检索结果-南通市图书馆

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

引用

Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan Hui-Yu Huang chieh-hsi wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cell Surface Transmembrane Protein Database for Detecting Potential Targets of Antibody Drug in Application of Cancer Therapies

引用

Journal of Life Sciences 2010年第7期4卷 46-52页

作者： Po-Yuan Chen Cheng-Shang Kao Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse Hsu Che-Yen Ou Tzu-Ching Shih chieh-hsi wu Department of Biological Science and Technology China Medical University Taichung 404 Taiwan Parexel-Apex International Taipei Taiwan Department of Medical Radiology Technology China Medical University and Department of Radiology China Medical UniversityHospital Taichung 404 Taiwan Department of Pharmacy China Medical University Taichung 404 Taiwan

Background： Antibody drug conjugated （ADC） is one kind of very important method of therapy to cancer diseases. In this research, the authors introduce BLAST and some other important algorithms to create transmembrane protein databases. These databases are acquired from well-known databases such as NCBI or Swiss-Prot as template, and then collect all possible transmembrane protein by using BLAST or physical character. After collect these databases, the authors will aim at each nucleotide sequences to design the probes of oligonucleotide microarray, which can detect the high express transmembrane proteins very efficiently. Finally, the authors can accelerate the anti-cancer drug discovery by using these databases. Result： This study constructed a web service, the Transmembrane Protein Database, to researchers that are interested in or need to oligonucleotide microarray probe design for detecting potential targets of antibody drug. With user friendly web based windows containing each necessary selections, users can easily choose the parameters and get the suitable probe design suggestions. Conclusion： Transmembrane protein database is very important and powerful in detecting cancers or other human disease. By using this database, the authors offer a good strategy in transmembrane protein research as well.

关键词： Antibody drug transmembrane protein databases.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Screening of Novel Mitogen-activated Protein Kinase Kinase-1 （MEK1） Inhibitors by Docking and Scoring

引用

Journal of Life Sciences 2011年第6期5卷 434-442页

作者： Po-Yuan Chen Hong-Jye Hong Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse Hsu chieh-hsi wu Che-YenOu Yeng-Ting Yui Jing-Pin Lin Jing-Gung Chung Department of Biological Science and Technology China Medical University Taichung 40402 Taiwan College of Chinese Medicine China Medical University Taichung 40402 Taiwan Schools of Pharmacy and Chinese Medicine China Medical University Taichung 40402 Taiwan Departments of Biotechnology Asia University Taichung 40402 Taiwan

The mitogen-activated protein kinase （MAPK） cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 （MEK1） in MAPK, and use computer aided drug design （CADD） to analyze the ligand activities of proteins in MEKL The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

关键词： Docking and scoring computational screening mitogen-activated protein kinase kinase-1 (MEK1).

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于超分辨率的选区激光熔融熔池形貌研究

引用

应用激光 2024年第4期44卷 28-37页

作者：吴磊孔令成傅盈西朱锟鹏中国科学院合肥物质科学研究院安徽合肥230031 中国科学技术大学研究生院科学岛分院安徽合肥230026 新加坡国立大学新国大苏州研究院江苏苏州215123

在选区激光熔融加工过程中,包含大量加工状态和工艺参数信息的熔池图像存在噪声污染、熔池边缘模糊等问题,因此提高熔池图像的分辨率对监测熔池状态具有重要意义。提出一种基于深度学习的熔池图像超分辨率重建算法,用于提取低分辨率熔... 详细信息

在选区激光熔融加工过程中,包含大量加工状态和工艺参数信息的熔池图像存在噪声污染、熔池边缘模糊等问题,因此提高熔池图像的分辨率对监测熔池状态具有重要意义。提出一种基于深度学习的熔池图像超分辨率重建算法,用于提取低分辨率熔池图像的浅层特征和深层特征并学习低分辨率图像到高分辨率图像之间的映射关系,使用亚像素卷积上采样完成熔池图像重建过程。分别对采集的高分辨率、退化后的低分辨率、重建的高分辨率熔池图像进行图像预处理和提取熔池形貌特征,以采集的高分辨率熔池图像的形貌特征为标签计算熔池特征误差率。结果显示,重建的熔池图像不仅可以提高分辨率,还大幅度降低了熔池形貌特征提取的误差率,为选区激光熔融成型过程监测和精准调控加工工艺参数提供了保证。

关键词：选区激光熔融熔池图像熔池形貌特征超分辨率重建

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Historical development of the Gauss-Bonnet theorem

引用

Science China Mathematics 2008年第4期51卷 777-784页

作者： wu Hung-hsi(H.wu) Department of Mathematics University of California

A historical survey of the Gauss-Bonnet theorem from Gauss to Chern.

关键词： Gauss-Bonnet theorem Chern classes characteristic classes 01-02 53-03 53C20

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Low Complexity Algorithm for Subcarrier-and-Bit Allocation in OFDMA-Based LTE Systems

引用

Journal of Electronic Science and Technology 2016年第4期14卷 355-361页

作者： Wei-Chiang wu chieh-Yen Hsu the Department of Electrical Engineering Da-Yeh University

In this paper, we propose optimum and sub-optimum resource allocation and opportunistic scheduling solutions for orthogonal frequency division multiple access （OFDMA）-based multicellular systems. The applicability, complexity, and performance of the proposed algorithms are analyzed and numerically evaluated. In the initial setup, the fractional frequency reuse （FFR） technique for inter-cell interference cancellation is applied to classify the users into two groups, namely interior and exterior users. Adaptive modulation is then employed according to the channel state information （CSI） of each user to meet the symbol error rate （SER） requirement. There then, we develop subcarrier-and-bit allocation method, which maximizes the total system throughput subject to the constraints that each user has a minimum data rate requirement. The algorithm to achieve the optimum solution requires high computational complexity which hinders it from practicability. Toward this suboptimum method with the reduced to the order of O（NIO, the total number of subcarriers end, we complexity propose a extensively where N and K denote and users, respectively. Numerical results show that the proposed algorithm approaches the optimum solution, yet it enjoys the features of simplicity, dynamic cell configuration, adaptive subearrier-and-bit allocation, and spectral efficiency.

