engineering of Singapore Reefs to Cope with Urbanization and Climate Change Impacts

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Journal of Civil Engineering and Architecture 2016年第8期10卷 932-936页

作者： Loke ming chou Tropical Marine Science Institute National University of Singapore Singapore 119227 Singapore

Over 60% of Singapore＇s coral reefs have been lost to decades of coastal urbanization and heavy sedimentation has restricted coral development to the upper 5 m of the reef slope. High species diversity, predictable mass spawning events and vigorous growth of larval recruits indicate that active rehabilitation can help enhance reef resilience to urbanization and climate change impacts. Rehabilitation techniques selected should address high sedimentation, destabilized reef substrate and reef community structure change. Coral species dominance has shifted to favor those more tolerant of reduced light. Initiating rehabilitation with these dominant species can stabilize the reef substrate quickly. Coral nurseries with raised mesh-net platforms prevent sediment smothering and improve survival of coral fragments and juveniles. Juveniles have also naturally recruited and developed on seawalls constructed in non-reef areas. Innovative design and engineering of coastal defenses can facilitate coral growth as sea level rises. Floating reefs and seawalls that incorporate terraced tidal pools can encourage continued growth and development of coral communities. Two approaches considered appropriate to rehabilitating coral communities exposed to impacts of urbanization and climate change are：（1） increase of live coral cover and diversity of degraded reefs; （2） creation of reef communities in non-reef areas.

关键词： Coral reef rehabilitation urban climate change impacts.

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Risk factors predict microscopic extranodal tumor deposits in advanced stage Ⅲ colon cancer patients

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World Journal of Gastroenterology 2023年第11期29卷 1735-1744页

作者： Yi-Han Jhuang Yu-Ching chou Yu-Chun Lin Je-ming Hu Ta-Wei Pu Chao-Yang Chen Division of Cardiovascular Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Tri-Service General Hospital Song-shan BranchNational Defense Medical CenterTaipei 114TaiwanChina

BACKGROUND Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant *** tumor deposits(TDs)are considered prognostically distinct from lymph node *** To investigate risk factors for extranodal TDs in stage III colon *** This was a retrospective cohort *** selected 155 individuals diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General *** patients were allocated into the groups with/without *** Cox regression analysis and Kaplan-Meier method were *** primary outcomes investigate the association between the covariates and extranodal TDs,and prognostic significance of the covariates regarding the *** There were 136 individuals in the non-N1c group and 19 individuals in the N1c *** with lymphovascular invasion(LVI)had a higher risk of *** survival rates of patients with and without LVI were 6.64 years and 8.61 years,respectively(P=0.027).The N1c patients without LVI had higher overall survival than those who with LVI(7.73 years vs 4.42 years,P=0.010).CONCLUSION Patients having stage III colon cancer with LVI have a higher probability of having TDs than those with stage III colon cancer without *** III colon cancer patients with TDs and LVI could have poor prognosis and outcome.

关键词： Colon cancer Tumor deposits Lymphovascular invasion Risk factor

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