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Evaluation and attribution of trends in compound dry-hot events for major river basins in China

Science China Earth Sciences 2024年第1期67卷 79-91页

作者： Shaotang XIONG Tongtiegang ZHAO chengchao GUO Yu TIAN Fang YANG Wenlong CHEN Xiaohong CHEN Key Laboratory of Water Security Guarantee in Guangdong-Hong Kong-Marco Greater Bay Area of Ministry of Water Resources&Sun Yatsen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China China Institute of Water Resource and Hydropower Research Beijing 100038China Pearl River Hydraulic Research Institute Guangzhou 510611China

Concurrent compound dry and hot events(CDHEs)amplified more damange on the ecosystems and human society than individual extremes.Under climate change,compound dry and hot events become more frequent on a global scale.This paper proposes a mathematical method to quantitatively attribute changes of CDHEs to changes of precipitation,change in temperature and change in the dependence between precipitation and temperature.The attribution is achieved by formulating the total differential equation of the return period of CDHEs among Meta-gaussian model.A case study of China is devised based on monthly precipitation and temperature data during the period from 1921 to 2020 for 80 major river basins.It is found that temperature is the main driving factor of increases in CDHEs for 49 major river basins in China,except for the upper and middle reaches of the Yangtze River.In West China,precipitation changes drove the increase in CDHEs in 18 river basins(23%),particularly in parts of North Xinjiang,Qinghai and Gansu.On the other hand,dependence between precipitation and temperature dominated changes of CDHEs in 13 river basins(16%)of China with other factors,including parts of South China,East China and Northwestern China.Furthermore,changes in both the mean and spread of precipitation and temperature can also contribute to changes in CDHEs.

关键词： Climate extreme Compound dry and hot extreme Precipitation Temperature Return period

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Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Research 2024年第1期2023卷 315-337页

作者： Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu chengchao Xu Qiuyan guo Jigang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic acids.However,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most important.This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms.These strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes.On the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

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Analyses of non-aqueous reactive polymer insulation layer in high geothermal tunnel

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第1期15卷 169-178页

作者： Yu Chen Shiyu Wang chengchao GUO Cungang Lin Chenyang Zhao School of Civil Engineering Sun Yat-sen UniversityZhuhai519082China Southern Institute of Infrastructure Testing and Rehabilitation Technology Huizhou516000China

The scenario of geothermal tunnel is commonly observed around the world,and increases with the new constructions in the long and deep tunnels,for example in China.Tunnel insulation is generally divided into active and passive insulation.In passive insulation,it is an effective way to set low thermal con-ductivity materials as the thermal insulation layer as the choice of insulation material mainly depends on the thermal conductivity.Polymer is a kind of material with good geothermal performance,but there are relatively few studies.In this context,the transient plane source(TPS)method was used to measure the thermal conductivity of the developed polymer.Then,the temperature field of the high geothermal tunnel insulated by the non-aqueous reactive polymer layer was simulated.With the parametric analysis results,the suggestions for the tunnel layers were proposed accordingly.It revealed that the thermal conductivity of polymer first increases and then decreases with temperature.There are two rising sec-tions(?40e10?C and 20e90?C),one flat section(10e20?C)and one descending section(>90?C).It is observed the thermal conductivity of polymer increases with increase of the density of insulation layer and the density,and the thermal conductivity decreases when exposed to high temperatures.The temperature of the surrounding rocks increases with increase of the thermal conductivity and the thickness of polymer.Finally,a more economical thickness(5 cm)was proposed.Based on the parametric study,a thermal insulation layer with thermal conductivity less than 0.045 W/(m K),thickness of 5 cm and a density less than 0.12 g/cm 3 is suggested for practice.

