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ATP translocation and chloroplast biology

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National Science Review 2019年第6期6卷 1073-1076页

作者： chia P.Voon boon L.Lim School of Biological Sciences University of Hong Kong

By studying changes in ATP levels in the plastids and cytosol of live plants using a Mg ATP2-specific F?rster resonance energy transfer（FRET）-based sensor, the entry of cytosolic ATP to the mature chloroplasts of Ar... 详细信息

关键词： ATP translocation and chloroplast biology

Multiplex real-time PCR revealed very high prevalence of soil-transmitted helminth infections among aborigines in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2020年第12期13卷 550-556页

作者： Nurulhasanah Othman Noorizan Miswan weng-kin Wong boon-huat Lim Rahmah Noordin Institute for Research in Molecular Medicine Universiti Sains Malaysia11800 PenangMalaysia School of Health Sciences Universiti Sains Malaysia16150 KelantanMalaysia

Objective:To determine the true prevalence of soil-transmitted helminth infections in the Malaysian aborigines using real-time ***:A total of 122 aborigines from seven tribes were recruited from settlements and nearby hospitals which served the communities,located in four states in Peninsular *** stool samples were examined for the presence of soil-transmitted helminth using real-time PCR and *** latter included the direct wet mount and formalin-ether concentration technique(FECT).The infection load in FECT-positive samples was determined by the Kato-Katz *** real-time analyzer detected five helminth species using two sets of ***:The real-time PCR detected soil-transmitted helminth in 98.4% samples(n=122),which were 1.56 times higher than by *** lumbricoides and Trichuris trichiura were detected in more than 90% of the samples,while hookworm was detected in 46.7%(Necator americanus) and 13.9%(Ancylostoma sp.)of the *** with previous reports on the Malaysian aborigines showed that the real-time PCR markedly improved the detection of Ascaris lumbricoides,hookworm and Strongyloides *** real-time PCR detected poly-helminths in 92.6%of the samples compared to 28.7% by *** addition,27 samples(22.1%) showed amplification of Strongyloides stercoralis ***:The real-time PCR showed very high prevalence rates of soil-transmitted helminth infections in the aborigines and is the recommended method for epidemiological investigation of soiltransmitted helminth infections in this population.

关键词： prevalence infections markedly

A cost-benefit analysis for the implementation of riparian buffer strips in the Shihmen reservoir watershed

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International Journal of Sediment Research 2011年第3期26卷 393-399页

作者： chia-Ling CHANG Ying-Sung HSU Bing-Jean LEE Li-Jung weng Department of Water Resources Engineering and Conservation Feng Chia University No.100 Wenhwa Rd. SeatwenTaichung40724TaiwanChina 3. No.100 Wenhwa Rd.SeatwenTaichung40724TaiwanChina Department of Civil Engineering Feng Chia University

The Shihmen reservoir is an important water source for about 3.4 million people in northern Taiwan. To protect reservoir water quality,it is necessary to conserve and manage the associated watersheds. Riparian buffer strips can trap pollutants emitted near a *** location and design of a buffer strip can influence its pollutant-trapping *** commitment of land for use as a riparian buffer strip must consider the project’s economic *** present research is a cost-benefit analysis of various possible land developments in the Shihmen reservoir *** study has applied a regression equation to evaluate pollutant-trapping efficiency levels of riparian buffer strips of various *** buffer strips have been evaluated in terms of net economic effectiveness and benefit-cost *** indicate that the optimal buffer strip width is 30 m for the Shihmen reservoir watershed.

关键词： Buffer strip Cost-benefit analysis Watershed conservation

A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 925-938页

作者： Chenhao Zhou Jialei weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang Zhou chia-Wei Li Jialei Sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren Department of Liver Surgery Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Biomedical Research Center Zhongshan HospitalFudan UniversityShanghaiChina Institute of Fudan Minhang Academic Health System and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer(SMHC)Minhang Hospital&AHSFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are *** the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in ***:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression *** associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy ***:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation ***,IGS_(HCC)stratified HCC patients with different outcomes in *** prognostic accuracy of IGS_(HCC)was better than three reported prognostic *** IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year ***_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score *** with low IGS_(HCC)scores were more likely than those with high scores to benefit from ***:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management.

