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Mechanical properties and thermal deformation behavior of low-cost titanium matrix composites prepared by a structure-optimized Y_(2)O_(3) crucible

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Journal of Iron and Steel Research(International) 2024年第3期31卷 738-751页

作者： Qian dang Gang Huang Ye Wang chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150004HeilongjiangChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina

A porous yttrium oxide crucible with both thermal shock resistance and erosion resistance was developed by structural *** structure-optimized yttrium oxide crucible was proved to be suitable for melting highly reactive titanium ***-cost(TiB+Y2O_(3))-reinforced titanium matrix composites were prepared by vacuum induction melting using the prepared *** thermal deformation behavior and microstructure evolution of(TiB+Y2O_(3))-reinforced tita-nium matrix composites were investigated at deformation temperatures of 900-1100℃with strain rates of 0.001-1 *** results showed that the prepared yttrium oxide crucible had both thermal shock and erosion resistance,the low-cost titanium matrix composites could be prepared by the developed yttrium oxide crucibles which were homogeneous in composition and highly sensitive to strain rate and deformation temperature,and the peak and theological stresses decreased with increasing deformation temperature or decreasing strain *** addition,the average thermal deformation activation energy of the composites was calculated to be 574.6 kJ/mol by establishing the Arrhenius constitutive equation in consideration of the strain variables,and the fitting goodness between the predicted stress value and the measured value was 97.624%.The calculated analysis of the hot processing map showed that the best stable thermal deformation zone was located in the deformation temperature range of 1000-1100℃and strain rate range of 0.001-0.01 s^(-1),where the peak dissipation coefficient wasη=71%.In this zone,the deformation of the reinforcement and matrix was harmonious,the reinforcement was less likely to fracture,dynamic recrystallization occurred more fully and the alloy exhibited near steady rheological characteristics.

关键词： Yttrium oxide crucible Titanium matrix composite Thermal deformation behavior Constitutive equation Hot processing map Microstructure evolution

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Identification of zinc-binding peptides in ADAM17-inhibiting whey protein hydrolysates using IMAC-Zn^(2+) coupled with shotgun peptidomics

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Food Production, Processing and Nutrition 2021年第1期3卷 70-79页

作者： M.chinonye Udechukwu chi dang chibuike C.Udenigwe Department of Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNova Scotia B2N 5E3Canada Department of Chemistry and Biomolecular Sciences Faculty of ScienceUniversity of OttawaOttawaOntario K1N 6N5Canada School of Nutrition Sciences Faculty of Health SciencesUniversity of OttawaOttawaOntario K1H 8M5Canada

Food components possessing zinc ligands can be used to inhibit zinc-dependent *** this study,zinc-binding peptides were derived from whey protein hydrolysates,and their ultrafiltration(>1 and<1 kDa)fractions,produced with Esperase(WPH-Esp),Everlase and *** metal affinity chromatography(IMAC-Zn^(2+))increased the zinc-binding capacity of the peptide fraction(83%)when compared to WPH-Esp(23%)and its<1 kDa fraction(40%).The increased zinc-binding capacity of the sample increased the inhibitory activity against the zinc-dependent“a disintegrin and metalloproteinase 17”.LC-MS/MS analysis using a shotgun peptidomics approach resulted in the identification of 24 peptides originating from bovineβ-lactoglobulin,α-lactalbumin,serum albumin,β-casein,κ-casein,osteopontin-k,and folate receptor-αin the *** identified peptides contained different combinations of the strong zinc-binding group of residues,His+Cys,Asp+Glu and Phe+Tyr,although Cys residues were absent in the *** silico predictions showed that the IMAC-Zn^(2+)peptides were ***,the peptides possessed poor drug-like and pharmacokinetic properties;this was possibly due to their long chain lengths(5–19 residues).Taken together,this work provided an array of food peptide-based zinc ligands for further investigation of structure-function relationships and development of nutraceuticals against inflammatory and other zinc-related diseases.

关键词： Zinc Zinc ligands Food protein Bioactive peptides Immobilized metal affinity chromatography Ultrafiltration ADAM17 Peptidomics Bioinformatics

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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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吉兰泰盐湖周边柽柳灌丛聚沙聚肥效应的研究

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干旱区资源与环境 2024年第4期38卷 155-161页

作者：张琪党晓宏崔向新迟旭王磊内蒙古农业大学沙漠治理学院呼和浩特010018

柽柳灌丛是吉兰泰盐湖外围重要的植被类型,通过测定分析柽柳灌丛垂直剖面上不同深度土层机械组成和养分含量,探讨盐湖周边柽柳灌丛生长发育过程中的聚沙聚肥效应,分析结果表明:1)柽柳灌丛下伏0-20cm土层平均体积百分含量为黏粒13.44%、... 详细信息

