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World Journal of Clinical Cases 2022年第7期10卷 2351-2356页

作者： Youngbeom Seo Jonghoon kim min cheol Chang Hyungkyu Huh Eun-Hee Lee Department of Neurosurgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Rehabilitation Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea Medical Interdisciplinary Team Medical Device Development CenterDaegu-Gyeongbuk Medical Innovation FoundationDaegu 41061South Korea

BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic ***,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are ***,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different *** SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was *** a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be *** Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.

关键词： Blood-brain barrier Ischemic stroke Dynamic contrast-enhanced magnetic resonance imaging Thrombectomy Penumbra Case report

Motor outcomes of patients with a complete middle cerebral artery territory infarct

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Neural Regeneration Research 2013年第20期8卷 1892-1897页

作者： Sung Ho Jang min cheol Chang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717Republic of Korea

Detailed knowledge of motor outcomes enables to establish proper goals and rehabilitation strate-gies for stroke patients. Several previous studies have reported functional or motor outcomes in patients with a middle cerebral artery territory infarct. However, little is known about motor outcome in patients with a complete middle cerebral artery territory infarct. In this study, we investigated the motor outcomes in 23 patients with a complete middle cerebral artery territory infarct. All of these patients received comprehensive rehabilitative management, including movement therapy and neuromuscular electrical stimulation of the affected finger extensors and ankle dorsiflexors, for more than 3 months. Motor outcomes were measured at 6 months after stroke onset using the Medical Research Council, Motricity Index, the modified Brunnstrom Classification, and Functional Ambula-tion Category scores. The motor function of the lower extremities was found to be better than that of the upper extremities. After receiving rehabilitation treatments for 3–6 months, about 70% of these patients were able to walk independently （Functional Ambulation Category scores 3）, but no pa-tient achieved functional hand recovery.

关键词： neural regeneration brain injury cerebral infarct motor function stroke middle cerebral artery hand function walking ability grants-supported paper neuroregeneration

Activation or exhaustion of CD8^(+) T cells in patients with COVID-19

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Cellular & Molecular Immunology 2021年第10期18卷 2325-2333页

作者： min-Seok Rha Eui-cheol Shin Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKorea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Otorhinolaryngology Yonsei University College of MedicineSeoulRepublic of Korea.3 The Center for Epidemic PreparednessKAISTDaejeonRepublic of Korea

In addition to CD4^(+)T cells and neutralizing antibodies,CD8^(+)T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019(COVID-19),an ongoing pandemic *** patients with COVID-19,CD8^(+)T cells exhibiting activated phenotypes are commonly observed,although the absolute number of CD8^(+)T cells is *** addition,several studies have reported an upregulation of inhibitory immune checkpoint receptors,such as PD-1,and the expression of exhaustion-associated gene signatures in CD8^(+)T cells from patients with ***,whether CD8^(+)T cells are truly exhausted during COVID-19 has been a controversial *** the present review,we summarize the current understanding of CD8^(+)T-cell exhaustion and describe the available knowledge on the phenotypes and functions of CD8^(+)T cells in the context of activation and *** also summarize recent reports regarding phenotypical and functional analyses of SARS-CoV-2-specific CD8^(+)T cells and discuss long-term SARS-CoV-2-specific CD8^(+)T-cell memory.

关键词： CD8^(+)T cell Activation T-cell exhaustion SARS-CoV-2 COVID-19

Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV: Lateral Motion

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Journal of Bionic Engineering 2020年第1期17卷 148-160页

作者： Loan Thi kim Au Hoon cheol Park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeoul 05029Korea

This paper reports the effect of the Center of Gravity(CG)position on lateral flight dynamic stability of hovering KUBeetle,a tailless FW-MAV,providing further insights on the effects of asymmetries in body mass distribution and wing *** the current study,the standard linearized equations of motion were applied as in the previous work on longitudinal dynamic *** stability derivatives were acquired using the computational fluid dynamic methods via the commercial software of ANSYS *** exists a stable region for CG between 2.6%and 3.5%of the mean chord below the wing pivot point,in which the lateral motion of hovering KUBeetle is passively *** CG below the stable region,because of an unstable oscillatory mode,the lateral motion of the FW-MAV is unstable but can be stabilized using rolling rate *** CG above the stable region,because of a divergence mode,the system remains unstable even with the rolling rate *** with other works on an FW-MAV based on a quasi-steady aerodynamic model and on insect showed similar characteristics for flapping *** is also interesting to note that the asymmetries in body mass and wing kinematics can enlarge the stable region of the system by a non-zero Ixz which approaches the root square of√IxIz,a negative LrNp,and a positive Ix2(Ir+Np).Combining the current result with that of the previous work on longitudinal motion,the most beneficial region of the CG for full 6-DOF flight dynamic stability of hovering KUBeetle was suggested.

