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Mechanical responses and crystal plasticity model of CoCrNi medium-entropy alloy under ramp wave compression

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Matter and Radiation at Extremes 2024年第5期9卷 93-108页

作者： Jinlei Dong Xuping Zhang Guiji Wang Xianqian Wu Binqiang Luo Xuemiao chen Fuli Tan Jianheng Zhao chengwei Sun Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621999China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang 621999China

It is of substantial scientific significance and practical value to reveal and understand the multiscale mechanical properties and intrinsic mechanisms of medium-entropy alloys(MEAs)under high strain rates and *** this study,the mechanical responses and deformation mechanisms of an equiatomic CoCrNi MEA are investigated utilizing magnetically driven ramp wave compression(RWC)with a strain rate of 105 s^(−1).The CoCrNi MEA demonstrates excellent dynamic mechanical responses and yield strength under RWC compared with other advanced *** characterizations reveal that grain refinement and abundant micromechanisms,including dislocation slip,stacking faults,nanotwin network,and Lomer–Cottrell locks,collectively contribute to its excellent performance during ***,dense deformation twins and shear bands intersect,forming a weave-like microstructure that can disperse deformation and enhance *** the basis of these observations,we develop a modified crystal plasticity model with coupled dislocation and twinning mechanisms,providing a relatively accurate quantitative description of the multiscale behavior under *** results of simulations indicate that the activation of multilevel microstructures in CoCrNi MEA is primarily attributable to stress inhomogeneities and localized strain during *** research offers valuable insights into the dynamic mechanical responses of CoCrNi MEA,positioning it as a promising material for use under extreme dynamic conditions.

关键词： deformation alloy microstructure

认真回顾研究史重视RUCAM量表在药物性肝损伤诊断中的应用

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中华肝脏病杂志 2016年第11期24卷 801-803页

作者：陈威伟解放军第八五医院肝病科上海200235

当前，在我国提交的有关临床药物性肝损伤（DILI）研究及相关文献中，相关的诊断标准采用非常混乱，使这些研究的结果、结论和经验无从比较和推广，因此，有必要认真回顾诊断量表的发展历史，统一标准和相关认识。RUCAM量表白1993年问... 详细信息

当前，在我国提交的有关临床药物性肝损伤（DILI）研究及相关文献中，相关的诊断标准采用非常混乱，使这些研究的结果、结论和经验无从比较和推广，因此，有必要认真回顾诊断量表的发展历史，统一标准和相关认识。RUCAM量表白1993年问世以来，不论是在文献中，还是在对有可能引起DILI的药物调控决策方面，已广泛用于评估因果关系，为临床医师提供一种诊断DILI的有益分析构架。除非将来发现具有明确诊断意义的标志物，目前仍应采用RUCAM作为DILI的因果关系评估和辅助诊断量表。

关键词：肝炎,慢性,药物性诊断因果关系评估量表 RUCAM量表

Late Mesozoic Exhumation of the Huangling Massif:Constraints on the Evolution of the Middle Yangtze River

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 250-264页

作者： SU Jianchao LIN Xu LI Chang’an Jolivet MARC WU Lin chenG Feng DENG Bin WU Zhonghai chen Xiaokang HU chengwei School of Geography and Information Engineering China University of GeosciencesWuhan 430074China College of Civil Engineering and Architecture China Three Gorges UniversityYichangHubei 443002China Géosciences Rennes CNRS-UMR6118Univ RennesRennesFrance State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBejing 100029China Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation/chengdu University of Technology Chengdu 100871China Institute of Geological Mechanics Chinese Academy of Geological ScienceBeijing 100081China

Plate subduction leads to complex exhumation processes on *** Huangling Massif lies at the northern margin of the South China *** the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under *** examined the exhumation history of the Huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)*** samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),*** modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous,late Early Cretaceous,and Late *** exhumation processes led to the high topographic relief responsible for the emergence of the Huangling *** integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the *** that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan *** subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block.