柽柳灌丛是吉兰泰盐湖外围重要的植被类型,通过测定分析柽柳灌丛垂直剖面上不同深度土层机械组成和养分含量,探讨盐湖周边柽柳灌丛生长发育过程中的聚沙聚肥效应,分析结果表明:1)柽柳灌丛下伏0-20cm土层平均体积百分含量为黏粒13.44%、粉粒25.27%、极细沙2.97%、细沙4.63%,无粗沙和极粗沙;对照区(空地)粗沙、极粗沙体积百分含量分别为41.47%、29.47%,几乎没有细沙以下颗粒的出现,柽柳聚集细沙,粉砂,黏粒的作用明显。2)柽柳灌丛碱解氮(3.29mg·kg^(-1))、速效磷(2.85mg·kg^(-1))、速效钾含量(162.16mg·kg^(-1)),分别高于空地38.64%、47.59%、46.79%(p<0.05),聚肥效应明显。3)柽柳灌丛改土作用的能力与灌丛发育阶段有关。灌丛发育初期、中期、衰退期速效钾含量较空地分别增加28.41%、64.55%、47.41%,说明柽柳生长的中期阶段也是柽柳生长的旺盛期聚集细颗粒和肥力的能力最强。吉兰泰盐湖周边柽柳灌丛沙堆改土固沙作用的研究可为盐湖绿洲防护林的建设提供依据和技术参考。

关键词：土壤粒度特征土壤养分聚沙聚肥作用柽柳灌丛吉兰泰盐湖

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Muscling up damaged hearts through cell therapy

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Journal of Geriatric Cardiology 2006年第3期3卷 161-页

作者： chi Van dang Johns Hopkins University School of Medicine

Molecular and cellular processes gleaned from the most fundamental of biomedical studies are now harnessed for their potential healing properties. In the US and throughout the world, millions of patients suffer from myocardial infarction and many succumb to the morbidity and mortality of the ensuing cardiac failure, a protracted condition in need of healing. While pharmacological agents have been the mainstay intervention that ameliorates cardiac failure through increased contractility or reduction of cardiac workload, these agents do not inherently heal the wounds inflicted by poor perfusion of the affected cardiac *** therapy, however, holds the promise of repleting the damage heart with new contractile cells that can be engineered to secrete concoctions that promote healing by recruiting new blood vessel development or *** cell therapeutic promise has already been fulfilled for many decades for hematological diseases through transplantation of bone marrow stem cells, which are now more broadly implicated for their healing potential of other tissues.

关键词： cell Muscling up damaged hearts through cell therapy

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基于Transformer结构增强的神经网络架构搜索性能预测器

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计算机学报 2024年第7期47卷 1469-1484页

作者：王继禾吴颖迟恒喆王党辉梅魁志西北工业大学计算机学院西安710129 嵌入式系统集成教育部工程中心西安710129 空天地海一体化大数据应用技术国家工程实验室西安710129 西安交通大学人工智能与机器人研究所西安710049

神经网络架构搜索(Neural Architecture Search,NAS)作为一种通过搜索算法设计神经网络架构的方法,在计算机视觉和自然语言处理等领域得到广泛应用,相较于人工设计网络,NAS方法可以减少设计成本并提高模型性能.但是NAS的性能评估需要对... 详细信息

神经网络架构搜索(Neural Architecture Search,NAS)作为一种通过搜索算法设计神经网络架构的方法,在计算机视觉和自然语言处理等领域得到广泛应用,相较于人工设计网络,NAS方法可以减少设计成本并提高模型性能.但是NAS的性能评估需要对候选架构进行大量训练,由此带来的计算量占整个NAS的80%以上.为降低计算开销和时间成本,近年来已提出许多基于Transformer的NAS预测器,由于Transformer出色的结构编码能力可以更好地表示拓扑信息,因而得到广泛应用.但是,现有基于Transformer的NAS预测器依然存在三个问题:其一是在预处理阶段,传统的One-hot编码方式描述节点特征的能力较弱,只能区分不同操作节点类型,而难以表达操作的细节特征,如卷积核尺寸等.其二是在编码阶段,Transformer的自注意力机制导致模型结构信息缺失;其三是在评估阶段,现有的Transformer预测器仅使用多层感知机(Multilayer Perceptron,MLP)对前向传播图进行精度预测,忽略了反向传播梯度流对预测精度的影响,因此难以真正拟合NAS评估中的正、反向交替信息流图,导致预测器精度与实际运行精度误差波动极大(10%~90%).为解决上述问题,本文提出了一种基于Transformer结构增强的NAS性能预测方法.首先,在预处理阶段,本文提出了一种超维嵌入方法增加输入数据维度以强化节点操作的参数描述能力,其次,在编码阶段将Transformer编码后的信息与图结构信息共同输人一个图卷积网络(Graph Convolutional Network,GCN),弥补由自注意力机制引起的结构缺失.最后,在性能评估阶段,本文构建了同时包含前向传播和反向传播的全训练图,并将数据集信息、图结构编码与梯度编码共同输入到GCN网络预测器中,使预测结果更贴近模型真实性能.实验结果表明,本方法与目前最先进方法相比,肯德尔相关系数提高了7.45%,训练时间减少了1.55倍。

