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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： Di wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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Optical Microsphere Nano-Imaging:Progress and Challenges

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Engineering 2024年第5期36卷 102-123页

作者： Guangxing wu Minghui Hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale *** the past decade,the optical microsphere nanoimaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about k6k8 in a real-time and label-free manner,making it highly competitive among numerous super-resolution imaging *** this review,we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement:first,to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level;second,to compose the microsphere compound lens;and third,to engineer the geometry or ingredients of *** also analyze challenges yet to be overcome in optical microsphere nano-imaging,followed by an outlook of this technique.

关键词： Microsphere Nano-imaging Virtual imaging Microsphere compound lens Engineered microsphere

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Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin wu Yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

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Dual-ion carrier storage through Mg^(2+) addition for high-energy and long-life zinc-ion hybrid capacitor

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 179-185页

作者： Junjie Zhang Xiang wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under ***,we modulate the electrolyte and achieve dual-ion storage by adding magnesium *** we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic *** zinc-ion capacitor with Mg^(2+)mixed solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 *** is superior to the other assembled zinc-ion devices in single-component *** finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.

关键词： zinc-ion hybrid capacitor MgSO_(4) electrolyte rate performance storage mechanism

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Partially-Observed Maximum Principle for Backward Stochastic Differential Delay Equations

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1524-1526页

作者： Shuang wu Department of Applied Mathematics China University of PetroleumQingdao 266580China

Dear Editor,This letter investigates a partially-observed optimal control problem for backward stochastic differential delay equations(BSDDEs).By utilizing Girsanov’s theory and convex variational method,we obtain a maximum principle on the assumption that the state equation contains time delay and the control domain is *** adjoint processes can be represented as the solutions of certain time-advanced stochastic differential equations in finite-dimensional *** backward stochastic differential equation(BSDE)was first introduced by Bismut in[1],while general BSDE was given by Pardoux and Peng[2].Since then,the theory of BSDEs developed *** corresponding optimal control problems,whose states are driven by BSDEs,have also been widely studied by some authors,see[3]-[5].

关键词： stochastic backward convex

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柴油淹没射流特性的试验

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内燃机学报 2018年第6期36卷 512-517页

作者：仇滔陈新宇刘雨薇吴成林高壮郭鹏北京工业大学环境与能源工程学院北京100124 北京电动车辆协同创新中心北京100081 中国矿业大学(北京)机电与信息工程学院北京100083

高压共轨喷油器控制腔为燃油淹没射流,由于压差变化大,该淹没射流常伴随空化.笔者设计了一套柴油圆管喷孔淹没射流装置,研究了不同进/出口压力改变后的射流规律.试验过程中,采用内窥镜拍摄到圆管出口的空化过程,并且对挡板上的射流冲击... 详细信息

高压共轨喷油器控制腔为燃油淹没射流,由于压差变化大,该淹没射流常伴随空化.笔者设计了一套柴油圆管喷孔淹没射流装置,研究了不同进/出口压力改变后的射流规律.试验过程中,采用内窥镜拍摄到圆管出口的空化过程,并且对挡板上的射流冲击力进行测量.结果表明:随出口压力的降低,空化首先在圆管内发生,并向出口延伸,根据空化是否发展到喷孔出口可将淹没射流分为两个阶段:第一阶段,空化没有发展到喷孔出口,随着出口压力的降低,射流冲击力不断增加,最大冲击力出现在空化达到喷孔出口截面时;第二阶段,空化离开喷孔出口并进入背景流体,随出口压力降低,淹没射流冲击力减小,并最终趋于稳定;随着入口压力的提高,淹没射流冲击力的最大值以及进/出口最大压差下的稳定冲击力均先增大之后保持不变.

关键词：淹没射流冲击力空化

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普惠金融发展对农村家庭创业的影响研究——基于CFPS2018数据

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长江大学学报（社会科学版） 2022年第6期45卷 96-104页

作者：徐辉吴程琳长江大学湖北农村发展研究中心湖北荆州434023 长江大学经济与管理学院湖北荆州434023

利用2018年中国家庭追踪调查(CFPS)数据库,通过构建普惠金融发展水平指数,建立Probit模型系统分析普惠金融发展对农村家庭创业的影响。研究发现:普惠金融发展促进了农村家庭创业,两者关系具有一定稳健性;普惠金融发展对存在信贷约束的... 详细信息

利用2018年中国家庭追踪调查(CFPS)数据库,通过构建普惠金融发展水平指数,建立Probit模型系统分析普惠金融发展对农村家庭创业的影响。研究发现:普惠金融发展促进了农村家庭创业,两者关系具有一定稳健性;普惠金融发展对存在信贷约束的农村家庭促进效果更显著;保险覆盖率的提高对风险厌恶型农村家庭选择创业的促进作用更明显;电子支付使用度的提高对低学历农村家庭创业行为的促进效果更明显;正规融资在普惠金融发展与农村家庭创业间起中介作用。因此,政府应重视农村地区普惠金融发展,完善农村保险保障体系,提高农村家庭综合素质和正规金融质量,进一步激发农村创业活力,助力乡村振兴。

