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Interplay of laser power and pore characteristics in selective laser melting of ZK60 magnesium alloys:A study based on in-situ monitoring and image analysis

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Journal of Magnesium and Alloys 2024年第4期12卷 1346-1366页

作者： Weijie Xie Hau-Chung Man chi-Wai chan Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT95AHUK Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This study offers significant insights into the multi-physics phenomena of the SLM process and the subsequent porosity characteristics of ZK60 Magnesium(Mg)***-speed in-situ monitoring was employed to visualise process signals in real-time,elucidating the dynamics of melt pools and vapour plumes under varying laser power conditions specifically between 40 W and 60 *** morphological analysis was performed using Scanning-Electron Microscopy(SEM),demonstrating a critical correlation between laser power and pore *** laser power led to increased pore coverage,whereas a denser structure was observed at higher laser *** laser power influence on porosity was further confirmed via Optical Microscopy(OM)conducted on both top and cross-sectional surfaces of the *** increase in laser power resulted in a decrease in pore coverage and pore size,potentially leading to a denser printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented these findings by providing a 3D volumetric representation of the sample internal structure,revealing an inverse relationship between laser power and overall pore *** laser power appeared to favour the formation of interconnected pores,while a reduction in interconnected pores and an increase in isolated pores were observed at higher *** interplay between melt pool size,vapour plume effects,and laser power was found to significantly influence the resulting porosity,indicating a need for effective management of these factors to optimise the SLM process of Mg alloys.

关键词： Selective laser melting(SLM) Magnesium(Mg)alloys Biodegradable implants Porosity In-situ monitoring

A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,china:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan ching-Ho Ko Cindy Yeuk-Lam Hong Samuel chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang chan Ho-Man Tam chi-Kwok chan chi-Fai Ng Peter Ka-Fung chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung Wong Hoi She Siu Lun Ho Albert chi Yan chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的肿瘤进展（英文）

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CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的...

All-plasmonic optical leaky-wave antenna with a low sidelobe level

2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：沈月洪陈羽菱林云涛李一村刘朋菲张璧茹王宇帆 King-chi chan Nai-Ki Mak Michael Kahn 齐众杨宏宇

Background: Head and neck squamous cell carcinoma(HNSCC) is a highly aggressive and frequently lethal malignancy. The 5-year survival rate of patients with HNSCC has remained low due to the tumor recurrence, metastasis, and treatment resistance. CDK5RAP2 is a microtubule regulatory protein. The role and underlying molecular mechanism of CDK5RAP2 in HNSCC are ***: CDK5RAP2 expression was examined using qRT-PCR and database analysis, and the biological role of CDK5RAP2 in HNSCC were investigated using colony formation assays,transwell assays, sphere formation assays, and in vivo tumorigenesis assays. Drug treatment,chromatin immunoprecipitation, and luciferase reporter assays were used to determine the regulation of CDK5RAP2 expression by the Wnt signaling pathway. Moreover, the gene expression profiles of CDK5RAP2-depleted cells were identified through RNA-sequencing and bioinformatics analyses. Lastly, spindle orientation was investigated through ***: CDK5RAP2 expression was upregulated in HNSCC tumor tissues and cells, and CDK5RAP2 knockdown inhibited cell tumorigenesis and migration. CDK5RAP2 expression was found to be regulated by the Wnt signaling pathway. Moreover, CDK5RAP2 depletion altered the cancer stem(-like) cell(CSC) signature of HNSCC cells. Notably, CDK5RAP2 was found to regulate spindle orientation in mitotic ***: CDK5RAP2 is identified here as a potential CSC marker of HNSCC that is regulated by the Wnt signaling pathway. CDK5RAP2 plays an indispensable role in HNSCC development and regulates the CSC signature of HNSCC by controlling spindle orientation during mitosis.

关键词： Head and neck squamous cell carcinoma(HNSCC) Wnt signaling pathway Cancer stem(-like) cell(CSC) CDK5RAP2 Spindle orientation

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Photonics Research 2023年第9期11卷 1500-1508页

作者： GUANG ZHU ZHOU BAO-JIE CHEN GENG-BO WU SHI-WEI QU chi HOU chan School of Electronic Science and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 611731China State Key Laboratory of Terahertz and Millimeter Wave City University of Hong KongHong Kong 999077China Department of Electrical Engineering City University of Hong KongHong Kong 999077China

