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Validity of fatty liver prediction scores for diagnosis of fatty liver by Fibroscan

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 353-360页

作者： Seogsong Jeong Sun Jae Park seong Kyun Na Sang Min Park Byung-cheol Song Yun Hwan Oh Department of Biomedical Sciences Seoul National University Graduate SchoolSeoul 03080Korea Department of Biomedical Informatics CHA University School of MedicineCHA UniversitySeongnam 13488Korea Department of Internal Medicine Inje University College of MedicineSeoul 50834Korea Department of Family Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Korea Department of Internal Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeong 14353Korea

Background:The Korea National Health and Nutrition Examination Survey nonalcoholic fatty liver disease(K-NAFLD)score was recently developed with the intent to operationally define nonalcoholic fatty liver disease(NAFLD).However,there remained an external validation that confirmed its diagnostic performance,especially in patients with alcohol consumption or hepatitis virus ***:Diagnostic accuracy of the K-NAFLD score was evaluated in a hospital-based cohort consisting of 1388 participants who received Fibroscan®.Multivariate-adjusted logistic regression models and the contrast estimation of receiver operating characteristic curves were used for validation of the K-NAFLD score,fatty liver index(FLI),and hepatic steatosis index(HSI).Results:K-NAFLD-moderate[adjusted odds ratio(aOR)=2.53,95%confidence interval(CI):1.13-5.65]and K-NAFLD-high(aOR=4.14,95%CI:1.69-10.13)groups showed higher risks of fatty liver compared to the K-NAFLD-low group after adjustments for demographic and clinical characteristics,and FLI-moderate and FLI-high groups revealed aORs of 2.05(95%CI:1.22-3.43)and 1.51(95%CI:0.78-2.90),*** addition,the HSI was less predictive for Fibroscan®-defined fatty *** K-NAFLD and FLI also demonstrated high accuracy in the prediction of fatty liver in patients with alcohol consumption and chronic hepatitis virus infection,and the adjusted area under curve values were comparable between K-NAFLD and ***:Externally validation of the K-NAFLD and FLI showed that these scores may be a useful,noninvasive,and non-imaging modality for the identification of fatty *** addition,these scores also predicted fatty liver in patients with alcohol consumption and chronic hepatitis virus infection.

关键词： Nonalcoholic fatty liver disease Fatty liver index Hepatic steatosis index

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Random pinhole attenuator for high-power laser beams

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High Power Laser Science and Engineering 2024年第3期 121-126页

作者： seong cheol Park Hyeok Yun Jin Woo Yoon seong Ku Lee Jae Hee Sung Il Woo Choi Chang Hee Nam Kyung Taec Kim Department of Physics and Photon Science Gwangju Institute of Science and Technology Center for Relativistic Laser Science Institute for Basic Science Advanced Photonics Research Institute Gwangju Institute of Science and Technology

The intensity attenuation of a high-power laser is a frequent task in the measurements of optical science. Laser intensity can be attenuated by inserting an optical element, such as a partial reflector, polarizer or absorption filter. These devices are, however, not always easily applicable, especially in the case of ultra-high-power lasers, because they can alter the characteristics of a laser beam or become easily damaged. In this study, we demonstrated that the intensity of a laser beam could be effectively attenuated using a random pinhole attenuator(RPA), a device with randomly distributed pinholes, without changing the beam properties. With this device, a multi-PW laser beam was successfully attenuated and the focused beam profile was measured without any alterations of its characteristics. In addition, it was confirmed that the temporal profile of a laser pulse, including the spectral phase, was preserved. Consequently, the RPA possesses significant potential for a wide range of applications.

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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian seong Hoon Goh Yundeok Kim cheol-Su Kim Doo-Sup Kim Kyu-Jae Lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

Automated Service Search Model for the Social Internet of Things

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Computers, Materials & Continua 2022年第9期72卷 5871-5888页

作者： Farhan Amin seong Oun hwang Department of Computer Engineering Gachon UniversitySeongnam13120Korea

The social internet of things(SIoT)is one of the emerging paradigms that was proposed to solve the problems of network service discovery,navigability,and service *** SIoT aims to socialize the IoT devices and shape the interconnection between them into social interaction just like human *** IoT,an object can offer multiple services and different objects can offer the same services with different parameters and interest *** proliferation of offered services led to difficulties during service customization and service *** problem is known as service *** selection of suitable service that fits the requirements of applications and objects is a challenging *** address these issues,we propose an efficient automated query-based service search model based on the local network navigability concept for the *** the proposed model,objects can use information from their friends or friends of their friends while searching for the desired services,rather than exploring a global *** employ a centrality metric that computes the degree of importance for each object in the social IoT that helps in selecting neighboring objects with high centrality *** distributed nature of our navigation model results in high scalability and short navigation *** verified the efficacy of our model on a real-world SIoT-related *** experimental results confirm the validity of our model in terms of scalability,navigability,and the desired objects that provide services are determined quickly via the shortest path,which in return improves the service search process in the SIoT.