关键词： apatite zircon (U-Th)/He fission track Huangling Massif Yangtze River

Enhancing the Performance of Perovskite Light-Emitting Diodes via Synergistic Effect of Defect Passivation and Dielectric Screening

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Nano-Micro Letters 2024年第10期16卷 244-256页

作者： Xuanchi Yu Jia Guo Yulin Mao chengwei Shan Fengshou Tian Bingheng Meng Zhaojin Wang Tianqi Zhang Aung Ko Ko Kyaw Shuming chen Xiaowei Sun Kai Wang Rui chen Guichuan Xing Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao 999078People's Republic of China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055People's Republic of China

Metal halide perovskites,particularly the quasi-two-dimensional perovskite subclass,have exhibited considerable potential for next-generation electroluminescent materials for lighting and ***,the presence of defects within these perovskites has a substantial influence on the emission efficiency and durability of the *** this study,we revealed a synergistic passivation mechanism on perovskite films by using a dual-functional compound of potassium *** dual functional potassium bromide on the one hand can passivate the defects of halide vacancies with bromine anions and,on the other hand,can screen the charged defects at the grain boundaries with potassium *** approach effectively reduces the probability of carriers quenching resulting from charged defects capture and consequently enhances the radiative recombination efficiency of perovskite thin films,leading to a significant enhancement of photoluminescence quantum yield to near-unity values(95%).Meanwhile,the potassium bromide treatment promoted the growth of homogeneous and smooth film,facilitating the charge carrier injection in the ***,the perovskite light-emitting diodes based on this strategy achieve a maximum external quantum efficiency of~21%and maximum luminance of~60,000 cd m^(-2).This work provides a deeper insight into the passivation mechanism of ionic compound additives in perovskite with the solution method.

关键词： Synergistic passivation strategy Defects passivation Dielectric screening Perovskite light-emitting diodes

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自身免疫性肝炎与药物性肝损害

中国实用内科杂志 2006年第12期26卷 1846-1849页

作者：陈成伟南京军区上海临床肝病研究中心上海200233

自身免疫性肝病系指其发病机制与自身免疫相关的炎症性肝病.有遗传易患性的个体,环境因素(感染或毒素等)可诱发自身免疫性肝病发生.根据累及细胞类型的不同可分为两大类,即肝细胞受累的自身免疫性肝炎(AIH)和胆管细胞受累的自身免疫性... 详细信息

自身免疫性肝病系指其发病机制与自身免疫相关的炎症性肝病.有遗传易患性的个体,环境因素(感染或毒素等)可诱发自身免疫性肝病发生.根据累及细胞类型的不同可分为两大类,即肝细胞受累的自身免疫性肝炎(AIH)和胆管细胞受累的自身免疫性胆管病,后者又分为原发性胆汁性肝硬化(PBC),原发性硬化性胆管炎(PSC)和自身免疫性胆管炎(AIC).许多基因相互影响构成"允许基因库"(permissive gene pool),决定着发病的危险程度和疾病的表型,阐明这个复杂的遗传基础是后基因时代的巨大挑战.药物诱导的自身免疫性肝病靶细胞多为肝细胞,故多表现为自身免疫性肝炎.

关键词：自身免疫性肝炎药物性肝损害自身免疫性肝病原发性胆汁性肝硬化原发性硬化性胆管炎自身免疫性胆管炎发病机制炎症性肝病

全自动分割的CT动脉期影像组学分值与胰腺癌新辅助治疗疗效的关系

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中华胰腺病杂志 2024年第3期24卷 190-197页

作者：朱蒙蒙边云陈成伟周健李娜郭逸飞李颖袁小涵俞婕妤陆建平海军军医大学第一附属医院放射诊断科上海200433

目的探讨CT动脉期影像组学分值与胰腺癌新辅助治疗疗效的相关性。方法回顾性分析2017年3月至2023年3月间海军军医大学第一附属医院243例新辅助治疗后进行手术治疗的胰腺癌患者的临床资料。根据病理肿瘤退缩分级,将患者分为治疗有效组(TR... 详细信息