关键词： Geothermal tunnel Non-aqueous reactive polymer Thermal conductivity Heat insulation

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Responses of calcareous sand foundations to variations of groundwater table and applied loads

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1266-1279页

作者： Dingfeng Cao Sanjay Kumar Shukla Linqing Yang chengchao GUO Jinghong Wu Fuming Wang School of Civil Engineering Sun Yat-sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China Discipline of Civil and Environmental Engineering School of EngineeringEdith Cowan UniversityPerth6027Australia School of Architectural Engineering Guangzhou Institute of Science and TechnologyGuangzhou510540China School of Civil Engineering Suzhou University of Science and TechnologySuzhou215011China

The long-term settlement of calcareous sand foundations caused by daily periodic fluctuations has become a significant geological hazard,but effective monitoring tools to capture the deformation profiles are still rarely reported.In this study,a laboratory model test and an in situ monitoring test were conducted.An optical frequency domain reflectometer(OFDR)with high spatial resolution(1 mm)and high accuracy(10-6)was used to record the soil strain responses to groundwater table and varied loads.The results indicated that the fiber-optic measurements can accurately locate the swelling and compressive zones.During the loading process,the interlock between calcareous sand particles was detected,which increased the internal friction angle of soil.The foundation deformation above the sliding surface was dominated by compression,and the soil was continuously compressed beneath the sliding surface.After 26e48 h,calcareous sand swelling occurred gradually above the water table,which was primarily dependent on capillary water.The swelling of the soil beneath the groundwater table was completed rapidly within less than 2 h.When the groundwater table and load remain constant,the compression creep behavior can be described by the Yasong-Wang model with R2¼0.993.The daily periodically varying in situ deformation of calcareous sand primarily occurs between the highest and lowest groundwater tables,i.e.4.2e6.2 m deep.The tuff interlayers with poor water absorption capacity do not swell or compress,but they produce compressive strain under the influence of deformed calcareous sand layers.

关键词： Distributed fiber optic sensing(DFOS) Calcareous sand Optical fiber Optical frequency domain reflectometer (OFDR) Soil foundation settlement

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Model test and numerical simulation of a new prefabricated double-row piles retaining system in silty clay ground

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Underground Space 2023年第6期13卷 262-280页

作者： Ruisong Wang Hao Yang Pengpeng Ni Chenyang Zhao chengchao GUO Huihuan Ma Pu Dong Huqing Liang Mengxiong Tang School of Civil Engineering Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Guangdong Key Laboratory of Oceanic Civil EngineeringGuangdong Research Center for Underground Space Exploitation TechnologyZhuhai 519082China Beijing Urban Rail Transit Construction Engineering Co. LtdBeijing 100088China BeSTDR Infrastucture Hospital Zhumadian 463400China School of Architecture and Civil Engineering Huizhou UniversityHuizhou 516008China Guangzhou Municipal Construction Group Co. LtdGuangzhou 510275China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

This paper introduces a new prefabricated recyclable double-row piles retaining system for excavations in silty clay ground.Laboratory model test and numerical simulation are conducted to study the system behavior upon excavation.The horizontal displacement(δ_(h)),Von Mises stress(δ_(M)),strain(ε),ground surface settlement(δ_(v)),and earth pressure are systematically investigated.Furthermore,the monitoring data of 13 excavation cases supported by double-row piles retaining system are presented and discussed.The experimental results can basically match the numerical results,and the maximumδ_(M),maximum bending moment(M_(max)),maximum horizontal displacement(δ_(hm))of structural members are all less than the tolerance limits.The ground surface settlement model of double-row piles retaining system consists of three zones,i.e.,rebound influence zone,primary influence zone and secondary influence zone.The dhm values are 0.07%–1.42%of the excavation depth(He).The maximum ground surface settlement(δ_(vm))is generally less than dhm.The ratio ofδ_(vm)=δ_(hm)varies between 0.09 and 0.76,with an average value of 0.5.The observed earth pressure on the retained side of front pile(paf)is about 0.53–0.57γH below the excavation surface.Above the excavation surface,p_(af)decreases dramatically when getting closer to the ground surface.

