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Comparative effectiveness of first-line therapies for eradication of antibiotic-resistant Helicobacter pylori strains:A network metaanalysis

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World Journal of Clinical Cases 2022年第35期10卷 12959-12970页

作者： Shu-Peng Zou Qian cheng cheng-yang feng Chan Xu Ming-Hui Sun Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND As a first-line treatment regimen for Helicobacter pylori(***)infection,antibiotic therapy is widely used ***,the question of increasing antibiotic resistance must be *** this issue,we need to find ways to reduce drug *** study examined all currently available first-line regimens and compared them with standard triple treatment through a network meta-analysis of randomized controlled trials(RCTs).AIM To compare first-line treatment regimens for eradication of antibiotic-resistant *** *** To compare the effectiveness of the first-line regimens for treating *** infection,a Bayesian network meta-analysis was applied to process data extracted from *** plausible ranking for each regimen was assessed by the surface under the cumulative ranking curve(SUCRA).In addition,we conducted a relevant search by reference citation *** Twenty-five RCTs involving 12029 participants[including 1602 infected with clarithromycin(CAM)-resistant strains and 1716 infected with metronidazole(MNZ)-resistant strains]were included,in which a total of seven regimens were used for *** *** results showed that dual therapy containing a high-dose proton pump inhibitor(HDDT)[odds ratio(OR):4.20,95%confidence interval(CI):2.29-8.13]was superior to other therapies for all patients,including those with CAM/MNZ-resistant *** *** the comparative effectiveness ranking,for CAM-resistant ***,HDDT(OR:96.80,95%CI:22.46-521.9)had the best results,whereas standard triple therapy ranked last(SUCRA:98.7%vs 0.3%).In the subgroup of high cure rates(≥90%),HDDT was also generally better than other *** For the eradication of CAM-and MNZ-resistant *** strains,HDDT exhibited considerable *** studies of CAM-resistant *** were based on small samples due to a lack of antibiotic sensitivity tests in many RCTs,but the results showed that all patients,including

关键词： Helicobacter pylori Clarithromycin resistance First-line therapy Proton pump inhibitors

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DNA Damage,Apoptosis and C-myc,C-fos,and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

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Biomedical and Environmental Sciences 2006年第3期19卷 197-204页

作者： RI-AN YU cheng-feng yang XUE-MIN CHEN Department of Occupational and Environmental Health MOE Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China

Objective To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes. Methods Sodium selenite at the doses of 5, 10, and 20 μmol/kg was given to rats by i.p. and there were 5 male SD rats in each group. Hepatocellular DNA damage was detected by single cell gel electrophoresis （or comet assay）. Hepatocellular apoptosis was determined by TUNEL （TdT-mediated dUTP nick end labelling） and flow cytometry. C-myc, c-fos, and c-jun expression in rat bepatocytes were assayed by Northern dot hybridization. C-myc, c-fos, and c-jun protein were detected by immunohistochemical method. Results At the doses of 5, 10, and 20μmol/kg, DNA damage was induced by sodium selenite in rat hepatocytes and the rates of comet cells were 34.40%, 74.80%, and 91.40% respectively. Results also showed an obvious dose-response relationship between the rates of comet cells and the doses of sodium selenite （r=0.9501, P〈0.01）. Sodium selenite at the doses of 5, 10, and 20μmol/kg caused c-myc, c-fos, and c-jun overexpression obviously. The positive brown-yellow signal for proteins of c-myc, c-fos, and c-jun was mainly located in the cytoplasm of bepatocytes with immunohistocbemical method. TUNEL-positive cells were detected in selenium-treated rat livers. Apoptotic rates （%） of selenium-treated liver cells at the doses of 5, 10, and 20 μmol/kg were （3.72±1.76）, （5.82±1.42）, and （11.76±1.87） respectively, being much higher than those in the control. Besides an obvious dose-response relationship between apoptotic rates and the doses of sodium selenite （r=0.9897, P〈0.01）, these results displayed a close relationship between DNA damage rates and apoptotic rates, and the relative coefficient was 0.9021, P〈0.01. Conclusion Selenium at 5-20μmol/kg can induce DNA damage, apoptosis, and overexpression of c-myc, c-fos, and c-jun in rat hepatocytes.

