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纵隔和松果体双病灶生殖细胞肿瘤1例

中华儿科杂志 2025年第1期63卷 87-89页

作者：刘晶赵文王希思金眉陈诚豪贾海威伏利兵于彤苏雁国家儿童医学中心首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科儿童肿瘤国家临床重点专科首都医科大学基础-临床联合实验室儿科重大疾病研究教育部重点实验室北京国家儿童医学中心首都医科大学附属北京儿童医院胸外科北京北京右安门医院放疗科北京国家儿童医学中心首都医科大学附属北京儿童医院病理科北京国家儿童医学中心首都医科大学附属北京儿童医院影像中心北京

患儿, 男, 13岁, 因"间断胸痛伴右侧背部、上臂痛2周"就诊。影像学提示前上纵隔和松果体区占位。外周血和脑脊液人绒毛膜促性腺激素均升高。外周血及脑脊液甲胎蛋白正常。纵隔占位病理诊断精原细胞瘤。颅内占位根据影像学特点、血和脑...

患儿, 男, 13岁, 因"间断胸痛伴右侧背部、上臂痛2周"就诊。影像学提示前上纵隔和松果体区占位。外周血和脑脊液人绒毛膜促性腺激素均升高。外周血及脑脊液甲胎蛋白正常。纵隔占位病理诊断精原细胞瘤。颅内占位根据影像学特点、血和脑脊液甲胎蛋白正常、脑脊液人绒毛膜促性腺激素轻度升高临床诊断颅内生殖细胞肿瘤, 生殖细胞瘤可能性大。经化疗、纵隔肿物切除术、纵隔和全脑放疗, 随访11个月完全缓解。

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MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma

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Science China(Life Sciences) 2021年第6期64卷 991-999页

作者： Yaqiong Jin Jin Shi Huanmin Wang Jie Lu chenghao chen Yongbo Yu Yaru Wang Yeran Yang Dong Ren Qi Zeng Xin Ni Yongli Guo Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of MajorDiseases in ChildrenBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Tuberculosis Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149China Department of Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Thoracic Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Allergy Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University&Capital Medical UniversityBeijing 100083China Department of Otolaryngology Head and Neck SurgeryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

Neuroblastoma(NB)is one of the most common malignant tumors in children,with variable clinical behaviors and a 15%death rate of all malignancies in ***,genetic susceptibility to sporadic NB in Han Chinese patients is largely *** identify genetic risk factors for NB,we performed an association study on 357 NB patients and 738 control subjects among Han Chinese *** focused on DEAD box 1(DDX1),a putative RNA helicase,which is involved in NB *** potential association of DDX1 polymorphisms with NB has not been *** results demonstrate that rs72780850(NM_004939.2:c.-1555 T>C)located in the DDX1 promoter region is significantly associated with higher expression of DDX1 transcript and increased NB risk(odds ratio=1.64,95%confidence interval=1.03%–2.60%,P=0.004),especially in aggressive NB compared with ganglioneuroma and ganglioneuroblastoma in a dominant model(TC+CC ***).Furthermore,the MYC-associated protein X(MAX)transcription factor showed stronger binding affinity to the DDX1 rs72780850 CC allele compared with the TT allele,explaining the molecular mechanism of the increased NB risk caused by the rs72780850 *** results highlight the involvement of regulatory genetic variants of DDX1 in NB.

关键词： neuroblastoma RNA helicase DEAD box 1 susceptibility

Diagnose and treatment of traumatic pleural-subarachnoid fistula in children: A case report and systematic review

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Chinese Neurosurgical Journal 2020年第4期6卷 251-256页

作者： Wei Yang Ming Ge chenghao chen Qi Zeng Department of Neurosurgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Thoracic Beijing Children’s HospitalCapital Medical University56 South Lishi RoadXicheng DistrictBeijing 100045China

