检索结果-南通市图书馆

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping Sun Yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie hu Nong Yang Xiangdong Zhou XiaohongWu chengping hu Zhihong Zhang You Lu Yanping hu Liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan Li Chunhong hu Wancheng Tong Helong Zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen Zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于SVM的台区线损异常数据治理方法

黑龙江电力 2024年第1期46卷 77-80页

作者：胡程平陆鑫陈婧胡剑地国网浙江省电力有限公司嘉兴供电公司浙江嘉兴314001 国网信通亿力科技有限责任公司福州350003

为降低台区异常数据造成的供电服务中线损率较高问题,引进支持向量机(support vector machine,SVM)技术,设计台区线损异常数据治理方法。使用传感器等相关设备,采集台区电力设备运行反馈数据;设定台区线损异常数据的聚类中心,辨识并聚... 详细信息

为降低台区异常数据造成的供电服务中线损率较高问题,引进支持向量机(support vector machine,SVM)技术,设计台区线损异常数据治理方法。使用传感器等相关设备,采集台区电力设备运行反馈数据;设定台区线损异常数据的聚类中心,辨识并聚类台区线损异常数据;应用VisuShrink技术,确定数据处理的阈值门限,使用小波阈值法,参照小波系数,重构异常信号,消除信号的背景噪声;引进SVM,设定训练样本集合,采用SVM中的机器学习算法,建立回归函数,辅助SVM的POS参数优化条件,控制空间粒子的粒距,通过对空间异常数据的重构,实现对台区线损异常数据的治理。以某地区大型电力企业为例,设计对比试验。试验结果表明,设计的治理方法在实际应用效果良好,实现将台区线损率稳定在5%以下。

关键词： SVM 数据重构数据治理异常数据线损率去噪处理

听觉词汇学习测验对于轻度认知障碍转归的预测价值研究

在线全文

学校读者我要写书评

暂无评论

同济大学学报（医学版） 2024年第3期45卷 354-358页

作者：秦虹云赵欣欣张雷王强胡承平同济大学附属精神卫生中心上海200124 同济大学医学院上海200072

目的研究听觉词汇学习测验(auditory vocabulary learning test,AVLT)对轻度认知障碍(mild cognitive impairment,MCI)进展为痴呆的预测能力。方法对257例MCI患者进行纵向随访,然后根据临床结果将其分为痴呆进展组和非痴呆进展组。比较... 详细信息

目的研究听觉词汇学习测验(auditory vocabulary learning test,AVLT)对轻度认知障碍(mild cognitive impairment,MCI)进展为痴呆的预测能力。方法对257例MCI患者进行纵向随访,然后根据临床结果将其分为痴呆进展组和非痴呆进展组。比较这些组的基线人口统计学信息和AVLT评分。构建受试者工作特征(receiver operating characteristic,ROC)曲线以评估AVLT评分对MCI转归的区分值。结果在6年后的随访中,有45例受试者进展为痴呆,归为痴呆进展组(MCI progression,MCIp),3例受试者恢复正常认知,209例受试者维持MCI,一同归为非痴呆进展组(MCI non-progression,MCInp)。在基线时,MCIp组的AVLT评分明显低于MCInp,差异有统计学意义(P<0.05)。ROC曲线分析显示,AVLT延迟回忆(delayed recall,AVLT-DR)在区分MCI患者进展为痴呆方面有最大的曲线下面积(largest area under the curve,AUC),是重要预测指标。结论AVLT,尤其是AVLT-DR评分较低能较好预测MCI进展为痴呆,但由于其特异度偏低,需要联合其他特异度高的量表综合使用来运用于临床工作。

关键词：听觉词汇学习测验轻度认知障碍社区调查进展为痴呆

Bronchial Fistula: Rare Complication of Treatment with Anlotinib

在线全文

学校读者我要写书评

暂无评论

中国肺癌杂志 2020年第10期23卷 858-865页

作者： Pengbo DENG chengping hu Yuanyuan LI Liming CAO huaping YANG Min LI Jian AN Juan JIANG Qihua GU Department of Respiratory Medicine Xiangya Lung Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China

Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula(BF) during the treatment of lung cancer patients and summarize the possible *** We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and Pub Med for medical literature published between 2018 and 2020 using the following search terms: "anlotinib," "lung cancer," and "fistula."Results Our literature search produced two case reports(three patients) which, in addition to our three patients. We collated the patients’ clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus(DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophagotracheobronchial fistula. Six patients all died within 6 *** Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients.

