检索结果-南通市图书馆

Bone biomaterials and interactions with stem cells

Bone Research 2017年第4期5卷 253-285页

作者： chengde gao Shuping Peng Pei Feng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangshaChina The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health Xiangya HospitalCentral South UniversityChangshaChina The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research InstituteCentral South UniversityChangshaChina Jiangxi University of Science and Technology GanzhouChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceXiangya HospitalCentral South UniversityChangshaChina

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues：（1） developing ideal biomaterials with a combination of suitable biological and mechanical properties; （2） constructing a cell microenvironment with pores ranging in size from nanoscale to submicro- and microscale; and （3） inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed, along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail. Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed.

关键词： Bone biomaterials and interactions with stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in biocermets for bone implant applications

引用

Bio-Design and Manufacturing 2020年第4期3卷 307-330页

作者： chengde gao Meng Yao Cijun Shuai Pei Feng Shuping Peng State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangshaChina Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchangChina Shenzhen Institute of Information Technology ShenzhenChina NHC Key Laboratory of Carcinogenesis School of Basic Medical ScienceCentral South UniversityChangshaHunanChina

As two promising biomaterials for bone implants,biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity;while bioceramics are known for good biocompatibility or even bioactivity but limited by their high ***,a kind of composites composing of bioceramics and biomedical metals,have been developed as an effective solution by combining their complementary *** paper focused on the recently studied biocermets for bone implant ***,biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase *** characteristics were systematically summarized,and the fabrication methods for biocermets were reviewed and *** were put on the interactions between bioceramics and biomedical metals,as well as the performance improvement *** importantly,the main methods for the interfacial reinforcing were summarized,and the corresponding interfacial reinforcing mechanisms were *** addition,the in vitro and in vivo biological performances of biocermets were also ***,future research directions were proposed on the advancement in component design,interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

关键词： Biocermets Advantageous complementarity Fabrication methods Interfacial reinforcing Bone implants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano-SiC reinforced Zn biocomposites prepared via laser melting:Microstructure,mechanical properties and biodegradability

引用

Journal of Materials Science & Technology 2019年第11期35卷 2608-2617页

作者： chengde gao Meng Yao Cijun Shuai Shuping Peng Youwen Deng State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Jiangxi University of Science and Technology Ganzhou 341000China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South UniversityChangsha 410013China Cancer Research Institute School of Basic Medical SciencesCentral South UniversityChangsha 410011China Department of Emergency The Second Xiangya Hospital of Central South UniversityChangsha 410011China

Zn has been regarded as new kind of potential implant biomaterials due to the desirable biodegradability and good biocompatibility,but the low strength and ductility limit its application in bone *** the present study,nano-SiC was incorporated into Zn matrix via laser melting,aiming to improve the mechanical *** microstructure analysis showed that nano-SiC distributed along Zn grain *** the laser rapid solidification,nano-SiC particles acted as the sites for heterogeneous nucleation,which resulted in the reduction of Zn grain size from 250μm to 15μm with 2 wt%SiC(Zn-2 SiC).Meanwhile,nano-SiC acted as a reinforcer by virtue of Orowan strengthening and dispersion *** a consequence,the nanocomposites showed maximal compressive yield strength(121.8±5.3 MPa)and high microhardness(72.24±3.01 HV),which were increased by 441%and 78%,respectively,compared with pure ***,fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of nano-SiC In addition,the nanocomposites presented favorable biocompatibility and accelerated degradation caused by intergranular *** findings suggested that the nano-SiC reinforced Zn biocomposites may be the potential candidates for orthopedic implants.