关键词： Prefabricated recyclable structure Double-row piles retaining system Physical model test Numerical simulation Deformation

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珊瑚钙质砂-聚氨酯高聚物复合体蠕变村山流变模型改进

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工程地质学报 2024年第1期32卷 295-302页

作者：黄锐郭成超曹鼎峰刘志遐中山大学土木工程学院珠海519082 南方海洋科学与工程广东省实验室(珠海) 珠海519082 广东省海洋土木工程重点实验室珠海519082 广东省地下空间开发工程技术研究中心广州510275

聚氨酯高聚物注浆可显著提高珊瑚钙质砂地基承载力,但目前缺乏模型准确描述注高聚物浆液加固后珊瑚钙质砂地基的蠕变。本文中推导了改进村山流变模型的理论公式,对复合体蠕变进行分段描述,采用一个与应力大小及时间有关的反比例函数代... 详细信息

聚氨酯高聚物注浆可显著提高珊瑚钙质砂地基承载力,但目前缺乏模型准确描述注高聚物浆液加固后珊瑚钙质砂地基的蠕变。本文中推导了改进村山流变模型的理论公式,对复合体蠕变进行分段描述,采用一个与应力大小及时间有关的反比例函数代替传统村山流变模型中的黏滞系数。设计了室内蠕变单轴压缩试验,分别在100 kPa,200 kPa和400 kPa轴向应力下测定并建立了珊瑚钙质砂-高聚物复合体的蠕变量与蠕变时间的关系。试验结果表明:改进村山流变模型可有效描述珊瑚钙质砂-高聚物复合体蠕变全过程,当蠕变时间小于临界时间时,传统村山流变模型有效;当蠕变时间大于临界蠕变时间后,传统村山流变模型偏差随着时间增长而增大,而改进村山流变模型预测值与实测值具有很好一致性;复合体所处的应力水平越高,蠕变量越大,发生加速蠕变的时间也越早。

关键词：蠕变珊瑚钙质砂高聚物村山流变模型

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沿海地面沉降对风暴潮作用下洪水淹没影响的析因试验

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水利水运工程学报 2024年第3期 42-51页

作者：黄光玮郭成超蔡华阳田雨赵铜铁钢中山大学南方海洋科学与工程广东省实验室(珠海) 广东珠海519000 中国水利水电科学研究院水资源研究所北京100038

地面沉降会加剧沿海地区潮灾风险。基于验证良好的MIKE 21水动力模型预测珠海市未来地面沉降和风暴潮影响下洪水淹没情况,引入并设计析因试验以量化地面沉降和风暴潮对洪水淹没的单独效应、主效应和交互效应。结果表明:珠海市地面沉降... 详细信息

地面沉降会加剧沿海地区潮灾风险。基于验证良好的MIKE 21水动力模型预测珠海市未来地面沉降和风暴潮影响下洪水淹没情况,引入并设计析因试验以量化地面沉降和风暴潮对洪水淹没的单独效应、主效应和交互效应。结果表明:珠海市地面沉降在平沙镇东北至白蕉镇西南呈条带状分布,对洪水淹没存在空间“放大效应”。地面沉降和风暴潮交互作用会加剧鸡啼门水道和泥湾门水道两侧洪水向内陆演进的趋势;与内陆相比,沿岸农田和水产养殖区的淹没对地面沉降更为敏感。交互作用时两个因素的单独效应均增强,二者对洪水淹没存在正向协同交互作用。未来100年地面沉降情景下,地面沉降主效应约为风暴潮主效应的1.11~29.49倍,这表明地面沉降在淹没效应中占主导地位,在预测未来风暴淹没时须考虑地面沉降的影响。

关键词：地面沉降风暴潮洪水淹没析因试验 MIKE 21

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基于双层Winkler地基的盾构穿越管线挠曲与脱空分析

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岩石力学与工程学报 2024年第5期43卷 1270-1281页

