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pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy

Acta Pharmaceutica Sinica B 2021年第2期11卷 520-533页

作者： Zhiming Zhangy chenlu huangy Li Zhang Qing Guo Yu Qin Fan Fan Boxuan Li Bao Xiao Dunwan Zhu Linhua Zhang Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Chemotherapy has been a major option in clinic treatment of malignant ***,single chemotherapy faces some drawbacks,such as multidrug resistance,severe side effects,which hinder its clinic application in tumor *** nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination *** the current study,a novel pH-sensitive and bubble-generating mesoporous silica-based drug delivery system(denoted as M(a)D@PI-PEG-RGD)was *** bicarbonate(NH4 HCO3;abc)and chemotherapeutic agent doxorubicin(DOX)were loaded into the pores of mesoporous *** green(ICG)as a photothermal and photodynamic agent was loaded onto the polydopamine(PDA)layer *** synthesized nanoparticles displayed a narrow polydispersity(PDI)and small particle size as characterized through dynamic light scattering-autosizer *** nanoparticles also showed high targeting efficacy through RGD modification as indicated by cellular uptake and animal *** release analysis confirmed that the nanoparticles were pH-dependent and that NH4 HCO3 accelerated drug *** the same time,the nanoparticles had obvious photothermal and photodynamic effects performed by ICG which restrained tumor growth *** summary,the multifunctional nanoparticles presented a promising system for combination therapy.

关键词： Mesoporous silica pH-sensitive Bubble-generating Targeting modification Combination therapy

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