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Differentiated super-enhancers in lung cancer cells

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Science China(Life Sciences) 2019年第9期62卷 1218-1228页

作者： Xin Li chengjun lu Qijue lu Chunguang Li Ji Zhu Tiejun Zhao Hezhong Chen Hai Jin Department of Cardiothoracic Surgery Changhai Hospital Second Military Medical University

Super-enhancers(SEs) are regulatory elements with enriched accumulation of key transcription *** studies were done investigating SEs in lung *** we analyzed epigenetic profiling data to identify SEs in lung cancer cell *** were classified as SEs and typical enhancers(TEs).Most of the TEs were overlapped between normal cell and cancer cells.A great portion of SEs were differentiated comparing these *** of GO terms associated with SEs revealed SE remodeling(lost on some sites while gain on others) between normal and lung cancer *** comparing the average number of SEs in each GO term in cancer cells with the number in control cells,surprisingly,no GO terms with significantly increased SE number in cancer condition were *** the contrary,in aspects such as "cell-cell adhesion","receptor activity" and"negative regulation of canonical Wnt signaling pathway",the related SEs were significantly reduced in cancer *** findings suggest that in lung cancer,cells may not gain decisive gene expression in the related aspect,instead,they may have lost control of the fateful *** together,our work with the usability of omics data identified SEs in lung cancer cells and further showed cancer-specific features of SE-related terms.

关键词： super-enhancer lung cancer genomics

一次性输尿管软镜与可重复使用输尿管软镜治疗上尿路结石有效性及安全性的Meta分析

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临床医学研究与实践 2024年第22期9卷 5-8页

作者：单保华何进张芳琼陈绪林鲁成军湖北省秭归县人民医院/湖北三峡职业技术学院第二附属医院湖北宜昌443600

目的评价一次性输尿管软镜(su-FURS)与可重复使用输尿管软镜(ru-FURS)治疗上尿路结石时的有效性及安全性。方法通过计算机检索PubMed、Embase、Cochrane Library、万方、维普和中国知网等数据库,检索时间均为建库至2023年8月13日,收集采... 详细信息

目的评价一次性输尿管软镜(su-FURS)与可重复使用输尿管软镜(ru-FURS)治疗上尿路结石时的有效性及安全性。方法通过计算机检索PubMed、Embase、Cochrane Library、万方、维普和中国知网等数据库,检索时间均为建库至2023年8月13日,收集采用su-FURS和ru-FURS治疗上尿路结石的随机对照试验(RCT)。应用Stata15.0软件对纳入的文献进行荟萃分析。结果共纳入8篇文献,累计1338例患者。Meta分析结果显示,su-FURS与ru-FURS治疗上尿路结石的结石清除率、手术时间、住院时间、术后血红蛋白下降值、并发症发生率比较,差异无统计学意义(P>0.05)。结论在治疗上尿路结石时,su-FURS与ru-FURS的有效性和安全性无明显差异,但采用su-FURS治疗的性价较高,值得推广应用。

关键词：一次性输尿管软镜可重复使用输尿管软镜上尿路结石随机对照试验 Meta分析

Evaluation of growth characteristics of Aspergillus parasiticus inoculated in different culture media by shortwave infrared(SWIR) hyperspectral imaging

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 69-83页

作者： Xuan Chu Wei Wang Xinzhi Ni Haitao Zheng Xin Zhao Hong Zhuang Kurt C.Lawrence Chunyang Li Yufeng Li chengjun lu College of Engineering China Agricultural University Beijing 100083P.R.China College of Mechanical and Electrical Engineering Zhongkai University of Agriculture Engineering Guangzhou 510225 P.R.China Crop Genetics and Breeding Research Unit USDA-ARS 2747 Davis RoadTiftonGA 31793USA College of Food Science&Nutritional Engineering China Agricultural University Beijing 100083PR.China Quality&Safety Assessment Research Unit U.S.National Poultry Research Center USDA-ARS 950 College Station Rd.AthensGA 30605USA Quality&Safety Assessment Research Unit USDA-ARS AthensGA 30605USA Institute of Food Science and Technology Jiangsu Academy of Agricultural Sciences Nanjing 210014 P.R.China Multidisciplinary Initiative Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 P.R.China Lingang Experimental Middle School Linyi 276624 P.R.China