关键词：普惠金融农村家庭创业信贷约束

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Recent advances and key perspectives of in-situ studies for oxygen evolution reaction in water electrolysis

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Green Energy & Environment 2024年第10期9卷 1497-1517页

作者： Yi Wang Zichen Xu Xianhong wu Zhong-Shuai wu State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Shijingshan District Dalian National Laboratory for Clean Energy Chinese Academy of Sciences

Electricity-driven water splitting to produce hydrogen is one of the most efficient ways to alleviate energy crisis and environmental pollution problems, in which the anodic oxygen evolution reaction(OER) is the key half-reaction of performance-limiting in water splitting. Given the complicated reaction process and surface reconstruction of the involved catalysts under actual working conditions, unraveling the real active sites, probing multiple reaction intermediates and clarifying catalytic pathways through in-situ characterization techniques and theoretical calculations are essential. In this review, we summarize the recent advancements in understanding the catalytic process, unlocking the water oxidation active phase and elucidating catalytic mechanism of water oxidation by various in-situ characterization techniques. Firstly, we introduce conventionally proposed traditional catalytic mechanisms and novel evolutionary mechanisms of OER, and highlight the significance of optimal catalytic pathways and intrinsic stability. Next, we provide a comprehensive overview of the fundamental working principles,different detection modes, applicable scenarios, and limitations associated with the in-situ characterization techniques. Further, we exemplified the in-situ studies and discussed phase transition detection, visualization of speciation evolution, electronic structure tracking, observation of reaction active intermediates, and monitoring of catalytic products, as well as establishing catalytic structure–activity relationships and catalytic mechanism. Finally, the key challenges and future perspectives for demystifying the water oxidation process are briefly proposed.

关键词： In-situ studies Water splitting Oxygen evolution reaction Catalytic mechanism

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Enhancing performance of low-temperature processed CsPbI2Br all-inorganic perovskite solar cells using polyethylene oxide-modified TiO_(2)

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 786-794页

作者： Xu Zhao Naitao Gao Shengcheng wu Shaozhen Li Sujuan wu School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute for Advanced Materials and Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China

CsPbX_(3)-based(X=I,Br,Cl)inorganic perovskite solar cells(PSCs)prepared by low-temperature process have attracted much attention because of their low cost and excellent thermal ***,the high trap state density and serious charge recombination between low-temperature processed TiO_(2)film and inorganic perovskite layer interface seriously restrict the performance of all-inorganic *** a thin polyethylene oxide(PEO)layer is employed to modify TiO_(2)film to passivate traps and promote carrier *** impacts of PEO layer on microstructure and photoelectric characteristics of TiO_(2)film and related devices are systematically *** results suggest that PEO modification can reduce the surface roughness of TiO_(2)film,decrease its average surface potential,and passivate trap *** optimal conditions,the champion efficiency of CsPbI_(2)Br PSCs with PEO-modified TiO_(2)(PEO-PSCs)has been improved to 11.24%from 9.03%of reference ***,the hysteresis behavior and charge recombination have been suppressed in PEO-PSCs.

关键词： polyethylene oxide-modified TiO_(2) film low-temperature process CsPbI_(2)Br-based all-inorganic perovskite solar cells photo-voltaic performance

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用于高(焦)炉煤气风机的非接触螺旋槽干气密封的设计与分析

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机械工程学报 2005年第9期41卷 194-197页

作者：徐万福刘雨川李福春吴成林沈阳理工大学万得孚工业公司沈阳110016 美国西北大学艾凡斯顿60208 四平鼓风机厂技术中心四平136001 攀枝花钢铁(集团)公司动力分厂攀枝花617062

论述了高(焦)炉煤气离心风机的转轴密封正被干运行非接触气体密封所取代的技术趋势。针对干式布袋除尘反吹煤气风机转速低、压力波动频繁的难点,设计了非接触螺旋槽干气密封,包括高刚度目标的螺旋槽型优化、干气密封零压力开启转速和角... 详细信息

论述了高(焦)炉煤气离心风机的转轴密封正被干运行非接触气体密封所取代的技术趋势。针对干式布袋除尘反吹煤气风机转速低、压力波动频繁的难点,设计了非接触螺旋槽干气密封,包括高刚度目标的螺旋槽型优化、干气密封零压力开启转速和角向动态失稳界限频率的分析、关键零件功能结构的选取以及干气密封支持系统的确定等。按照美国石油协会(API)617的规定及沈阳万得孚工业公司的标准对所设计的干气密封进行了性能检验和试验,并经历了工业现场令人满意的运行。

关键词：干运行非接触气体密封螺旋槽干气密封高(焦)炉煤气离心风机

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