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Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity

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Signal Transduction and Targeted Therapy 2020年第1期5卷 249-251页

作者： Xiaoyi jiang Zhengrong Zhang chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun Beijing Institute of Biotechnology 20 Dongda StreetBeijing 100071China Department of Oncology Beijing Shijitan Hospital of Capital Medical University10 TIEYI RoadBeijing 100038China Department of Microbiology Second Military Medical UniversityShanghai 200433China

Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S ***,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation.

关键词： glycoprotein acute respiratory

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

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Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du chenxi Wang Zhangsheng jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to *** dysregulation of double-negative(DN)T cells is considered as a crucial commander during ***,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune ***,the function of neddylation in SLE is still ***,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus *** investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus *** double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus *** findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus ***,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was ***,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation ***,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE ***,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

Repetition rate locked single-soliton microcomb generation via rapid frequency sweep and sideband thermal compensation

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Photonics Research 2022年第8期10卷 1859-1867页

作者： RUNLIN MIAO chenxi ZHANG XIN ZHENG XIANG’AI CHENG KE YIN TIAN jiang College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China State Key Laboratory of Pulsed Power Laser Technology Changsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology Changsha 410073China Defense Innovation Institute Academy of Military Sciences PLA ChinaBeijing 100071China Beijing Institute for Advanced Study National University of Defense TechnologyBeijing 100000China

Dissipative Kerr solitons(DKSs)with mode-locked pulse trains in high-Q optical microresonators possess lownoise and broadband parallelized comb lines,having already found plentiful cutting-edge ***,thermal bistability and thermal noise caused by the high microresonator power and large temperature exchange between microresonator and the environment would prevent soliton microcomb formation and deteriorate the phase and frequency ***,a novel method that combines rapid frequency sweep with optical sideband thermal compensation is presented,providing a simple and reliable way to get into the single-soliton ***,it is shown that the phase and frequency noises of the generated soliton are greatly ***,by closing the locking loop,an in-loop repetition rate fractional instability of 5.5×10^(-15)at 1 s integration time and a triangular linear repetition rate sweep with 2.5 MHz could be *** demonstration provides a means for the generation,locking,and tuning of a soliton microcomb,paving the way for the application of single-soliton microcombs in low-phase-noise microwave generation and laser ranging.

关键词： resonator tuning soliton

Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis

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Acta Epileptologica 2024年第3期7卷 204-214页

作者： chenxi Qiu chenxi Zhong Ying Liu Liju Wang Yingying Tang Zhiyi Liu Sijia Guo Yingqi jiang Enzhi Li Jing Lu Bo Yan Xiaoting Hao Dong Zhou MOE Key Lab for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan611731China Department of Neurology West China HospitalSichuan UniversityChengduSichuan610041China School of Nursing Sichuan UniversitySichuan610041China Department of Neurology Chengdu Shangjin Nanfu HospitalChengduSichuan Province611730China School of Public Health Sichuan UniversityChengdu610044China

Background There is a lack of further exploration of the epileptogenic network of specific types of epilepsy,such as unilateral hippocampal sclerosis(HS),and there is an urgent need to find exact evidence to confirm the consistency of its brain network *** We enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis(mTLE-HS)patients to compare the differences in brain activity between 22 healthy controls(HCs)and ***-state electroencephalography(EEG)was also ***,we calculated the power spectral density and phase locking values in and between these *** The results showed the increased theta power was related to the high severity of epilepsy in the temporal,parietal,and central regions in mTLE-HS patients,and there were positive correlations between theta power in the contralateral temporal region and seizure *** power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications(ASMs),but not with the usage of third-generation ***,the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.

关键词： Mesial temporal lobe epilepsy Hippocampal sclerosis Electroencephalography Anti-seizure medications Theta oscillation

What is the meaning of health literacy?A systematic review and qualitative synthesis

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Family Medicine and Community Health 2020年第2期8卷 27-34页

作者： chenxi Liu Dan Wang Chaojie Liu Junnan jiang Xuemei Wang Haihong Chen Xin Ju Xinping Zhang School of Medicine and Health Management Huazhong University of Science and Technology Tongji Medical CollegeWuhanChina Public Health La Trobe UniversityMelbourneVictoriaAustralia

The objective of this review was to clarify what health literacy represents.A systematic review with qualitative syntheses was performed(CRD42017065149).Studies concerning health literacy in all settings were *** before 15 March 2017 were identified from PubMed,Medline,Embase,Web of Science,Scopus,PsycARTICLES and the Cochrane *** included literature either had defined the concept of health literacy or made a detailed explanation of health literacy.A total of 34 original studies met the inclusion criteria,including 13 involved in previous systematic reviews and 21 new *** literacy was commonly conceptualised as a set of knowledge,a set of skills or a hierarchy of functions(functional-interactive critical).The construct of health literacy covers three broad elements:(1)knowledge of health,healthcare and health systems;(2)processing and using information in various formats in relation to health and healthcare;and(3)ability to maintain health through self-management and working in partnerships with health *** literacy is defined as the ability of an individual to obtain and translate knowledge and information in order to maintain and improve health in a way that is appropriate to the individual and system *** definition highlights the diversity of needs from different individuals and the importance of interactions between individual consumers,healthcare providers and healthcare systems.

