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Case Reports in Clinical Medicine 2019年第5期8卷 127-133页

作者： chien-Ting Wu chieh-Tsung yen Hsiu-Lan Cheng chi-Hui Lee Department of Pharmacy Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Taiwan

Posterior reversible encephalopathy syndrome (PRES), a rare disease is characterized by multiple neurological complications. It has been reported to be associated with the use of angiogenesis inhibitors such as sorafenib, sunitinib, pazopanib, regorafenib, and lenvatinib. We reported a case of 76-year-old woman with history of stage III hepatocellular carcinoma (HCC), who developed adverse drug reactions related to pazopanib induced PRES. Pazopanib, an angiogenesis inhibitor which inhibits the vascular endothelial growth factor (VEGF) pathway may lead to vascular endothelial damage, and these pathophysiological changes may lead to vascular leaks and brain edema. Medical staff must be aware of the possible association between angiogenesis inhibitors and the development of PRES. In patients with retroperitoneal soft-tissue sarcoma undergoing treatment with pazopanib, regular monitoring of their blood pressure and following-up brain magnetic resonance imaging (MRI) should be encouraged.

关键词： Posterior Reversible Encephalopathy Syndrome Pazopanib Hepatocellular Carcinoma Vascular Endothelial Growth Factor Magnetic Resonance Imaging

Relationship between severity of venous calcifications and symptoms of phlebosclerotic colitis

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World Journal of Gastroenterology 2015年第26期21卷 8148-8155页

作者： Tsung-Shuo yen chien-An Liu Nai-chi chiu Yi-You chiou Yi-Hong Chou Cheng-yen Chang Department of Radiology Wei Gong Memorial Hospital Department of Radiology Taipei Veterans General Hospital School of Medicine National Yang-Ming University

AIM: To examine the correlation between the severity of venous calcifications and the clinical symptoms of phlebosclerotic ***: This was a retrospective *** data,including the numbers of episodes of active disease,were collected from the medical records at Taipei Veterans General Hospital and Wei Gong Memorial Hospital in Taiwan between January 2005 and December *** computed tomography images with or without contrast enhancement were obtained using a multiple detector computed tomography *** scanning range reached from the dome of the diaphragm to the *** severity of calcification at the tributaries of the portal vein was measured using a four-grade scoring system of the calcification of phlebosclerotic *** episodes of active disease were defined as symptoms of fever,abdominal pain,severe constipation,bowel obstruction,vomiting or diarrhea based on a review of the medical ***'s correlation analysis was used to examine the correlation between the numbers of episodes of active disease and the severity of the calcification of the mesenteric ***: More than 3000 cases were reviewed from 2005 to 2014,and a total of 12 patients from Taipei Veterans General Hospital and Wei Gong Memorial Hospital were enrolled according to our inclusion *** these 12 patients,the mean age of the six males and the six females was 61.8 ± 11.5 *** patients exhibited typical imaging characteristics,consisting of threadlike calcifications and colonic wall thickening in the standard radiographs and calcifications along the colonic and mesenteric vessels or associated with colonic wall thickening and adjacent fat stranding in the computed tomography *** median score of the severity of the venous calcifications was 18 ± 13,and the median number of active disease episodes was 1 ± ***'s correlation analysis revealed that the number of episodes of active phlebosclerotic colitis disease significantly p

关键词： Phlebosclerotic colitis Calcification of themesenteric veins Symptoms of phlebosclerotic colitis Computed tomography Ischemic bowel disease

Cellular factors involved in the hepatitis C virus life cycle

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World Journal of Gastroenterology 2021年第28期27卷 4555-4581页

作者： Hui-Chun Li Chee-Hing Yang Shih-yen Lo Department of Biochemistry Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 970Taiwan

The hepatitis C virus(HCV),an obligatory intracellular pathogen,highly depends on its host cells to propagate *** HCV life cycle can be simply divided into several stages including viral entry,protein translation,RNA replication,viral assembly and *** of cellular factors involved in the HCV life cycle have been identified over more than thirty years of *** of these cellular factors has provided extensive insight into HCV replication *** of these cellular factors are targets for anti-HCV *** this review,we summarize the well-characterized and recently identified cellular factors functioning at each stage of the HCV life cycle.

