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Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 271-276页

作者： Basak Gümüs Güler Sibel Ozler Department of Health Sciences Istinye UniversityIstanbul 34010Turkey Department of Perinatology Selcuk University Faculty of MedicineKonya 42130Turkey

Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy *** study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA ***:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the *** increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to *** adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA ***:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment.

关键词： Intrahepatic cholestasis of pregnancy Syndecan-1 Glypican-3 Adverse perinatal outcome Response to UDCA

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最后的苍凉与神秘第三次驱车进藏纪实

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世界汽车 2007年第1期 124-129页

作者：津ak8360 都市牧人

第一次进藏,激动,面对神奇圣洁的土地,见到什么就拍什么,恨不能将所见所闻一并带走。但仅用取景器看、用胶片感光,对西藏的认识始终是肤浅的。第二次进藏,感动,总是迟迟不肯按动快门,有时甚至不想拿出相机,只想潜移默化地感受、不知不... 详细信息

第一次进藏,激动,面对神奇圣洁的土地,见到什么就拍什么,恨不能将所见所闻一并带走。但仅用取景器看、用胶片感光,对西藏的认识始终是肤浅的。第二次进藏,感动,总是迟迟不肯按动快门,有时甚至不想拿出相机,只想潜移默化地感受、不知不觉地吸纳。用眼睛去看,用灵魂去体会,开始明白今生或许再去10次,西藏也依然陌生。第三次开车进藏,火车通了,柏油路修好了,而心里却产生了一丝遗憾和失落。担心西藏能否依旧,害怕这片净土会被蜂拥而来的文明逐渐淹没。这次“西游”依然选择穿越艰难的藏北大地,试图再次体味她的苍凉与神秘……

关键词：取景器西藏柏油路火车

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新西兰全国范围高精度GPS网

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测绘译丛 1992年第5期 15-18,26页

作者： Chong,ak 张献州

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Bioactivity guided isolation of mosquito larvicide from Piper longum

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 112-116页

作者： Madhu.S Kumar Vijayan VA Shaukath ak Vector Biology Research Lab Department of Studies in ZoologyUniversity of MysoreManasagangotriMysore 570 006KarnatakaIndia Department of Studies in Zoology University of MysoreManasagangotriMysore 570 006KarnatakaIndia Department of Chemistry Yuvaraja's CollegeUniversity of MysoreMysore-05India

Objective:To isolate the larvicidal component from the fruits of Piper longum（***） against the filariasis vector,Culex quinquefasciatus（***）.Methods:Pulverized fruits of *** were subjected to soxhlet extraction using series of organic solvents of increasing *** the solvent extracts were verified for their larvicidal efficacy against 4th instar larvae of *** employing standard WHO *** fractionation through column chromatography lead to the isolation of a bioactive amide, pipyahyine from the petroleum ether ***:Petroleum ether extract was found to be the most active fraction among all the extracts tested with LC50 and LC90 being 1.03 and 2.04 ppm ***,pipyahyine,an isolated component of the same fraction was found to be even more effective than the parent extract in terms of LC50 being 0.58 and 1.88 ppm respectively. Conclusions:From the results,it is evident that *** can be considered as a powerful arsenal for the control of mosquito population.

关键词： Piper longum Bioassay Pipyahyine Culex quinquefasciatus Filariasis Larvicide

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The analysis of determinants of going concern audit report

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Journal of Modern Accounting and Auditing 2010年第4期6卷 26-37页

作者： Oni Currie Masyitoh Desi Adhariani SE.ak, Msi Faculty of Economy University of Indonesia Kampus UI Depok 16424 Indonesia

Going concern is one of essential things for user to make a financial decision. This research aims to explore factors that caused the issuance of going concern audit report by auditor. This research adds two new variables, audit size and audit committee, besides the other factors that cause auditor issue a going concern audit report. This research uses a regression logistic analysis to determine the relationship of each variable （liquidity, solvability, profitability, cash flow, audit firm size and audit committee） to going concern audit report. Different from previous researches, the results of this research show that liquidity, profitability, cash flow, and audit committee are not significant to influence the issuance of audit opinion. Audit size has a more significant relationship to audit opinion, while solvability is the most significant factor.

关键词： liquidity solvability profitability cash flow audit firm size audit committee going concernaudit report

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The Number of Lymph Nodes and Relationship with Presence of Thyroiditis and Thymic Tissue in the Central Neck Dissection Materials for Thyroid Papillary Carcinoma: Pathologic Analysis

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International Journal of Clinical Medicine 2016年第9期7卷 566-576页

作者： Banu Bilezikçi Seyfettin Ilgan Serdar Özbaş Savaş Koçak Departments of Pathology Guven Hospital Ankara Turkey Departments of Nuclear Medicine Guven Hospital Ankara Turkey Departments of Endocrine Surgery Guven Hospital Ankara Turkey

Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.

