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Evaluation of the Potential Inhibitory Activity of A Combination of ***,*** and *** on Helicobacter Pylori：A Randomized Double-Blind Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2017年第3期23卷 176-182页

作者： chien-Ying lee Hung-Che Shih Min-chien Yu Ming-Yung lee Ya-Lan Chang Ya-Yun Lai Yi-Ching lee Yu-Hsiang Kuan Chun-Che Lin Institute of Medicine Chung Shan Medical UniversityTaichungTaiwan 40201China Department of Pharmacy Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Medicine Chung Shan Medical UniversityTaichungTaiwanChina Department of Integrated Chinese and Western Medicine Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Statistics and Informatics Science Providence UniversityChina 43301 Department of Applied Cosmetology National Tainan Junior College of NursingTaiwan 700 China Division of Hepatogastroent erology Department of Internal MedicineChung Shan Medical University HospitalTaichungTaiwan 40201China

Objective： To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had significant inhibitive effects on Helicobacter pylori（H. pylori）. Methods： This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test（△UBT） result 〉 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1：1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. Results： The △UBT values during the 4-week treatment period and the 2-week follow-up period were not significantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count（%） was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group（P=0.044）, and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group（P=0.024） at week 2 of the treatment period, both of which reached statistical significance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period（P=0.003）. Conclusions： There was no significant inhibitive effects of the three probiotic strains（L. acidophilus, L. rhamnosus, and L. sporogenes） on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.

关键词： probiotics Helicobacter pylori urea breath test randomized double-blind placebo-controlled trial

Pediatric gastric cancer presenting with massive ascites

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World Journal of Gastroenterology 2015年第11期21卷 3409-3413页

作者： chien-Heng Lin Wei-Ching Lin I-hsiu Lai Shu-Fen Wu Kang-Hsi Wu An-Chyi Chen Department of Pediatrics Children’s HospitalChina Medical University Hospital College of Medicine School of MedicineChina Medical University Department of Radiology China Medical University Hospital College of Chinese Medicine School of Chinese MedicineChina Medical University

Gastric adenocarcinoma is quite rare in children and as a result very little experience has been reported on with regards to clinical presentation,treatment and *** describe the case of a 16-year-old boy presenting with abdominal fullness and poor appetite for 7 *** showed massive ascites and computed tomography imaging revealed the presence of gastric mucosa thickness with omentum *** diagnosis of gastric adenocarcinoma was biopsyproven *** gastric adenocarcinoma being quite rare in the pediatric patient population,we should not overlook the possibility of gastric adenocarcinoma when a child presents with distended abdomen and massive ascites.

关键词： Gastric adenocarcinoma Ascites Children

Streptococcal toxic shock syndrome after hemorrhoidectomy: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10238-10243页

作者： chien-Yu lee Yuarn-Jang lee Chia-Che Chen Li-Jen Kuo Department of Pediatrics Taoyuan General HospitalMinistry of Health and WelfareTaoyuan 32748Taiwan Division of Infectious Diseases Department of Internal MedicineTaipei Medical University HospitalTaipei 11031Taiwan Division of Infectious Diseases Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan Division of Colorectal Surgery Department of SurgeryTaipei Medical University HospitalTaipei 11031Taiwan Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan

BACKGROUND Streptococcal toxic-shock syndrome after hemorrhoidectomy is rare but may be *** A streptococci have produced various surface proteins and exotoxins due to genetic changes to fight the human body’s immune *** life threatening infection after hemorrhoidectomy rarely occurs,all surgeons should be aware of the potential complications of severe sepsis after hemorrhoidectomy and keep in mind their clinical presenting features in order to diagnose early and administer appropriate and effective therapeutic drugs *** SUMMARY Here,we present a case of a 56-year-old man with a painful thrombotic external hemorrhoid who presented to our outpatient department for *** was no history of systemic diseases or recent disease *** was suggested and *** surgery,the patient developed hypotension,tachycardia,fever with chills and renal function impairment on day 2 *** clinical condition progressed to severe septic shock and metabolic *** patient responded poorly to treatment and expired after 1 d even with use of extracorporeal membrane *** results of the blood and wound cultures showed group A streptococcus *** Although extremely uncommon,all surgeons should be aware of these potential life-threatening septic complications and alert to the presenting features for patients receiving hemorrhoidectomy.

