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Fucoxanthin promotes the chain lengthening reaction of polyunsaturated fatty acids in vivo by enhancing FADS2 enzyme activity

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Food Science and Human Wellness 2024年

作者： Xiao-yue Li Tian-xin Yang Ying-Cai Zhao cheng-cheng Wang Chang-Hu Xue Teruyoshi Yanagita yu-Ming Wang Tian-Tian Zhang SKL of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China Laboratory of Nutrition Biochemistry， Department of Applied Biochemistry and Food Science， Saga University

Alpha-linolenic acid (ALA) is capable of synthesizing EPA and DHA in vivo， but the conversion rate is hard to meet the body's need for rapid DHA supplementation. Studies have shown that fucoxanthin can increase DHA content in the liver of mice， but the mechanism is not clear. Moreover， the effect of fucoxanthin and its metabolite fucoxanthinol on the chain lengthening reaction of n-6 polyunsaturated fatty acids (PUFAs) is little studied. In this study， the effects of fucoxanthin and fucoxanthinol on the chain elongation of n-3 and n-6 series PUFAs were investigated in mice. Results showed that fucoxanthin and fucoxanthinol significantly increased the conversion of n-3 series ALA to DHA and n-6 series LA to AA in the serum， liver， small intestine， and heart of mice. In addition， fucoxanthin accelerated the rate of DHA supplementation by ALA in the brain. Further mechanistic studies revealed that the role of fucoxanthin in promoting PUFAs conversion was not regulated at transcriptional level， but by increasing the activity of fatty acid desaturase 2 (FADS2)， a key enzyme of chain elongation reaction of n-3 and n-6 PUFAs. This study fundamentally provided theoretical bases for a new strategy of dietary supplementation of n-3 and n-6 PUFAs.

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Single transition-metal atoms anchored on a novel Diracdispersiveπ-πconjugated holey graphitic carbon nitride substrate:computational screening toward efficient bifunctional OER/ORR electrocatalysts

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Rare Metals 2024年第8期43卷 3819-3832页

作者： Chun-Yao Fang Xi-Hang Zhang Qiang Zhang Di Liu Xiao-Meng Cui Jing-cheng Xu cheng-Long Shi Meng-yu Yang College of Science University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Nonprecious-metal-group single-metal-atom catalysts with bifunctional catalytic capabilities toward the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)are highly sought after in energy-conversion and storage ***,producing renewable and sustainable energy sources remains ***,single-transition metal atoms anchored onπ-πconjugated two-dimensional(2D)graphitic carbon nitride substrates formπ-d conjugated conductive channels that enhance the overall electrocatalytic ***,firstprinciples calculations were carried out to design and demonstrate a novel macropore graphitic carbon nitride(gC_(10)N_(3))as a promising 2D electrocatalyst substrate to support single-transition metal(TM,from Sc to Au).The"donation-acceptance"charge interaction in the TM-N_(2)moiety effectively balances the adsorption strength of oxygenated intermediates in Ni@g-C_(10)N_(3)and Rh@gC_(10)N_3,making them effective bifunctional OER/ORR electrocatalysts with IrO_(2)/Pt-beyond overpotentials being as low as 0.39/0.38 V and 0.54/0.44 V,***,they possess high stability and conductivity and are less susceptible to oxidation and corrosion under working *** guarantees high activity under ambient ***,the origin of the OER/ORR activity of TM@g-C_(10)N_(3) is explained using multilevel descriptors:intrinsic(p,Bader charge,integral crystal orbital Hamilton population(ICOHP),bond length,and d-band center(εd).In particular,for optimal Ni@g-C_(10)N_(3),the clear hybridization between the Ni-d orbital and surface O-p orbital causes the paired electrons to occupy the bonding *** enables OH~*to be adsorbed on the Ni@g-C_(10)N_(3),thereby achieving the highest catalytic performance.

关键词： First-principles calculation Oxygen evolution reaction Oxygen reduction reaction Bifunctional electrocatalysts Single-metal-atom electrocatalysts

A columnar multi-layer sliding triboelectric nanogenerator for water wave energy harvesting independent of wave height and direction

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Nano Research 2024年第4期17卷 3029-3034页

作者： Xue Miao Hanxiao Yang Zekun Li Meifei cheng Yilin Zhao Lingyu Wan Aifang yu Junyi Zhai Center on NanoEnergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Beijing Institute of Nano Energy and Nano Systems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of ScienceBeijing 101408China