关键词： Selenium DNA damage Apoptosis C-myc C-fos C-jun

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Reconstruction of a muon bundle in the JUNO central detector

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Nuclear Science and Techniques 2022年第5期33卷 78-90页

作者： cheng-feng yang Yong-Bo Huang Ji-Lei Xu Di-Ru Wu Yong-Peng Zhang Wu-Ming Luo Miao He Guo-Ming Chen Si-Yuan Zhang School of Physical Science and Technology Guangxi UniversityNanning 530004China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino *** of the main goals is to determine the neutrino mass ordering by precisely measuring the energy spectrum of reactor *** the detection of reactor antineutrinos,cosmogenic backgrounds,such as^(9)Li/^(8)He and fast neutrons induced by cosmic muons,should be rejected carefully by applying muon veto cuts,which require good muon track *** a 20-kton liquid scintillator detector,the simulation shows the proportion of muon bundles(muon multiplicity≥2)to be approximately 8%in JUNO,whereas its reconstruction has been rarely discussed in previous *** study proposes an efficient algorithm for muon track reconstruction based on the charge response of a photomultiplier tube *** is the first reconstruction of muon bundles in a large-volume liquid scintillator *** addition,the algorithm shows good performance and potential for reconstruction for both a single muon and double muons(muon multiplicity=2).The spatial resolution of a single-muon reconstruction was20 cm,and the angular resolution was 0.5°.For doublemuon reconstruction,the spatial and angular resolutions could be 30 cm and 1.0°,***,this paper also discusses muon classification and the veto strategy.

关键词： JUNO Liquid scintillatordetector Muon reconstruction Muon bundle Veto strategy

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Design of an Adaptive Particle Filter Based on Variance Reduction Technique

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自动化学报 2010年第7期36卷 1020-1024页

作者： ZHANG Gong-Yuan cheng Yong-Mei yang feng PAN Quan LIANG Yan Department of Automation Northwestern Polytechnical University Xi′an 710072 P. R. China

The main problem of particle filter(PF)in nonlinear state estimation is the particle degeneracy. Resampling operation solves degeneracy to some extent, but it results in the problem of sample impoverishment. Variance reduction technique is proposed to deal with the degeneration phenomenon in this paper, which reduces the variance of the particle weights by selecting an exponential fading factor, and this factor can be chosen adaptively and iteratively in terms of the e-ective particle number.A theorem is presented to show that this idea is feasible, and the procedure of this new adaptive particle filtering (APF)algorithm is presented. Then, the principle of parameter choice and the limitation of APF are discussed. Finally, a numerical example illustrates that the proposed APF has a higher estimation precision than particle filter-sampling importance resampling(PF-SIR), genetic particle filter(GPF), and particle swarm optimization particle filter(PSOPF), while the computation load of APF is mild.

关键词：粒子滤波器非线性状态估计方法精度

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The Study of Health Effects of Vinyl Chloride AirPollution on Population

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Biomedical and Environmental Sciences 1994年第2期7卷 136-143页

作者： ZHAO MEI-YING YING CHEN-JIANG SHAO NING yang YING yang cheng-feng SHI LEI AND LIU WEN-QING(Department of Environmental Health, School of Public Health, Tongji Medical University, Wuhan 430030)(Environmental Sanitation and Monitoring Station, Sanxi In Department of Environmental Health School of Public Health Tongji Medical University Wuhan China.

