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Expression of β2-integrin on leukocytes in liver cirrhosis

World Journal of Gastroenterology 2006年第38期12卷 6193-6197页

作者： Anatol Panasiuk Janusz ■ak Elzbieta Maciorkowska Bozena Panasiuk Danuta Prokopowicz Department of Infectious Diseases Medical University of Bialystok Poland Department of Pediatrics Diagnostics Medical University of Bialystok Poland Department of Pediatric Nursing Medical University of Bialystok Poland

AIM： To analyze β2-integrin expression on blood leukocytes in liver drrhosis.METHODS： In 40 patients with liver cirrhosis and 20 healthy individuals, the evaluation of expression of CD11a （LFA-1α）, CD11b （Mac-1α）, CD11c （αX） and CD49d （VLA-4α） on peripheral blood leukocytes was performed using flow cytometry. The analysis was carried out in groups of patients divided into B and C according to Child-Pugh＇s classification. RESULTS： An increased CDlla, CD11b, CD11c and CD49d integrin expression was observed on peripheral blood leukocytes in liver cirrhosis. The integrin levels were elevated as the advancement of liver failure progressed. The highest expression of integrins occurred predominantly on monocytes. A slight expression of VLA-4 was found on lymphocytes and granulocytes and it increased together with liver failure. A positive correlation was noted between median intensity of fluorescence （MIF） expression on polymorphonuclear cells of CD11a and CD11c and CD49d （r = 0.42, P 〈 0.01; r = 053, P 〈 0.01, respectively） in liver cirrhosis stage C. However, no correlation was observed between integrin expression on leukocytes. The concentrations of sICAM-1, sVCAM-1, and TNFα, were significantly elevated in liver cirrhosis. CONCLUSION： β2-integrin expression on leukocytes increases in liver cirrhosis decornpensated as the stage of liver failure increases, which is a result of permanent activation of leukooytes circulating through the inflamed liver environment.β2-integrin expression on circulating leukocytes can intensify liver cirrhosis,

关键词： β2-integrin Liver cirrhosis Flow cytometry Leukocytes

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Differences in individual susceptibility affect the development of trigeminal neuralgia

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Neural Regeneration Research 2013年第14期8卷 1337-1342页

作者： Yusuf Kurtulus Duransoy Mesut Mete Emrah akay Mehmet Seluki Department of Neurosurgery Celal Bayar University School of Medicine Clinic of Neurosurgery Anamur State Hospital

Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain.

关键词： neural regeneration peripheral nerve injury asymptomatic vascular compression of the cranialnerves cranial nerves dorsal root entry zone dorsal root exit zone etiology hyperactivedysfunction syndrome individual susceptibility risk factors trigeminal neuralgia neuroregeneration

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Implications of a Crisis on Small Businesses in the European Union and Republic of Croatia

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Chinese Business Review 2013年第3期12卷 172-185页

作者： Goran Kutnj ak Matija Radovic Dejan Miljenovic University of Rijeka Rijeka Croatia

Until the early 1990s Croatia has been neglecting, and even underestimating the significance, the role, the needs, and the results of small businesses （small and medium entrepreneurship）. Complete attention was focused on big companies. Relatively late, in 2002, small businesses, within the statutory legislation, have gotten its appropriate legal status and economic relevance. Today it is treated as a ＂basic necessity＂ of every society and a generator of economic development. But, economic crisis that has been present since 2008 has manifested all of its negativities, which has reflected on the present state of the economy, the whole society, and it is also shown from the results and some relevant indicators.

关键词： mall- and medium-entrepreneurship European Union Republic of Croatia crisis

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Production of Catecholate Siderophores by a Manglicolous fungus Emericella nidulans:A Novel Observation

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Studies in Fungi 2016年第1期1卷 146-146,I0001,147-149页

作者： Trivedi HB Vala ak Dave BP Department of Life Sciences Maharaja Krishnakumarsinhji Bhavnagar UniversityBhavnagar-364002India

Mangrove ecosystem is a rich source of manglicolous *** much information is available on diversity of these fungi,their siderophores have not been explored *** present study was carried out with a view to explore siderophore production potential of manglicolous fungi along Ghogha Coast,Gulf of Khambhat,Gujarat,*** four different mangrove samples ***,rhizoplane,water and sediment,thirteen fungi belonging to Ascomycota were isolated,which were all siderophore *** chemical characterization indicated siderophores of twelve fungi to be hydroxamates while one isolate Emericella nidulans exhibited a novel *** nidulans a producer of both;hydroxamate and catecholate siderophore,a behaviour uncommon amongst *** data revealed that exploring manglicolous fungi could reveal novelty in structural diversity of siderophore reflecting their unique ecological roles like avoiding siderophore piracy and oxidative stress for reclamation of mangrove associated coastal habitats.

