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International Journal of Disaster Risk Science 2024年第1期15卷 116-133页

作者： Hengxu Jin yu Zhao Pengcheng lu Shuliang Zhang Yiwen Chen Shanghua Zheng Zhizhou Zhu Key Laboratory of VGE of Ministry of Education Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

This study presents a novel method for optimizing parameters in urban flood models,aiming to address the tedious and complex issues associated with parameter ***,a coupled one-dimensional pipe network runoff model and a two-dimensional surface runoff model were integrated to construct an interpretable urban flood ***,a principle for dividing urban hydrological response units was introduced,incorporating surface attribute *** K-means algorithm was used to explore the clustering patterns of the uncertain parameters in the model,and an artificial neural network(ANN)was employed to identify the sensitive ***,a genetic algorithm(GA) was used to calibrate the parameter thresholds of the sub-catchment units in different urban land-use zones within the flood *** results demonstrate that the parameter optimization method based on K-means-ANN-GA achieved an average Nash-Sutcliffe efficiency coefficient(NSE) of *** to the ANN-GA and K-means-deep neural networks(DNN) methods,the proposed method better characterizes the runoff generation and flow *** study demonstrates the significant potential of combining machine learning techniques with physical knowledge in parameter optimization research for flood models.

关键词： Artifcial neural network Coupled urban fooding model Genetic algorithm K-means algorithm Subcatchment delineation Uncertain parameters

Oral delivery of insulin by barbed microneedles actuated by intestinal peristalsis

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Chinese Chemical Letters 2024年第9期35卷 6-8页

作者： Qin yu Haisheng He Jianping Qi Yi lu Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China

Oral formulations are always preferred to injections due to the advantages of high patient compliance,no biohazardous needle waste,and low requirements for administration ***,the presence of multiple gastrointestinal(GI)barriers,including extreme gastric acidity and a broad pH gradient,digestive enzymes,thick and variable mucus layers,and tight junctions in the enteric epithelia,restricts the rate and extent of oral *** active ingredients with favorable physicochemical properties.

关键词： needle extreme formulation

A long-term histological research on human frontalis muscle flap specimens from recurrent blepharoptosis patients

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1161-1163页

作者： lu Zhou yu-Cheng Yan Jin-Cai Fan Department of Plastic and Reconstructive Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China

Dear Editor,We present two patients with recurrent severe blepharoptosis after frontalis muscle(FM)flap *** we describe long-term histological changes of the FM flaps observed in revision *** flap suspension is widely applied in treating severe ptosis with poor levator function(<4 mm),and its effect is relatively stable and lasting[1].FM flap suspension is reliable and recurrent cases are observed only *** longterm research about FM flap is rare,we investigated tissue samples of revision surgery flaps which could reflect trends of morphological changes within the functioning FM flaps to some extent.

关键词： patients histological surgery

Spatio-temporal Evolution Characteristics and Driving Forces of Winter Urban Heat Island:A Case Study of Rapid Urbanization Area of Fuzhou City,China

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Chinese Geographical Science 2024年第1期34卷 135-148页

作者： WANG Zili lu Chunyan SU Yanlin SU yue yu Qianru LI Wenzhe YANG Nuocheng College of Computer and Information Sciences Fujian Agriculture and Forestry UniversityFuzhou350002China Key Laboratory of Smart Agriculture and Forestry(Fujian Agriculture and Forestry University) Fujian Province UniversityFuzhou350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou350002China

Under the influence of anthropogenic and climate change,the problems caused by urban heat island(UHI)has become increasingly *** order to promote urban sustainable development and improve the quality of human settlements,it is significant for exploring the evolution characteristics of urban thermal environment and analyzing its driving *** the Landsat series images as the basic data sources,the winter land surface temperature(LST)of the rapid urbanization area of Fuzhou City in China was quantitatively retrieved from 2001 to *** comprehensively the standard deviation ellipse model,profile analysis and GeoDetector model,the spatio-temporal evolution characteristics and influencing factors of the winter urban thermal environment were systematically *** results showed that the winter LST presented an increasing trend in the study area during 2001–2021,and the winter LST of the central urban regions was significantly higher than the *** was a strong UHI effect from 2001 to 2021with an expansion trend from the central urban regions to the suburbs and coastal areas in space *** LST of green lands and wetlands are significantly lower than croplands,artificial surface and unvegetated *** and water bodies had a significant mitigation effect on UHI,especially in the *** winter UHI had been jointly driven by the underlying surface and socio-economic factors in a nonlinear or two-factor interactive enhancement mode,and socio-economic factors had played a leading *** research could provide data support and decision-making references for rationally planning urban layout and promoting sustainable urban development.