关键词： Social internet of things service discovery local navigability object discovery query generation model

A probabilistic model of quantum states for classical data security

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Frontiers of physics 2023年第5期18卷 281-292页

作者： Muhammad Waseem Hafiz seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam 13120South Korea Department of Computer Engineering Gachon UniversitySeongnam 13120South Korea

The phenomenal progress of quantum information theory over the last decade has substantially broadened the potential to simulate the superposition of states for exponential speedup of quantum algorithms over their classical ***,the conventional and modern cryptographic standards(encryption and authentication)are susceptible to Shor’s and Grover’s algorithms on quantum *** significant improvement in technology permits consummate levels of data protection by encoding classical data into small quantum states that can only be utilized once by leveraging the capabilities of quantum-assisted classical *** the frequent data breaches and increasingly stringent privacy legislation,we introduce a hybrid quantum-classical model to transform classical data into unclonable states,and we experimentally demonstrate perfect state transfer to exemplify the classical *** alleviate implementation complexity,we propose an arbitrary quantum signature scheme that does not require the establishment of entangled states to authenticate users in order to transmit and receive arbitrated states to retrieve classical *** consequences of the probabilistic model indicate that the quantum-assisted classical framework substantially enhances the performance and security of digital data,and paves the way toward real-world applications.

关键词： information security quantum-classical cryptography quantum information processing quantum spin states spin-1/2 algebra user authentication

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An Enhanced Privacy Preserving, Secure and Efficient Authentication Protocol for VANET

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Computers, Materials & Continua 2022年第5期71卷 3703-3719页

作者： Safiullah Khan Ali Raza seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam13320Korea ENSAIT GEMTEX-Laboratoire de Genie et Materiaux TextilesUniversity of LilleLilleF59000France School of Computing&Institute of Cyber Security(ICSS) University of KentUnited Kingdom Department of Computer Engineering Gachon UniversitySeongnam13320Korea

Vehicular ad hoc networks (VANETs) have attracted growing interest in both academia and industry because they can provide a viable solutionthat improves road safety and comfort for travelers on roads. However, wireless communications over open-access environments face many security andprivacy issues that may affect deployment of large-scale VANETs. Researchershave proposed different protocols to address security and privacy issues in aVANET, and in this study we cryptanalyze some of the privacy preservingprotocols to show that all existing protocols are vulnerable to the Sybilattack. The Sybil attack can be used by malicious actors to create fakeidentities that impair existing protocols, which allows them to imitate trafficcongestion or at worse cause an accident that may result in the loss of humanlife. This vulnerability exists because those protocols store vehicle identitiesin an encrypted form, and it is not possible to search over the encryptedidentities to find fake vehicles. This attack is serious in nature and veryprevalent for privacy-preserving protocols. To cope with this kind of attack,we propose a novel and practical protocol that uses Public key encryptionwith an equality test (PKEET) to search over the encrypted identities withoutleaking any information, and eventually eliminate the Sybil attack. Theproposed approach improves security and at the same time maintains privacyin VANET. Our performance analysis indicates that the proposed protocoloutperforms state-of-the-art protocols: The proposed beacon generation timeis constant compared to a linear increase in existing protocols, with beaconverification shown to be faster by 7.908%. Our communicational analysisshows that the proposed protocol with a beacon size of 322 bytes has the leastcommunicational overhead compared to other state-of-the-art protocols.

