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Aggregate 2024年第1期5卷 331-336页

作者： Wu-Jie Guo Shixiang Ma Hui Wang Lu Qiao Lei Chen chenyu hong Bin Liu Xiaoyan Zheng Hui-Qing Peng State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsKey Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Quantitatively establishing the correlation between nanoparticle size and fluorescence is essential for understanding the behavior and functionality of fluorescent nanoparticles(FNPs).However,such exploration focusing on organic FNPs has not been achieved to ***,we employ the use of supramolecular polymeric FNPs prepared from tetraphenylethylene-based bis-ureidopyrimidinone monomers(bis-UPys)to relate the size to the fluorescence of organic *** an equal concentration of bis-UPys,a logarithmic relationship between them is built with a correlation coefficient higher than *** calculations indicate that variations in fluorescence intensity among FNPs of different sizes are attributed to the distinct molecular packing environments at the surface and within the interior of the *** leads to different nonradiative decay rates of the embedded and exposed bis-UPys and thereby changes the overall fluorescence quantum yield of nanoparticles due to their different specific surface *** established fluorescence intensity-size correlation possesses fine universality and reliability,and it is successfully utilized to estimate the sizes of other nanoparticles,including those in highly diluted dispersions of *** work paves a new way for the simple and real-time determination of nanoparticle sizes and offers an attractive paradigm to optimize nanoparticle functionalities by the size effect.

关键词： aggregation-induced emission fluorescence detection fluorescent nanoparticle nanoparticle size supramolecular polymer

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Successful transplantation of double unit umbilical-cord blood from unrelated donors in high risk leukemia with a long follow-up

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Chinese Medical Journal 2005年第9期118卷 772-776页

作者： WANGFeng-rong HUANGXiao-jun ZHANGYao-chen chenyu-hong LUDao-pei PekingUniversityPeople＇sHospital InstituteofHematologyBeijing100044China PekingUniversityPeople＇sHospital InstituteofHematologyBeijing100044China

Umbilical-cord blood (UCB) is a source of hematopoietic stem cells that has been successfully used for transplantation, primarily in children. But the low cell dose severely limits the application of unrelated umbilical-cord blood transplantation (UCBT) in adult patients, particularly in those with high body weight. We hypothesized that the combined transplantation of two partially matched UCB units would improve engraftment without crossed immunological rejection. Since May 2000, six adult patients with high risk leukemia have been transplanted in this study.

关键词： cord blood stem cell transplantation unrelated donor double leukemia

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Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2137-2155页

作者： chenyu Xue hongpeng Jia Rujing Cao Wenjie Cai Weichen hong Jianing Tu Songtao Wang Qianzhi Jiang Chongpeng Bi Anshan Shan Na Dong The Laboratory of Molecular Nutrition and Immunity College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinP.R.China

Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal *** acid(OA)is a pentacyclic triterpene that is ubiquitous in *** previous work demonstrated the protective effect of OA on intestinal health,but the underlying molecular mechanisms remain *** study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli(ETEC)in *** key molecular role of bile acid receptor signaling in this process has also been *** Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets(P<0.05).OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum(P<0.05).This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged *** addition,as a natural ligand of bile acid receptors,OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR(P<0.05).Specifically,OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream c AMP-PKA-CREB signaling pathway(P<0.05).Furthermore,OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR(P<0.05),thereby upregulating the expression of endogenous defense molecules in intestinal epithelial *** In conclusion,our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response,which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in pig

关键词： Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid

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Interpretable foundation models as decryptors peering into the Earth system

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The Innovation 2024年第5期5卷 21-22页

作者： chenyu Li Danfeng hong Bing Zhang Tianjun Liao Naoto Yokoya Pedram Ghamisi Min Chen Lizhe Wang Jon Atli Benediktsson Jocelyn Chanussot Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Electronic Electricaland Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Academy of Military Sciences Beijing 100000China Graduate School of Frontier Sciences The University of TokyoChiba 277-8561Japan Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource Technology09599 FreibergGermany Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China School of Computer Science China University of GeosciencesWuhan 430078China Faculty of Electrical and Computer Engineering University of Iceland102 ReykjavikIceland University Grenoble Alpes InriaCNRSGrenoble INPLJK38000 GrenobleFrance

THE EARTH SYSTEM AMID THE BIG DATA *** processes of the Earth system drive interactions between energy,matter,and life,and a comprehensive understanding of their full evolutionary trajectory is critical for sustainable human *** modeling primarily relies on a set of theoretical equations to simulate dynamic process such as the carbon-nitrogen cycle,solar radiation dynamics,and terrestrial ecosystem dynamics.1 Despite the extensive modeling experience of Earth scientists,the rapid advancement of Earth observation techniques has led to a significant increase in the volume of databases,with data accumulating daily or even *** has exacerbated the conflict between the capacity for data collection and utilization for big Earth ***,there is an urgent need to enhance the intelligent processing and analysis of big Earth data.