关键词： winter urban heat island(UHI) rapid urbanization area land surface temperature(LST)retrieval profile analysis GeoDetector model Fuzhou City,China

Transient Damping of Virtual Synchronous Generator for Enhancing Synchronization Stability during Voltage Dips

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 143-151页

作者： Shitao Sun yu Lei Guowen Hao Yi lu Jindong Liu Zhaoxin Song Jie Zhang North China Electric Power Research Institute Co. Ltd.Beijing 100045China State Grid Xinyuan Co. Ltd.Beijing 100761China Hebei Fengning Pumped Storage Energy Co.Ltd. Chengde 068350China

Virtual synchronous generators(VSGs)are widely introduced to the renewable power generation,the variablespeed pumped storage units,and so on,as a promising gridforming *** is noted that VSGs can provide virtual inertia for frequency support,but the larger inertia would worsen the synchronization stability,referring to keeping synchronization with the grid during voltage ***,this paper presents a transient damping method of VSGs for enhancing the synchronization stability during voltage *** is revealed that the loss of synchronization(LOS)of VSGs always accompanies with the positive frequency deviation and the damping is the key factor to remove LOS when the equilibrium point *** order to enhance synchronization stability during voltage dips,the transient damping is proposed,which is generated by the frequency deviation in active power ***,the proposed method can realize seamless switching between normal state and grid ***,detailed control design for transient damping gain is given to ensure the synchronization stability under different inertia requirements during voltage ***,the experimental results are presented to validate the analysis and the effectiveness of the improved transient damping method.

关键词： Virtual synchronous generator(VSG) Transient damping Synchronization stability Voltage dips

Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography

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Eye and Vision 2024年第3期10卷 21-30页

作者： Huixun Jia Bing lu Zhi Zhao Yang yu Fenghua Wang Minwen Zhou Xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of Medicine100 Hai Ning RoadShanghai200080People’s Republic of China Shanghai Key Laboratory of Ocular Fundus Diseases ShanghaiChina National Clinical Research Center for Eye Diseases ShanghaiChina Shanghai Engineering Center for Visual Science and Photomedicine ShanghaiChina Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases ShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related macular degeneration(nAMD)after anti-vascular endothelial growth factor(anti-VEGF)*** Patients with type 1,type 2,or mixed-type neovascularization(NV)were prospectively *** underwent an initial loading phase of three consecutive monthly intravitreal injections of Conbercept(0.5 mg)and were switched to a pro re nata(PRN)treatment *** images were evaluated for eyes that underwent follow-up assessments for more than 6 *** lesions were manually segmented,and the CNV area,vessel area,greatest vascular caliber(GVC),and greatest linear dimension(GLD)were compared between responders and *** masked graders independently measured the above-mentioned parameters using OCTA,and consistency was assessed using the intraclass correlation coefficient(ICC)*** logistic regression analysis was performed to evaluate the effect of a 3-month change in the CNV area,GLD,and GVC on the 6-month response to anti-VEGF *** Among the 60 eyes of 60 patients with nAMD,39 were responders and 21 were *** proportion of CNV types was significantly different between responders and non-responders(P=0.009).Patients with type 2 or mixed NV seemed more likely to respond to the treatment(28.2%vs.0.0%,and 30.8%vs.23.8%,respectively).The change in GVC showed a significant difference between responders(−4.98±17.17μm)and non-responders(11.01±14.10μm)after three monthly intravitreal anti-VEGF *** logistic regression analysis showed that only the change in GVC remained significant after controlling for baseline GVC,injection number,and CNV type(adjusted OR=1.083;P=0.008).Conclusions Type 2 and mixed-type NV were significantly associated with a better response to anti-VEGF *** i

关键词： Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Anti-VEGF

Novel umami peptides from two Termitomyces mushrooms and molecular docking to the taste receptor T1R1/T1R3

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Food Science and Human Wellness 2024年第2期13卷 1055-1064页

作者： Lanyun Zhang Li Zhang Jesus Pérez-Moreno lu Bin Fengming Zhang Fuqiang yu The Germplasm Bank of Wild Species Yunnan Key Laboratory for Fungal Diversity and Green DevelopmentKunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Chemical Science and Technology Yunnan UniversityKunming 650091China College of Food Science and Technology Yunnan Agricultural UniversityKunming 650201China Colegio Postgraduados Campus MontecilloEdafologíaTexcoco 56230México Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China Southwest Forestry UniversityKunming 650224China

Wild edible Termitomyces mushrooms are popular in Southwest China and umami is important flavor qualities of edible *** study aimed to understand the umami taste of Termitomyces intermedius and Termitomyces *** umami peptides from aqueous extracts were separated using a Sephadex G-15 gel filtration *** intense umami fraction was evaluated by both sensory evaluation and electronic *** were identified as KLNDAQAPK,DSTDEKFLR,VGKGAHLSGEH,MLKKKKLA,SLGFGGPPGY,TVATFSSSTKPDD,AMDDDEADLLLLAM,VEDEDEKPKEK,SPEEKKEEET and *** peptides,except VEDEDEKPKEK,SPEEKKEEET and PEGADKPNK were selectively synthesized to verify their taste *** these 10 peptides had umami or salt *** 10 peptides were conducted by molecular docking to study their interaction with identified peptides and the umami taste receptor T1R1/*** these 10 peptides perfectly docked the active residues in the T1R3 *** results provide theoretical basis for the umami taste and address the umami mechanism of two wild edible Termitomyces mushrooms.

