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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu Lin Hung Ju Chen Yi Kit chan.Wei Ping Hsia Yu Len Huang chia jen chan. Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

Behcet's disease-related panuveitis following COVID-19 vaccination:A case report

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World Journal of Radiology 2024年第9期16卷 460-465页

作者： Rou-Ting Lin Pei-Kang Liu chia-Wei chan. Kai-Chun Cheng Kuo-jen Chen Yo-Chen chan. School of Medicine College of MedicineChung Shan Medical UniversityTaichung 40201Taiwan Department of Clinical Education and Training Kaohsiung Medical University HospitalKaohsiung 80756Taiwan Department of Ophthalmology School of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiung 80737Taiwan Department of Ophthalmology Kaohsiung Medical University HospitalKaohsiung 80756Taiwan Department of Ophthalmology Kaohsiung Municipal Siaogang HospitalKaohsiung Medical UniversityKaohsiung 81201Taiwan

BACKGROUND Behcet's disease(BD)is an inflammatory disorder known for various symptoms,including oral and genital ulcers and ocular ***,a severe eye condition,is rare as the first sign of *** SUMMARY We present an unusual case of a 30-year-old man who developed panuveitis after receiving the mRNA-based coronavirus disease 2019(COVID-19)vaccine(Moderna).Laboratory tests ruled out infections,but he had a positive HLA-B51 result and a history of genital ulcer and oral ulcers,leading to a BD *** with corticosteroids improved his ***,he had another episode of panuveitis after the second mRNA vaccine dose,which also responded to *** This case highlights the rare onset of BD following mRNA COVID-19 vaccination,suggesting a potential link between these vaccines and BD's eye symptoms,emphasizing the importance of quick treatment in similar cases.

关键词： Behcet’s disease mRNA COVID-19 vaccine Ocular inflammation Panuveitis Case report

An Analytical Solution for Wave Transformation Over Axi-Symmetric Topography

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China Ocean Engineering 2019年第6期33卷 694-703页

作者： CUONG San Sieu chan. jen-Yi TSAI chia-Cheng CHOU Wan-Rong aInstitute of Oceanography National Taiwan UniversityTaipei 10617China Tainan University of Technology Tainan 71002China Department of Marine Environmental Engineering National Kaohsiung University of Science and TechnologyKaohsiung 81164China Department of Marine Environment and Engineering National Sun Yat-Sen UniversityKaohsiung 80424China Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701China

The present study considers wave scattering phenomena around a cylindrical island mounted on a general axisymmetric topography or a general submerged truncated axi-symmetric shoal based on the mild-slope equation. The method of separation of variables and Taylor series expansion are invoked to find the approximate solution to the variable water depth region which varies proportionally to an arbitrary power of radial distance. Validations against the solutions for the combined wave refraction and diffraction around a cylindrical island mounted on a paraboloidal shoal of Liu et al. in 2004 and the scattering and trapping of wave energy by a submerged truncated paraboloidal shoal of Lin and Liu in 2007 show excellent agreements as the power of radial distance being equal to two. For the solutions of wave refraction and diffraction around a cylindrical island mounted on a shoal with depth proportionally to an arbitrary power of radial distance, good agreements with Zhai et al.’s(2013) solutions are demonstrated. Since the robustness of the assumption of a general axi-symmetric geometry based on an arbitrary power variability of the radial distance, the present solution can be very conveniently employed to investigate the effects of bottom topography on wave scattering and trapping patterns.