关键词： Zn Nano-SiC Biocomposites Laser melting Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetostrictive alloys:Promising materials for biomedical applications

引用

Bioactive Materials 2022年第2期7卷 177-195页

作者： chengde gao Zihao Zeng Shuping Peng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha410083China NHC Key Laboratory of Carcinogenesis The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of EducationSchool of Basic Medical ScienceCentral South UniversityChangsha410078HunanChina School of Energy and Machinery Engineering Jiangxi University of Science and TechnologyNanchang330013China Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang330013China Shenzhen Institute of Information Technology Shenzhen518172China

Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic *** review focuses on the advances in magnetostrictive alloys and their biomedical *** theories of magnetostriction are systematically *** different types of magnetostrictive alloys and their preparation methods are also reviewed in *** magnetostrictive strains and phase compositions of typical magnetostrictive alloys,including iron based,rare-earth based and ferrite materials,are ***,a variety of approaches to preparing rods,blocks and films of magnetostriction materials,as well as the corresponding methods and setups for magnetostriction measurement,are summarized and ***,the interactions between magnetostrictive alloys and cells are analyzed and emphasis is placed on the transduction and transformation process of mechanochemical signals induced by *** latest applications of magnetostrictive alloys in remote microactuators,magnetic field sensors,wireless implantable devices and biodegradable implants are also ***,future research directions of magnetostrictive alloys are prospected with focus on their potential applications in remote cell actuation and bone repair.

关键词： Magnetostriction alloys Magnetostriction theories Preparation techniques Measurement methods Biomedical applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting

引用

Journal of Magnesium and Alloys 2021年第1期9卷 305-316页

作者： chengde gao Sheng Li Long Liu Shizhen Bin Youwen Yang Shuping Peng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Jiangxi University of Science and Technology Ganzhou 341000China Department of Oncology Third Xiangya Hospital of Central South UniversityChangsha 410013China NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South UniversityChangshaHunan China

Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological *** study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser *** observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification ***,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 *** improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the *** addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion ***,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical *** could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation ***,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 *** findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants.

关键词： Dual alloying Mg alloys Selective laser melting Corrosion resistance Cytocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique

引用

Journal of Materials Science & Technology 2018年第10期34卷 1944-1952页

作者： Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo chengde gao Fulai Yuan State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical Engineering Central South University Changsha410083 China Jiangxi University of Science and Technology Ganzhou 341000 China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province Changsha 410008 China School of Material Science and Engineering Central South University Changsha 410083 China Health Management Center Xiangya Hospital Central South University Changsha 410008 China

Magnesium （Mg） alloys are receiving increasing attention for body implants owing to their good bio- compatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-xCu （x = O, 0.2, 0.4, 0.6 and 0.8 wt%） alloys were prepared by selective laser melting （SLM） with alloying copper （Cu） to enhance their antibacterial ability. Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure, denaturing enzymes and inhibiting deoxyribonucleic acid （DNA） replication. In addition, their compres- sive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be Dromising implants for biomedical anDlications.

关键词： Magnesium alloys Copper Antibacterial ability Cytocompatibility Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of graphene oxide(GO)on microstructure and biodegradation of ZK30-xGO composites prepared by selective laser melting

引用

Journal of Magnesium and Alloys 2020年第3期8卷 952-962页

作者： Jun-Xi Tao Ming-Chun Zhao Ying-Chao Zhao Deng-Feng Yin Long Liu chengde gao Cijun Shuai Andrej Atrens School of Materials Science and Engineering Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Division of Materials The University of QueenslandBrisbaneQld 4072Australia

Different graphene oxide(GO)contents were chosen as the addition to prepare ZK30-xGO composites by selective laser melting(SLM).The microstructure and biodegradation of the SLMed ZK30-xGO composites were *** results indicated that(i)SLM effectively produced a small grain size,(ii)the incorporation of GO into ZK30 caused a further decrease in grain size,and(iii)GO has a strong effect on the formation of the MgZn2 *** SLMed ZK30-0.6GO had the lowest biodegradation rate,which is attributed to the fact that the effect of the increased grain refinement and decreased amount of the MgZn?precipitates counteracted the effect of the increased GO content on the biodegradation ***,the SLMed ZK30-xGO composites had good *** work provided a novel approach to the composition design and fabrication of novel biodegradable GO reinforced Mg-based biomedical implants.