关键词： Termitomyces Non-volatile flavor compounds Umami peptides Taste characteristics Molecular docking

The size effect and analogous boundary states in a circular non-Hermitian chain

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Communications in Theoretical Physics 2024年第2期76卷 157-165页

作者： Xin-yu Ma Yi-Han Guan Qiao-Nan Li Ai-Lei He lu Qi School of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

We investigate the size effect and boundary states based on a circular non-Hermitian chain under the nonreciprocal intra-cell coupling and inter-cell coupling *** find that the circular non-Hermitian chain exhibits an even–odd effect on the unit cell corresponding to a large chain,which is different from the open non-Hermitian chain only exhibiting the same effect for a small ***,we find that the originally localized bulk states become totally extended via designing the boundary coupling strength *** extended bulk states reveal the fact of the disappearance of the non-Hermitian skin *** particular,we show that the circular non-Hermitian chain also possesses the analogous edge states under some parameter regimes,which is pretty counterintuitive since the circular chain usually cannot define a *** investigations supply the different non-Hermitian phenomena in a circular non-Hermitian chain.

关键词： boundary states non-Hermitian chain topological state

MGCPN:An Efficient Deep Learning Model for Tibetan Plateau Precipitation Nowcasting Based on the IMERG Data

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Journal of Meteorological Research 2024年第4期38卷 693-707页

作者： Mingyue lu Zhiyu HUANG Manzhu yu Hui LIU Caifen HE Chuanwei JIN Jingke ZHANG Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Department of Geography Pennsylvania State UniversityUniversity ParkPA 16802USA ZhenhaiDistrict Meteorological Bureau Ningbo315200China Geographic Science College Nanjing University of Information Science&TechnologyNanjing 210044China School of Remote Sensing&Geomatics Engineering Nanjing University of Information Science&TechnologyNanjing 210044China

The sparse and uneven placement of rain gauges across the Tibetan Plateau(TP) impedes the acquisition of precise,high-resolution precipitation measurements,thus challenging the reliability of forecast *** address such a challenge,we introduce a model called Multisource Generative Adversarial Network-Convolutional Long Short-Term Memory(GAN-ConvLSTM) for Precipitation Nowcasting(MGCPN),which utilizes data products from the Integrated Multi-satellite Retrievals for global precipitation measurement(IMERG) data,offering high spatiotemporal resolution precipitation forecasts for upcoming periods ranging from 30 to 300 *** results of our study confirm that the implementation of the MGCPN model successfully addresses the problem of underestimating and blurring precipitation results that often arise with increasing forecast *** issue is a common challenge in precipitation forecasting ***,we have used multisource spatiotemporal datasets with integrated geographic elements for training and prediction to improve model *** model demonstrates its competence in generating precise precipitation nowcasting with IMERG data,offering valuable support for precipitation research and forecasting in the TP *** metrics results obtained from our study further emphasize the notable advantages of the MGCPN model;it outperforms the other considered models in the probability of detection(POD),critical success index,Heidke Skill Score,and mean absolute error,especially showing improvements in POD by approximately 33%,19%,and 8% compared to Convolutional Gated Recurrent Unit(ConvGRU),ConvLSTM,and small Attention-UNet(SmaAt-UNet) models.

关键词： precipitation nowcasting Generative Adversarial Network-Convolutional Long Short-Term Memory(GAN-ConvLSTM)for Precipitation Nowcasting(MGCPN) Integrated Multi-satellite Retrievals for globalprecipitation measurement(IMERG) deep learning Tibetan Plateau

Longitudinal transducer driven by NiMnGa magnetic shape memory alloy

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Chinese Journal of Acoustics 2024年第2期43卷 232-247页

作者： LAN yu WANG Houqi lu Wei National Key Laboratory of Underwater Acoustic Technology Harbin Engineering UniversityHarbin 150001 Key Laboratory of Marine Information Acquisition and Security(Harbin Engineering University) Ministry of Industry and Information TechnologyHarbin 150001 College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001

In order to realize a low-frequency and small-size underwater acoustic source,an underwater acoustic transducer has been designed by using Ni Mn Ga alloy, which has the advantages of large strain, rapid response and high energy density. Based on the deformation principle of Ni Mn Ga alloy, a physical model of a Ni Mn Ga longitudinal transducer is established, and the equivalentcircuit of the transducer is derived.A multi-physics coupling model of electromagnetic, mechanical and acoustic fields is established by using the finite element method to predict the underwater acoustic performance of the transducer.A small-scale prototype of the Ni Mn Ga longitudinal transducer is fabricated and its sound source level is tested in water within the frequency range from 500 Hz to 800 Hz. Experimental results demonstrate that the Ni Mn Ga transducer with an 8 mm diameter of the radiation surface, achieves sound source level of 115.5 d B at 700 Hz.

关键词： alloy NiMnGa density