The growth characteristics of Aspergillus parasitic us incubated on two culture media were ex-amined using shortwave infrared(SWIR,1000-2500 nm)hyperspectral imaging(HSI)in this *** images of the *** colonies growing on rose bengal medium(RBM)and maize agar medium(MAM)were recorded daily for 6 *** growth phases of *** were indicated through the pixel number and average spectra of *** score plot of the first principal component(PC1)and PC2,four growth zones with varying mycelium densities were *** characteristic wavelengths(1095,1145,1195,1279,1442,1655,1834 and 1929 nm)were selected from PC1 loading,average spectra of each colony as well as each growth zone.F urthermore,support vector machine(S VM)classifier based on the eight wavelengths was built,and the classification accuracies for the four zones(from outer to inner zones)on the colonies on RBM were 99.77%,9935%,99.75%and 99.60%and 99.77%,9939%,99.31%and 98.22%for colonies on *** addition,a new score plot of PC2 and PC3 was used to differ-entiate the colonies incubated on RBM and MAM for 6 *** characteristic wavelengths of 1067,1195,1279,1369,1459,1694,1834 and 1929 nm were selected from the loading of PC2 and *** on them,a new SVM model was developed to diferentiate colonies on RBM and MAM with accuracy of 100.00%and 9999%,*** conclusion,SWIR hyperspectral image is a powerful tool for evaluation of growth characteristics of *** incubated in diferent culture media.

关键词： Aspergilus parasiticus growth characteristics characteristic wavelengths shortwave infrared(SWIR)hyperspectral imaging

输尿管软镜碎石术后患者发生并发症的影响因素分析

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临床医学研究与实践 2024年第26期9卷 17-20页

作者：单保华向丹何进孙薇胡晓莉张芳琼陈绪林鲁成军湖北省秭归县人民医院/湖北三峡职业技术学院第二附属医院湖北宜昌443600

目的分析输尿管软镜碎石术(FURL)后患者发生并发症的影响因素。方法回顾性分析接受FURL治疗的278例肾结石患者的临床资料,依据术后是否发生并发症分为并发症组和非并发症组。采用多因素Logistic回归分析探讨FURL术后患者发生并发症的影... 详细信息

目的分析输尿管软镜碎石术(FURL)后患者发生并发症的影响因素。方法回顾性分析接受FURL治疗的278例肾结石患者的临床资料,依据术后是否发生并发症分为并发症组和非并发症组。采用多因素Logistic回归分析探讨FURL术后患者发生并发症的影响因素。结果FURL术后,51例发生并发症,227例未发生并发症。单因素分析结果显示,两组的糖尿病、输尿管狭窄、结石直径、术前尿培养、手术时间比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,糖尿病、输尿管狭窄、结石直径、术前尿培养、手术时间是FURL术后发生并发症的影响因素(P<0.05)。结论糖尿病、输尿管狭窄、结石直径≥2 cm、术前尿培养阳性、手术时间≥90 min是导致FURL术后发生并发症的影响因素,临床医师应高度重视以上影响因素,并采取合理的预防措施以减少术后并发症。

关键词：输尿管软镜碎石术肾结石并发症

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缓存机制及其在数据存取层中的应用模型研究

计算机应用与软件 2008年第12期25卷 172-174,201页

作者：卢成均重庆文理学院应用技术学院重庆402160

数据库应用领域中的缓存技术是将频繁访问的数据对象按照一定规则存入内存,从而有效提高整个系统的响应速度,它是增强并发承载能力的重要措施之一。为研究缓存技术对应用系统性能的影响,按照多层模式的架构理念,充分利用.NET中最新的缓... 详细信息

数据库应用领域中的缓存技术是将频繁访问的数据对象按照一定规则存入内存,从而有效提高整个系统的响应速度,它是增强并发承载能力的重要措施之一。为研究缓存技术对应用系统性能的影响,按照多层模式的架构理念,充分利用.NET中最新的缓存机制,设计实现了数据缓存机制组件化模型;实例化该模型实时产生缓存命中情况日志,并定期或不定期产生命中情况统计表,以此作为修改配置文件的主要依据,实现缓存策略的实时修改,使之最终趋于合理有效。应用结果表明,该设计应用思想,是一套科学合理的缓存可控机制与方法论,是提高运行性能的有效手段之一,具有良好的经济性与可操作性。