关键词： general axi-symmetric topography mild-slope equation submerged truncated shoal wave refraction wave diffraction

A Comparative Study on Polynomial Expansion Method and Polynomial Method of Particular Solutions

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Advances in Applied Mathematics and Mechan.cs 2022年第3期14卷 577-595页

作者： jen-Yi chan. Ru-Yun Chen chia-Cheng Tsai Tainan University of Technology Tainan 71002Taiwan China Department of Harbor and River Engineering Taiwan Ocean UniversityKeelung 202301Taiwan China Bachelor Degree Program in Ocean Engineering and Technology Taiwan Ocean UniversityKeelung 202301Taiwan China Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung 202301Taiwan China

In this study,the polynomial expansion method(PEM)and the polynomial method of particular solutions(PMPS)are applied to solve a class of linear elliptic partial differential equations(PDEs)in two dimensions with constant coefﬁ*** the solution procedure,the sought solution is approximated by the Pascal polynomials and their particular solutions for the PEM and PMPS,*** multiple-scale technique is applied to improve the conditioning of the resulted linear equations and the accuracy of numerical results for both of the PEM and *** mathematical statements are provided to demonstrate the equivalence of the PEM and PMPS bases as they are both bases of a certain polynomial vector ***,some numerical experiments were conducted to validate the implementation of the PEM and *** results demonstrated that the PEM is more accurate and well-conditioned than the PMPS and the multiple-scale technique is essential in these polynomial methods.

关键词： Pascal polynomial polynomial expansion method polynomial method of particular solutions collocation method multiple-scale technique

Streptococcal toxic shock syndrome after hemorrhoidectomy: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10238-10243页

作者： Chien-Yu Lee Yuarn-Jang Lee chia-Che Chen Li-jen Kuo Department of Pediatrics Taoyuan General HospitalMinistry of Health and WelfareTaoyuan 32748Taiwan Division of Infectious Diseases Department of Internal MedicineTaipei Medical University HospitalTaipei 11031Taiwan Division of Infectious Diseases Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan Division of Colorectal Surgery Department of SurgeryTaipei Medical University HospitalTaipei 11031Taiwan Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan

BACKGROUND Streptococcal toxic-shock syndrome after hemorrhoidectomy is rare but may be *** A streptococci have produced various surface proteins and exotoxins due to genetic chan.es to fight the human body’s immune *** life threatening infection after hemorrhoidectomy rarely occurs,all surgeons should be aware of the potential complications of severe sepsis after hemorrhoidectomy and keep in mind their clinical presenting features in order to diagnose early and administer appropriate and effective therapeutic drugs *** SUMMARY Here,we present a case of a 56-year-old man with a painful thrombotic external hemorrhoid who presented to our outpatient department for *** was no history of systemic diseases or recent disease *** was suggested and *** surgery,the patient developed hypotension,tachycardia,fever with chills and renal function impairment on day 2 *** clinical condition progressed to severe septic shock and metabolic *** patient responded poorly to treatment and expired after 1 d even with use of extracorporeal membrane *** results of the blood and wound cultures showed group A streptococcus *** Although extremely uncommon,all surgeons should be aware of these potential life-threatening septic complications and alert to the presenting features for patients receiving hemorrhoidectomy.

关键词： Hemorrhoid Sepsis Streptococcus pyogenes Streptococcal toxic shock syndrome Case report

Disseminated peritoneal leiomyomatosis with malignant transformation involving right ureter:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1639-1644页

作者： Chen-Yueh Wen Herng-Sheng Lee jen-Tai Lin chia-Cheng Yu Division of Urology Department of SurgeryKaohsiung Veterans General HospitalKaohsiung 81346Taiwan Lee Department of Pathology and Laboratory MedicineKaohsiung Veterans General HospitalKaohsiung 81346Taiwan School of Medicine National Yang-Ming UniversityTaipei 814Taiwan Department of Pharmacy Tajen UniversityPingtung 900Taiwan

BACKGROUND Disseminated peritoneal leiomyomatosis(DPL)with myxoid leiomyosarcoma is a rare variant of leiomysosarcoma,and hematuria as a presenting symptom has never been *** this case report,we emphasize the investigation of the etiology,clinical presentation,diagnosis,treatment,and prognosis of DPL with malignant chan.es mimicking metastatic urinary tract cancer and to help develop further clinical *** SUMMARY We describe a case of DPL with malignant transformation involving the right ureter after laparoscopic *** exploratory laparotomy was performed and all visible nodules were surgically *** with focal malignant transformation to myxoid leiomyosarcoma was confirmed based on pathology *** Professionals who preoperatively diagnose DPL with malignant chan.e to myxoid leiomyosarcoma involving the genitourinary tract should consider symptoms of abdominal pain,hematuria,and imaging of disseminated pelvic tumors in women,especially those with prior history of laparoscopic *** complete removal of all tumors is the cornerstone to prevent DPL from malignant chan.es.