Background:Pleural-subarachnoid fistula(PSF)is a rare disease that is difficult to diagnose and *** intracranial hypertension and the treatment are seldom mentioned previously among *** presentation:A 1-year-old boy diagnosed PSF developed into secondary intracranial hypertension after conservative *** was finally cured by down-step treatment of mannitol,avoiding form ventricleperitoneal ***,we reviewed the literature of pleural-subarachnoid ***-six cases have been reported so *** of the cases(51.8%)were caused by surgery;only 17.9%were caused by car *** the treatment,half of the cases cured by surgery and the other by conservative *** case is the first one involving secondary intracranial hypertension and cured by down-step treatment of ***:A comprehensive examination should be performed before the treatment to avoid any inappropriate medical *** acute intracranial hypertension may be cured by down step treatment of mannitol,evading from the long-term ventriculoperitoneal shunt.

关键词： Pleural-subarachnoid fistula Intracranial hypertension Treatment Complications

Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu Run Hou chenghao Wu Ruishan Xie Shujun chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

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达芬奇机器人手术系统在儿童胸外科的应用

中华小儿外科杂志 2022年第1期43卷 83-87页

作者：陈天陈诚豪曾骐国家儿童医学中心首都医科大学附属北京儿童医院胸外科北京100045

达芬奇机器人手术系统突破了传统胸腔镜技术的局限性,在其安全性和有效性被广泛认可的同时,更提高了精细、复杂手术微创化的可行性。近年来,达芬奇机器人手术系统在成人外科的开展过程中已积累了丰富的经验,且其应用范围已拓展到儿童外... 详细信息

达芬奇机器人手术系统突破了传统胸腔镜技术的局限性,在其安全性和有效性被广泛认可的同时,更提高了精细、复杂手术微创化的可行性。近年来,达芬奇机器人手术系统在成人外科的开展过程中已积累了丰富的经验,且其应用范围已拓展到儿童外科领域。目前,达芬奇机器人手术系统在儿童胸外科的应用发展相对缓慢,本文通过总结达芬奇机器人手术系统在成人及儿童胸外科的应用现状以做出展望,认为在谨慎、认真商榷手术适应证的前提下,应该积极开展达芬奇机器人手术系统在儿童胸外科领域的应用。

关键词：外科手术,微创性达芬奇机器人儿童胸外科手术

GENERALIZED GREEN’S FUNCTIONS OF SURFACE EXCITATION OF ELASTIC WAVE FIELDS IN A PIEZOELECTRIC HALF-SPACE

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Chinese Journal of Acoustics 1985年第4期 297-313页

作者：汪承灏陈东培

Since the generalized Green’s functions,which correspond to surface excitation of elastic wavefields in a half-space of piezoelectric crystal,are independent of excitation conditions and only depen-dent on material parameters and orientation,they can be investigated in advance and independently. It is shown that the generalized Green’s functions can be written as a sum of three parts repre-senting separately a surface wave,a bulk wave and an electrostatic effect. We also confirm that the surface wave part and the bulk wave part at the far field of the generalizedGreen’s functions can be expressed by analytical expressions,and thus,the surface wave field and thefar field of bulk wave among the excited elastic wave fields can be evaluated exactly. Finally,as an example,the generalized Green’s functions for the 6 mm crystal are given.

关键词： GENERALIZED GREEN’S FUNCTIONS OF SURFACE EXCITATION OF ELASTIC WAVE FIELDS IN A PIEZOELECTRIC HALF-SPACE exp

Comparison of magnetic resonance imaging and computed tomography to measure preoperative parameters of children with pectus excavatum

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Pediatric Investigation 2019年第2期3卷 102-109页

作者： Jihang Sun chenghao chen Yun Peng Yue Zhang Hongwei Tian Jie Yu Jun Cao Qi Zeng Imaging Center Beijing Children’s Hospital.Capital Medical UniversityNational Center for Children’s Health.BeijingChina Department of Thoracic Surgery Beijing Children’s Hospital.Capital Medical UniversityNational Center for Children’s HealthBe JjingChina Department of Orthopedics Beij ing Children’s Hospital.CapitaI Medical UniversityNational Center for Children’s HealthBej-jingChina

