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The expression and clinical significance of ADHs in hepatocellular carcinoma

Journal of Hainan Medical University 2021年第17期27卷 26-29页

作者： cheng-zhou pa Shan-Min Wu Department of Hepatobiliary Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Objective:To explore the expression and prognostic significance of ADHs in Hepatocellular carcinoma(HCC).Methods:The clinical data in this study were obtained from The Cancer Genome Atlas(TCGA).The expression of ADHs was differentially analyzed in normal liver tissues and HCC using the Metabolic gEne RApid Visualizer and the TCGA database,and the differentially expressed ADHs were selected for kaplan-meier survival *** analysis was performed to select factors that may influence the prognosis of HCC and to verify independent risk factors for HCC *** interaction among ADHs was explored at the gene level and protein expression level through GeneMAMIA and STRING,and the functional enrichment analysis of ADH family was carried out using DAVID bioinformatics ***:The expression of ADH1A,ADH1B,ADH1C,ADH4 and ADH7 in HCC is *** low-expression groups of ADH1A,ADH1B,ADH1C and ADH4 had poor survival rates,which may be related to the poor prognosis of HCC *** Cox regression analysis showed that the expression levels of ADH1A,ADH1C and ADH4,as well as the clinical stage,T stage and M stage of the tumor were closely related to the overall survival rate of the *** Cox regression analysis further suggested that the low expression of ADH1A,ADH1C and ADH4 was an independent risk factor affecting the prognosis of HCC *** is a pathway between ADH1A-ADH1B,ADH1B-ADH1C,ADH1A-ADH1C,and the ADHs is closely related to Esterase D and Aldehyde *** ADHs is mainly involved in biological processes such as Ethanol oxidation and Retinol metabolism,and plays a biological role in Glycolysis/Gluconeogenesis,Chemical carcinogenesis and Metabolism of xenobiotics by cytochrome ***:ADH1A,ADH1C and ADH4 may be biomarkers for the prognosis of HCC,providing reference value for the practical application of ADHs in HCC.

关键词： Hepatocellular carcinoma Alcoholic dehydrogenase TCGA

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Differential expression and function prediction of miRNAs in Hepatocellular carcinoma based on bioinformatics

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Journal of Hainan Medical University 2020年第10期26卷 38-41页

作者： cheng-zhou pa Shan-Min Wu Department of Hepatobiliary Surgery Renmin Hospital of Wuhan University wuhan 430060 China

Objective:To analyze the differential expression and function prediction of miRNAs in Hepatocellular carcinoma (HCC) based on Bioinformatics, and to provide new ideas for early diagnosis and late intervention of ***: The expression dataset of HCC non-coding RNA was obtained by GEO database, and differential miRNAs were screened and visualized by limma R package and pheatmap R package using R (v 3.6.0). Transcriptional factors of differential miRNAs were predicted, signaling pathway analysis and GO enrichment analysis were performed and ***: A total of 37 miRNAs were selected in HCC tissues with differential expressions, and the significant transcription factors were EGR1, POU2F1, SP1, NKX6-1, MEF2A, FOXA1, SP4, NFIC, RREB1, ARID3A, HOXA5, HNF4A, HOXD8, RORA, LHX3, POU3F2, FOXJ2, POU5F1, NKX2-1, SOX1. Differential miRNAs were found to be mainly located in the Nucleus and Cytoplasm, It has molecular functions such as Protein serine/threonine kinase activity, Receptor signaling complex scaffold activity, Transcription regulator activity and Transcription factor activity, Involved in Nucleic acid metabolism and Signal transduction and Cell communication. Through The epidermal growth factor receptor (EGFR), IGF-1,γ-IFN, Plasma membrane estrogen receptor signaling pathways play a role, and differential miRNAs is associated with VEGF, VEGFR, PDGF, Hepatocyte Growth Factor Receptor (c-Met), Protein serine/threonine kinase mediated signaling ***:Differential mirnas in hepatocellular carcinoma are closely related to tumor development and progression, and differential miRNAs can be used as potential markers for early diagnosis of HCC, providing new ideas for late intervention.

关键词： Hepatocellular carcinoma MiRNA GEO

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A Comprehensive Review of Thermal Performance Improvement of High-Temperature Heat Pipes

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Journal of Thermal Science 2024年第2期33卷 625-647页

作者： CHEN Qihan zhou Jingzhi zhou Guohui cheng Keyong HUAI Xiulan WEI Gaosheng School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing100096China Nanjing Institute of Future Energy System Nanjing211135China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China

Energy efficiency issues are being focused on the growing concern of global warming and environmental *** high-temperature heat pipe(HTHP) is an effective and environmental-friendly heat transfer device employed in many industries,including solar power generation,high-temperature flue gas waste heat recovery,industrial furnaces,nuclear industries,and *** a critical factor in HTHPs,thermal performance is mainly introduced in the entire *** date,most reviews have been published concerning one or several application ***,to the best of authors' knowledge,it is hard to find a review discussing how to improve the thermal performance of HTHPs ***,the impact on the performance of three main components of HTHPs over the past 30 years is introduced:the working fluid,the HTHP structure,and the wick ***,it is a considerable review of the optimal operating conditions for each direction,and we expect this paper contribute to improving the thermal performance of ***,current numerical simulations and theoretical research on the heat transfer limit of HTHPs are *** significant hypotheses used in numerical simulations and the present theoretical studies are compiled ***,some potential future directions and tentative suggestions for HTHP research are put forward.

