检索结果-南通市图书馆

Bounding surface plasticity model for stress-strain and grain-crushing behaviors of rockfill materials

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第2期11卷 495-510页

作者： Yang Xiao Zengchun Sun Armin WStuedlein chenggui wang Zhijun Wu Zhichao Zhang School of Civil Engineering Chongqing University83 Shabei StreetChongqing 400045China State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining&TechnologyXuzhou 221116China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing 400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China School of Civil and Construction Engineering Oregon State Univ101 Kearney HallCorvallisOR97331USA School of Civil Engineering Wuhan UniversityWuhan 430072China

Crushing of grains can greatly influence the strength,dilatancy,and stress-strain relationship of rockfill *** critical state line(CSL)in the void ratio versus mean effective stress plane was extended to the breakage critical state plane(BCSP).A state void-ratio-pressure index that incorporated the effect of grain crushing was proposed according to the ***’s stress-dilatancy equation was modified by adding the breakage voidratio-pressure index,which was also incorporated into the formulations of the bounding stress ratio and plastic modulus.A BCSP-based bounding surface plasticity model was proposed to describe the state-dependent stressstrain behaviors and the evolution of grain crushing during shearing process of rockfill materials,and was shown to sufficiently capture the breakage phenomenon.

关键词： Constitutive model Grain crushing Critical state Dilatancy Strength State parameter

A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第8期6卷 2523-2534页

作者： chenggui wang Min wang Kaishun Xia Jingkai wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining Xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen Department of Orthopedics Surgery 2nd Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangPR China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an710054PR China

The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide *** inflammatory microenvironment is one of main obstacles on inhibiting the recovery of *** mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment ***,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not ***,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after *** orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal *** study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.

关键词： Bioactive biomaterials Multifunctional hydrogel Extracellular vesicles release Spinal cord injury repair

A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第9期7卷 103-119页

作者： Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke wang Jiawei Shu Xianpeng Huang Jingkai wang Kaishun Xia Liwei Ying Kesi Shi chenggui wang Xuhua wang Fangcai Li Qian Zhao Qixin Chen Department of Orthopedics Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangChina Orthopedics Research Institute of Zhejiang University Hangzhou310009ZhejiangChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009ZhejiangChina Ningbo Research Institute of Zhejiang University Ningbo315100ZhejiangChina State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027ZhejiangChina NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310003ZhejiangChina

The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair ***,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue *** the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and *** gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels *** vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of *** in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity *** vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional *** sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling ***,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord.

关键词： Conducting polymer Supramolecular hydrogels Biomimetic scaffolds Nerve regeneration Spinal cord injury

A vicinal oxygen chelate protein facilitates viral infection by triggering the unfolded protein response in Nicotiana benthamiana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第7期66卷 1481-1499页

作者： Zhihong Guo Ning Jiang Menglin Li Hongfang Guo Qi Liu Xinyu Qin Zongying Zhang chenggui Han Ying wang Ministry of Agriculture and Rural Affairs Key Laboratory of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

Vicinal oxygen chelate(VOC)proteins are members of an enzyme superfamily with dioxygenase or non-dioxygenase ***,the biological functions of VOC proteins in plants are poorly ***,we show that a VOC in Nicotiana benthamiana(NbVOC1)facilitates viral ***1 was significantly induced by infection by beet necrotic yellow vein virus(BNYVV).Transient overexpression of NbVOC1 or its homolog from Beta vulgaris(BvVOC1)enhanced BNYVV infection in ***,which required the nuclear localization of *** with this result,overexpressing NbVOC1 facilitated BNYVV infection,whereas,knockdown and knockout of NbVOC1 inhibited BNYVV infection in transgenic *** ***1 interacts with the basic leucine zipper transcription factors bZIP17/28,which enhances their self-interaction and DNA binding to the promoters of unfolded protein response(UPR)-related *** propose that bZIP17/28 directly binds to the NbVOC1 promoter and induces its transcription,forming a positive feedback loop to induce the UPR and facilitating BNYVV ***,our results demonstrate that NbVOC1 positively regulates the UPR that enhances viral infection in plants.

关键词： beet necrotic yellow vein virus bZIP17/28 Nicotiana benthamiana unfolded protein response VOC1

Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第10期6卷 3568-3579页

作者： Chao Yu Dongdong Li chenggui wang Kaishun Xia Jingkai wang Xiaopeng Zhou Liwei Ying Jiawei Shu Xianpeng Huang Haibin Xu Bin Han Qixin Chen Fangcai Li Jianbin Tang Chengzhen Liang Nigel Slater Department of Orthopedics Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejiang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang310027China Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUnited Kingdom

Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration(IVDD).However,the increased levels of reactive oxygen species(ROS)in the degenerated region will impede the efficiency of human adipose-derived stem cells(human ADSCs)transplantation *** inhibits human ADSCs proliferation,and increases human ADSCs ***,we firstly devised a novel amphiphilic copolymer PEG-PAPO,which could self-assemble into a nanosized micelle and load lipophilic kartogenin(KGN),as a single complex(PAKM).It was an injectable esterase-responsive micelle,and showed controlled release ability of KGN and apocynin(APO).Oxidative stimulation promoted the esterase activity in human ADSCs,which accelerate degradation of esterase-responsive *** its monomer,the PAKM micelle possessed better bioactivities,which were attributed to their synergistic *** enhanced the viability,autophagic activation(P62,LC3 II),ECM-related transcription factor(SOX9),and ECM(Collagen II,Aggrecan)maintenance in human ***,it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in ***,PAKM micelles perform promoting cell survival and differentiation effects,and may be a potential therapeutic agent for IVDD.