Optical antennas have received considerable attention in recent years due to their unique ability to convert localized energy to freely propagating radiation and vice *** level(SLL)is one of the most crucial parameters in antenna design.A low SLL is beneficial to minimize the antenna interference with other optical *** a plasmonic optical leaky-wave antenna with low SLL is *** spatial frequency by periodically modulating the electric-field amplitude in a plasmonic gap waveguide enables a free-space coupled wave out of the *** the same time,precise control of the aperture fields by the modulation depth allows for reducing *** results indicate that the proposed design can achieve a high directivity of 15.8 dB and a low SLL of-20 dB at the wavelength of 1550 nm.A low SLL below-15 dB is experimentally demonstrated within the wavelength range from 1527 to 1570 *** addition,the low-SLL property is further verified by comparing it with a uniformly modulated *** modulating the guided waves in the plasmonic gap waveguide in different forms,the aperture fields can be flexibly arranged to achieve arbitrary wavefront *** bridges the gap between guided and free-space waves and empowers plasmonic integrated devices to control free-space light,thus enabling various free-space functions.

关键词： antenna waveguide optical

Distribution of a Certain Partition Function Modulo Powers of Primes

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Acta Mathematica Sinica,English Series 2011年第4期27卷 625-634页

作者： Hei-chi chan Department of Mathematical Sciences University of Illinois at Springfield Springfield IL 62703-5407 USA

In this paper, we study a certain partition function a（n） defined by ∑n≥0 a（n）qn ：= ∏n=1（1- qn）-1（1 -2n）-1. We prove that given a positive integer j 〉 1 and a prime m _〉 5, there are infinitely many congruences of the type a（An ＋ B） ≡ 0 （rood m3）. This work is inspired by Ono＇s ground breaking result in the study of the distribution of the partition function p（n）.

关键词： Distribution of partition function Ono's theorem Ramanujan's congruences

Urocortin and cardiovascular protection

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Acta Pharmacologica Sinica 2004年第3期25卷 3-11页

作者： chi-wai LAU,Yau-chi chan,Suk-ying TSANG,Franky Leung chan The chinese University of Hong Kong Hong Kong china Department of Anatomy The chinese University of Hong Kong Hong Kong china Department of Anatomy The chinese University of Hong Kong Hong Kong china Department of Anatomy The chinese University of Hong Kong Hong Kong china Department of Anatomy

Urocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.

关键词： urocortin corticotropin-releasing hormone vascular smooth muscle heart vasodilaion second messenger system protein kinases

Successful capture of red thrombus in acute inferior ST-elevation myocardial infarction

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Journal of Geriatric Cardiology 2018年第10期15卷 647-648页

作者： Wai-Kin chi chi-Yuen chan Division of Cardiology Department of Medicine and TherapeuticsPrince of Wales Hospitalthe Chinese University of Hong KongHong KongChina

A 50-year-old gentleman with past medical history of hypertension presented with acute inferior ST-segment elevation myocardial infarction (STEMI).He complained severe chest pain despite onset time was more than *** p... 详细信息

关键词： Embolic protection device Successful capture Thrombus

Systematic investigation of millimeter-wave optic modulation performance in thin-film lithium niobate

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Photonics Research 2022年第10期10卷 2380-2387页

作者： YIWEN ZHANG LINBO SHAO JINGWEI YANG ZHAOXI CHEN KE ZHANG KAM-MAN SHUM DI ZHU chi HOU chan MARKO LONČAR CHENG WANG Department of Electrical Engineering City University of Hong KongKowloonHong KongChina John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburgVirginia 24061USA State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong KongChina Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A^(*)STAR)Singapore 138634Singapore

Millimeter-wave(mmWave)band(30–300 GHz)is an emerging spectrum range for wireless communication,short-range radar,and sensor ***-optic modulators that could efficiently convert mmWave signals into the optical domain are crucial components for long-haul transmission of mmWave signals through optical *** these ultrahigh frequencies,however,the modulation performances are highly sensitive to the transmission line loss as well as the velocity-and impedance-matching conditions,while precise measurements and modeling of these parameters are often *** we present a systematic investigation of the mmWave-optic modulation performances of thin-film lithium niobate modulators through theoretical modeling,electrical verifications,and electro-optic measurements at frequencies up to 325 *** on our experimentally verified model,we demonstrate thin-film lithium niobate mmWave-optic modulators with a measured 3-dB electro-optic bandwidth of 170 GHz and a 6-dB bandwidth of 295 *** device also shows a low RF half-wave voltage of 7.3 V measured at an ultrahigh modulation frequency of 250 *** work provides a comprehensive guideline for the design and characterization of mmWave-optic modulators and paves the way toward future integrated mmWave photonic systems for beyond-5G communication and radar applications.

关键词： millimeter lithium film