A series of indicators, including serum lysozyme activity, G-banding chromosome aberration (G-banding CA) analysis, sister chromatid exchanges (SCEs), chromosome aberration (CA), T-lymphocyte transformation rate (TcTR),-GT, GPT and AKP, were employed in the present survey among occupationally vinyl chloride (VC) exposed workers and inhabitants living in VC polluted area in a polyvinyl chloride (PVC) factory. The results showed that the serum lysozyme (S-LZM) activities in Group 3 (adult inhabitants exposed to 0.20 mg/m3 VC for at least 8 years), Group 2 (workers exposed to 4.1 mg/m3for at least 7 years occupationally), Group 1 (workers exposed to 25.7 mg/m3 for at least 2 years) were significantly higher than control. G-banding CA analysis showed that the total chromosome breakage rates in both Groups 1 and 2 were higher, but no difference existed between Group 3 and control. Only Group 1 was observed having higher SCEs, CA level and lower TcTR than control. AKP levels in Groups 1 and 2 were higher than control,but noγ-GT and GPT differences were found among groups. The study also suggests that G-banding CA analysis is more sensitive than CA and SCEs

关键词： The Study of Health Effects of Vinyl Chloride AirPollution on Population Res

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高旋转雷诺数下预旋进气转-静盘腔流动换热特性

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航空动力学报 2006年第2期21卷 326-330页

作者：杨成凤张靖周南京航空航天大学能源与动力学院江苏南京210016

运用RNG k-ε湍流模型对高旋转雷诺数和预旋进口速度下,静盘外缘预旋进气、转盘外缘轴向出流模型的流动和换热过程进行了三维数值模拟,主要研究了冷气流量Cw、旋转雷诺数R ee等参数对转盘对流换热系数和出流口温度分布的影响,并与垂直... 详细信息

运用RNG k-ε湍流模型对高旋转雷诺数和预旋进口速度下,静盘外缘预旋进气、转盘外缘轴向出流模型的流动和换热过程进行了三维数值模拟,主要研究了冷气流量Cw、旋转雷诺数R ee等参数对转盘对流换热系数和出流口温度分布的影响,并与垂直进气方式进行了对比。研究表明:预旋进气方式与垂直进气相比可降低涡轮叶片冷气入口总温;冷气流量增大以及旋转雷诺数增大均使得转盘平均换热增强;涡轮叶片入口温度随冷气流量增大而降低,随着旋转雷诺数的增大先升高后降低。

关键词：航空航天推进系统预旋转-静盘流动传热数值模拟

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全覆盖气膜孔阵列方式对冷却特性的影响

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航空动力学报 2010年第7期25卷 1524-1529页

作者：杨成凤张靖周杨卫华南京航空航天大学能源与动力学院南京210016

运用标准k-ε湍流模型对不同吹风比下正菱形、长菱形和超长菱形三种气膜孔阵列方式的多孔全覆盖气膜冷却的气膜出流流场特性、气膜绝热冷却效率和气膜综合冷却效率进行了数值模拟对比研究.结果表明:气膜孔阵列超长菱形排布是较优的排布... 详细信息

运用标准k-ε湍流模型对不同吹风比下正菱形、长菱形和超长菱形三种气膜孔阵列方式的多孔全覆盖气膜冷却的气膜出流流场特性、气膜绝热冷却效率和气膜综合冷却效率进行了数值模拟对比研究.结果表明:气膜孔阵列超长菱形排布是较优的排布方案,在该排布方式下,气膜出流向主流的穿透相对较弱,气膜沿展向的覆盖率也较高,因而气膜绝热冷却效率相对最高;气膜孔排布方式对气膜综合冷却效率的影响规律与气膜绝热冷却效率的基本一致,超长菱形排布仍然是较优的排布方案.