关键词：预测器 NAS Transformer GCN Embedding

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Please join us for the 4th New Horizons in Cancer Research Conference

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Cancer Biology & Medicine 2017年第2期 105-105页

作者： Nancy E.Davidson chi Van dang Kornelia Polyak Hongyang Wang Fred Hutchinson Cancer Center Abramson Cancer Center of University of Pennsylvania Philadelphia Dana Farber Cancer Institute BostonMAUSA

On behalf of the American Association for Cancer Research(AACR),we have the great pleasure to invite you to attend the 4th AACR New Horizons in Cancer Research Conference:Research Propelling Cancer Prevention and Cures,which will be held from November 6-9,2017,in Shanghai,*** year,we are honored that Fudan University will be a partner for the *** outstanding

关键词： AACR MD Ph Please join us for the 4th New Horizons in Cancer Research Conference

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铁路枢纽区域调机集中调度模式研究

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综合运输 2024年第7期46卷 82-88,124页

作者：党湉湉宋瑞迟居尚北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044

为减少调机及机车组人员,提高运用效率,均衡作业量,在“中心站”模式基础上,提出铁路枢纽区域调机集中调度模式,将调机集中到技术站,由技术站领导指挥调车作业。为最小化调机数及总走行距离,在列车运行图基础上考虑列车运行时间范围及... 详细信息

为减少调机及机车组人员,提高运用效率,均衡作业量,在“中心站”模式基础上,提出铁路枢纽区域调机集中调度模式,将调机集中到技术站,由技术站领导指挥调车作业。为最小化调机数及总走行距离,在列车运行图基础上考虑列车运行时间范围及车站作业时间窗约束,构建多技术站下的区域调机集中作业模型。基于自适应大邻域搜索(Adaptive Large Neighborhood Search,ALNS)及随机邻域下降(Random Variable Neighborhood Descent,RVND),设计两阶段启发式算法求解。对国内某铁路枢纽展开案例分析,结果证明:区域调机集中作业模式技术经济效果显著,可在完成作业的前提下,削减65%的调机及约17%的总走行距离,大幅度缩减调机及机车组人员成本,优化枢纽资源配置,改进调车作业方案,为优化调车作业质量提供参考。

关键词：铁路运输区域调机集中调度模式自适应大邻域搜索调车作业铁路枢纽

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SPP1 and the risk score model to improve the survival prediction of patients with hepatocellular carcinoma based on multiple algorithms and back propagation neural networks

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BIOCELL 2023年第3期47卷 581-592页

作者： WENLI ZENG FENG LING KAINUO dang QINGJIA chi Nursing Department Renmin Hospital of Wuhan UniversityWuhan430060China Oncology Department Renmin Hospital of Wuhan UniversityWuhan430060China Department of Engineering Structure and Mechanics School of ScienceWuhan University of TechnologyWuhan430070China

Hepatocellular carcinoma(HCC)is associated with poor prognosis and fluctuations in immune *** studies have found that secreted phosphoprotein 1(SPP1)is involved in HCC progression,its independent prognostic value and immune-mediated role remain *** The Cancer Genome Atlas and Gene Expression Omnibus data,we found that low expression of SPP1 is significantly associated with improved survival of HCC patients and that SPP1 expression is correlated with clinical *** and multivariate Cox regression confirmed that SPP1 is an independent prognostic factor of ***,we found that T cell CD4 memory-activated monocytes,M0 macrophages,and resting mast cells showed significant differences in penetration in the high and low SPP1 expression ***,we used the Weighted Gene Co-Expression Network and Least Absolute Shrinkage Sum Selection Operator algorithms to construct a risk score for the 9-immune-related genes *** risk score showed a good ability to identify high and low-risk patients and improved survival *** also used multivariate Cox regression to validate that risk score was significantly correlated with SPP1 and overall ***,the Back-Propagation Neural Network confirmed the reliability of the results of multiple *** conclusion,the findings suggest that SPP1 is an independent marker of HCC survival and immunotherapy.

关键词： SPP1 Hepatocellular carcinoma BPNN Survival Immune cells

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Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-Dao Kim-Tuyen Huynh-Dam dang-Thuc Ngo-Luong Quang-Luan Le Thanh-Thao Vo-Nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

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