关键词： Hepatocellular carcinoma Gene signature Immune microenvironment Prognosis Immunotherapy

Analysis of risk factors for central venous port failure in cancer patients

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World Journal of Gastroenterology 2009年第37期15卷 4709-4714页

作者： Ching-Chuan Hsieh Hsu-Huei weng Wen-Shih Huang Wen-Ke Wang Chiung-Lun Kao Ming-Shian Lu chia-Siu Wang Division of General Surgery Department of Surgery ChangGung Memorial Hospital Chiayi 613 Taiwan China GraduateInstitute of Clinical Medical Science College of MedicineChang Gung University Taoyuan 333 Taiwan China Department of Diagnostic Radiology ChangGung Memorial Hospital Chiayi 613 Taiwan China Division of Colon and Rectal Surgery Department of Surgery Chang Gung Memorial Hospital Chiayi613 Taiwan China Division of Thoracic andCardiovascular Surgery Department of Surgery Chang GungMemorial Hospital Chiayi 613 Taiwan China Division of General Surgery Department ofSurgery Chang Gung Memorial Hospital Chiayi 613 TaiwanChina

AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and openended catheter use were signifi cant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically signifi cant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a signifi cant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, openended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.

关键词：风险因素端口静脉患者癌症中央

Development of a rapid test kit for SARS-CoV-2:an example of product design

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Bio-Design and Manufacturing 2020年第2期3卷 83-86页

作者： Zhanfeng Cui Hong Chang Hui Wang boon Lim chia-Chen Hsu Yejiong Yu Huidong Jia Yun Wang Yida Zeng Mengmeng Ji Weizhi Liu Catriona Inverarity Wei E.Huang Oxford Suzhou Centre for Advanced Research(OSCAR) University of OxfordSuzhouJiangsuPeople's Republic of China Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Department of Engineering Science Institute of Biomedical EngineeringUniversity of OxfordOxford OX37DQUK

We present an example of applying'need-driven'product design principle to the development of a rapid test kit to detect SARS-COV-2(COVID-19).The tests are intended for use in the field and,longer term,for home *** detect whether a subject is currently infected with the virus and is *** urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment,laboratories and skilled technicians to perform the test and interpret *** meet these needs,an antigen test based on RT-LAMP with colorimetric readout was *** use of swab sample with no RNA extraction was *** extensive experimental study(reported elsewhere),a rapid test kit has been fabricated to satisfy all design criteria.

关键词： COVID-19 Antigen detection Rapid test Product design SAR-Cov-2 RT-LAMP

Involvement of P53 and Bax/Bad triggering apoptosis in thioacetamide-induced hepatic epithelial cells

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世界胃肠病学杂志：英文版 2006年第32期12卷 5175-5181页

作者： Li-Hsuen Chen chia-Yu Hsu Ching-Feng weng Institute of Biotechnology National Dong Hwa University HualienTaiwanChina

瞄准：Thioacetamide (TAA ) 在然而，学习肝纤维变性和肝硬化被使用了在肝的导致 TAA 的 apoptosis 的机制仍然是不清楚的。肝的上皮的房间线克隆 9 与 TAA 有教养、对待调查细胞死亡的原因。方法：导致 TAA 的克隆的房间生存能力 9 ... 详细信息