关键词： Hepatitis C virus Cellular factor Viral entry Translation Replication Assembly Release

Long noncoding RNAs in hepatitis B virus replication and oncogenesis

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World Journal of Gastroenterology 2022年第25期28卷 2823-2842页

作者： Hui-Chun Li Chee-Hing Yang Shih-yen Lo Department of Biochemistry Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 97004Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 97004Taiwan

Several diverse long noncoding RNAs(lncRNAs)have been identified to be involved in hepatitis B virus(HBV)replication and oncogenesis,especially those dysregulated in HBV-related hepatocellular carcinoma(HCC).Most of these dysregulated lncRNAs are modulated by the HBV X *** regulatory mechanisms of some lncRNAs in HBV replication and oncogenesis have been *** polymorphisms of several lncRNAs affecting HBV replication or oncogenesis have also been *** prognosis of HCC remains *** is important to identify novel tumor markers for early diagnosis and find more therapeutic targets for effective treatments of *** dysregulated lncRNAs in HBV-related HCC may become biomarkers for early diagnosis and/or the therapeutic targets of *** mini-review summarizes these findings briefly,focusing on recent developments.

关键词： Hepatitis B virus Hepatocellular carcinoma Long noncoding RNAs Hepatitis B virus X protein Biomarker

Differential Effect of Shikonin-induced Immunogenic Cell Death Versus Autophagy:Mechanisms and Application for DC-based Cancer Vaccine

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Differential Effect of Shikonin-induced Immunogenic Cell Dea...

Characteristics and Prescription Pattern of Traditional chinese Medicine Use in Patients with Stroke in Taiwan:a Nationwide Population-Based Study

第十四届全国中药和天然药物学术研讨会

作者： Sheng-yen Lin Wen-chi Wei Pei-Wen Hsiao Ning-Sun Yang Academia Sinica National Defense Medical Center

＜正＞Tumor immunogenicity can be characterized by the exposure of damage-associated molecular patterns（DAMPs）on cell surface,which can recruit dendritic cells（DCs）and enhance DC *** studies have demonstrated that chemotherapy-induced autophagy may positively regulate immunogenic cell death（ICD）.We recently showed that

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Characteristics and Prescription Pattern of Traditional Chin...

Image features of two rare mediastinal tumors: schwannoma of intrathoracic phrenic nerve and clear cell chondrosarcoma of the rib

第十四届全国中药和天然药物学术研讨会

作者： chia-chi Chang Hung-Rong yen Yu-Chen Lee Mao-Feng Sun china Medical University Hospital china Medical University

Objective Cerebrovascular Accident（stroke） has been the leading causes of death *** aim of this study is to evaluate the characteristics and prescription pattern of TCM among stroke patients in *** and Methods This study examined datasets from the National Health Insurance Research Database in ***（n=23,816） newly diagnosed as stroke and admitted to hospital between January 2001 and December 2009 were included in this *** who had at least one TCM outpatient clinical record were defined as TCM users（n=2,862）,whereas those without TCM outpatient records were defined as non-TCM users（n=20,954）.The demographic data,treatment modalities,disease distributions,comorbidities,and prescription pattern of the TCM users were *** Among the stroke patients,18.1%（n=4302） of them had hemorrhagic stroke,and 81.9%（n=19,514） of them had ischemic *** average interval to visit TCM clinic after onset of stroke is 12.2 *** of the TCM users combined herbal remedies,acupuncture and traumatology（52.7%）.The most commonly prescribed formula and single herb was Bu-Yang-Huan-Wu-Tang and Radix et Rhizoma Salviae Miltiorrhizae,*** who had insomnia and fasciitis or myalgia were prone to have more TCM visits compared to non-TCM *** Our nationwide population-based study revealed the characteristics and specific usage patterns of TCM in the stroke patients in *** results provided valuable information for further pharmacologic investigation and clinical studies on the treatment of stroke and its related complications.

关键词： Cerebrovascular Accident National Health Insurance Database Stroke Traditional chinese medicine

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chinese Medical Journal 2005年第17期118卷 1493-1496页

作者： Ting-Kai Leung chien-Jui Cheng chi-Ming Lee Li-Kuo Shen Hung-Jung Wang Ya-yen Chen Diagnostic Radiology Department of Taipei Medical University Hospital Taipei Medical University Taipei China Pathology Department of Taipei Medical University Hospital Taipei Medical University Taipei China

The current report focuses on two patients of the same age who presented similar appearances on initial anteroposterior chest images. Follow-up images showed superoanterior and superoposterior mediastinal lesions. The first patient with noninvasive cystic thymoma was suspected before surgery, while the pathologic diagnosis was intrathoracic phrenic nerve schwannoma. The second patient was with an asymmetric, dumbbell-shaped paravertebral tumor over T3 and T4 on the left side. The preoperative diagnostic images were interpreted as showing a neurogenic tumor. However, the pathologic report was cell chondrosarcoma.