关键词： Intervertebral disc degeneration Polymer-drug conjugates Mesenchymal stem cell Reactive oxygen species Stem cell therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

OFDM中的混合QAM-TCM设计与实现

信号处理 2005年第6期21卷 646-648页

作者：王呈贵解放军理工大学通信工程学院南京210007

在高速率的OFDM设计中,MQAM-TCM调制已被广泛采用。本文提出了一种适用于OFDM的混合 QAM-TCM设计,并对两种不同的实现方案与MQAM-TCM进行了仿真比较,结果表明混合QAM-TCM的性能优于 MQAM-TCM。

关键词：正交频分复用正交幅度调制格状编码调制混合的正交幅度调制

Asymmetric Two-Component Alkenyl Catellani Reaction for the Construction of C—N Axial Chirality

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第7期42卷 699-704页

作者： chenggui Wu Ze-Shui Liu Yong Shang Chang Liu Shuang Deng Hong-Gang Cheng Hengjiang Cong Yinchun Jiao Qianghui Zhou Sauvage Center for Molecular Sciences Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)Hubei Key Lab on Organic and Polymeric OptoElectronic MaterialsCollege of Chemistry and Molecular SciencesThe Institute for Advanced Studiesand TaiKang Center for Life and Medical SciencesWuhan UniversityWuhanHubei 430072China Key Laboratory of Xin'an Medicine Ministry of EducationAnhui University of Chinese MedicineHefeiAnhui 230038China School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtanHunan 411201China

Herein,we report an asymmetric two-component alkenyl Catellani reaction for the construction of C—N axial chirality through a palladium/chiral norbornene cooperative catalysis and an axial-to-axial chirality transfer *** partially aromatic iodinated 2-pyridones,quinolones,coumarin and uracil substrates react with 2,6-disubstituted aryl bromides with a tethered amide group,to afford a wide variety of polycyclic C—N atropisomers(38 examples,up to 97%e.e.).The obtained C—N axial chirality originates from the preformed transient C—C axial chirality with high *** synthetic utility of this chemistry is demonstrated by facile prepa-ration of complex quinoline and pyridine based C—N atropisomers through a N-deprotection and aromatization *** addi-tion,a remote axial-to-central diastereoinduction process dictated by C—N axial chirality is observed with excellent diastereocontrol.

关键词： Alkenyl Catellani reaction Asymmetric catalysis Atropisomerism Axial-to-axial chirality transfer Heterocycles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

设计与开发基于Web的网络管理系统

电信科学 2000年第2期16卷 20-22页

作者：王呈贵邵军力中国人民解放军理工大学通信工程学院南京210016

基于Web 的网络管理WBM( Webbased Management) 是Web 技术在网络管理环境中的应用, 为网管人员提供了比传统网管工具更强有力的能力。本文提出了一种基于网管平台的WBM 应用开发结构和实现方案。该方案被实践证明是有效的、可行的。

关键词： Web 网络管理系统计算机网络

在线全文

学校读者我要写书评

暂无评论

考虑钙质砂颗粒破碎的分数阶边界面本构模型

岩土工程学报 2023年第6期45卷 1162-1170页

作者：汪成贵束善治肖杨路德春刘汉龙重庆大学土木工程学院重庆400045 Kiewit 10055 Trainstation CircleLone TreeCO 80124 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 库区环境地质灾害防治国家地方联合工程研究中心重庆400045 北京工业大学城市与工程安全减灾教育部重点实验室北京100124

钙质砂作为海洋工程中广泛应用的建筑材料,颗粒破碎会导致其强度和剪胀性降低,压缩性增加,影响构筑物的安全和稳定。通过引入破碎应力建立考虑颗粒破碎的临界状态线来描述破碎对临界状态线位置和形状的影响;并基于分数阶微分和状态相关... 详细信息

钙质砂作为海洋工程中广泛应用的建筑材料,颗粒破碎会导致其强度和剪胀性降低,压缩性增加,影响构筑物的安全和稳定。通过引入破碎应力建立考虑颗粒破碎的临界状态线来描述破碎对临界状态线位置和形状的影响;并基于分数阶微分和状态相关理论建立了统一的状态相关分数阶塑性流动法则;在边界面塑性理论和临界状态理论框架下建立了考虑钙质砂颗粒破碎和状态相关特性的分数阶塑性边界面本构模型。模型能够模拟不同初始密实度和围压条件下钙质砂三轴排水试验结果和颗粒破碎影响下的状态相关行为,并验证了模型的适用性。

关键词：钙质砂颗粒破碎状态相关分数阶本构模型