关键词：全覆盖气膜冷却流场气膜绝热冷却效率气膜综合冷却效率排布方式

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Off-pump anteroapical aneurysm plication for left ventricular post-infarction aneurysm： long-term results

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Chinese Medical Journal 2012年第18期125卷 3228-3235页

作者： HUANG Xin-sheng GU cheng-xiong yang Jun-feng WEI Hua LI Jing-xing YU yang FANG Ying LIU Rui LI Hai-tao ZHOU Qi-wen Department of Cardtiac Surgery Beijing An Zhen Hospital CapitalMedical University China Beijing 100029

Background The temporal response to off-pump anteroapical aneurysm plication has not been well defined. We have evaluated the long-term clinical and functional results of this technique and compared the efficacy with the patch modeling repair. Methods From March 2005 to May 2010, 163 （115 men and 48 women） consecutive patients were operated on for post-infarction left ventricular aneurysm （LVA）, 54 patients underwent patch remodeling （group A） and 109 patients underwent off-pump anteroapical aneurysm plication repair （group B）. All patients had simultaneous coronary revascularization, other operative procedures included septoplasty in eight and ablation of ventricular tachycardia in six. Follow-up ranged from 1 to 5 years, short-term and mid-term outcomes, including complications, cardiac function, and mortality, were assessed. Results Early mortality was 1.8% for all patients （group A 1 death vs. group B 2 deaths, not significant （NS））. Peri-operative support included intraaortic balloon pumping in 16 （9.8%）, （group A 6 patients vs. group B 10 patients, NS） and inotropic drugs in 84 （51.5%）, （group A 34 vs. group B 50, NS）. During a mean follow-up of （3.7±0.8） years, eight patients died, with four due to cardiac-related causes. No patient required transplantation, and two required use of an implantable cardioverter-defibrillator for ventricular tachycardia. Survival at 1 and 5 years was 95% and 86%, respectively. It did not differ significantly between group A and group B. Functional class improved from 2.90±0.59 to 1.65±0.54 among the mid-term survivors （P 〈0.001）, with no significant difference between the two groups. Pre-operative risk factors for mortality or poor function were ejection fraction （EF）〈0.35 （OR=7.9, 95% CI 1.6-40.0）; congestive heart failure （CHF）（OR=4.4, 95% CI 1.0-19.0）; end-systolic volume index （ESVI）〉80 ml/m2 （OR=3.7, 95% CI 1.0-14.0）; and advanced age 〉70 years （OR=2.4, 95% CI 1.0-12.0）.

关键词： coronary artery bypass, off-pump cardiac surgical procedures, aneurysm myocardial infarction

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Localizing base stations with measured data:a concatenated image-based deep learning approach

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Science China(Information Sciences) 2025年

作者： yang CHEN Ziyuan LIU feng JIANG Hong SHEN Wei XU Mengyu LI Ritao cheng National Mobile Communications Research Laboratory Southeast University China Mobile Group Design Institute Co. Ltd.

Localization has become an indispensable function of modern cellular communication systems[1]. In a cloud radio access network （C-RAN）, the remote radio head （RRH） is the actual signal transmitter, whose location ...

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新型非对称交错混合励磁同步电机电磁设计

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中国电机工程学报 2008年第24期28卷 82-87页

作者：杨成峰林鹤云刘细平东南大学电气工程学院江苏省南京市210096

分析了新型非对称交错混合励磁同步电机的结构特征与工作原理。阐述电机的电磁设计理论与设计方法,包括电磁负荷与电机主要尺寸确定、定转子结构设计和励磁绕组的设计等。据此设计并制作一台2kW、8极样机,对样机进行不同负载条件下的调... 详细信息

分析了新型非对称交错混合励磁同步电机的结构特征与工作原理。阐述电机的电磁设计理论与设计方法,包括电磁负荷与电机主要尺寸确定、定转子结构设计和励磁绕组的设计等。据此设计并制作一台2kW、8极样机,对样机进行不同负载条件下的调磁性能测试,给出不同转速和励磁电流时空载线反电动势变化及负载输出转矩变化情况。实验结果表明:该电机结构新颖,调磁性能较好,只需相对较小的励磁电流便可实现气隙磁通的宽范围调节。

关键词：混合励磁同步电机爪极电磁设计三维有限元调磁

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