关键词： lung cancer fistula

Low-intensity aerobic exercise training attenuates airway inflammation and remodeling in a rat model of steroid-resistant asthma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第17期127卷 3058-3064页

作者： Qin Qingwu Chen Xi Feng Juntao Qin Ling hu chengping Department of Respiratory Medicine Xiangya Hospital Central South University National Clincial Research Center for Respirator3[ Disease Changsha Hunan 410008 China Bronchial Asthma Research Center of hunan Province Changsha Hunan 410008 China

Background Aerobic exercise can improve symptoms,reduce airway inflammation,and even ameliorate airway remodeling in asthmatic animals and ***,previous studies have focused mainly on the effect of aerobic exercise on steroid-sensitive asthma （SSA）.The goals of this study were to determine the effect of low-intensity aerobic exercise training on airway hyperresponsiveness,inflammation,and remodeling in a rat model of steroid-resistant asthma （SRA） and to identify the potential mechanisms underlying these *** Endotoxin-free ovalbumin with or without lipopolysaccharide were applied to establish rat models of SRA and SSA,*** hyperresponsiveness,inflammation,remodeling,expression of interleukin （IL）-25,IL-33,thymic stromal lymphopoietin （TSLP）,high mobility group box-1 （HMGB1）,and IL-17 in bronchoalveolar lavage fluid （BALF）,and the role of dexamethasone （DXM） were compared between these two asthmatic rat *** effect of low-intensity aerobic exercise training and anti-HMGB1 treatment on airway hyperresponsiveness,inflammation,and remodeling in SRA rats also was *** SRA rats developed neutrophil-dominated airway inflammation （（29.5±4.1）％ of the total cell numbers in BALF）,whereas SSA rats developed eosinophil-dominated airway inflammation （（24.0±6.1）％ of the total cell numbers in BALF）.Compared with SSA rats,SRA rats had more severe airway hyperresponsiveness,lower levels of IL-25 （（33.6±10.3） vs.（104.8±24.9） pg/ml）,IL-33 （（87.5±25.0） vs.（226.6±40.7） pg/ml）,and TSLP （（1 933.2±899.5） vs.（7 224.0±992.1） pg/ml）,and higher levels of HMGB1 （（21.2±4.5） vs.（5.4±1.6） ng/ml） and IL-17 （（780.5±261.7） vs.（291.4±76.4） pg/ml） in BALF （all P ＜0.05）.However,there was no significant difference in goblet cell hyperplasia,subepithelial collagen thickness,and airway smooth muscle remodeling between the two *** with control SSA rats,airway hyperresponsiveness,inflammation,and remodeling in SRA rats were less sensitive t

关键词： aerobic exercise inflammation airway remodeling steroid-resistant asthma high mobility group box-1

Theanine improves the function of dendritic cells via the downregulation of cyclooxygenase-2 expression

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第8期127卷 1545-1549页

作者： Lei Mingsheng Zuo Jianhong Li Min Gu Qihua hu chengping Department of Respiratory and Critical Care Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Respiratory and Critical Care Medicine Zhangiiajie City Hospital Zhangjiajie Hunan 427000 China Medical School University of South China Hengyang Hunan 421001 China

Background Tumor cells can reduce the number of dendritic cells （DCs） in the tumor environment and cause DC dysfunction through autocrine or paracdne pathways. We sought to measure cyclooxygenase-2 （COX-2） expression in bombesin-inhibited DCs treated with theanine in vitro and to explore the protection and activation effects of theanine on DCs. Methods Enzyme-linked immunosorbent assay （ELISA）, reverse transcription-polymerase chain reaction （RT-PCR）, and Western blotting were used to analyze the effects of theanine on COX-2 expression and interleukin （IL）-12/IL-10 secretion of bombesin-treated DCs. Results DCs acquired an impaired phenotype as a result of bombesin treatment. Theanine increased the expression of mature DC surface molecules. The number of cell apoptosis with the treatment of bombesin and theanine significantly decreased, accounting for 15.9%, compared with 26.1% of cell apoptosis with bombesin. COX-2 expression in bombesin- treated DCs was inhibited by theanine in a dose-dependent manner. Theanine promoted DC secretion of IL-12. IL-12 levels reached （137.4_＋4.9） pg/ml with theanine at 200 pmol/L. However, theanine inhibited the secretion of IL-10 in a dose-dependent manner. IL-10 levels were only （58.4_＋6.9） pg/ml with theanine at 200 IJmol/L. Conclusion Theanine inhibits the transcription and translation of COX-2 and regulates the balance of IL-10/IL-12 secretion in bombesin-inhibited DCs, leadincl to the recovery of a state of activation in DCs.