作者：林存刚王忠杰郭成超王复明陈瑜赵辰洋丁智中山大学土木工程学院广东省地下空间开发工程技术研究中心广东广州510275 隧道工程灾变防控与智能建养全国重点实验室广东广州510275 南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 广东省海洋土木工程重点实验室广东广州510275 浙江省城市盾构隧道安全建造与智能养护重点实验室浙江杭州310015

盾构掘进诱发上覆管线的挠曲和脱空分析对其结构保护至关重要。基于双层Winkler地基并考虑管线上覆与下卧地基刚度差异,对盾构隧道开挖上覆管线挠曲和脱空进行理论与模型试验证实分析。基于荷载板试验对传统管线砂土地基承载理论加以修... 详细信息

盾构掘进诱发上覆管线的挠曲和脱空分析对其结构保护至关重要。基于双层Winkler地基并考虑管线上覆与下卧地基刚度差异,对盾构隧道开挖上覆管线挠曲和脱空进行理论与模型试验证实分析。基于荷载板试验对传统管线砂土地基承载理论加以修正,提出适用于盾构穿越管土相互作用分析的砂土地基刚度和极限承载力取值建议。参数分析发现,管线脱空宽度随管线抗弯刚度和隧道开挖地层损失增大而变大,但变化速率递减;当地层损失或管线抗弯刚度较大时,管土线弹性相互作用理论和考虑界面脱空的单层地基计算方法均高估了管线挠曲和弯矩,而考虑界面脱空的双层Winkler地基计算方法可更准确地预估管线挠曲。

关键词：隧道工程双层Winkler地基盾构掘进管土相互作用界面脱空模型试验地基承载理论

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Study on Ground-Penetrating Radar (GPR) Application in Pavement Deep Distress Detection

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Journal of Transportation Technologies 2019年第2期9卷 232-259页

作者： Songtao Li chengchao GUO College of Water Conservancy and Environment Zhengzhou University Zhengzhou China Industrial Technology Research Institute Chongqing University Chongqing China School of Civil Engineering Sun Yat-sen University Guangzhou China

As some deep distresses exist in pavement structures, ground-penetrating radar (GPR) reflected waves will vary at interfaces and defects. Aimed at detecting the distresses in terms of position, severity and degree, electromagnetic forward simulations based on 400 MHz and 900 MHz antennas were conducted respectively. The dielectric models concerning homogeneous or coupling distresses of pavements were established, and the effects of various distresses on detection were analyzed through reflected wave images. Relying on GPR tests and field tests, coring and excavation data acquired before rehabilitation were compared and verified. The calculation results match the field measurement results. Thus, the detection method based on GPR was proposed for pavement deep distresses.

关键词： Pavement Deep Distress GPR Electromagnetic Forward Simulation Dielectric Model Detection

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Automatic diagnosis of multiple fundus lesions based on depth graph neural network

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Optoelectronics Letters 2023年第5期19卷 307-315页

作者： JIANG Jiewei guo Liufei LIU Wei WU chengchao GONG Jiamin LI Zhongwen School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi'an 710071China School of Communication Engineering Xi’an University of Posts and TelecommunicationsXi'an 710071China Ningbo Eye Hospital Wenzhou Medical UniversityNingbo 315000China

Fundus images are commonly used to capture changes in fundus structures and the severity of fundus lesions,and are the basis for detecting and treating ophthalmic diseases as well as other important diseases.This study proposes an automatic diagnosis method for multiple fundus lesions based on a deep graph neural network(GNN).2083 fundus images were collected and annotated to develop and evaluate the performance of the algorithm.First,high-level semantic features of fundus images are extracted using deep convolutional neural networks(CNNs).Then the features are input into the GNN to model the correlation between different lesions by mining and learning the correlation between lesions.Finally,the input and output features of the GNN are fused,and a multi-label classifier is used to complete the automatic diagnosis of fundus lesions.Experimental results show that the method proposed in this study can learn the correlations between lesions to improve the diagnostic performance of the algorithm,achieving better performance than the original Res Net and Dense Net models in both qualitative and quantitative evaluation.

关键词： neural diagnosis networks

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