关键词： Hemorrhoid Sepsis Streptococcus pyogenes Streptococcal toxic shock syndrome Case report

Observations on the application of artificial neural network to predicting ground motion measures

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Earthquake Science 2012年第2期25卷 161-175页

作者： Hanping Hong Taojun Liu chien-Shen lee Department of Civil and Environmental Engineering University of Western Ontario London Ontario N6A 5B9 Canada

Application of the artificial neural network （ANN） to predict pseudospectral acceleration or peak ground acceleration is explored in the study. The training of ANN model is carried out using feed-forward backpropagation method and about 600 records from 39 California earthquakes. The statistics of the residuals or modeling error for the trained ANN-based models are almost the same as those for the parametric ground motion prediction equations, derived through regression analysis; the residual or modeling error can be modeled as a normal variate. The similarity and differences between the predictions by these two approaches are shown. The trained ANN-based models, however, are not robust because the models with almost identical mean square errors do not always lead to the same predictions. This undesirable behaviour for predicting the ground motion measures has not been shown or discussed in the literature; the presented results, at least, serve to raise questions and caution on this problem. A practical approach to ameliorate this problem, perhaps, is to consider several trained ANN models, and to take the average of the predicted values from the trained ANN models as the predicted ground motion measure.

关键词： neural network peak ground acceleration pseudospectral acceleration seismic ground motion measures uncertainty

Posterior Reversible Encephalopathy Syndrome Induced by Pazopanib in a Patient with Soft-Tissue Sarcoma: A Case Report

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Case Reports in Clinical Medicine 2019年第5期8卷 127-133页

作者： chien-Ting Wu Chieh-Tsung Yen hsiu-Lan Cheng Chi-Hui lee Department of Pharmacy Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Taiwan

Posterior reversible encephalopathy syndrome (PRES), a rare disease is characterized by multiple neurological complications. It has been reported to be associated with the use of angiogenesis inhibitors such as sorafenib, sunitinib, pazopanib, regorafenib, and lenvatinib. We reported a case of 76-year-old woman with history of stage III hepatocellular carcinoma (HCC), who developed adverse drug reactions related to pazopanib induced PRES. Pazopanib, an angiogenesis inhibitor which inhibits the vascular endothelial growth factor (VEGF) pathway may lead to vascular endothelial damage, and these pathophysiological changes may lead to vascular leaks and brain edema. Medical staff must be aware of the possible association between angiogenesis inhibitors and the development of PRES. In patients with retroperitoneal soft-tissue sarcoma undergoing treatment with pazopanib, regular monitoring of their blood pressure and following-up brain magnetic resonance imaging (MRI) should be encouraged.

关键词： Posterior Reversible Encephalopathy Syndrome Pazopanib Hepatocellular Carcinoma Vascular Endothelial Growth Factor Magnetic Resonance Imaging

Dynamic Gain-Clamped Amplifier with Backward-Injection of a Fabry-Perot Laser

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光学学报 2003年第S1期23卷 499-500页

作者： chien-Hung Yeh Chih-Yang Chen chien-Chung lee Sien Chi Institute of Electro-Optical Engineering Chiao-Tung University 1001 Ta Hsueh Road Hsinchu Taiwan 300

We have been experimentally demonstrated an active control technique of dynamic gain-clamped spectra for theerbium-doped fiber amplifiers (EDFA's) by a backward-injected Fabry-Perot (F-P) laser into this EDFA. In addition, employing a short length erbium-doped fiber (EDF) that not cause any gain saturation for preamplification in front of this amplifier module, it can reduce the noise figure degradation and simultaneously achieve gain variation from 11.1 dB to 0.5 dB for 10 dB input power level change.