关键词： chemical characterization fungi mangrove

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长期挤压综合征的早期病原治疗原则

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国外医学（军事医学分册） 1991年第2期8卷 74-75页

作者： PeBc.,ak 肖力

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Quantitative Ultrasound Elastography of Breast: A Review and Update with Emphasis on Shear Wave Imaging (ARFI)

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Open Journal of Medical Imaging 2021年第2期11卷 58-72页

作者： Duzgun Yildirim Özlem akıncı Deniz Esin Tekcan Department of Medical Imaging Acibadem University Vocational School of Health Sciences Istanbul Turkey Department of Radiology Sancaktepe Prof. Dr. Ilhan Varank Training and Research Hospital Istanbul Turkey Department of Radiology Acibadem University Istanbul Turkey

Elastography is a method which determines the stiffness of tissues with the help of ultrasound technology and exhibits more quantitative data according to palpation that made during physical examination. Elastography has relatively entered to routine use in the breast evaluation with imaging techniques. Although palpation has a very long history, elastography has been used since 1990s. Elastography is used as an adjunct to conventional gray scale ultrasound and can identify the stiffness of the tissues non-invasively. Today, it is used as two separate technological modalities: strain elastography and shear wave elastography. The aims of these modalities are to increase the sensitivity of the separation between malignant and benign lesions, reduce the unnecessary biopsy processes and to provide a more accurate Breast Imaging Reporting and Data System (BIRADS) categorization of the breast lesions. In this article, we aimed to review the clinical utilization and benefits of elastography in differantial diagnosis of breast lesions, BIRADS categorization, and biopsy decision making in the light of current literature.

关键词： Breast Elastography Shear Wave Elastography Ultrasound

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Winner-takes-all decision-making in Fruit Fly Drosophila

Winner-takes-all decision-making in Fruit Fly Drosophila

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中国神经科学学会第十二届全国学术会议

作者： ak Guo Ke Zhang Haifeng SU Institute of Neuroscience State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Institute of Biophysics State Key Laboratory of Brain and Cognitive Science Chinese Academy of Sciences

"Nothing in neurobiology makes sense except in the light of behaviour"（***, 1994）. "Action selection is the main task of the brain"（***,2013）. How can we generate the right behavior at the right moment and the right place? Decision making is essential for the behaviorselection. We have designeda ‘color/position’ dilemma in the visual flight simulator to study the value–based decision-makingin Drosophila. Individual flies were conditioned to choose a flight path in accordance with the color（green and blue） and position（upper and lower） cues and then confronted with choice test with color and position cues reversed after *** results revealed that wild-type flies are able to resolve this paradoxical situation by evaluating the ‘relative value’ of the current information and making a nonlinear ‘winner-takes-all’ *** decision curve exhibited a clear-cut and sigmoid-like function（Tang and Guo, 2001）. We found that flies with defective dopamine system or MBs（mushroom bodies, a part of fly’s central brain, as a centerof free will or intelligent control） functionhave trouble in deciding between the two conflicting visual features（Zhang et al,2007）.Lastly we have found thata pair of APLneuron（the anterior paired lateral GABAergic inhibitory neuron）（Liu and Davis,2009）, which densely innervate the MB, is also involved in the salience-based decision-making that genetic silencing of APL neurons turns the nonlinear choice behavior into linear one（Su et al., in preparation）. This effect was mediated by ionotropic GABAA receptors, RDL, which is highly expressed in all lobes of the MB（Liu et al., 2009）.Together, we suggest a Gain-Gating Mechanism of decision making that during decision making process the one option（"winner"）will be inflated by the Dopamine Gain Mechanism, while the alternative one（"loser"） will be rejected by GABA Inhibition Gating resulting in "Winner takes all".We believe that our Gain-Gating framework may provide a template for