关键词： qualitative maintain synthesis

左心室肥厚对合并高血压阵发性心房颤动患者射频消融术后复发的影响

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中华心律失常学杂志 2018年第5期22卷 412-418页

作者：王璐李松南董建增喻荣辉龙德勇汤日波蒋晨曦桑才华刘念白融杜昕马长生国家心血管病临床医学研究中心、首都医科大学附属北京安贞医院心内科、心血管内科北京市心肺血管疾病研究所 100029

目的本研究旨在探讨左心室肥厚伴或不伴劳损对合并高血压阵发性心房颤动（房颤）患者射频消融术后复发的影响。方法连续入选2007年1月至2014年5月于北京安贞医院第一次接受导管射频消融术的280例抗心律失常药物治疗无效或不能耐受并同... 详细信息

目的本研究旨在探讨左心室肥厚伴或不伴劳损对合并高血压阵发性心房颤动（房颤）患者射频消融术后复发的影响。方法连续入选2007年1月至2014年5月于北京安贞医院第一次接受导管射频消融术的280例抗心律失常药物治疗无效或不能耐受并同意手术治疗的合并高血压的症状性阵发性房颤患者。根据患者术前窦性心律心电图，依据左心室肥厚Romhilt-Estes评分系统及是否伴有ST-T劳损性改变，将患者共分为3组[1组（正常组，140例）；2组（左心室肥厚不伴劳损组，114例）；3组（左心室肥厚伴劳损组，26例）]，手术方式均为三维电解剖标测系统指导下行左心房重建及环肺静脉电隔离术，术后由随访人员定期随访患者主诉、心电图、24 h动态心电图、超声心动图等。结果截至2017年1月，平均手术1.19±0.46次，中位随访42（四分位数24~66）个月，169例维持窦性心律，104例复发，失访7例；1组患者窦性心律维持率明显高于2组及3组患者，分别为74.3%（1组）、48.2%（2组）、38.5%（3组），差异有统计学意义（P〈0.001）。单因素回归分析中，血栓栓塞评分（CHA2DS2-VASc积分），心电图异常包括左心室肥厚及左心室肥厚伴劳损，左心房内径以及脑钠肽是患者复发的危险因素；在多因素分析中，仅有心电图异常包括左心室肥厚及左心室肥厚伴劳损是合并高血压阵发性房颤患者射频消融术后复发的独立危险因素（HR=2.103，95% CI 1.231~3.590；HR=2.621，95% CI 1.238~5.550）。结论心电图异常左心室肥厚伴或不伴劳损是合并高血压阵发性房颤患者射频消融术后复发的独立危险因素。

关键词：心房颤动左心室肥厚导管消融

心房颤动导管消融术后复发时间对再次消融预后的影响

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中国医药 2018年第7期13卷 961-964页

作者：郭雪原龙德勇喻荣辉汤日波桑才华蒋晨曦李松南杜昕董建增马长生首都医科大学附属北京安贞医院心内科 100029

目的探讨心房颤动患者初次导管消融术后复发时间对再次消融预后的影响。方法连续入选2009年1月至2011年6月于首都医科大学附属北京安贞医院心房颤动中心初次消融后复发接受第2次导管消融的228例患者。根据复发时间将患者分为早期复发组... 详细信息

目的探讨心房颤动患者初次导管消融术后复发时间对再次消融预后的影响。方法连续入选2009年1月至2011年6月于首都医科大学附属北京安贞医院心房颤动中心初次消融后复发接受第2次导管消融的228例患者。根据复发时间将患者分为早期复发组(初次消融后3个月内复发,3个月后仍然有心房颤动发作,128例)、晚期复发组(初次消融后3~12个月复发,59例)、极晚期复发组(初次消融后超过12个月复发,41例)。再次消融术后3、6、12个月和以后每6个月随访1次,比较未服用抗心律失常药物的情况下各组患者窦性心律的维持率。分析初次导管消融术后复发时间对再次消融预后的影响。结果所有患者再次消融术后平均随访(30±7)个月,在未服用抗心律失常药物的情况下,早期复发组共79例(61.7%)维持窦性心律,晚期复发组44例(74.6%)维持窦性心律,极晚期复发组33例(80.5%)维持窦性心律,极晚期复发组窦性心律维持率明显高于早期复发组和晚期复发组,差异有统计学意义(P=0.038)。单因素Cox回归分析结果显示,持续性心房颤动(风险比=1.600,95%置信区间:1.006~2.542,P=0.047)和极晚期复发(风险比=0.446,95%置信区间:0.211~0.942,P=0.034)与再次消融后心房颤动复发相关。多因素Cox回归分析显示,极晚期复发(风险比=0.448,95%置信区间:0.212~0.946,P=0.035)是再次消融后维持窦性心律的预测因素。结论心房颤动射频消融术后复发时间显著影响临床预后。与早期复发相比,晚期复发和极晚期复发的患者再次消融后成功率更高。