Importance:Pectus excavatum (PE) is the most common thoracic wall deformity in children,we need a method which could be used to evaluate pulmonary functions and effects on ***:To evaluate the use of 3D T 1-weighted (3 DT 1) and mDIXON magnetic resonance imaging (MRI) sequences for measuring the thoracic parameters and morphology of children with PE,comparing the measurements with those made on computed tomography (CT).Methods:This is a retrospective study of children with thoracic deformities who were hospitalized at the Department of Thoracic Surgery of the Heart Center,Beijing Children's Hospital,between June 2014 and June *** CT was performed first,with the MRI scanning then being performed 0-3 days *** mDIXON sequences were obtained in inspiratory and expiratory phases and the 3DT1 sequences were obtained during free *** volume was measured using the acquired ***:The lung volumes measured on mDIXON MRI and CT were highly correlated,with the Haller index not being significantly different between the two ***-Altman analyses showed that lung,cardiac,and retrosternal parameters were similar between the two *** parameters were higher with the end-inspiratory phase mDIXON images than with the end-expiratory phase images,as expected,while cardiac parameters were unaffected by the respiratory ***:Thoracic volumes measured on mDIXON MRI in combination with held respiration could reflect lung volume functions and help in observing the movement functions of the lungs and *** method could be used instead of CT,avoiding subjecting the patient to potentially harmful radiation.

关键词： Lung volume measurements Magnetic resonance imaging Thoracic wall X-ray computed tomography

SCATTERING OF RAYLEIGH WAVE THROUGH A GROOVE ON SURFACE OF PIEZOELECTRIC CRYSTAL

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中国科学A辑(英文版) 1985年第3期 286-300页

作者：汪承灏陈东培 Institute of Acoustics Academia Sinica Beijing Beijing

A normally incident Rayleigh wave will be scattered on a groove on the surface of a piezoelectric crystal. The investigation of such a scattered field as a fundamental problem on surface wave propagation lays a foundation for analyzing groove grating array devices. In this paper we have taken anisotropy and piezoelectricity of substrate into account and applied the boundary perturbation method to finding a more exact general integral expression of soattored field. Then the integral at a pole of the integrand will contribute to the solution of the reflected surface wave and the reflection coefficient, including its magnitude and phase. As an example, the reflection coefficients of three kinds of crystals, YZ-LiNbO3, ST-quartz and （001）（110）-Bi12GeO20, have been numerically computed and they are in good agreement with the experimental results. Furthermore, with the saddle-point method an asymptotic approach to scattered bulk wave at the far field is deduced and the numerical results of bulk wave r

关键词： SURFACE scattered groove WAVE Rayleigh piezoelectric exact normally grating deduced

对如何全面、安全、细致开展微创胸壁矫形手术的思考

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临床小儿外科杂志 2023年第6期22卷 501-505页

作者：曾骐陈诚豪国家儿童医学中心、首都医科大学附属北京儿童医院胸外科北京100045

漏斗胸微创Nuss手术已广泛开展30余年,总体手术的安全性、手术技术的可行性以及远期效果的优良率都已得到普遍认可。Nuss手术已经不单纯是一种治疗漏斗胸的微创手术方式,更是一种不截骨内固定的微创手术理念,该理念已成为绝大部分胸壁... 详细信息

漏斗胸微创Nuss手术已广泛开展30余年,总体手术的安全性、手术技术的可行性以及远期效果的优良率都已得到普遍认可。Nuss手术已经不单纯是一种治疗漏斗胸的微创手术方式,更是一种不截骨内固定的微创手术理念,该理念已成为绝大部分胸壁畸形的解决方案。本文结合近年来儿童胸壁畸形矫形手术领域的微创方法与进展进行述评,从微创手术技术的应用广度、手术的安全性以及手术治疗效果相关因素等方面进行分析,提出解决方案和建议,为小儿胸外科医师学习和应用微创手术技术治疗胸壁畸形提供参考。

关键词：漏斗胸胸壁,畸形矫形外科手术最小侵入性外科手术儿童