关键词： mediastinal tumors schwannoma phrenic nerve clear cell chondrosarcoma

Rapid synthesis of Ti-MCM-41 by microwave-assisted hydrothermal method towards photocatalytic degradation of oxytetracycline

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Journal of Environmental Sciences 2016年第6期28卷 76-87页

作者： Hanlin Chen yen-Ping Peng Ku-Fan Chen chia-Hsiang Lai Yung-Chang Lin College of Environment and Energy South China University of Technology Department of Environmental Science and Engineering Tunghai University Department of Civil Engineering "National"Chi Nan University Department of Safety Health and Environmental EngineeringCentral Taiwan University of Science and Technology Department of Electrical Engineering Cheng Shiu University

This study employed microwave-assisted hydrothermal method to synthesize Ti-MCM-41,which are mesoporous materials with a high surface area and excellent photocatalytic ability. Fourier transform infrared spectroscopy（FTIR）, X-ray diffraction（XRD）, X-ray photoelectron spectroscopy（XPS）, transmission electron microscopy（TEM）, and ultraviolet–visible spectroscopy（UV–Vis） were employed. The XRD findings showed that Ti-MCM-41 exhibited a peak at 2θ of 2.2°, which was attributed to the hexagonal MCM-41 structure. The BET（Brunauer–Emmett–Teller） results agreed with the TEM findings that Ti-MCM-41 has a pore size of about 3–5 nm and a high surface area of 883 m-2/g. FTIR results illustrated the existence of Si–O–Si and Si–O–Ti bonds in Ti-MCM-41. The appearance of Ti2 p peaks in the XPS results confirmed the FTIR findings that the Ti was successfully doped into the MCM-41 structure. Zeta（ζ）-potential results indicated that the iso-electric point（IEP） of Ti-MCM-41 was at about pH 3.02. In this study, the photocatalytic degradation of oxytetracycline（OTC） at different pH was investigated under Hg lamp irradiation（wavelength 365 nm）. The rate constant（K′obs） for OTC degradation was 0.012 min-1at pH 3. Furthermore, TOC（total organic carbon） and high resolution LC–MS（liquid chromatography–mass spectrometry） analyses were conducted to elucidate the possible intermediate products and degradation pathway for OTC. The TOC removal efficiency of OTC degradation was 87.0%, 74.4% and 50.9% at pH 3, 7 and 10, respectively. LC–MS analysis results showed that the degradation products from OTC resulted from the removal of functional groups from the OTC ring.

关键词： Oxytetracycline Ti-MCM-41 Microwave hydrothermal synthesis Photocatalytic degradation

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multicentre registry network

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World Journal of Gastroenterology 2022年第17期28卷 1830-1844页

作者： James Guoxian Huang Yoko Kin Yoke Wong Kee Seang Chew Pornthep Tanpowpong Karen Sophia Calixto Mercado Almida Reodica Shaman Rajindrajith Kai-chi Chang yen-Hsuan Ni Suporn Treepongkaruna Way-Seah Lee Marion Margaret Aw Khoo Teck Puat-National University children’s Medical Institute National University Health SystemSingapore 119228Singapore Department of Pediatrics Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore Epidemiology Singapore Clinical Research InstituteSingapore 138669Singapore Department of Paediatrics Faculty of MedicineUniversity MalayaKuala Lumpur 50603Malaysia Department of Pediatrics Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Department of Pediatrics Makati Medical CentreManila 1229Philippines Department of Pediatrics The Medical CityManila 0900Philippines Department of Pediatrics Faculty of MedicineUniversity of ColomboColombo 00800Sri Lanka Department of Pediatrics National Taiwan University HospitalTaipei 100229Taiwan

BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease(PIBD).AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data *** Clinical,endoscopic and radiologic data at diagnosis from the registry were extracted between 1^(st) January 1995 to 31^(st) December *** phenotypic characteristics were classified as per the Paris classification *** There was a distinct rise in new PIBD cases:Nearly half(48.6%)of the cohort was diagnosed in the most recent 5 years(2015-2019).The ratio of Crohn’s disease(CD):Ulcerative colitis(UC):IBDUnclassified was 55.9%:38.3%:5.8%.The mean age was 9.07 years with a high proportion of very early onset IBD(VEO-IBD)(29.3%)and EO-IBD(52.7%).An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort(6.8%-9.0%Indians in census).Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease(P=0.003).CD patients presented with significantly more constitutional symptoms(fever,anorexia,malaise/fatigue and muscle-wasting)than UC and higher inflammatory indices(higher C-reactive protein and lower albumin levels).CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian *** Asian CD patients were more likely to have symptomatic perianal disease.

关键词： Asia Inflammatory bowel disease Paediatrics Crohn’s disease Ulcerative colitis Registry

Ambient Mass Spectrometry for Clinical Medicine: Rapid Diagnosis of Toxins for Emergency Care

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Ambient Mass Spectrometry for Clinical Medicine: Rapid Diagn...