关键词：信息检索 Cache策略组件化模型 XML信息交换多层模式系统设计

Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

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Bone Research 2024年第2期12卷 314-333页

作者： chengjun Li Tian Qin Jinyun Zhao Yuxin Jin Yiming Qin Rundong He Tianding Wu Chunyue Duan Liyuan Jiang Feifei Yuan Hongbin lu Yong Cao Jianzhong Hu Department of Sports Medicine Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceXiangya Road 87Changsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Department of Spine Surgery and Orthopaedics Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China

Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory *** extensive investigations into vascular senescence associated with aging and degenerative diseases,the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress,particularly its involvement in senescence-induced inflammation,remain insufficiently *** this study,we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury(SCI).Lysine demethylase 6A(Kdm6a),commonly known as UTX,emerges as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells(SCMECs).Upregulation of UTX induces senescence in SCMECs,leading to an amplified release of proinflammatory factors,specifically the senescenceassociated secretory phenotype(SASP)components,thereby modulating the inflammatory ***,the deletion of UTX in endothelial cells shields SCMECs against senescence,mitigates the release of proinflammatory SASP factors,and promotes neurological functional recovery after *** forms an epigenetic regulatory axis by binding to calponin 1(CNN1),orchestrating trauma-induced SCMECs senescence and SASP secretion,thereby influencing neuroinflammation and neurological functional ***,local delivery of a senolytic drug reduces senescent SCMECs and suppresses proinflammatory SASP secretion,reinstating a local regenerative microenvironment and enhancing functional repair after *** conclusion,targeting the UTX-CNN1 epigenetic axis to prevent trauma-induced SCMECs senescence holds the potential to inhibit SASP secretion,alleviate neuroinflammation,and provide a novel treatment strategy for SCI repair.

关键词： inflammation epigenetic neurological

Recent advancements in the diagnosis and treatment of acral melanoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 106-122页

作者： Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI chengjun YAO Vishnu Goutham KOTA Mohamed Hasan Abdulla Hasan ABDULLA Hui lu Department of Orthopedics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Orthopaedics Third Xiangya HospitalCentral South UniversityChangsha410013China Zhejiang University School of Medicine Hangzhou310058China Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare Zhejiang UniversityHangzhou310058China

Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late *** of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood *** surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the *** checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for *** this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关键词： Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma Dermoscopy Oncolytic virotherapy

弯曲阵面机载共形阵列雷达方向图与杂波相关性研究

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电子与信息学报 2021年第3期43卷 572-579页

作者：张涛宋婷李晓明路成军中国航空工业集团公司雷华电子技术研究所无锡214063

针对载体弯曲效应对机载共形阵列雷达方向图和杂波特性的影响,该文在正侧视条件下评估均匀圆环阵方向图性能,分析不同位置阵元对弯曲阵面方向图合成效率的影响,发现边缘阵子不仅对共形阵列方向图主瓣增益贡献较小,反而更易引起旁瓣抬升... 详细信息

针对载体弯曲效应对机载共形阵列雷达方向图和杂波特性的影响,该文在正侧视条件下评估均匀圆环阵方向图性能,分析不同位置阵元对弯曲阵面方向图合成效率的影响,发现边缘阵子不仅对共形阵列方向图主瓣增益贡献较小,反而更易引起旁瓣抬升等挑战,降低共形阵的孔径利用效率。另一方面,通过严格的理论推导完成共形阵列雷达方向图特性与杂波扩展效应内在物理联系的分析,发现弯曲阵面引起的方向图非理想畸变是共形阵杂波非均匀扩展的核心影响因素。在此基础上,进一步分析共形雷达单个贴片微带阵元加工和安装结构组件将增大阵元物理尺寸,使得共形阵列雷达相邻阵元间距大于半波长,当阵元间隔增大到一定程度时,在方向图远区会形成较高的栅瓣,进一步影响机载共形阵列雷达的杂波分布,通过仿真分析发现在特定的脉冲重复频率(PRF)条件下,“栅瓣杂波”折叠进入主瓣杂波,该文提出通过优化雷达PRF设计,避免栅瓣杂波的折叠效应对机载共形阵列雷达信号处理性能的影响,相关仿真结果验证了所提方法的有效性。

关键词：共形阵列雷达弯曲阵面机载方向图杂波

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin lu Jianzhong Hu Yong Cao chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2