关键词： VANET authentication protocol cryptanalysis privacy preserving intelligent systems

Fiber-based quantum-dot pulse oximetry for wearable health monitoring with high wavelength selectivity and photoplethysmogram sensitivity

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npj Flexible Electronics 2023年第1期7卷 413-424页

作者： Ho Seung Lee Byeongju Noh seong Uk Kong Yong Ha hwang Ha-Eun Cho Yongmin Jeon Kyung cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Biomedical Engineering Gachon UniversitySeongnamRepublic of Korea

Increasing demand for real-time healthcare monitoring is leading to advances in thin and flexible optoelectronic device-based wearable pulse *** previous studies have used OLEDs for this purpose,but did not consider the side effects of broad full-width half-maximum(FWHM)characteristics and single *** this study,we performed SpO_(2)measurement using a fiber-based quantum-dot pulse oximetry(FQPO)system capable of mass production with a transferable encapsulation technique,and a narrow FWHM of about 30 *** on analyses we determined that uniform angular narrow FWHM-based light sources are important for accurate SpO_(2)measurements through multi-layer structures and human skin *** FQPO was shown to have improved photoplethysmogram(PPG)signal sensitivity with no waveguide-mode noise signal,as is typically generated when using a single substrate(30–50%).We successfully demonstrate improved SpO_(2)measurement accuracy as well as all-in-one clothing-type pulse oximetry with FQPO.

关键词： pulse waveguide quantum

Amine functionalization on thermal and mechanical behaviors of graphite nanofibers-loaded epoxy composites

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Journal of Materials Science & Technology 2023年第20期151卷 80-88页

作者： seong-hwang Kim Sang-Jin Park Seul-Yi Lee Soo-Jin Park Department of Chemistry Inha University100 InharoIncheon 22212the Republic of Korea

With the growing demand for faster and more powerful computing,effective heat dissipation is essential to ensure the longevity,reliability,and high performance of electronic *** the field of modern electronic packaging materials,there is a great need for graphitic material-loaded polymeric composites(GPCs)with excellent thermal ***,the enhancement efficiency of GPCs is hindered by the agglomeration of fillers and the interfacial thermal resistance caused by the lack of continuous thermally conductive pathways between the filler and *** the interfaces between filler and matrix is of great importance in optimizing the performances of ***,we fabricated graphite nanofibers(GNF)-loaded nanocomposites using acid-functionalized GNF(AGNF)and acidtetraethylenepentamine-functionalized(TGNF)as a filler and epoxy resin as a matrix with different GNF loading contents to explore the interfacial properties of the *** optimal GNF loading for AGNF was 0.5 wt.%,while the TGNF showed 0.75 wt.%.The highest thermal conductivity(0.51 W m^(−1) K^(−1))and fracture toughness(25.8 MPa m^(1/2))values were found in the TGNF-loaded nanocomposites with a fraction of 0.75 wt.%,representing enhancements of∼145%and∼400%,respectively,compared to those of neat *** experimental data presented herein demonstrate that the interfacial properties play a significant role in enhancing the thermal and mechanical performances of the *** present approach is expected to serve as a valuable tool in the design of conductive polymeric nanocomposites for further practical applications,such as thermal interface materials and packaging of high-power electric devices.

关键词： Graphite nanofiber Nanocomposites Interfacial interaction Thermal conductivity Fracture resistance

Management of symptomatic cervical facet cyst with cervical interlaminar epidural block: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11936-11941页

作者： seong Min hwang Min Kyu Lee Saeyoung Kim Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Symptomatic cervical facet cysts are relatively rare compared to those in the lumbar *** cysts are usually located in the 7th cervical and 1st thoracic vertebral(C7/T1)area,and surgical excision is performed in most ***,facet cysts are associated with degenerative conditions,and elderly patients are often ineligible for surgical *** interlaminar epidural block has been used in patients with cervical radiating symptoms and achieved good ***,cervical interlaminar epidural block may be the first-choice treatment for symptomatic cervical facet *** SUMMARY A 70-year-old man complained of a tingling sensation in the left hand,focused on the 4th and 5th fingers,for 1 year,and posterior neck pain for over 5 *** patient’s numeric rating scale(NRS)score was 5/*** patient was diagnosed with symptomatic cervical facet cyst at the left C7/T1 facet *** cervical interlaminar epidural block at the C7/T1 level with 20 mg triamcinolone and 5 mL of 0.5%lidocaine was *** patient's symptoms improved immediately after the block,with an NRS score of 3 *** 3 mo,his left posterior neck pain and tingling along the left 8th cervical dermatome were relieved,with an NRS score of *** A cervical interlaminar epidural block is a good alternative for managing symptomatic cervical facet cysts.

关键词： Cervical vertebrae Cysts Epidural Injections Neck pain Therapeutics Zygapophyseal joint Case report