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Evidence-based practices in sustainable travel behavior intervention: A knowledge graph-based systematic review

Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 293-311页

作者： Jian Li chenjie xu Key Laboratory of Road and Traffic Engineering of the Ministry of Education College of Transportation EngineeringTongji UniversityShanghai 201804China

Sustainable travel behavior intervention is an essential strategy to promote the development of urban *** interventions offer personalized strategies based on certain scenario and participants to promote its effectiveness over hard travel ***,personalized strategies may also bring about difficulties to identify the actual effect of the ***,based on current practice,to make full use of travel behavior interventions,it is necessary to construct a unified methodological evidencebased framework to assess the reliability and effectiveness of travel behavior intervention *** response to these issues,we applied evidence-based knowledge graph to the field of sustainable travel behavior interventions to help decision supporters design sustainable travel behavior interventions wisely and in turn avoid excessive use of hard travel *** introduced concept of evidence-based practice to conduct a systematic analysis concerning reliability and validity of current full volume empirical studies by dimensions of scenarios,types of interventions and *** addition,we took advantage of high extensivity and integrability of knowledge graph to organize evidence-based related *** of the systematic analysis shows that in terms of reliability of evidence,school intervention is the best scenario,knowledge incentive is the best intervention type and promoting public transit and walking proportion are the best ***,the reliability of interventions in workplace,belonging to reward and threat along with aiming at changing travel patterns generally and lowering travel carbon emission need to be *** the study,various research prospects are raised to promote evidence quality in the field of travel behavior intervention *** a pioneer study,our research contributes to the field of urban transportation in introducing concepts of evidence-based practice and enabling optimization and

关键词： Evidence-based decision-making Evidence assessment Knowledge graph Travel behavior intervention Sustainable travel

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Trajectories of depressive symptoms and risk of cardiovascular disease,cancer and mortality:a prospective cohort study

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General Psychiatry 2024年第3期37卷 401-411页

作者： Jiahao Min Zhi Cao Han Chen Xiaohe Wang chenjie xu School of Public Health Hangzhou Normal UniversityHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina

Background Depressive symptoms are established risk factors for various health ***,previous studies assessed depressive symptoms at a single time point,neglecting individual variations over *** To identify depressive symptoms trajectories through repeated measures and examine their associations with cardiovascular disease(CVD),cancer and *** This study included 20634 UK Biobank participants free of CVD and cancer at baseline with two or more assessments of depressive symptoms during ***-based trajectory modelling identified depressive symptoms *** CVD,cancer and mortality were followed up until 2021 through linked *** Six depressive symptoms trajectories were identified:no symptoms(n=6407),mild-stable(n=11539),moderate-stable(n=2183),severe-decreasing(n=206),moderate-increasing(n=177)and severe-stable(n=122).During a median follow-up of 5.5 years,1471 CVD cases,1275 cancer cases and 503 deaths were *** with the no symptoms trajectory,the mildstable,moderate-stable and severe-stable trajectories exhibited higher CVD risk,with hazard ratios(HRs)(95%CIs)of 1.19(1.06 to 1.34),1.32(1.08 to 1.34)and 2.99(1.85 to 4.84),***-increasing and severe-stable trajectories were associated with higher mortality risks,with HRs(95%CIs)of 2.27(1.04 to 4.93)and 3.26(1.55 to 6.88),***,the severedecreasing trajectory was not associated with higher risks of adverse *** did not find significant associations between any trajectory and *** Trajectories related to stable and increasing depressive symptoms,but not the trajectory associated with severe depressive symptoms at the initial assessment but decreasing at the follow-up,were associated with higher risks of CVD and *** severe depressive symptoms at the initial onset may mitigate CVD and mortality risks.

关键词： symptoms depress mortality

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Harnessing exosomes for targeted therapy:strategy and application

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Biomaterials Translational 2024年第1期5卷 46-58页

作者： Xiaoxiang Ren Ruixue xu chenjie xu Jiacan Su Organoid Research Center Institute of Translational MedicineShanghai UniversityShanghaiChina Department of Microbial Pathogenesis Yale University School of MedicineNew HavenCTUSA Department of Biomedical Engineering City University of Hong KongHong Kong Special Administrative RegionChina Department of Orthopedic Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghaiChina

Exosomes,nanoscopic extracellular vesicles produced by cells,are pivotal in mediating intracellular communication by transporting nucleic acids,proteins,lipids,and other bioactive molecules,thereby influencing physiological and pathological *** endogenous origin and inherent diversity confer distinct advantages over synthetic vehicles like liposomes and nanoparticles in diagnostic and therapeutic *** their potential,the clinical utility of exosomes is hampered by challenges such as limited storage stability,yield,purity,and targeting *** review focuses on exosomes as targeted therapeutic agents,examining their biogenesis,classification,isolation,and characterisation,while also addressing the current limitations in yield,purity,and *** delve into the literature to propose optimisation strategies that can enhance their therapeutic efficacy and accelerate the translation of exosome-based therapies into clinical practice.