关键词： high-temperature heat pipe review alkali metal heat pipe thermal performance

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Laser welding study of vacuum sintered HUST-1 lunar regolith simulant

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Science China(Technological Sciences) 2024年第9期67卷 2905-2918页

作者： HAN WenBin DING LieYun zhou cheng zhou Yan DANG Fen National Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 730074China

Efforts are underway to establish a permanent lunar base on the Moon. In situ lunar regolith is anticipated to be useful as a building material after sintering. However, sintering lunar regolith into a large-scale structure presents challenges. Therefore, the key to lunar construction lies in assembling multiple small-sized sintered modules into a stable, large-sized structure. This study explored the feasibility of welding the sintered HUST-1 lunar regolith simulant(HLRS) using a laser device and conducted experiments using lasers of varying power. The microstructure, mineral composition, element distribution, and shear strength of the welded joint were investigated. A few low-melting minerals were fused and vaporized during welding, leading to the generation of thermal decomposition gas. Furthermore, the welded joint exhibited numerous micro-cracks, pores, and bubbles,resulting in reduced weld shear strength. Finally, the influence of laser power on weld shear strength was investigated, revealing that the highest shear strength(15.69 N/cm) was achieved at a laser power of 1000 W. This study demonstrates the feasibility of laser welding of sintered HLRS for the first time, with potential applications in lunar base construction.

关键词： lunar regolith vacuum sintering laser welding weld shear strength lunar base

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Properties and Characteristics of Regolith-Based Materials for Extraterrestrial Construction

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Engineering 2024年第6期37卷 159-181页

作者： cheng zhou Yuyue Gao Yan zhou Wei She Yusheng Shi Lieyun Ding Changwen Miao National Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Southeast UniversityNanjing 214135China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The construction of extraterrestrial bases has become a new goal in the active exploration of deep *** the construction techniques,in situ resource-based construction is one of the most promising because of its good sustainability and acceptable economic cost,triggering the development of various types of extraterrestrial construction materials.A comprehensive survey and comparison of materials from the perspective of performance was conducted to provide suggestions for material selection and *** types of typical construction materials are discussed in terms of their reliability and applicability in extreme extraterrestrial ***,thermal and optical,and radiation-shielding properties are *** influencing factors and optimization methods for these properties are *** the perspective of material properties,the existing challenges lie in the comprehensive,long-term,and real characterization of regolith-based construction ***,the suggested future directions include the application of high-throughput characterization methods,accelerated durability tests,and conducting extraterrestrial experiments.

关键词： Extraterrestrial construction Characterization Mechanical property Thermal property Optical property Radiation-shielding

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Shock Initiation Experiments with Modeling on a DNAN Based MeltCast Insensitive Explosive

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Defence Technology（防务技术） 2024年第2期32卷 655-662页

作者： Feichao Miao Dandan Li Yangfan cheng Junjiong Meng Lin zhou School of Chemical Engineering Anhui University of Science and TechnologyHuainan 232001China Composite Explosive Research Department Xi'an Modern Chemistry Research InstituteXi'an 710065China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

2,4-dinitroanisole(DNAN)is a good replacement for 2,4,6-trinitrotoluene(TNT)in melt-cast explosives due to its superior *** the increasing use of DNAN-based melt-cast explosives,the prediction of reaction violence and hazard assessment of the explosives subjected to shock is of great *** study investigated the shock initiation characteristics for a DNAN-based melt-cast explosive,DHFA,using the one-dimensional Lagrangian *** embedded manganin gauges in the apparatus record the pressure histories at four Lagrangian positions and show that shock-todetonation transition in DHFA needs a high input shock *** experimental data are analyzed to calibrate the Ignition and Growth *** calibration is performed using an objective function based on both pressure history and the arrival time of *** agreement between experimental and calculated pressure histories indicates the high accuracy of the calibrated parameters with the optimization method.

关键词： 2,4-Dinitroanisole(DNAN) Shock initiation Insensitive explosives Ignition and growth model Equation of state(EOS)

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Thickness regression for backfill grouting of shield tunnels based on GPR data and CatBoost&BO-TPE:A full-scale model test study

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Underground Space 2024年第4期17卷 100-119页

作者： Kang Li Xiongyao Xie Biao zhou Changfu Huang Wei Lin Yihan zhou cheng Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Geotechnical and Underground of Ministry of Education Tongji UniversityShanghai 200092China China Railway 15th Bureau Group Co.Ltd. Shanghai 200070China State Grid Shanghai Municipal Electric Power Company Shanghai 200122China