目的探讨CT动脉期影像组学分值与胰腺癌新辅助治疗疗效的相关性。方法回顾性分析2017年3月至2023年3月间海军军医大学第一附属医院243例新辅助治疗后进行手术治疗的胰腺癌患者的临床资料。根据病理肿瘤退缩分级,将患者分为治疗有效组(TRG 0、1级,30例)和治疗无效组(TRG 2、3级,213例),比较两组的临床、影像学和病理学特征。使用全自动分割工具对治疗前后胰腺肿瘤动脉期横断面CT图像进行分割,利用Python程序包提取组学特征,采用最小绝对收缩和选择算子(Lasso)进行特征选择,利用Lasso公式得到动脉期影像组学分值。采用单因素和多因素logistic回归分析动脉期影像组学分值和新辅助治疗疗效之间的相关性。绘制受试者工作特征曲线(ROC),计算曲线下面积(AUC)和灵敏度、特异度、准确率。采用决策曲线分析(DCA)评估动脉期影像组学分值对胰腺癌新辅助治疗疗效的临床应用价值。结果共获得330个动脉期组学影像学特征,经Lasso回归降维后得到9个与新辅助治疗疗效相关的组学特征。单因素分析结果显示,动脉期影像组学分值、新辅助治疗后肿瘤三维直径、胰腺轮廓异常、肿瘤T分期、N分期、胰周神经侵犯、脉管内癌栓浸润、十二指肠侵犯均与新辅助治疗疗效相关(P值均0.2时,使用动脉期影像组学分值诊断新辅助治疗疗效比不使用更能使患者在临床中获益。结论CT动脉期影像组学分值与胰腺癌新辅助治疗疗效显著相关,可以准确预测胰腺癌患者新辅助治疗疗效。

关键词：胰腺肿瘤肿瘤辅助疗法肿瘤退缩分级影像组学体层摄影术,X线计算机

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药物诱导的自身免疫性肝损伤

胃肠病学 2009年第4期14卷 221-224页

作者：陈成伟南京军区上海肝病研究中心 200235

药物引起的免疫介导性肝损伤一般为特异质性，相对较少，但往往较为严重。一些药物性肝损伤（DIU）患者具有自身免疫性肝炎的临床特征。药物在肝内代谢过程中产生的反应性中间代谢物在免疫介导的DILI发病过程中发挥重要作用。

关键词：肝炎慢性药物性肝炎自身免疫性自身抗体

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药物性肝损伤的研究进展及我国存在的问题

临床肝胆病杂志 2018年第6期34卷 1147-1151页

作者：陈成伟上海南京军区临床肝病研究中心上海200035

目前,药物性肝损伤(DILI)已成为临床最常见急性肝损伤的原因。从DILI的发病机制、新的生物标志物、肝脏对药物毒性的耐受、适应与易感性、ALT诊断阈值等方面进行了阐述,提醒应了解诊断量表发展史,以统一标准和认识,要重视草药和膳食补... 详细信息

目前,药物性肝损伤(DILI)已成为临床最常见急性肝损伤的原因。从DILI的发病机制、新的生物标志物、肝脏对药物毒性的耐受、适应与易感性、ALT诊断阈值等方面进行了阐述,提醒应了解诊断量表发展史,以统一标准和认识,要重视草药和膳食补充剂引起的DILI,并深入研究其导致DILI的发病机制,从而预防或减少DILI的发生。我国DILI研究存在的问题和差距是明显的,基础研究相当匮乏,在临床方面也有很多空白,因此,我们要努力跟上国际研究的步伐,使药物更好地为人类服务。

关键词：药物性肝损伤述评

3-year Treatment of Tenofovir Alafenamide *** Disoproxil Fumarate for Chronic HBV Infection in China

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 324-334页

作者： Jinlin Hou Qin Ning Zhongping Duan You chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong cheng Gregory Camus chengwei chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators Nanfang Hospital of Southern Medical University GuangzhouGuangdongChina Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina Shanghai Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing 302 Hospital BeijingChina The First Affiliated Hospital of Nanchang University NanchangJiangxiChina Shanghai Public Health Clinical Center ShanghaiChina West China Hospital Sichuan UniversityChengduSichuanChina The First Affiliated Hospital with Nanjing Medical University NanjingJiangsuChina Hainan General Hospital HaikouHainanChina Nanjing No.2 Hospital NanjingJiangsuChina The 2nd Xiangya Hospital Central South UniversityChangshaHunanChina Gilead Sciences Foster CityCAUSA Liver Disease Center of Naval 905 Hospital ShanghaiChina Xiangya Hospital Central South UniversityChangshaHunanChina Beijing Friendship Hospital Capital UniversityBeijingChina The Sixth People’s Hospital of Shenyang ShenyangLiaoningChina 不详

Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of *** report 3-year results from two phase 3 studies with TAF in China(***:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled ***:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between *** overall mean age was 38 years and 73%were *** mean HBV DNA was 6.4 log10 IU/*** median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral *** week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%*** at 79%,and TAF at 93%*** at 92%for the HBeAg-positive and-negative patients,*** each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were *** was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density *** at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years.

关键词： Chronic hepatitis B virus Antiviral therapy Bone safety Renal safety