关键词： Mg alloy ZK30-xGO composite Selective laser melting(SLM) Biodegradation Cytocompatibility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Additive manufacturing of promising heterostructure for biomedical applications

引用

International Journal of Extreme Manufacturing 2023年第3期5卷 363-405页

作者： Cijun Shuai Desheng Li Xiong Yao Xia Li chengde gao State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China Research Center for Macromolecules and Biomaterials National Institute for Materials Science(NIMS)1-1NamikiTsukubaIbaraki 305-0044Japan

As a new generation of materials/structures,heterostructure is characterized by heterogeneous zones with dramatically different mechanical,physical or chemical *** endows heterostructure with unique interfaces,robust architectures,and synergistic effects,making it a promising option as advanced biomaterials for the highly variable anatomy and complex functionalities of individual ***,the main challenges of developing heterostructure lie in the control of crystal/phase evolution and the distribution/fraction of components and *** recent years,additive manufacturing techniques have attracted increasing attention in developing heterostructure due to the unique flexibility in tailored structures and synthetic *** review focuses on the additive manufacturing of heterostructure for biomedical *** structural features and functional mechanisms of heterostructure are *** typical material systems of heterostructure,mainly including metals,polymers,ceramics,and their composites,are *** the resulting synergistic effects on multiple properties are also systematically discussed in terms of mechanical,biocompatible,biodegradable,antibacterial,biosensitive and magnetostrictive ***,this work outlines the research progress of additive manufacturing employed in developing heterostructure from the aspects of advantages,processes,properties,and *** review also highlights the prospective utilization of heterostructure in biomedical fields,with particular attention to bioscaffolds,vasculatures,biosensors and ***,future research directions and breakthroughs of heterostructure are prospected with focus on their more prospective applications in infection prevention and drug delivery.

关键词： additive manufacturing heterostructure synergistic effects integrated properties biomedical applications

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spiral-eutectic-reinforced Biodegradable Zn-Mg-Ag Alloy Prepared via Selective Laser Melting

引用

Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第2期1卷 25-35页

作者： chengde gao Chuanzhi Li Shuping Peng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha410083China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South UniversityChangsha410078China Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSC 29425USA Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang330013China

Zn is a promising biodegradable metal owing to its moderate degradation rate and acceptable ***,the insufficient mechanical strength and plasticity of pure Zn limits its application in bone *** this study,a spiral eutectic structure is constructed in Zn-Mg-Ag alloys prepared via selective laser melting to improve their mechanical *** show that the prepared Zn-Mg-Ag alloys are composed of a primary Zn matrix and a eutectic phase,which is composed of alternating𝛼-Zn and an intermetallic compound,MgZn ***,the eutectic phase resembles a spiral and increases with Ag content in the *** eutectic pinning effect hinders dislocation and hence results in dislocation ***,the spiral structure alters the propagation direction and dissipates the propagation energy of cracks layer by ***,a compressive strength of up to 309±15 MPa and an improved strain of 27%are exhibited in Zn-3Mg-1Ag ***,the Zn-Mg-Ag alloys show high biocompatibility with MG-63 cells and antibacterial activity against Escherichia *** findings indicate the potential of spiral eutectic structures for enhancing both the mechanical strength and plasticity of biodegradable Zn alloys.

关键词： Selective laser melting Spiral eutectic Zn–Mg–Ag alloy Mechanical properties Biodegradability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science　and　Technology　of　China　Onshore　Petroleum　Industry　Towards　21st　Century（part　2）

引用

China Oil & Gas 1995年第4期2卷 15-18页

作者： Fu chengde,Liu Bingyi and gao Chao(Science and Technology Development Bureau,CNPC) Science and Technology Development Bureau CNPC

ＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏｇｙｏｆＣｈｉｎａＯｎｓｈｏｒｅＰｅｔｒｏｌｅｕｍＩｎｄｕｓｔｒｙＴｏｗａｒｄｓ２１ｓｔＣｅｎｔｕｒｙ（ｐａｒｔ２）￥ＦｕＣｈｅｎｇｄｅ，ＬｉｕＢｉｎｇｙｉａｎｄＧａｏＣｈａｏ（Ｓ... 详细信息

ＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏｇｙｏｆＣｈｉｎａＯｎｓｈｏｒｅＰｅｔｒｏｌｅｕｍＩｎｄｕｓｔｒｙＴｏｗａｒｄｓ２１ｓｔＣｅｎｔｕｒｙ（ｐａｒｔ２）￥ＦｕＣｈｅｎｇｄｅ，ＬｉｕＢｉｎｇｙｉａｎｄＧａｏＣｈａｏ（ＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏ...

关键词： Land Petroleum industry Science and technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：