关键词： theanine dendritic cells bombesin cyclooxygenase-2

Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2019年第3期16卷 556-564页

作者： Xingsheng hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai huang Qian Chu chengping hu Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing100021China Department of Pulmonary Medicine Second Affiliated Hospital of Fujian Medical UniversityQuanzhou362100China Department of Respiratory Medicine West China HospitalSichuan UniversityChengdu610041China Department ofRespiratory Medicine Daping HospitalChongqing400042China Department of Respiratory Medicine Xinqiao HospitalArmy Medical UniversityChongqing400037China Department of Medical Oncology Tianjin Medical University CancerInstitute and HospitalNational Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Tianjin300060China Department of Thoracic Oncology TianjinMedical University General HospitalTianjin300052China Department of Medical Oncology Hunan Cancer HospitalChangsha410006China Department of Pathology Xiangya HospitalCentral South UniversityChangsha410008China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangsha410008China Burning RockBiotech Guangzhou510300China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhongUniversity of Science and TechnologyWuhan430022China

Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach *** evidence suggests inherited genetic susceptibility to lung *** present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) ***: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 ***: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline ***: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC *** suggested a lack of association between germline BRCA status and treatment outcome of *** addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC.

关键词： Germline BRCA mutations non-small cell lung cancer prevalence BRCA1 BRCA2

Fluorofenidone Attenuates Bleomycin-Induced Pulmonary Inflamation and Fibrosis in Mice via Restoring Caveolin-1 Expression and Inhibiting MAPK Signaling Pathway

在线全文

学校读者我要写书评

暂无评论

Fluorofenidone Attenuates Bleomycin-Induced Pulmonary Inflam...

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Jie Meng Yeqiang Zou chengping hu Department of Pulmonary Medicine Xiangya Hospital

Idiopathic pulmonary fibrosis(IPF) is a progressive, life-threatening,interstitial lung disease with no effective *** this study,we evaluated the effects of fluorofenidone(FD),a novel pyridone agent,on a murine model of bleomycin(BLM)-induced pulmonary inflammation and *** for Cancer Research (ICR) mice were intravenously injected with BLM or saline(SA) for 14 consecutive ***,pirfenidone (PD)(500 mg·kg·day,respectively) or vehicle was administered by gastrogavage one day before

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

脑转移肿瘤细胞及其微环境

中国肺癌杂志 2016年第9期19卷 626-635页

作者：钟文胡成平中南大学湘雅医院呼吸内科长沙410008

近年来,随着早期诊断的方法的出现及精准治疗的应用,肺癌患者的生存及生活质量都得到很大改善。然而,对于肺癌的脑转移病灶,目前仍缺乏一个理想的治疗方案,严重影响了该部分患者生存状态。了解肿瘤细胞如何在中枢神经系统定植、生长和... 详细信息

近年来,随着早期诊断的方法的出现及精准治疗的应用,肺癌患者的生存及生活质量都得到很大改善。然而,对于肺癌的脑转移病灶,目前仍缺乏一个理想的治疗方案,严重影响了该部分患者生存状态。了解肿瘤细胞如何在中枢神经系统定植、生长和侵袭等相关生物学行为及其产生机制对预防及治疗肿瘤细胞脑转移病灶具有重大的意义。"种子-土壤"这一假说可以很好的解释这一过程,这一假说的关键即肿瘤细胞可与中枢神经系统微环境各组成之间产生相互适应性变化,正是这种相互作用决定了脑转移病灶的发生发展。本文就脑转移肿瘤细胞、脑转移肿瘤微环境及他们之间的相互作用进行综述,旨在为脑转移病灶的治疗提供新的思路。

关键词：肿瘤脑转移肿瘤微环境星形胶质细胞少突胶质细胞血脑屏障血管形成