关键词： Disseminated peritoneal leiomyomatosis Leiomyosarcoma Laparoscopic hysterectomy Hematuria Ureteroneocystostomy Case report

The study of using infrared thermal image to assist surgery of coronary artery bypass

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红外与毫米波学报 2018年第1期37卷 1-7页

作者： chan. chia-Jui TSAI Chien-Sung TANG Shiang-Feng YANG Chi-Shih LIN Wen-jen LIU chiang-Lung CHEN Tzu-chiang Defense Science Chung Cheng Institute of Technology National Defense University National Defense Medical Center Department of Surgery Materials & Electro-Optics Research Division National Chung Shun Institute of Technology Lee-Ming Institute of Technology Department of Mechanical Engineering

Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a thermal coronary angiography alias. This study proposes a digital image processing methodology for locating blood clot blockage. This methodology contains four consequent processes. The two-dimensional gray scale infrared thermograph pixels are first binarized and classified as background or coronary arteries using multi-thresh adaptive *** coronary artery contours are extracted from segmented raw pixels using continuous pepper-like pixel removal,erosion,subtraction,recursive neighborhood visiting,contour point-list construction and short edge *** the third process one coronary artery branch is selected by physicians for calculating the longest curved central axis using morphological thinning and neighborhood analysis. In the last process the nearest left and right distances from each pixel along the directional central axis to its corresponding boundary contour are added as the coronary artery variable diameter at the current pixel's position. A variable diameter versus straighten length diagram along this axial curved path is plotted to provide useful physiological information to the physician. An obstruction rate equation is then defined to calculate the possible vascular blockage positions with the local minimal rates. Finally,preoperative cases are tested to prove the predictive positions are correct in comparison to individual patient myocardial perfusion imaging.

关键词：红外技术毫米波光源仪器

Intraocular retinal thickness asymmetry in early stage of primary open angle glaucoma and normal tension glaucoma

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1342-1351页

作者： Pei-Wen Lin Hsueh-Wen chan. Ing-Chou Lai jen-chia Tsai Yi-Chieh Poon Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Biological Sciences Sun Yat-Sen University

AIM： To investigate the intraocular retinal thickness asymmetry of peripapillary retinal nerve fiber layer（pR NFL） and macular layers measured by spectral-domain optical coherence tomography（SD-OCT） in patients with early stage of primary open angle glaucoma（POAG） and normal tension glaucoma（NTG）.METHODS： A total of 117 patients with early stage of glaucoma（54 patients with POAG and 63 patients with NTG） and 32 normal subjects were recruited for the study. The pR NFL thickness, total macular layer（TML） thickness, and isolated inner macular layer（IML） thickness were measured by SD-OCT. Hemisphere TML thickness asymmetry measured by the posterior pole asymmetry scan was evaluated. Thickness differences of pR NFL and IML between superior and inferior quadrants were calculated. Asymmetry indices（AIs） of the p RNFL, TML and isolated IML were also computed. Areas under the receiver-operating characteristic curves（AROCs） were generated to determine the diagnostic capabilities of different parameters. RESULTS： Intraocular p RNFL thickness differences and AIs between the superior and inferior quadrants were significantly different between normal and NTG groups（P=0.009 and P〈0.001, respectively）. Intraocular p RNFL thickness differences and AIs between the temporal-superior and temporal-inferior sectors were also significantly different between normal and NTG groups（P=0.035 and P〈0.001, respectively）. The thickness differences and AIs of TML between superior and inferior hemispheres were significantly different between normal and NTG groups（P=0.001 and P=0.001, respectively） and between normal and POAG groups（P=0.032 and P=0.020, respectively）. The thickness differences and AIs of macular ganglion cell layer（mG CL） between superior and inferior quadrants were significantly different between normal and NTG groups（P=0.013 and P=0.004, respectively）, and between NTG and POAG groups（P=0.015 and P=0.012, respectively）. The thickness difference of TML between superior and inferior

