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Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats

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World Journal of Gastroenterology 2016年第8期22卷 2566-2575页

作者： Tie-Ming Ma Na Xu Xian-De Ma Zeng-Hua Bai Xing Tao Hong-chi yan Liaoning University of Traditional chinese Medicine Shenyang 110847 Liaoning Province China

AIM: To observe the efficacy and mechanism of grain-sized moxibustion at different acupoints in a rat model of ulcerative colitis (UC). METHODS: Sprague-Dawley rats were randomly divided into control, UC model, grain-sized moxibustion at a single acupoint (CV 12), grain-sized moxibustion at two acupoints (CV 12 and CV 4), grain-sized moxibustion at three acupoints (CV 12, CV 4, and ST 36), and medication groups (n = 8/group). The UC model was established by enema of trinitrobenzene sulfonic acid. Direct moxibustion was used once a day for 7 d. Disease activity index (DAI) was evaluated before and after the treatment. Morphologic changes of intestinal tissue were observed under an optical microscope. The expression of tumor necrosis factor (TNF)-alpha and p38 mitogen-activated protein kinase (p38MAPK) in colonic tissue was detected using Western blot, and the levels of occludin and zonula occludens-1 (ZO-1) mRNAs were detected using reverse transcription PCR. RESULTS: Compared with the control group, the intestinal mucosae were incomplete in the model group, glandular structures were irregular, and submucosae were edematous, hyperemic, and infiltrated with inflammatory cells. The DAI scores and expression of TNF-alpha and p38MAPK were increased significantly in the model group compared to controls (Ps < 0.01), while the mRNA levels of occludin and ZO-1 were reduced significantly (Ps < 0.01). Compared with the model group, colonic mucosa and the arrangement of glands were complete and regular in the treatment groups. DAI scores and the expression of TNF-alpha and p38MAPK were reduced significantly in moxibustion groups compared to controls (Ps < 0.01), while the mRNA levels of occludin and ZO-1 were increased significantly (Ps < 0.01). The improvements in the above indices in the three acupoints group and the medication group were superior to those in the single and two acupoints groups (all P < 0.05). CONCLUSION: Reduction of TNF-alpha and p38MAPK and increased expre

关键词： Different acupoints Grain-sized moxibustion Inflammatory factors Intestinal mucosal barrier Ulcerative colitis

如何理解教育哲学——与保罗·斯坦迪什教授的对话

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教育学报 2018年第2期14卷 3-6页

作者：迟艳杰保罗.斯坦迪什沈阳师范大学教育科学学院沈阳110034 伦敦大学学院教育学院

教育哲学的探究要有批判性,教育哲学意蕴的论文要有论证,辩护和理性的论证是教育哲学探究的核心。保罗·斯坦迪什认为我们割裂了哲学和哲学在教育中的应用,教育哲学不是哲学的一个分支,也不是哲学在教育中的应用,教育处于哲学的核心。... 详细信息

教育哲学的探究要有批判性,教育哲学意蕴的论文要有论证,辩护和理性的论证是教育哲学探究的核心。保罗·斯坦迪什认为我们割裂了哲学和哲学在教育中的应用,教育哲学不是哲学的一个分支,也不是哲学在教育中的应用,教育处于哲学的核心。因为教育哲学探究是要对价值、课程选择和安排等给以辩护和论证,要回答"我们该怎样生活"等核心问题。对话还涉及了教育哲学存在形态,而保罗·斯坦迪什对教师教育、对语言的看法,体现了他思考的广度和深度。

关键词：哲学教育哲学价值论证

Analgesic Activity of Jin Ling Zi Powder and Its Single Herbs:A Serum Metabonomics Study

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chinese Journal of Integrative Medicine 2022年第11期28卷 1007-1014页

作者： WANG Cui-fang CAI Xiao-rong chi yan-ni MIAO Xiao-yao yanG Jian-yun XIAO Bing-kun HUANG Rong-qing Institute of Radiation Medicine Academy of Military Medical SciencesBeijing(100850)China School of chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou(510006)China School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang(330000)China

Objective:To compare the analgesic effect of Jin Ling Zi Powder(JLZ)and its two single ***:The hot plate method was used to induce *** 36 mice were randomly divided into 6 groups by a complete random design,including control,model,aspirin(ASP,0.14 g/kg body weight),JLZ(14 g/kg body weight),Corydalis yanhusuo(YHS,14 g/kg body weight),and Toosendan Fructus(TF,14 g/kg body weight)groups,6 mice in each *** mice in the control and model groups were given the same volume of saline,daily for 2 consecutive *** 30,60,90,and 120 min after the last administration,the pain threshold of mice in each group was measured,and the improvement rate of pain threshold was *** endogenous metabolites were analyzed by gas chromatography–mass spectrometry(GC–MS).Results:There was no statistical difference in pain threshold among groups before administration(P>0.05).After 2 weeks of administration,compared with the model group,the pain threshold in JLZ,YHS,TF and ASP groups were increased to varying degrees(P<0.05).JLZ had the best analgesic effect and was superior to YHS and TF groups.A total of 14 potential biomarkers were screened in serum data analysis and potential biomarkers levels were all reversed to different degrees after the treatment with JLZ and its single *** potential biomarkers were mainly related to glyoxylate and dicarboxylate metabolism,glycine,serine and threonine metabolism,valine,leucine and isoleucine biosynthesis,aminoacyl-t RNA biosynthesis and inositol phosphate ***:The analgesic mechanism of JLZ and YHS was mainly due to the combination of glycine and its receptor,producing post-synaptic potential,reducing the excitability of neurons,and weakening the afferent effect of painful information.