关键词： FW-MAV center of gravity flight dynamic stability lateral motion asymmetry computational fluid dynamics bioinspired flight

Non-Jumping Take off Performance in Beetle Flight （Rhinoceros Beetle Trypoxylus dichotomus）

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Journal of Bionic Engineering 2014年第1期11卷 61-71页

作者： Tien Van Truong Tuyen Quang Le Hoon cheol Park Kwang Joon Yoon min Jun kim Doyoung Byun Department of Aerospace and Information Engineering Konkuk University Seoul South Korea Department of Mechanical Engineering National University of Singapore Singapore KoreaInstitute of Ocean Science and Technology PO Box 29 Ansan 425-600 South Korea Department of Advanced Technology Fusion Konkuk University Seoul South Korea Department of Mechanical Engineering and Mechanics Drexel University Philadelphia PA 19104 USA Department of Mechanical Engineering Sungkyunkwan University Suwon South Korea

In recent decades, the take-off mechanisms of flying animals have received much attention in insect flight initiation. Most of previous works have focused on the jumping mechanism, which is the most common take-off mechanism found in flying animals. Here, we presented that the rhinoceros beetle, Trypoxylus dichotomus, takes offwithout jumping. In this study, we used 3-Dimensional （3D） high-speed video techniques to quantitatively analyze the wings and body kinematics during the initiation periods of flight. The details of the flapping angle, angle of attack of the wings and the roll, pitch and yaw angles of the body were investigated to understand the mechanism of take-off in T. dichotomus. The beetle took off gradually with a small velocity and small acceleration. The body kinematic analyses showed that the beetle exhibited stable take-off. To generate high lift force, the beetle modulated its hind wing to control the angle of attack; the angle of attack was large during the upstroke and small during the downstroke. The legs of beetle did not contract and strongly release like other insects. The hind wing could be con- sidered as a main source of lift for heavy beetle.

关键词： take-oft non-jumping mechanism rhinoceros beetle kinematics

Enhancing Hydrophilicity of Thick Electrodes for High Energy Density Aqueous Batteries

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Nano-Micro Letters 2023年第7期15卷 110-121页

作者： Jungeun Lee Hyeonsoo Lee cheol Bak Youngsun Hong Daeha Joung Jeong Beom Ko Yong min Lee Chanhoon kim Sustainable Technology and Wellness R&D Group Korea Institute of Industrial Technology(KITECH)102 Jejudaehak-RoJeju-SiJeju-do 63243Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Physics Virginia Commonwealth UniversityRichmondVA 23284USA

Thick electrodes can substantially enhance the overall energy density of ***,insufficient wettability of aqueous electrolytes toward electrodes with conventional hydrophobic binders severely limits utilization of active materials with increasing the thickness of electrodes for aqueous batteries,resulting in battery performance deterioration with a reduced ***,we demonstrate that controlling the hydrophilicity of the thicker electrodes is critical to enhancing the overall energy density of *** binders are synthesized via a simple sulfonation process of conventional polyvinylidene fluoride binders,considering physicochemical properties such as mechanical properties and *** introduction of abundant sulfonate groups of binders(i)allows fast and sufficient electrolyte wetting,and(ii)improves ionic conduction in thick electrodes,enabling a significant increase in reversible capacities under various current ***,the sulfonated binder effectively inhibits the dissolution of cathode materials in reactive aqueous ***,our findings significantly enhance the energy density and contribute to the development of practical zinc-ion batteries.

关键词： Thick electrodes Hydrophilic binder Sulfonation Aqueous zinc-ion batteries High areal capacity

Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SEN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jong Un Lee Hyun Ji kim Sang-cheol Jin Ye Jin kim Young min kim Bong Sun You Jun Ho Bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research Institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SEN alloys)recently developed at the Korea Institute of Materials *** alloys are produced by adding small amounts of Ca and Y(eachminor amounts of Ca and Y renders excellent mechanical properties due to improved strengthening *** enhanced properties are attributed to more pronounced dynamic recrystallization and grain refining behaviors caused by the second-phase particles during extrusion.(4)Despite the presence of various types of second-phase particles,the fatigue properties of SEN9 alloys are similar to those of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elongation of aged SEN alloys.(6)Adding mischmetal into the SEN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SEN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SEN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties Extrudability.

Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion

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Neural Regeneration Research 2019年第7期14卷 1230-1236页

作者： min cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul kim Department of Rehabilitation Medicine College of MedicineYeungnam University Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of Medicine Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of Medicine Department of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely *** study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without *** in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive *** reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St *** expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex *** MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct *** was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St *** study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic ***,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function *** experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126).

关键词： ischemic stroke early exercise macrophage migration inhibitory factor brain-derived neurotrophic factor motor recovery neural regeneration

Effectiveness of pulsed radiofrequency on the medial cervical branches for cervical facet joint pain

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World Journal of Clinical Cases 2022年第22期10卷 7720-7727页

作者： min cheol Chang Seoyon Yang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityTaegu 42415South Korea Department of Rehabilitation Medicine School of MedicineEwha Woman's University Seoul HospitalSeoul 07804South Korea

BACKGROUND Cervical facet joint pain(CFP)is one of the most common causes of neck pain and *** CFP deteriorates the quality of life of patients and reduces their productivity at *** To investigate the effectiveness of pulsed radiofrequency(PRF)stimulation of cervical medial branches in patients with chronic *** We retrospectively included 21 consecutive patients(age=50.9±15.3 years,range 26-79 years;male:female=8:13;pain duration=7.7±5.0 mo)with chronic CFP,defined as≥4 on the numeric rating scale(NRS).We performed PRF stimulation on the cervical medial *** outcomes of the PRF procedure were evaluated by comparing the NRS scores for CFP before treatment and 1 and 3 mo after *** pain relief was defined as a≥50%reduction in the NRS score at 3 mo when compared with the pretreatment NRS *** No patient had immediate or late adverse effects following *** average NRS score for CFP decreased from 5.3±1.1 at pre-treatment to 2.4±0.6 at the 1 mo follow-up,and 3.1±1.1 at the 3 mo *** to the NRS scores before PRF stimulation,those at 1 and 3 mo after PRF stimulation had significantly *** of the 21 patients(52.4%)reported successful pain relief 3 mo after the PRF *** stimulation on cervical medial branches may be a useful therapeutic option to control chronic *** PRF stimulation of the cervical medial branches may be used as an alternative treatment method in patients with *** can effectively alleviate CFP,and is safe to perform.

关键词： Pulsed radiofrequency treatment Zygapophyseal joint Chronic pain Pain Neck pain Pain management

The Phytophthora nucleolar effector Pi23226 targets host ribosome biogenesis to induce necrotrophic cell death

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Plant Communications 2023年第5期4卷 263-276页

作者： Soeui Lee Jaehwan kim Myung-Shin kim cheol Woo min Sun Tae kim Sang-Bong Choi Joo Hyun Lee Doil Choi Plant Immunity Research Center Seoul National UniversitySeoul 08826Republic of Korea Plant Genomics and Breeding Institute Department of AgricultureForestry and BioresourcesCollege of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Programs in Agricultural Genomics College of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Division of Bioscience and Bioinformatics Myongji UniversityYongin 449-728Republic of Korea

Pathogen effectors target diverse subcellular organelles to manipulate the plant immune *** the nucleolus has emerged as a stress marker and several effectors are localized in the nucleolus,the roles of nucleolar-targeted effectors remain *** this study,we showed that Phytophthora infestans infection of Nicotiana benthamiana results in nucleolar inflation during the transition from the biotrophic to the necrotrophic *** *** effectors were localized in the nucleolus:Pi23226 induced cell death in *** and nucleolar inflation similar to that observed in the necrotrophic stage of infection,whereas its homolog Pi23015 and a deletion mutant(Pi23226DC)did not induce cell death or affect nucleolar *** immunoprecipitation and individual-nucleotide-resolution UV crosslinking and immunoprecipitation sequencing analysis indicated that Pi23226 bound to the 30 end of 25S rRNA precursors,resulting in accumulation of unprocessed 27S *** nucleolar stress marker NAC082 was strongly upregulated under Pi23226-expressing ***23226 subsequently inhibited global protein translation in host cells by interacting with ***23226 enhanced *** pathogenicity,indicating that Pi23226-induced ribosome malfunction and cell death were beneficial for pathogenesis in the *** results provide evidence for the molecular mechanism underlying RNA-binding effector activity in host ribosome biogenesis and lead to new insights into the nucleolar action of effectors in pathogenesis.

关键词： Phytophthora infestans hemibiotroph nucleolar effector cell death ribosome biogenesis translation inhibition