关键词： retinal nerve fiber layer macular thickness primary open angle glaucoma normal tension glaucoma hemisphere retinal asymmetry optical coherence tomography

Percutaneous transgastric computed tomography-guided biopsy of the pancreas using large needles

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World Journal of Gastroenterology 2009年第47期15卷 5972-5975页

作者： Hsiuo-Shan Tseng chia-Yuen Chen Wing P chan.jen-Huey chiang Department of Radiology Taipei Veterans General HospitalTaipei 112Taiwan China Department of Radiology School of MedicineNational Yang-Ming UniversityTaipei 112TaiwanChina Department of Radiology Taipei Medical University-Municipal Wan Fang HospitalTaipei 116TaiwanChina Department of Radiology School of MedicineTaipei Medical UniversityTaipei 116TaiwanChina

AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major *** needle passed through the liver in one case(3%).Nine passes(26%)were made through the *** nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this *** and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all *** patient,who had a rare sarco-matoid carcinoma,received a second *** patient had a complication of transient pneumoperitoneum but no subjective *** immediate imaging study and clinical follow-up detected neither hemorrhage nor *** delayed procedure-related complication was seen during the survival period of our ***:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding.

关键词： Biopsy Computed tomography Pancreas Stomach

Nomogram to predict permanent stoma in rectal cancer patients after sphincter-saving surgery

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 765-777页

作者： Chih-Yu Kuo Po-Li Wei chia-Che Chen Yen-Kuang Lin Li-jen Kuo Department of Surgery Taipei Medical University HospitalTaipei 11031Taiwan Division of Colorectal Surgery Department of SurgeryTaipei Medical University HospitalTaipei 11031Taiwan Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031Taiwan Graduate Institute of Athletics and Coaching Science National Taiwan Sport UniversityTaoyuan 33301Taiwan Taipei Cancer Center Taipei Medical UniversityTaipei 11031Taiwan

BACKGROUND Approximately 20 percent of patients with a tumour localized in the low rectum still encounter the possibility of requiring permanent stoma(PS), which can cause drastic chan.es in lifestyle and physical *** To determine the risk factors for PS and to develop a prediction model to predict the probability of PS in rectal cancer patients after sphincter-saving *** A retrospective cohort of 421 rectal cancer patients who underwent radical surgery at Taipei Medical University Hospital between January 2012 and December 2020 was included in this study. Univariate and multivariate analyses were performed to identify the independent risk factors for PS. A nomogram was developed according to the independent risk factors obtained in the multivariate analysis. The performance of the nomogram was assessed using a receiver operating characteristic curve and a calibration *** The PS rate after sphincter-saving surgery was 15.1%(59/391) in our study after a median follow-up of 47.3 mo(range 7–114 mo). Multivariate logistic regression analysis demonstrated that local recurrence, perirectal abscess, anastomosis site stenosis, perineural invasion, tumor size and operative time were independent risk factors for PS. These identified risk factors were incorporated into the nomogram, and the concordance index of this model was 0.903(95%CI: 0.851-0.955). According to the calibration curves, the nomogram represents a perfect prediction *** Several risk factors for PS after sphincter-saving surgery were identified. Our nomogram exhibited perfect predictive ability and will improve a physician’s ability to communicate the benefits and risks of various treatment options in shared decision making.

关键词： Nomogram Permanent stoma Risk factor Shared decision making Sphincter-saving operation Rectal cancer