关键词： Jin Ling Zi Powder chinese medicine metabonomics gas chromatography coupled to mass spectrometry analgesic Corydalis yanhusuo Toosendan Fructus

The ‘Unsigned highway’:An alternative route for portal vein anastomosis for non-malignant portal vein thrombosis during pediatric re-transplantation

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 193-195页

作者： Albert chi yan Chan Wing chiu Dai Patrick Ho Yu Chung Wong Hoi She Sui Ling Sin Division of Liver Transplantation Department of SurgeryThe University of Hong KongHong KongChina Division of Paediatric Surgery Department of SurgeryThe University of Hong KongHong KongChina

To the Editor:Non-malignant portal vein thrombosis(PVT)remains an important issue in liver transplantation due to the technical challenges in re-establishing the portal flow to the liver *** prevalence of complex PVT(*** grade 4)was reported to be around 2.0%[1].In the early history of liver transplantation,PVT was regarded as a contraindication.

关键词： malignant thrombosis anastomosis

Impact Factor:1.90 Total flavonoids from Saussurea involucrata attenuate inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages via modulating p65,c-Jun,and IRF3 signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 273-284页

作者： Li-Shan yan Li Wang Brian chi-yan Cheng Yu Ding Jing Kong Qing Gao Wang Xiu-Qiong Fu Shuo-Feng Zhang Gan Luo Yi Zhang School of chinese Materia Medica Beijing University of Chinese MedicineBeijingChina College of Professional and Continuing Education Hong Kong Polytechnic UniversityHong KongChina The First Affiliated Hospital Guangxi University of Chinese MedicineGuangxiChina Centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong KongChina

Objective:To investigate the anti-inflammatory effects of the total flavonoids from Saussurea involucrata on lipopolysaccharides(LPS)-stimulated murine RAW264.7 macrophages and explore its underlying mechanism of ***:Total flavonoids from Saussurea involucrata were extracted using chromatographic column *** viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide *** production of nitric oxide was detected by Griess assay and the release of cytokines(IL-10 and TNF-α)and chemokines(MCP-1,MIP-1α,and CCL5/RANTES)was determined by ELISA to evaluate the anti-inflammatory activity of total flavonoids from Saussurea ***,nuclear translocation of p65,c-Jun,and IRF3 was detected by immunofluorescence microscopy and Western blotting analysis was performed to determine the expression of related ***:Total flavonoids extracted from Saussurea involucrata were 751.5 mg/g and the content of rutin was 506.5 mg/*** production of inflammatory mediators including nitric oxide,cytokines,and chemokines was effectively inhibited by total flavonoids from Saussurea ***,total flavonoids also suppressed the nuclear translocation of p65,c-Jun,and IRF3 in LPS-stimulated RAW264.7 *** LPS-induced expression of iNOS and COX-2 was remarkably reduced by treatment with total flavonoids from Saussurea ***,total flavonoids decreased the expression levels of p-IKKα/β,p-TBK1,p-p38,p-ERK,p-JNK,p-p65,p-c-Jun,and p-IRF3 in LPS-exposed RAW264.7 ***:Total flavonoids from Saussurea involucrata potentially inhibit the secretion of pro-inflammatory mediators,which may be related to inhibition of p65,c-Jun,and IRF3 signaling pathways in LPS-stimulated RAW264.7 cells.

关键词： Saussurea involucrata Cytokines Proinflammatory Macrophages Flavonoids

Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 322-334页

作者： Ka Wing Ma Wong Hoi She Albert chi yan Chan Tan To Cheung James yan Yue Fung Wing chiu Dai Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery the University of Hong Kong Department of Surgery and State Key Laboratory for Liver Research the University of Hong Kong Department of Medicine and State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive *** To develop a scoring system to predict HCC recurrence after LT in an Asian *** Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic *** In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordin

关键词： Hepatocellular carcinoma Liver transplantation Post-transplant recurrence Predictive model

Advance in Forest Entomology

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Advance in Forest Entomology

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

作者： chi Defu,yan Shanchun

＜正＞This report has analyzed the forest entomology discipline present situations and the trend of development in domestic and foreign *** was considered that forest entomology discipline in our country has passed

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung Wong Hoi She Siu Lun Ho Albert chi yan Chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

Settlement and Stability Analysis on Soft Clay Under Cyclic Loading

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china Ocean Engineering 1992年第4期7卷 483-490页

作者： yan Shuwang , yang Jinliang yan chi Professor, Tianjin University, 300072 TianjinAssoc. Professor, Tianjin University, 300072 Tianjin Lecturer, Tianjin University, 300072 Tianjin

The results of undrained cyclic triaxial tests on three types of clays are collected and a relationship among the accumulated strain, the initial stress state, cyclic stress in the soil, as well as the number of cycles is established based on the experimental data. With this relationship, a procedure is proposed for subsidence and stability analysis on soft clay under the action of cyclic loads.

关键词： soft clay cyclic loading triaxial test accumulated strain cyclic stress