关键词：心房颤动射频消融术复发时间

Frequency and risk factors of psychological distress among individuals with epilepsy before and during the outbreak of the SARS-CoV-2 Omicron variant in China:an online questionnaire survey

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Acta Epileptologica 2024年第1期7卷 36-43页

作者： Xiaoting Hao Qi Zhang chenxi Zhong Enzhi Li Yingqi jiang Jiajun Xu Yuanyuan Li Dong Zhou Bo Yan Department of Neurology West China HospitalSichuan University No37 Guoxue AlleyChengduSichuan Province610000China Department of Psychiatry and Mental Health West China HospitalSichuan University/West China School of Clinical MedicineSichuan UniversityChengdu610000China Department of Neurology Chengdu Shangjin Nanfu HospitalChengdu611730China West China School of Nursing Sichuan University Chengdu610000China Department of Clinical Research Management West China HospitalSichuan UniversityChengdu610000China

Background The COVID-19 pandemic substantially increases the risk of severe psychological distress among people with epilepsy(PWE),especially those with monthly household income12 should consult a psychiatrist,especially during major *** study was aimed to compare the frequency of psychological distress among Chinese PWE before and during the outbreak of the SARS-CoV-2 Omicron variant,and to identify risk factors for such *** In this prospective study,we collected sociodemographic data of PWE aged>14 years,who were treated at our center during December 1 to 15,*** participants completed the 6-item Kessler Psychological Distress Scale before the outbreak and again during the *** visitors who were unrelated to those patients during the outbreak were included as a *** logistic regression analysis was performed to identify risk factors of severe psychological distress and its *** Of the 223 PWE,127 were tested positive for SARS-CoV-2,while 174 of 218 controls were positive for *** neurological symptoms were similar between PWE and controls with *** average Kessler score of PWE was significantly higher during the outbreak than before it(9.93±3.98 vs.8.52±0.23,P<0.001).The average score of controls during the outbreak(5.146±0.35,P<0.001)was significantly lower than that of the *** identified three independent predictors for severe psychological distress in PWE during the outbreak,i.e.,monthly household income<5000 RMB(OR=0.252,95%CI 0.064–0.998,P=0.048),severe psychological distress before the outbreak(OR=0.067,95%CI 0.026–0.174,P<0.001),and seizure onset within 30 days before the assessment during the outbreak(OR=0.356,95%CI 0.157–0.805,P=0.013).Of the three predictors,the last one was also an independent predictor for exacerbation of psychological distress during the outbreak(OR=0.302,95%CI 0.123–0.741,P

关键词： Epilepsy Neurological symptoms Psychological distress COVID-19 pandemic

Dual-microcomb generation via a monochromatically pumped dual-mode microresonator

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Photonics Research 2024年第1期12卷 163-171页

作者： RUNLIN MIAO KE YIN CHAO ZHOU chenxi ZHANG ZHUOPEI YU XIN ZHENG TIAN jiang National Innovation Institute of Defense Technology Academy of Military Sciences PLA ChinaBeijing 100071China Beijing Institute for Advanced Study National University of Defense TechnologyBeijing 100000China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China Institute for Quantum Science and Technology College of ScienceNational University of Defense TechnologyChangsha 410073China

Microcombs have enabled a host of cutting-edge applications from metrology to communications that have garnered significant attention in the last ***,due to the thermal instability of the microresonator,additional control devices like auxiliary lasers are indispensable for single-soliton generation in some ***,the increased system complexity would be too overwhelming for dual-microcomb ***,we put forward a novel approach to mitigate the thermal instability and generate the dual-microcomb using a compact *** process is akin to mode-division multiplexing,as the dual-microcombs are generated by pumping the dual-mode of a single Si_(3)N_(4) microresonator with a continuous-wave *** numerical simulations and experimental measurements indicate that this innovative technique could offer a straightforward way to enlarge the soliton existence range,allowing entry into the multistability regime and triggering another microcomb alongside the main soliton *** outcome not only shines new light on the interaction mechanism of microresonator modes but also provides an avenue for the development of dual-microcomb-based ranging and low phase noise microwave generation.

关键词： resonator pumped pumping