关键词： dynamics. system foundation

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深度展开网络的高光谱异常探测

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遥感学报 2024年第1期28卷 69-77页

作者：李晨玉洪丹枫张兵中国科学院空天信息创新研究院北京100094 东南大学数学学院南京210089 中国科学院大学电子电气与通信工程学院北京100049 中国科学院大学资源与环境学院北京100049

在现有基于物理模型的高光谱异常探测HAD(Hyperspectral Anomaly Detection)方法中,低秩表示LRR(Low-Rank Representation)模型以其强大的背景和目标特征分离能力而受到广泛的关注和采用。然而,由于依赖手动参数的选择以及较差的泛化性... 详细信息

在现有基于物理模型的高光谱异常探测HAD(Hyperspectral Anomaly Detection)方法中,低秩表示LRR(Low-Rank Representation)模型以其强大的背景和目标特征分离能力而受到广泛的关注和采用。然而,由于依赖手动参数的选择以及较差的泛化性,导致其实际应用受到限制。为此,本文将LRR模型与深度学习技术相结合,提出了一种新的适用于HAD的基础深度展开网络,称为LRR-Net。该方法借助交替方向乘法ADMM(Alternating Direction Method of Multipliers)优化器高效地求解LRR模型,并将其求解步骤耦合至深度网络中以指导其搜索过程,为深度网络提供了一定的理论基础,具有较强的可解释性。此外,LRR-Net以端到端的方式将一系列正则化的参数转换为可学习的网络参数,从而避免了手动调参。4组不同的高光谱异常探测实验证明了LRR-Net的有效性,与其他无监督的异常探测方法相比,LRR-Net具有较强的泛化性和鲁棒性,能够提高HAD的精度。

关键词：高光谱遥感影像异常探测深度展开低秩表示(LRR) 交替方向乘子法(ADMM)

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Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan Liangbin Zhou chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina Dongguan Key Laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C19 transcription through the nuclear factor-􀇉B signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

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卟啉半遥爪聚合物的制备及其在光动力疗法中的应用探讨

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华东理工大学学报（自然科学版） 2020年第3期46卷 349-359页

作者：陈帅庞瑞淇刘思奕洪晨雨马绍花杲云田佳华东理工大学材料科学与工程学院上海200237

通过"点击化学"偶联反应将不同分子量(Mn=1 000,2 000,5 000)的亲水性高分子聚乙二醇(PEG)与卟啉光敏剂(TPP)键合在一起,成功合成了一系列水溶性很好的卟啉半遥爪聚合物光敏剂(TPP-PEG),并探讨了高分子链长对TPP-PEG的单线态氧(1O2)产... 详细信息

通过"点击化学"偶联反应将不同分子量(Mn=1 000,2 000,5 000)的亲水性高分子聚乙二醇(PEG)与卟啉光敏剂(TPP)键合在一起,成功合成了一系列水溶性很好的卟啉半遥爪聚合物光敏剂(TPP-PEG),并探讨了高分子链长对TPP-PEG的单线态氧(1O2)产率和细胞毒性的影响。相比于自由的卟啉小分子,这类亲水高分子光敏剂在水溶液中以单个分子存在,有效地减少了卟啉分子之间的π-π堆积,提高了光敏剂的1O2产率,同时改善了生物相容性。以1,3-二苯基异苯并呋喃(DPBF)为捕获剂检测1O2,结果表明,接枝分子量分别为1 000、2 000、5 000的TPP-PEG光敏剂的1O2产率比卟啉小分子如四苯基卟啉的1O2产率有显著提高,而且1O2产率随着PEG链长的增加而降低。HeLa细胞的毒性实验证明TPP-PEG几乎没有暗毒性,并且在655 nm光照下表现出很好的光毒性,证明TPP-PEG可以作为潜在的大分子光敏剂用于光动力疗法。

关键词：卟啉光敏剂聚乙二醇单线态氧高分子链长

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新型生物膜载体在污水处理中的研究现状

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化工进展 2024年第10期43卷 5805-5819页

