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Overview of Adrenals Tumors in Dakar Hospitals

Open Journal of Internal Medicine 2024年第2期14卷 141-150页

作者： Nafy Ndiaye Yakham mohamed Leye Mouhamadou Moustapha Ndong Ngoné Diaba Diack Amadou Fall Cisse Abdoulaye Leye Baidy Sy Kane Alpha Omar Touré cherif mohamed dial Pape Saloum Diop Internalmedeccine and Endocrinology Department Teaching Hospital of Pikine Dakar Senegal General Surgery Department Aristide Le Dantec Teaching Hospital of Dakar Dakar Senegal Anatomo-Pathology Department General Hospital of Grand Yoff Dakar Dakar Senegal General Surgery Department General Hospital of Grand Yoff Dakar Dakar Senegal

Introduction: Adrenal tumours (AT) are commonly encountered in clinical practice. For any patient presenting an adrenal mass, there are two crucial points to consider: is the adrenal mass malignant and is it hormonally active? The objective of our study was to evaluate the epidemiological, diagnostic, therapeutic, and evolutionary aspects of AT in a developing country. Methodology: We conducted a retrospective study spanning 17 years (from January 2005 to October 2022) in four Dakar hospital services. We included all patient medical records with explored AT. Results: AT was diagnosed in 35 patients who had a mean age of 36.62 years (range: 12-79), and a female predominance (26 women to 9 men). Among these patients, 17.2 % had incidental AT. Hypertension was the commonest presenting symptom in 27 patients (77%), which was associated with Mnards triad in 14 patients (40%). Abdominal pain was reported by 20 patients (57%), and 14 presented with an abdominal mass. Among the patients, 29 had functional AT: 22 with pheochromocytoma, 5 with primary hyperaldosteronism, and 2 with hypercortisolism. Imaging evaluations revealed that 33 patients had unilateral AT and one had bilateral AT. Tumour sizes varied, 5 patients had tumours 10 cm. Two patients presented with metastases. The therapeutic approach involved adrenalectomy in 32 patients. Perioperative complications were observed in five patients, including haemorrhage (two patients), hypotension (two cases), and hypertensive crisis (one case). One patient with bilateral pheochromocytoma developed acute adrenal insufficiency postoperatively, followed by abdominal herniation. Histopathological examination confirmed pheochromocytoma in 21 patients, Conns adenoma in 5, adrenocortical carcinoma in 3, cortisol adenoma in 2, and adrenal cyst in 1 patient. Non-functional AT included adrenocortical carcinoma (three patients), adrenal cyst (one patient), and pheochromocytoma (two patients). After a one-year follow-up, 29 patients wit

关键词： Tumour Adrenal Pheochromocytoma Conn Adrenocortical Carcinoma Dakar

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Contribution of Anti-p63 Antibodies in the Interpretation of Benign Label Prostatic Biopsies

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Open Journal of Pathology 2024年第2期14卷 31-44页

作者： Ibou Thiam Fabrice Senghor Frenette Codja Kor Ndiaye mohamed Moustapha cherif dial Pathological Anatomy Department Aristide Le Dantec University Hospital Dakar Senegal Pathological Anatomy Department H&#244pital de la Paix Ziguinchor Senegal Pathological Anatomy Department Idrissa Pouye University Hospital Dakar Senegal