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98洪灾对制定林业规划的启示

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世界林业研究 1998年第6期11卷 29-33页

作者：刘勇 Bane.,ak 北京林业大学

农村集体林的林业规划多年来一直是由林业部门来制定，农民很少参与。这种获益者不参与规划的状况常常会出现农民想要的没规划，规划好的又没人想要的尴尬局面。也就造成了农民不珍惜林地，对林地破坏严重的现象，这也是多年来造林不成... 详细信息

农村集体林的林业规划多年来一直是由林业部门来制定，农民很少参与。这种获益者不参与规划的状况常常会出现农民想要的没规划，规划好的又没人想要的尴尬局面。也就造成了农民不珍惜林地，对林地破坏严重的现象，这也是多年来造林不成林的一个根本原因之一。９８洪灾之后，大江大河上游的造林活动必将更为人们所重视。但如果还按老方法对造林项目进行规划，结果令人担忧。如何将森林的生态效应和农民所期望的经济效益有效地结合起来，是今后林业或造林规划工作中一项重要的任务。结合中国国情，介绍了一种在国际上普遍采用的由下而上制定规划的方法。该方法能广泛发动农民，征求农民意见，并使其积极参与林业规划的制定。

关键词：洪涝灾害森林经营规划

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正发党执政时期土耳其的对华关系分析

正发党执政时期土耳其的对华关系分析

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作者： Ramazan （?）amil A（?）ak 华东师范大学

学位级别：硕士

土耳其民族和中华民族是两个古老的民族,它们位于欧亚大陆的两个极端。这两个国家在历史上就有着频繁的交流,在21世纪中更是如此。本文主要分析土耳其正发党执政期间对华政策的发展演变。2002-2006年间,正发党政府在成为欧盟正式成员国... 详细信息

土耳其民族和中华民族是两个古老的民族,它们位于欧亚大陆的两个极端。这两个国家在历史上就有着频繁的交流,在21世纪中更是如此。本文主要分析土耳其正发党执政期间对华政策的发展演变。2002-2006年间,正发党政府在成为欧盟正式成员国的战略指导下,优先考虑了发展欧盟与土耳其的政治、经济、军事关系,而土耳其对华贸易逆差增加的主要因素结果形成了土耳其对“中国威胁”的看法。正发党政府无法实现加入欧盟的目标,自2006年以来一直希望发展土中关系,特别是希望减少两国之间的贸易不平衡。此后,由于双方高层互访增多,两国关系在各个领域开始发展。2009年,土耳其前总统居尔访华后,两国关系预计会有新的发展。在此期间,双边高层军事谈判和两国部长的互访产生了积极影响。两国关系随着中国总理温家宝于2010年10月7日访问土耳其时发展成为战略伙伴关系。两国战略合作进入了一个新时代。土耳其在2010年与中国进行了军事演习,演习后得到了北约的大力回应。土耳其和中国从2010年开始的战略合作,在2013年宣布的“一带一路”项目双赢政策的框架内,提供了进一步发展的机会。这个项目不仅增进了两国经济关系,从而推动了两国人民文化和历史联系,也增进了他们之间的相互了解。土耳其2013年曾决定从中国购买34亿美元导弹防御系统,但在北约强烈回应后,于2015年取消了招标。2002年,两国之间的贸易总额为16亿美元。2018年,这一总额为236亿美元。然而两国之间有严重的贸易逆差,为了消除这一问题,土耳其需要实施长期战略计划。尽管近年来两国关系有所发展,但两国之间仍有一些问题有待解决。两国在中东和中亚战略上有所不同。应该为两国建立协商和对话机制,以加强在第三国的合作。

关键词：正义与发展党 21世纪土中关系土耳其对华政策土耳其对华政策演变

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对目前葡萄球菌分类的补充意见

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国外医学(微生物学分册) 1990年第2期13卷 82-83页

作者： akaTob ak 桂海泉

本文介绍了到目前为止已被发现的葡萄球菌至少有23种,这些种均经DNA同源性测定和DNA杂交证明其成立。

关键词：葡萄球菌亚种血浆凝固酶微球菌

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