Ground penetrating radar(GPR)is a vital non-destructive testing(NDT)technology that can be employed for detecting the backfill grouting of shield *** achieve intelligent analysis of GPR data and overcome the subjectivity of traditional data processing methods,the CatBoost&BO-TPE model was constructed for regressing the grouting thickness based on GPR waveforms.A full-scale model test and corresponding numerical simulations were carried out to collect GPR data at 400 and 900 MHz,with known backfill grouting *** model test helps address the limitation of not knowing the grout body condition in actual field *** data were then used to create machine learning *** method of feature selection was proposed based on the analysis of feature importance and the electromagnetic(EM)propagation law in *** research shows that:(1)the CatBoost&BO-TPE model exhibited outstanding performance in both experimental and numerical data,achieving R^(2)values of 0.9760,0.8971,0.8808,and 0.5437 for numerical data and test data at 400 and 900 *** outperformed extreme gradient boosting(XGBoost)and random forest(RF)in terms of performance in the backfill grouting thickness regression;(2)compared with the full-waveform GPR data,the feature selection method proposed in this paper can promote the performance of the *** selected features within the 5–30 ns of the A-scan can yield the best performance for the model;(3)compared to GPR data at 900 MHz,GPR data at 400 MHz exhibited better performance in the CatBoost&BO-TPE *** indicates that the results of the machine learning model can provide feedback for the selection of GPR parameters;(4)the application results of the trained CatBoost&BO-TPE model in engineering are in line with the patterns observed through traditional processing methods,yet they demonstrate a more quantitative and objective nature compared to the traditional method.

关键词： Shield tunnel Backfill grouting GPR Model test gprMax Machine learning CatBoost&BO-TPE Thickness regression

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Solving Multi-Objective Vehicle Routing Problems with Time Windows: A Decomposition-Based Multiform Optimization Approach

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Tsinghua Science and Technology 2024年第2期29卷 305-324页

作者： Yiqiao Cai Zifan Lin Meiqin cheng Peizhong Liu Ying zhou Xiamen Key Laboratory of Data Security and Blockchain Technology College of Computer Science and TechnologyHuaqiao UniversityXiamen361021China College of Engineering Huaqiao UniversityQuanzhou362000China School of Computer Sciences Shenzhen Institute of Information TechnologyShenzhen518000China

In solving multi-objective vehicle routing problems with time windows (MOVRPTW),most existing algorithms focus on the optimization of a single problem formulation. However,little effort has been devoted to exploiting valuable knowledge from the alternate formulations of MOVRPTW for better optimization performance. Aiming at this insufficiency,this study proposes a decomposition-based multi-objective multiform evolutionary algorithm (MMFEA/D),which performs the evolutionary search on multiple alternate formulations of MOVRPTW simultaneously to complement each other. In particular,the main characteristics of MMFEA/D are three folds. First,a multiform construction (MFC) strategy is adopted to construct multiple alternate formulations,each of which is formulated by grouping several adjacent subproblems based on the decomposition of MOVRPTW. Second,a transfer reproduction (TFR) mechanism is designed to generate offspring for each formulation via transferring promising solutions from other formulations,making that the useful traits captured from different formulations can be shared and leveraged to guide the evolutionary search. Third,an adaptive local search (ALS) strategy is developed to invest search effort on different alternate formulations as per their usefulness for MOVRPTW,thus facilitating the efficient allocation of computational resources. Experimental studies have demonstrated the superior performance of MMFEA/D on the classical Solomon instances and the real-world instances.

关键词： MOVRPTW multiform optimization multiform construction knowledge transfer adaptive local search

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Theoretical insights into efficient oxygen evolution reaction using non-noble metal single-atom catalysts on W2CO2 MXene

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Rare Metals 2024年第10期43卷 5082-5094页

作者： Jing-Yu zhou Zhi-cheng Han Shu Zhao Tao Yang Da-zhou Yan Hai-Jun Yu Institute of Advanced Battery Materials and Devices College of Materials Science and EngineeringBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of Technology China ENFI Engineering Corporation National Engineering Research Center of Silicon-Based Materials Manufacturing Technology

The pursuit of highly active oxygen evolution reaction （OER） catalysts,especially those free of noble metals,is a focal point in fuel cell *** extensive density functional theory calculations,this study designed and evaluated the activity and stability of singleatom catalysts （SACs） composed of 3d,4d and 5d transition metals supported on tungsten-based MXene for OER *** highlighted the exceptional OER performance of Ni@W2CO2,Rh@W2CO2and Pt@W2CO2,displaying remarkably low overpotentials The catalytic activity of TM@W2CO2SACs exhibited a robust correlation with surface properties,particularly the d-band center index and surface work *** Ni@W2CO2,Rh@W2CO2and Pt@W2CO2emerged as promising candidates for OER and oxygen reduction reaction （ORR） bifunctional catalysis,while Pt@W2CO2and Rh@ W2CO2showed high potential for OER and hydrogen evolution reaction （HER） bifunctional catalysis The effectiveness of tungsten-based MXene as a substrate for non-noble-metal SACs marks a breakthrough in OER catalyst design,driving advancements towards sustainable energy solutions and addressing critical challenges in energy conversion and storage.

关键词： Density functional theory MXene Non-noble metal Oxygen evolution reaction Single-atom catalysts

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New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： Wei Wang Hang-Yuan cheng Jian-Min zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

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