Introduction: Prostate cancer is the second most common cancer in men. The diagnosis is most often based on the prostate biopsies’ analysis and on histological criteria recognizable on standard coloring. In some cases, the use of immunohistochemistry is important. Objectives: This paper aims to specify the p63 phenotypic profile of lesions diagnosed benign, with minimal suspect foci, difficult to interpret, HGPIN (high grade intraepithelial neoplasia) and LGPIN (low-grade prostatic intraepithelial neoplasia) and evaluate the manual technique of p63 immunohistochemistry. Patients and Method: This was a retrospective, descriptive study of prostate biopsies recorded in the PAC service of the HALD from January 1st, 2018 to December 31st, 2018. It was completed by a manual immunohistochemical study of the blocks enrolled from November 19th to December 4th, 2020 in the PAC department of the HPD. The studied parameters were: registry number, age, clinical stage, prostate volume, PSA level, microscopic appearance and p63 immunohistochemical profile. Results: Our study included 60 prostate biopsies. The ages of our patients varied from 45 to 77 years, with an average of 64.2 years and a standard deviation of 6.2. The majority of patients were at clinical stage cT2b (33%) with a prostate volume varying between 33.15 and 169.4 cc. The minimum value of PSA in our series is 5 ng/ml, the maximum being 100 ng/ml with an average level of 24.1 ng/ml and a standard deviation of 21.2. Our series included 50 adenomyomatous hyperplasias, 7 adenomyomatous hyperplasias associated with chronic prostatitis, 2 HGPIN and 1 LGPIN. After re-reading we found 5 discordant cases, which corresponded to minimal suspect foci (kappa = 0.5098). The p63 marking was informative in 53 cases, i.e. 88%, and non-informative in 7 cases, i.e. 12%. Among the uninformative markings, 2 were due to lack of tissue adhesion to the slides. Among the informative markings, 11 were negative. p63 immunohistochemistry was

关键词： Prostate Cancer Diagnosis Anti-p6 Antibody

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Intraductal Prostatic Carcinoma: Epidemiological and Anatomopathological Aspects in Dakar

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Open Journal of Pathology 2024年第2期14卷 54-63页

作者： Ibou Thiam Fabrice Senghor Omar Sow Kor Ndiaye mohamed Moustapha Chérif dial Anatomical Pathology Department Aristide Le Dantec University Hospital Dakar Senegal Anatomical Pathology Department Peace Hospital Ziguinchor Senegal General Surgery Department Peace Hospital Ziguinchor Senegal Anatomical Pathology Department Idrissa Pouye University Hospital Dakar Senegal

Introduction: Intraductal carcinoma is often associated with high-grade, high-stage adenocarcinoma. Its frequency is variable and it is considered a poor prognostic factor. In our context, when prostatic carcinoma is diagnosed, pathologists do not always report the presence of this anatomopathological entity. We therefore conducted a study to determine the epidemiological and anatomopathological profile of patients with this lesion in Dakar. Materials and Methods: This is a retrospective descriptive study covering a 1-year period from January to December 2022. It focused on cases of intraductal carcinoma diagnosed among prostatic carcinomas collected in the anatomopathology laboratories of Hôpital Général Idrissa Pouye (HOGIP) and Hôpital Militaire de Ouakam (HMO). It was based on archives of anatomopathological reports, blocks and slides. A total of 200 cases of prostatic carcinoma were collated and reviewed to identify those presenting with intraductal carcinoma according to the diagnostic criteria of Guo and Epstein. Results: 87 cases of intraductal carcinoma were found, representing 43.5% of prostatic carcinomas. The mean age was 71 years. Patients in their seventh decade were the most represented, i.e. 42.5%. The majority of samples examined were biopsies (72.4%). The mean PSA level was 965.91 ng/ml, with extremes ranging from 0.03 to 10,000 ng/ml. Histologically, 96.5% of cases (N = 84) were invasive prostatic carcinoma. Gleason score 8 (4 + 4) was the most common, accounting for 42.53% (N = 37). On average, the study found four (04) foci of intraductal carcinoma per specimen, with extremes ranging from 1 to 30. Dense cribriform architecture accounted for 78.16%, loose cribriform for 11.5%, solid for 8.04% and micropapillary for 2.3%. Six cases (6.9%) showed foci of comedonecrosis. The vast majority of radical prostatectomies (87.5%) were classified as pT3. Node invasion and perineural sheathing were observed in 12.5% and 52.32% of cases respectively. Conclusi

关键词： Intraductal Carcinoma Prostate Pathological Anatomy Senegal

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A Distributionally Robust Optimization Scheduling Model for Regional Integrated Energy Systems Considering Hot Dry Rock Co-Generation

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1387-1404页

作者： Hao Qi mohamed Sharaf Andres Annuk Adrian Ilinca mohamed A.mohamed College of Electrical and New Energy China Three Gorges UniversityYichang443002China Department of Industrial Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia Institute of Forestry and Engineering Estonian University of Life SciencesTartu51006Estonia Department of Mechanical Engineering école de Technologie SupérieureMontréalQC H3C 1K3Canada Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia61519Egypt