作者：刘亚雯贾方旭贾非睿刘晨雨赵星程姚宏北京交通大学环境学院水中典型污染物控制与水质保障北京重点实验室北京100044

生物处理法是污水处理领域的核心技术,其中的生物膜法因具有耐冲击负荷、污泥产量少、运行管理方便等优势,已在全球范围内得到广泛关注。生物膜载体作为微生物附着生长材料,在生物膜处理工艺中起到关键作用,直接影响工艺的处理效果。然... 详细信息

生物处理法是污水处理领域的核心技术,其中的生物膜法因具有耐冲击负荷、污泥产量少、运行管理方便等优势,已在全球范围内得到广泛关注。生物膜载体作为微生物附着生长材料,在生物膜处理工艺中起到关键作用,直接影响工艺的处理效果。然而,目前所开发的生物膜载体大多只能为微生物提供适宜稳定的生态位,并不具有强化污水处理效果的能力。为此,本文围绕五种能够提高污染物降解效率的新型生物膜载体(缓释生物膜载体、氧化还原介体生物膜载体、磁性生物膜载体、亲水改性生物膜载体、亲电改性生物膜载体)进行讨论,详细阐述了其具体分类与作用机理,并针对其今后研究方向与未来发展提出建设性建议,以期为未来大范围提标改造污水处理厂提供理论参考。

关键词：新型生物膜载体缓释生物膜载体氧化还原介体生物膜载体磁性生物膜载体亲水改性生物膜载体亲电改性生物膜载体

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高通量rGO微球@PVDF纳米纤维复合膜的制备及其油水分离性能研究

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化学工业与工程 2024年第2期41卷 47-56页

作者：来晨雨王瑞程丝楠范红玮孟洪北京化工大学化学工程学院北京100029 新疆大学化学学院乌鲁木齐830017

采用静电纺丝法制备了聚偏氟乙烯(PVDF)纳米纤维膜,并采用共混纺丝法和真空抽滤两种方式将还原氧化石墨烯微球(rGO)负载于其上,获得高通量rGO微球@PVDF纳米纤维复合油水分离膜。通过调整静电纺丝过程参数(如推注速率和电场强度等)和纺... 详细信息

采用静电纺丝法制备了聚偏氟乙烯(PVDF)纳米纤维膜,并采用共混纺丝法和真空抽滤两种方式将还原氧化石墨烯微球(rGO)负载于其上,获得高通量rGO微球@PVDF纳米纤维复合油水分离膜。通过调整静电纺丝过程参数(如推注速率和电场强度等)和纺丝液配方,对PVDF纳米纤维膜结构进行优化,并采用不同的rGO微球负载量、负载方式、黏结剂含量来提高纳米纤维膜的表面粗糙度和疏水性。利用扫描电子显微镜和接触角测试对纤维膜的表面形貌和亲疏水性进行表征,并通过二氯甲烷-水体系进行油水分离实验,测试了不同配方下杂化膜的重力驱动油水分离性能。结果表明,当静电纺丝溶液中PVDF含量为14%时,以1 mL·h^(-1)的推注速率,在15 kV下制得的PVDF纳米纤维膜,并将1%PVDF溶液、3 mg rGO微球(与黏结剂中有效成分PVDF质量比为3∶1)和溶剂组成的铸膜液抽滤在膜表面,复合膜表面水接触角为130.9°,其油水分离过程中的有机溶剂透过通量可达5641.3 L·h^(-1)·m^(-2),水相的截留率为99.28%。

关键词：静电纺丝聚偏氟乙烯还原氧化石墨烯微球油水分离膜

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农民农村共同富裕:内涵特征、生成逻辑与实践路径

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重庆社会科学 2024年第2期 6-16页

作者：廖祖君卢晨瑜四川省社会科学院中国农民合作社研究中心四川成都610072 四川农业大学经济学院四川成都611130 香港大学经管学院中国香港999077

促进农民农村共同富裕具有一般性,也有其特殊性。对农民农村共同富裕的特殊性内涵和特征的系统阐释,有利于揭示并避免当前理论界存在的认识误区。从历史昭示、现实需要与战略考量三个维度出发,对农民农村共同富裕的生成逻辑进行细致描述... 详细信息

促进农民农村共同富裕具有一般性,也有其特殊性。对农民农村共同富裕的特殊性内涵和特征的系统阐释,有利于揭示并避免当前理论界存在的认识误区。从历史昭示、现实需要与战略考量三个维度出发,对农民农村共同富裕的生成逻辑进行细致描述,有利于回答为什么要促进农民农村共同富裕的时代命题。促进农民农村共同富裕,应当在脱贫地区接续推进乡村振兴,推动小农户融入农业高质量发展,促进城乡要素双向有序流动,实现城乡基本公共服务均等化。

关键词：农民农村共同富裕城乡融合中国式现代化

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