The ocean,with its highly variable and complex meteorological conditions,harbors enormous renewable *** nanogenerators(TENGs),which possess unique advantages,show exciting prospects in water wave energy *** to design and optimize TENGs to cover all characteristic water wave energies and achieve efficient energy utilization is *** this paper,we carefully designed and fabricated a columnar multi-layer sliding TENG(CMLS-TENG)that can harvest water wave energy independent of wave height and *** rods with a hollow acrylic spherical shell were introduced to deliver wave energy,ensuring that the CMLS-TENG can work in all directions from 0°to 360°.Based on the sliding structure,switching the optimized CMLS-TENG is independent of wave *** optimized CMLS-TENG can achieve a total power density of 730 mW/m^(3) at a wave height of only 4.8 cm regardless of wave direction,which can illuminate multiple light-emitting diodes(LEDs)to provide lighting and provide power to a watch and a hygrometer for temperature and humidity *** work provides new choices and hopes for the effective collection of full-range water wave energy.

关键词： triboelectric nanogenerator wave energy multi-direction columnar slide

Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-Shan Lai Hao Chen Chu-Hao Xia Si-yuan yu cheng He Yan-Feng Chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3493-3512页

作者： Longhao cheng Xiaoxue Wang Aijun Liu Ying Zhu Hu cheng Jiangling yu Lili Gong Honglin Liu Guolin Shen Lihong Liu Institute of Clinical Medical Sciences ChinaeJapan Friendship HospitalCapital Medical UniversityBeijing 100029China Department of Pharmacy ChinaeJapan Friendship HospitalBeijing 100029China Beijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China Institute of Chemicals Safety Chinese Academy of Inspection and QuarantineBeijing 100020China

Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino *** acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stimulate cancer ***,the role of phenylalanine in multiple myeloma(MM)remains ***,we demonstrate that phenylalanine levels in MM patients are decreased in plasma but elevated in bone marrow(BM)*** the treatment,phenylalanine levels increase in plasma and decrease in *** suggests that changes in phenylalanine have diagnostic value and that phenylalanine in the BM microenvironment is an essential source of nutrients for MM *** requirement for phenylalanine by MM cells exhibits a similar *** phenylalanine utilization suppresses MM cell growth and provides a synergistic effect with Bortezomib(BTZ)treatment in vitro and murine ***,phenylalanine deprivation induces excessive endoplasmic reticulum stress and leads to MM cell apoptosis through the ATF3eCHOPeDR5 *** with ATF3 significantly affects phenylalanine deprivation *** conclusion,we have identified phenylalanine metabolism as a characteristic feature of MM metabolic *** is necessary for MM proliferation,and its aberrant demand highlights the importance of lowphenylalanine diets as an adjuvant treatment for MM.

关键词： Multiple myeloma Phenylalanine Amino acid metabolism Nutrient deprivation Cancer therapy Endoplasmic reticulum stress ATF3 Apoptosis

Study on hydrodynamic diffusion law of the swelling particle slurry in karst pipeline

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Particuology 2024年第4期87卷 218-231页

作者： Bingchuan cheng Haibo Li Guangming Pan Runhuai Deng yu'an Gong Shujun Xu Kun Zhou Zhuo Zheng School of Civil Engineering Geotechnical and Structural Engineering Research CenterShandong UniversityJinan250061China The Fourth Prospecting of Shandong Coal Geology Bureau Weifang261000China China Railway 14th Bureau Group Corporation Limited Jinan250101China School of Trafic Engineering Shandong Jianzhu University.Fengming RoadLingang Development ZoneJinan250101China

The swelling particle grouting material has demonstrated remarkable plugging effectiveness in high-pressure and large-flow burst water within karst ***,current research on the rheolog-ical model,flow computation theory,and plugging mechanism of this material is *** conven-tional grouting slurry diffusion process,using the liquid-liquid two-phase flow method,fails to accurately simulate high solubility slurry and particle *** address these limitations,this study established a precise constitutive model to describe the swelling particle slurry diffusion process in dynamic ***,a coupling calculation method was proposed to analyze the spatiotemporal heterogeneity of viscosity during slurry diffusion by considering the migration of slurry and the changes in *** investigate the interaction between particle swelling and flow field changes,a Compu-tational Fluid Dynamics-Discrete Element Method(CFD-DEM)coupling model was developed for the diffusion of swelling particle *** is demonstrated that slurry viscosity increases exponentially within the diffusion front as the particle swelling rate rises,and the drag force exhibits an intriguing behavior of initially increasing and then decreasing as the slurry flows through the ***-more,the CFD-DEM coupling model proved to be more accurate in describing viscosity distribution and diffusion distance compared to the finite element *** primary objective of this paper is to reveal the plugging mechanism and provide theoretical support for the engineering application of the swelling particle grouting material.