Hot dry rock(HDR)is rich in reserve,widely distributed,green,low-carbon,and has broad development potential and *** this paper,a distributionally robust optimization(DRO)scheduling model for a regionally integrated energy system(RIES)considering HDR co-generation is ***,the HDR-enhanced geothermal system(HDR-EGS)is introduced into the ***-EGS realizes the thermoelectric decoupling of combined heat and power(CHP)through coordinated operation with the regional power grid and the regional heat grid,which enhances the system wind power(WP)feed-in ***,peak-hour loads are shifted using price demand response guidance in the context of time-of-day ***,the optimization objective is established to minimize the total cost in the RIES scheduling cycle and construct a DRO scheduling model for RIES with *** simulating a real small-scale RIES,the results show that HDR-EGS can effectively promote WP consumption and reduce the operating cost of the system.

关键词： Energy harvesting integrated energy systems optimum scheduling time-of-use pricing demand response geothermal energy

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Privacy-preserved learning from non-i.i.d data in fog-assisted IoT:A federated learning approach

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Digital Communications and Networks 2024年第2期10卷 404-415页

作者： mohamed Abdel-Basset Hossam Hawash Nour Moustafa Imran Razzak mohamed Abd Elfattah Faculty of Computers and Informatics Zagazig UniversityZagazigSharqiyah44519Egypt School of Engineering and Information Technology University of New South Wales@ADFACanberraACT2600Australia Deakin University Geelong Waurn Ponds CampusAustralia Computer Science Department Misr Higher Institute for Commerce and ComputersMansoura35511Egypt

With the prevalence of the Internet of Things(IoT)systems,smart cities comprise complex networks,including sensors,actuators,appliances,and cyber *** complexity and heterogeneity of smart cities have become vulnerable to sophisticated cyber-attacks,especially privacy-related attacks such as inference and data poisoning *** Learning(FL)has been regarded as a hopeful method to enable distributed learning with privacypreserved intelligence in IoT *** though the significance of developing privacy-preserving FL has drawn as a great research interest,the current research only concentrates on FL with independent identically distributed(i.i.d)data and few studies have addressed the non-i.i.d *** is known to be vulnerable to Generative Adversarial Network(GAN)attacks,where an adversary can presume to act as a contributor participating in the training process to acquire the private data of other *** paper proposes an innovative Privacy Protection-based Federated Deep Learning(PP-FDL)framework,which accomplishes data protection against privacy-related GAN attacks,along with high classification rates from non-i.i.d ***-FDL is designed to enable fog nodes to cooperate to train the FDL model in a way that ensures contributors have no access to the data of each other,where class probabilities are protected utilizing a private identifier generated for each *** PP-FDL framework is evaluated for image classification using simple convolutional networks which are trained using MNIST and CIFAR-10 *** empirical results have revealed that PF-DFL can achieve data protection and the framework outperforms the other three state-of-the-art models with 3%–8%as accuracy improvements.

关键词： Privacy preservation Federated learning Deep learning Fog computing Smart cities

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A New Speed Limit Recognition Methodology Based on Ensemble Learning:Hardware Validation

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Computers, Materials & Continua 2024年第7期80卷 119-138页

作者： mohamed Karray Nesrine Triki mohamed Ksantini ESME ESME Research LabIvry Sur Seine94200France CEM Lab ENISUniversity of SfaxSfax3038Tunisia