关键词： control technique fiber amplifiers noise figure input power

How does Bank Capital Affect Bank Profitability and Risk？ Evidence from China＇s WTO Accession

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China & World Economy 2015年第4期23卷 19-39页

作者： chien-Chiang lee Shao-Lin Ning Chi-Chuan lee Department of Finance National Sun Yat-sen University Kaohsiung Taiwan School of Management Beijing Normal University Zhuhai Guangdong

This paper examines how bank capital affects bank profitability and risk in China, and how its impact differed before and after the nation entered the WTO. Our study uses the dynamic generalized method of moments approach with a panel database containing 171 Chinese commercial banks. We ftnd that bank capital has significant influence on bank profitability and risk, but its impact has declined since China joined the WTO in 2001. For different sized groups, the impact of capital on profitability exhibits a distinct trend. The effects of capital on bank risk are different for large and small banks depending on the risk variables used for the Chinese banking industry.

关键词： bank capital China dynamic panel data model profitability risk WTO

Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia

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World Journal of Gastroenterology 2014年第20期20卷 6244-6251页

作者： Hwai-I Yang Mei-Hsuan lee Jessica Liu chien-Jen Chen Genomics Research Center Academia Sinica Graduate Institute of Clinical Medical Science China Medical University Taichung Molecular and Genomic Epidemiology Center China Medical University Hospital Institute of Clinical Medicine National Yang Ming University Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National TaiwanUniversity

Risk calculators are widely used in many clinical fields, and integrate several important risk factors through the conversion of a risk function into a single measure of risk. Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk score, which incorporated five clinical variables to predict HCC risk. This risk score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel marker was incorporated into a risk calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk calculators can be used to support clinical practice, and to establish preventive measures; several “off-label” extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk calculators. The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk parameters.

关键词： Chronic hepatitis B Hepatocellular carcinoma Risk calculator Hepatitis B virus

Thickness Effect of Nanocrystalline Layer on the Deformation Mechanism of Amorphous/Crystalline Multilayered Structure

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 293-304页

作者： Wen-Jay lee Yu-chien Lo Anchen Yang Kuanpeng Chen Nan-Yow Chen National Center for High-Performance Computing No.22Keyuan Rd.Central Taiwan Science ParkTaichung City 40763Taiwan Department of Materials Science and Engineering National Chiao Tung UniversityNo.1001 University Rd.Hsinchu 30010Taiwan National Center for High-Performance Computing No.7R&D 6th Rd.Hsinchu Science ParkHsinchu City 30076Taiwan

Different thickness of amorphous/nanocrystalline multi-layered structure can be used to modulate the strength and ductility of the composite *** this work,molecular dynamics simulations were conducted to study the thickness effect of nanocrystalline layer on mechanical properties and deformation behavior of the Cu64Zr36/Cu multi-layer *** stress-strain relationship,local stress,local strain,and deformation mechanism are *** results reveal that the change of thickness of the crystalline layer significantly affects the mechanical properties and deformation *** the strain at the elastic region,the amorphous Cu64Zr36 layer dominates the mechanical behavior,leading the fact that Young’s modulus,first yielding stress,and first yielding strain are close to that of Cu64Zr36 *** the strain at the plastic region,the contribution of the crystalline layer on the mechanical behavior becomes more and more significant with increasing the thickness of the crystalline *** the thickness ratio(amorphous/crystalline)of 4,the shear band deformation of amorphous layer dominates the mechanical *** the thickness ratio is 1,the glide dislocation of the crystalline layer dominates the stress-strain behavior.

关键词： Molecular dynamics Cu64Zr36 bulk metallic glass Cu64Zr36/Cu layered structure shear band mechanical property deformation