关键词： Karst pipeline Swelling particle grouting material Dynamic water diffusion Spatiotemporal variation of viscosity CFD-DEM coupling model

Data augmentation method for insulators based on Cycle-GAN

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Journal of Electronic Science and Technology 2024年第2期22卷 36-47页

作者： Run Ye Azzedine Boukerche Xiao-Song yu cheng Zhang Bin Yan Xiao-Jia Zhou School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu611731China School of Electrical Engineering and Computer Science University of OttawaOttawaK1N6N5Canada Yangtze River Delta Research Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China

Data augmentation is an important task of using existing data to expand data *** generative countermeasure network technology to realize data augmentation has the advantages of high-quality generated samples,simple training,and fewer restrictions on the number of generated ***,in the field of transmission line insulator images,the freely synthesized samples are prone to produce fuzzy backgrounds and disordered samples of the main insulator *** solve the above problems,this paper uses the cycle generative adversarial network(Cycle-GAN)used for domain conversion in the generation countermeasure network as the initial framework and uses the self-attention mechanism and channel attention mechanism to assist the conversion to realize the mutual conversion of different insulator *** attention module with prior knowledge is used to build the generation countermeasure network,and the generative adversarial network(GAN)model with local controllable generation is built to realize the directional generation of insulator belt defect *** experimental results show that the samples obtained by this method are improved in a number of quality indicators,and the quality effect of the samples obtained is excellent,which has a reference value for the data expansion of insulator images.

关键词： Data expansion Deep learning Generate confrontation network Insulator

Short-term Association of Meteorological Elements on COVID-19 Pandemic in a Semi-arid City of Northwest China,2021-2022

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Biomedical and Environmental Sciences 2024年第5期37卷 537-542页

作者： FENG Feng Liu MA yu Xia cheng Bo Wen LIU Zong Rui ZHAO yu Han YANG Jie College of Atmospheric Sciences Key Laboratory of Semi-Arid Climate ChangeMinistry of EducationLanzhou UniversityLanzhou 730000GansuChina Minhe Meteorological Bureau Minhe 810800QinghaiChina

The coronavirus disease 2019(COVID-19)outbreak in late 2019 significantly impacted global *** virus’s rapid spread,with its long incubation period and high infection level,caused substantial disruption to regular social frameworks,production,and lifestyles^([1]).COVID-19 is primarily transmitted through close contact,long-range contaminants,and airborne routes.

关键词： Northwest COV primarily

The effect of seismic action on stability of saline soil subgrade in cold region based on isothermal stratification method

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Earthquake Research Advances 2024年第3期4卷 66-81页

作者： Jie cheng yu Zhang Ying Ma Xuerui Chen Ning An School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou730070China Key Laboratory of Railway Industry of Plateau Railway Transportation Intelligent Management and Control Lanzhou Jiaotong UniversityLanzhou730070China Gansu Institute of Engineering Geology Lanzhou730030China

With the change of seasons, the shear strength of saline soil subgrade filler will change with the change of external temperature, which will aggravate the adverse effects of seismic on the subgrade. To explore the influence of seismic action on the stability of saline soil subgrade under the influence of temperature on the strength of saline soil subgrade filler, this paper first carried out saline soil shear tests at different temperatures to obtain the influence of temperature on the shear strength of saline soil. Then, the temperature field of the saline soil subgrade was simulated, and then based on the subgrade isothermal stratification model and FLAC3D, the displacement and acceleration amplification effects of seismic action on the shady slope, sunny slope and subgrade of saline soil subgrade in different months were analyzed. The following conclusions were finally drawn: under the action of seismic, In the process of the change of subgrade temperature of Qarhan-Golmud Expressway between 7.7°C and 27°C, the change of saline soil cohesion is the main factor affecting the stability of subgrade slope, and the maximum and minimum values of subgrade surface settlement appear in September and June of each year,respectively. In August, the differences of settlement between the shady slope and the sunny slope shoulder of the subgrade were the largest, and the acceleration of the shady slope and the sunny slope and the inside of the subgrade changed most significantly in the vertical direction. Special attention should be paid to the seismic early warning in the above key months;In the range from both sides of the shoulder to the centerline of the roadbed,the acceleration amplification effect starts to increase significantly from about 3m from the centerline of the roadbed to the centerline, so it is necessary to pay attention to the seismic design of this range.

关键词： Subgrade stability Saline soils Acceleration amplification effect Seismic design