Advanced DriverAssistance Systems(ADAS)technologies can assist drivers or be part of automatic driving systems to support the driving process and improve the level of safety and comfort on the *** Sign Recognition System(TSRS)is one of themost important components *** the challengeswith TSRS is being able to recognize road signs with the highest accuracy and the shortest processing ***,this paper introduces a new real time methodology recognizing Speed Limit Signs based on a trio of developed ***,the Speed Limit Detection(SLD)module uses the Haar Cascade technique to generate a new SL detector in order to localize SL signs within captured ***,the Speed Limit Classification(SLC)module,featuring machine learning classifiers alongside a newly developed model called DeepSL,harnesses the power of a CNN architecture to extract intricate features from speed limit sign images,ensuring efficient and precise *** addition,a new Speed Limit Classifiers Fusion(SLCF)module has been developed by combining trained ML classifiers and the DeepSL model by using the Dempster-Shafer theory of belief functions and ensemble learning’s voting *** rigorous software and hardware validation processes,the proposedmethodology has achieved highly significant F1 scores of 99.98%and 99.96%for DS theory and the votingmethod,***,a prototype encompassing all components demonstrates outstanding reliability and efficacy,with processing times of 150 ms for the Raspberry Pi board and 81.5 ms for the Nano Jetson board,marking a significant advancement in TSRS technology.

关键词： Driving automation advanced driver assistance systems(ADAS) traffic sign recognition(TSR) artificial intelligence ensemble learning belief functions voting method

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Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 663-675页

作者： mohamed Naguib Abouelsaad Mohammed Shaaban Salah El Bagalaty mohamed E.El Madawy Structural Engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

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Exact and heuristic formulae to compute the geodetic height from the ellipse equation

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Geodesy and Geodynamics 2024年第2期15卷 150-155页

作者： mohamed Eleiche Ahmed Hamdi Mansi Construction Department Faculty of EngineeringEgyptian Russian UniversityCairoEgypt Istituto Nazionale di Geofisica e Vulcanologia Sezione di PisaPisaPlItaly

The conversion of the cartesian coordinates of a point to its geodetic equivalent coordinates in reference to the geodetic ellipsoid is one of the main challenges in *** ellipse equation in the meridian plane significantly influences the value of the geodetic *** research analyzes this influence and how it can contribute to their *** study investigates the mathematical relation between them and presents an exact formula relating to the geodetic height and the ellipse *** addition,a heuristic formula for the relation between the geodetic height and the ellipse equation is proposed,which is independent of the geodetic latitude and has a relative accuracy better than 99.9 %.The calculation is stable,and the cost is low.

关键词： Ellipse equation Geodetic height Heuristic geodetic height

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Impact of lifestyle interventions on pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2633-2637页

作者： Wafaa mohamed Ezzat Department of Internal Medicine Medical Research and Clinical Studies InstituteNational Research CenterGiza 12311Egypt

This editorial builds on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et *** carried out a critical examination of nonalcoholic fatty liver disease(NAFLD)pathogenesis and how lifestyle interventions could facilitate disease resolution,particularly highlighting that non-alcoholic steatohepatitis(NASH)is a severe form of *** discussion details that weight loss is a pivotal factor in disease outcomes:A 3%-5%reduction is enough for resolution in 50%of non-obese individuals,while a 7%-10%reduction achieves similar benefits in obese individuals,as demonstrated by magnetic resonance ***,the editorial underscores that such lifestyle changes are instrumental not only in resolving NAFLD but also in reversing hepatic steatosis and *** insights,derived from the research,emphasize the critical role of personalized lifestyle modifications in halting the progression of NAFLD to NASH and even reversing fibrosis,thus offering a template for effective patient management.

关键词： Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Diet Physical activity Life style

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Enteric neuropathy in diabetes:Implications for gastrointestinal function

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World Journal of Gastroenterology 2024年第22期30卷 2852-2865页

作者： Mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes,commonly known for its metabolic effects,also critically affects the enteric nervous system(ENS),which is essential in regulating gastrointestinal(GI)motility,secretion,and *** development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions,such as gastroparesis and irregular bowel habits,primarily due to disruptions in the function of neuronal and glial cells within the ENS,as well as oxidative stress and *** editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic ***,it discusses the latest advances in diagnostic approaches,emphasizing the need for early detection and intervention to mitigate GI complications in diabetic *** editorial also reviews current and emerging therapeutic strategies,focusing on pharmacological treatments,dietary management,and potential neuromodulatory ***,this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes,aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.

关键词： Diabetic neuropathy Gastrointestinal Insulin resistance Diabetes Enteric nervous system Enteric neuropathy

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