关键词： Thyroid Papillary Carcinoma Central Lymph Node Dissection Thyroiditis Thymus

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阿富汗政府军外科救护的组织

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国外医学（军事医学分册） 1990年第2期7卷 63-64页

作者： Tyto.,ak 缪其宏

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保护工作面电动机的热敏电阻线路

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煤矿机电 1989年第1期10卷 60-62页

作者： DK MITTRA ak SINGH 施鹏志

矿井电力驱动装置的传统过载保护电路是依靠检测电动机电流来检测电动机故障。如果电流值不超过,则总是认为电动机工作在规定的正常温度范围内。但是检测电流不能检测电动机冷却系统和通风障碍故障,例如采煤机电动机的定子机座中冷却循... 详细信息

矿井电力驱动装置的传统过载保护电路是依靠检测电动机电流来检测电动机故障。如果电流值不超过,则总是认为电动机工作在规定的正常温度范围内。但是检测电流不能检测电动机冷却系统和通风障碍故障,例如采煤机电动机的定子机座中冷却循环水不足,可能使电动机过热;

关键词：热敏电阻线路保护

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Physico-Chemical Characterization of Two Dabou Clays with a View to Use Them in the Treatment of Dyeing Wastewater

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Journal of Minerals and Materials Characterization and Engineering 2022年第6期10卷 505-517页

作者： Wilfried Aristide Atsé Marc Marie-Maurice Mélèdge Essi Bi Irié Hervé Gouré Doubi Mahamadou Kamagaté aké Pierre aké Alfred Niamien Kouamé Laboratory of Constitution and Reaction of Matter Félix Houphou&#235 t Boigny University Abidjan C&#244 te d’Ivoire Biological Sciences Training and Research Unit Péléforo Gon Coulibaly University Korhogo C&#244 te d’Ivoire Central Analysis Laboratory University of Man Man C&#244 te d’Ivoire

This work falls within the general framework of the valorization of the clays of Ivory Coast in order to propose innovative solutions in the resolution of certain problems related to development such as the depollution of water. Its main objective is therefore to study the physico-chemical properties of two Dabou clays with a view to using them in chemical processes for the treatment of dyeing wastewater. The results of the chemical analysis and the ray diffraction showed that the DAB 1 and DAB 2 samples are clays of the kaolinitic type consisting mainly of kaolinite with 51.17% for DAB 1 against 65.81% for DAB 2 and quartz with respectively 41.76% and 25.8% for DAB 1 and DAB 2. They also contain relatively large amounts of goethite with 9.96% for DAB 1 and 12.8% for DAB 2. The specific surfaces measured in both samples are greater than 25 m2/g. All the results of the physico-chemical characterization, in particular the presence in significant quantity of clay minerals, the presence of iron compounds and the large specific surface area of both samples, allow the conclusion that they can be used in adsorption studies and in the heterogeneous Fenton process for water treatment.

关键词： Clays Physico-Chemicals Water Treatment

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Mechanical properties and stress corrosion cracking behaviour of AZ31 magnesium alloy laser weldments

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Transactions of Nonferrous Metals Society of China 2011年第1期21卷 1-8页

作者： P.B.SRINIVASAN S.RIEKEHR C.BLAWERT W.DIETZEL M.KO ak Institute of Materials Research GKSS-Forschungszentrum Geesthacht GmbH Geesthacht D-21502Germany

An AZ31 HP magnesium alloy was laser beam welded in autogenous mode with AZ61 filler using Nd-YAG laser *** examination revealed that the laser beam weld metals obtained with or without filler material had an average grain size of about 12 μ*** microhardness and the tensile strength of the weldments were similar to those of the parent ***,the stress corrosion cracking （SCC） behaviour of both the weldments assessed by slow strain rate tensile （SSRT） tests in ASTM D1384 solution was found to be slightly inferior to that of the parent *** was observed that the stress corrosion cracks originated in the weld metal and propagated through the weld metal-HAZ regions in the autogenous *** the other hand,in the weldment obtained with AZ61 filler material,the crack initiation and propagation was in the HAZ *** localized damage of the magnesium hydroxide/oxide film formed on the surface of the specimens due to the exposure to the corrosive environment during the SSRT tests was found to be responsible for the SCC.

关键词： AZ31 magnesium alloy laser welding microstructure mechanical properties slow strain rate tensile test stress corrosion cracking fractography

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