关键词： biomedical engineering exosomes modification nanotechnology targeted therapy

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Enhanced angiogenesis in porous poly(ε-caprolactone)scaffolds fortified with methacrylated hyaluronic acid hydrogel after subcutaneous transplantation

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Biomaterials Translational 2024年第1期5卷 59-68页

作者： Huaxin Yang Mengjia Zheng Yuyue Zhang Chaochang Li Joseph Ho Chi Lai Qizheng Zhang Kannie WY Chan Hao Wang Xin Zhao Zijiang Yang chenjie xu Department of Biomedical Engineering City University of Hong KongHong Kong Special Administrative RegionChina Center for Pluripotent Stem Cell Research and Engineering Research Institute of TsinghuaGuangzhouGuangdong ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

A composite scaffold composed of a porous scaffold and hydrogel filling can facilitate engraftment,survival,and retention in cell transplantation *** study presents a composite scaffold made of poly(ε-caprolactone)(PCL)and methacrylated hyaluronic acid(MeHA)hydrogel and describes the corresponding physical properties(surface area,porosity,and mechanical strength)and host response(angiogenesis and fibrosis)after subcutaneous ***,we synthesise MeHA with different degrees of substitution and fabricate a PCL scaffold with different ***,we construct a series of PCL/MeHA composite scaffolds by combining these hydrogels and *** experiments with mice,the scaffold composed of 3%PCL and 10-100 kDa,degree of substitution 70%MeHA results in the least fibrosis and a higher degree of *** study highlights the potential of PCL/MeHA composite scaffolds for subcutaneous cell transplantation,given their desirable physical properties and host response.

关键词： angiogenesis cell transplantation hyaluronic acid poly(ε-caprolactone) scaffold

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A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

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Nano-Micro Letters 2018年第1期10卷 85-94页

作者： Malathi Mathiyazhakan Christian Wiraja chenjie xu School of Chemical and Biomedical Engineering Nanyang Technological University

The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications.

关键词： Photo-responsive liposome Controlled release Drug delivery Gold nanoparticles

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Wearable patches for transdermal drug delivery

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药学学报:英文版 2023年第6期13卷 2298-2309页

作者： Jiahui He Yuyue Zhang Xinge Yu chenjie xu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong 999077China

Transdermal drug delivery systems(TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials,design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and *** development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery.

关键词： Wearable patch Transdermal delivery Microneedles Drug delivery Biomaterials

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Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection

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药学学报:英文版 2023年第6期13卷 2296-2297页

作者： Wei He Alejandro Sosnik chenjie xu School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Department of Biomedical Engineering City University of Hong KongHong Kong 999077China

Our immune system has a vital role,and any variation because of either heritable or non-heritable stimuli might cause health disorders such as cancer,diabetes,and cardiovascular *** addition,the complexity of the anatomical barriers,such as the blood brain barrier,challenges the therapy of central nervous system(CNS)*** goal of nano-dimensional drugs(nanomedicines)is to improve the efficacy of treatments while minimizing systemic toxicity and side effects.

关键词： drugs cardiovascular Immune

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Leucocyte telomere length,brain volume and risk of dementia:a prospective cohort study

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General Psychiatry 2023年第4期36卷 239-247页

作者： Zhi Cao Yabing Hou chenjie xu School of Public Health Hangzhou Normal UniversityHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Yanjing Medical College Capital Medical UniversityBeijingChina

Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and *** To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective *** LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until *** health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were *** restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for ***,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.

关键词： prospective shorter restricted

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Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2937-2944页

作者： Xiaoyu Ning Christian Wiraja Wan Ting Sharon Chewa Chen Fan chenjie xu NTU Institute for Health Technologies Interdisciplinary Graduate GroupNanyang Technological UniversitySingapore 639798Singapore School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore Skin Research Institute of Singapore 8A Biomedical GroveSingapore 138648Singapore Department of Biomedical Engineering City University of Hong KongHong Kong SAR 999077China

Hypertrophic scars are unfavorable skin diseases characterized by excessive collagen *** systemic treatments exist in clinic to manage hypertrophic scars,they pose significant side effects and tend to lose efficacy over prolonged *** Chinese medicine(TCM)offers as a promising candidate to treat pathological scars.A large number of TCMs have been studied to show anti-scarring effect,however,the natural barrier of the skin impedes their penetration,lowering its therapeutic ***,we reported the use of dissolvable hyaluronic acid(HA)microneedles(MNs)as a vehicle to aid the transdermal delivery of therapeutic agent,a model TCM called shikonin for the treatment of hypertrophic ***,shikonin was mixed with HA to make MNs with adequate mechanical strength for skin penetration,making its dosage controllable during the fabrication *** therapeutic effect of the shikonin MNs was studied in vira using HSFs and then further verified with quantitative reverse transcriptase polymerase chain *** data suggest that the shikonin HA MNs significantly reduce the viability and proliferation of the HSFs and downregulate the fibrotic-related genes(i.e.,TGFβ1,FAP-αand COL1 A1).Furthermore,we observed a localized therapeutic effect of the shikonin HA MNs that is beneficial for site-specific treatment.

关键词： Traditional Chinese medicine Shikonin Hyaluronic acid Microneedle Hypertrophic scarring Drug delivery Transdermal delivery Skin

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Biological drug and drug delivery-mediated immunotherapy

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Acta Pharmaceutica Sinica B 2021年第4期11卷 941-960页

作者： Qingqing Xiao Xiaotong Li Yi Li Zhenfeng Wu chenjie xu Zhongjian Chen Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 210009China Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

The initiation and development of major infammatory diseases,i.e.,cancer,vascular infammation,and some autoimmune diseases are closely linked to the immune ***-based immunotherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial *** delivery strategies are potent to promote their ***,we reviewed the potential targets for immunotherapy against the major infammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this feld.

关键词： Inflammatory diseases Cancer immunotherapy Atherosclerosis Pulmonary artery hypertension Biologics Adoptive cell transfer Immune targets Drug delivery

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