瞄准：Thioacetamide (TAA ) 在然而，学习肝纤维变性和肝硬化被使用了在肝的导致 TAA 的 apoptosis 的机制仍然是不清楚的。肝的上皮的房间线克隆 9 与 TAA 有教养、对待调查细胞死亡的原因。方法：导致 TAA 的克隆的房间生存能力 9 个房间用 MTT 被决定试金。在导致 TAA 的克隆的全部的细胞的 GSH 9 个房间用 Tietze 试金的细微修正被测量。caspase 的活动 3 在导致 TAA 的克隆， 9 个房间被 DEVD-p-nitroanaline 的劈开监视。TUNEL 试金和流动血细胞计数被申请 DNA 破碎的决心和在导致 TAA 的克隆的 apoptosis 的比例 9 个房间分别地。caspase 的改变 3，坏，在导致 TAA 的克隆的 Bax 和 Phospho-P53 内容 9 个房间被西方的污点测量。结果：试验性的数据显示 TAA 在剂量引起了老鼠肝的上皮的房间线克隆 9 细胞死亡 -- 并且时间依赖者举止；60% 房间死了(MTT 试金) 在在 100 mg/L 以后的 24 h 以内， TAA 被使用。Apoptotic 房间百分比(TUNEL 试金) 和 caspase 在 100 mg/L TAA 为 8 h 被增加以后， 3 项活动最高。在在 TAA 处理以后的 caspase 内容的 GSH 和举起的版本经由氧化应力和 caspase 依赖的机制导致了克隆 9 房间 apoptosis。在克隆 9 房间的 phospho-p53， Bax 和坏蛋白质表情在 TAA 处理以后被增加。结论：这些结果表明 TAA 激活 p53，增加 caspase 3， Bax 和坏蛋白质内容，也许从线粒体和膜的崩溃引起细胞色素 c 的版本，导致房间的 apoptosis。

关键词：细胞凋亡硫代乙酰胺肝脏上皮细胞临床

Clinical presentation and surgical treatment of scoliosis in Marfan syndrome

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Chinese Medical Journal 2005年第15期118卷 1313-1317页

作者： LI Qi-yi QIU Gui-xing WANG Yi-peng ZHANG Jian-guo SHEN Jian-xiong weng Xi-sheng Wang Ting LEE chia-I YU Sheng-ji Department of Orthopedic Surgery Peking Union Medical College Hospital Peking Union Medical College Beijing 100730 China

Marfan syndrome （MFS） as an autosomal dominant connective tissue disease is characterized by ocular, cardiovascular, and skeletal deformities including scoliosis. A group of 12 patients with Marfan syndrome associa... 详细信息

关键词： Marfan syndrome· scoliosis surgery

Enabling Extraordinary Rate Performance for Poorly Conductive Oxide Pseudocapacitors

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Energy & Environmental Materials 2020年第3期3卷 405-413页

作者： Mozaffar Abdollahifar Hao-Wen Liu chia-Hsin Lin Yu-Ting weng Hwo-Shuenn Sheu Jyh-Fu Lee Meng-Lin Lu Yen-Fa Liao Nae-Lih Wu Department of Chemical Engineering National Taiwan UniversityTaipei 106Taiwan National Synchrotron Radiation Research Center Hsinchu 30076Taiwan Taiwan Beamline Office at SPring-8 1-1-1 KoutoMikazukiSayoHyogo 679-5198Japan Advanced Research Center for Green Materials Science and Technology National Taiwan UniversityTaipei 10617Taiwan

Pseudocapacitive transition metal oxides(PTMOs)have the advantages of high areal capacitance and material density suitable for high-energy supercapacitor devices,but they are typically marred by insufficient rate performance,which in turn deteriorates cyclic stability at high current *** the example of spinel manganese oxide,herein we demonstrate that a pseudocapacitive oxide electrode of remarkable rate performance and cyclic stability may be realized by adopting oxide nanocrystallites,which are derived based on a novel solution chemistry,and carbon additive(CA)nanoparticles with highly uniform of size *** controlling the particle morphology and size distribution of the active material and conductive additive(CA)in the nanometer range can maximize the density of active material-CA-electrolyte three-phase contact points,thus facilitating synchronized electron and cation flow for the completion of surface faradaic *** resultant Mn3O4 pseudocapacitive electrode exhibits rate capability and cycle stability,including 60%capacity retention at 60 A g-1 and no capacity fade over 100000 cycles under dynamic current densities,far superior to the state-of-the-art PTMO *** electrode design strategy is in general applicable to pseudocapacitors containing poorly conductive active materials.

关键词： high-rate performance pseudocapacitor electrodes single nanoparticles three-phase contact point ultra-long cycle life