关键词： Adaptive modulation fractional frequency reuse multiuser subcarrier-and-bit allocation,opportunistic scheduling orthogonal frequency division multiple access.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hyperspectral imaging for one-step growth simulation of Brochothrix thermosphacta in chilled beef during storage

引用

Food Science and Human Wellness 2024年

作者： Xiaohua Liu Binjing Zhou Jin Song Kang Tu Jing Peng Weijie Lan Jing Xu Jie wu Juqing wu Leiqing Pan School of Food and Biological Engineering， Bengbu University College of Food Science and Technology， Nanjing Agricultural University College of Artificial Intelligence， Nanjing Agricultural University

In this work， one-step growth models using hyperspectral imaging (hsi) (400–1 000) nm were successfully developed in order to estimate the microbial loads， minimum growth temperature (Tmin) and maximum specific growth rate (μmax) of Brochothrix thermosphacta in chilled beef at isothermal temperatures (4–25) ℃. Three different methods were compared for model development， particularly using (Model I) the predicted microbial loads from partial least squares regression of the whole spectral variables; (Model II) the selected spectral variables related to microbial loads; and (Model III) the first principal scores of hsi spectra by principal component analysis. Consequently， Model I showed the best ability to predict the microbial loads of B. thermosphacta， with the coefficient of determination (Rv2) and root mean square error in internal validation (RMSEV) of 0.921 and 0.498 (lg (CFU/g)). The Tmin(–12.32 ℃) and μmaxcan be well estimated with R2and RMSE of 0.971 and 0.276 (lg (CFU/g))， respectively. The upward trend of μmaxwith temperature was similar to that of the plate count method. hsi technique thus can be used as a simple method for one-step growth simulation of B. thermosphacta in chilled beef during storage.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Superior mesenteric artery syndrome in a diabetic patient with acute weight loss

引用

World Journal of Gastroenterology 2009年第47期15卷 6004-6006页

作者： Meng-chieh wu I-Chen wu Jeng-Yih wu Deng-Chyang wu Wen-Ming Wang Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China

Superior mesenteric artery(SMA)syndrome is an un- common disease resulting compression of the third portion of the duodenum from the superior mesenteric *** disease shares many common manifestations with diabetic gastroparesis,including postprandial fullness,nausea,vomiting,and ***,it is often overlooked in diabetic ***,we report a 41-year-old man with poorly controlled diabetic mellitus who developed SMA syndrome due to rapid weight loss. The diagnosis was confirmed by computed tomography and an upper gastrointestinal *** condition improved after parenteral nutrient,strict sugar control, and gradual weight gain.

关键词： Diabetes mellitus Superior mesenteric artery syndrome Gastroparesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oviraptorosaurian Eggs (Dinosauria) with Embryonic Skeletons Discovered for the First Time in China

引用

Acta Geologica Sinica(English Edition) 2008年第6期82卷 1089-1094页

作者： Yen-nien CHENG JI Qiang Xiao-chun wu hsi-yin SHAN Museum of Natural Science 1 Kuan Chien RD. Taichung Taiwan 40453 China Institute of Geology Chinese Academy of Geological Sciences 26 Baiwanzhuang Road Beijing 100037 China Canadian Museum of Nature P.O. Box 3443 STN ＇D＇ Ottawa ON KIP 6P4 Canada

Two elongatoolithid dinosaur eggs from the Upper Cretaceous of Ganzhou, Jiangxi Province and the embryonic skeletons they bear are described. They represent the first oviraptorosaurian eggs with embryonic skeletons in China and provide the first example that an oospecies can be correlated to certain dinosaur taxon/taxa. The two eggs are the same as the pair of the eggs inside a female oviraptorosaurian pelvis from the same horizon of the same area in both macro- and micro-structures of the egg shells, and can he referred to the oospecies, Macroolithus yaotunensis Zhao, 1975. The morphology of the preserved part of the embryonic skeletons indicates that they may have been laid by an oviraptorid, Heyuannia huangi from Guangdong Province or a closely related oviraptorosaurian, which may have been lived in the Ganzhou area too in the Late Cretaceous. The embryonic skeletons of the two eggs are not in the same developing stage. In one of the eggs, the postzygapophysis of the preserved vertebrae are well ossified, indicating that it was just hatched.

关键词： oviraptorosaurian Elongatoolithidae Macroolithus embryonic skeleton Upper Cretaceous Jiangxi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrosion assessment for spent nuclear fuel disposal in crystalline rock,using variant cases of hydrogeological modeling

引用

Nuclear Science and Techniques 2020年第12期31卷 20-31页

作者： Chi-Che Hung Fraser King Yun-Chen Yu Chi-Jen Chen Yuan-chieh wu Wei-Ting Lin 机构不详

This paper presents a corrosion assessment of copper spent nuclear fuel disposal canisters in crystalline rock,using hydrogeological modeling.A simplified approach is considered,to avoid complex and time-consuming computer *** simplified case is presented as a base case,with changes in the hydrogeological parameters presented as variant *** results show that in Taiwan’s base case,decreasing the hydraulic conductivity of the rock or decreasing the hydraulic conductivity of dikes results in a shorter transport path for sulfide and an increase in corrosion ***,the estimated canister failure time is still over one million years in the variant cases.

关键词： Spent nuclear fuel disposal Corrosion assessment Hydrogeological modeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：