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Indocyanine green fluorescence imaging for spleen preservation in laparoscopic splenic artery aneurysm resection:A case report

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World Journal of Gastrointestinal Surgery 2022年第7期14卷 714-719页

作者： Jian cheng Li-Yang Sun Jie Liu cheng-wu zhang Department of General Surgery Cancer CenterDivision of Hepatobiliary and Pancreatic SurgeryZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Splenic artery aneurysm(SAA)is a rare vascular lesion conventionally treated by resection or interventional *** surgical procedure usually involves splenectomy,and interventional therapy may cause post-embolization *** of the spleen and its function is rarely reported during the management of *** SUMMARY We report a patient with an asymptomatic SAA(3.5 cm in diameter),which was en-bloc resected laparoscopically using indocyanine green(ICG)fluorescence imaging to preserve the spleen and its *** ICG fluorescence imaging for spleen preservation in laparoscopic SAA resection is safe and may be beneficial in avoiding splenectomy and maintaining splenic function.

关键词： Laparoscopic Indocyanine green Fluorescence imaging Splenic artery Aneurysm Spleen-preserving Case report

Indocyanine green retention is a potential prognostic indicator after splenectomy and pericardial devascularization for cirrhotic patients

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 386-390页

作者： Yuan-Biao zhang Yi Lu Wei-Ding wu cheng-wu zhang Guo-Liang Shen De-Fei Hong Department of Hepatopancreaticobiliary Surgery&Laparoscopic Minimally hwasive Surgery Zhejiang Provincial People's HospitalHangzhou 310014China

BACKGROUND：Splenectomy and pericardial devascularization（SPD）is an effective treatment of upper gastrointestinal bleeding and hypersplenism in cirrhotic patients with portal *** green retention at 15 minutes（ICGR15）was reported to offer better sensitivity and specificity than the Child-Pugh classification in hepatectomy,but few reports describe ICGR15 in *** present study was to evaluate the prognostic value of ICGR15 for cirrhotic patients with portal hypertension who underwent ***：From January 2012 to January 2015,43 patients with portal hypertension and hypersplenism caused by liver cirrhosis were admitted in our center and received *** ICGR15,Child-Pugh classification,model for end-stage liver disease（MELD）score,and perioperative characteristics were analyzed ***：Preoperative liver function assessment revealed that 34 patients were Child-Pugh class A with ICGR15 of13.6%-43.0%and MELD score of 7-20;8 patients were class B with ICGR15 of 22.8%-40.7%and MELD score of 7-17;1patient was class C with ICGR15 of 39.7%and MELD score of *** optimal ICGR15 threshold for liver function compensation was 31.2%,which offered a sensitivity of 68.4%and a specificity of 70.8%.Univariate analysis showed preoperative ICGR15,MELD score,surgical procedure,intraoperative blood loss,and autologous blood transfusion were significantly different between postoperative liver function compensated and decompensated *** regression analysis revealed that ICGR15 was an independent risk factor of postoperative liver function recovery（P=0.020）.CONCLUSIONS：ICGR15 has outperformed the Child-Pugh classification for assessing liver function in cirrhotic patients with portal ***15 may be a suitable prognostic indicator for cirrhotic patients after SPD.

关键词： indocyanine green liver function test liver cirrhosis splenectomy pericardial devascularization

Pancreatic cancer: open or minimally invasive surgery?

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World Journal of Gastroenterology 2016年第32期22卷 7301-7310页

作者： Yu-Hua zhang cheng-wu zhang Zhi-Ming Hu De-Fei Hong Division of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s Hospital

Pancreatic duct adenocarcinoma is one of the most fatal malignancies, with R0 resection remaining the most important part of treatment of this malignancy. However, pancreatectomy is believed to be one of the most challenging procedures and R0 resection remains the only chance for patients with pancreatic cancer to have a good prognosis. Some surgeons have tried minimally invasive pancreatic surgery, but the shortand long-term outcomes of pancreatic malignancy remain controversial between open and minimally invasive procedures. We collected comparative data about minimally invasive and open pancreatic surgery. The available evidence suggests that minimally invasive pancreaticoduodenectomy(MIPD) is as safe and feasible as open PD(OPD), and shows some benefit, such as less intraoperative blood loss and shorter postoperative hospital stay. Despite the limited evidence for MIPD in pancreatic cancer, most of the available data show that the short-term oncological adequacy is similar between MIPD and OPD. Some surgical techniques, including superior mesenteric artery-first approach and laparoscopic pancreatoduodenectomy with major vein resection, are believed to improve the rate of R0 resection. Laparoscopic distal pancreatectomy is less technically demanding and is accepted in more pancreatic centers. It is technically safe and feasible and has similar short-term oncological prognosis compared with open distal pancreatectomy.

关键词： Laparoscopic Minimally invasive Robotic Pancreaticoduodenectomy Distal pancreatectomy Pancreatic cancer

Field testing of geosynthetic-reinforced and column-supported earth platforms constructed on soft soil

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Frontiers of Structural and Civil Engineering 2014年第2期8卷 124-139页

作者： Qiangong cheng Jiujiang wu Dongxue zhang Fengping MA Department of Geological Engineering Southwest Jiaotong University Chengdu 610031 China

This paper is focused on the behavior of geosynthetic-reinforced and column-supported （GRCS） earth platforms in soft soil. By analyzing the data of a 15-month long field monitoring project, the bearing behavior and effectiveness of GRCS earth platforms are discussed in detail. It can be found that the soil arching is generated when the filling reaches a certain height. The measured pressure acting on the soil in the center of four piles was smaller than that acting on the soil between two piles. The elongation and the tension of the geogrid located in the soil between piles are both larger than the corresponding values on the pile top. The skin friction of piles is relatively small in the soil layer with low strength and the load transfer of the axial force in those layers is significant; meanwhile, the opposite situation occurs in the soil layer with high strength. The pore water pressure at shallow locations increases slightly with the filling height and is greatly affected by the increasing filling load. The layered settlement is directly proportional to the filling height, and the corresponding amount is relevant to the locations and the properties of specific soil layers. Additionally, the lateral displacement of the embankment increases with greater loading and decreases with increased depth. These suggest that the use of GRCS system can reduce lateral displacements and enhance the stability of an embankment significantly.

关键词： geosynthetic-reinforced and column-supported (GRCS) earth platforms soft soil bearing behavior settlementand deformation field testing

Performance of Sm_(0.7)Sr_(0.3)CoO_(3-δ) dmembrane under CO_2-containing atmosphere

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Rare Metals 2016年第9期35卷 723-728页

作者： Yu-Wen zhang Fan-Lin Zeng Chen-Chen Yu cheng-zhang wu Wei-Zhong Ding Xiong-Gang Lu Shanghai Key Laboratory of Modern Metallurgy and Materials Processing Shanghai University

The permeability and stability of Sm_（0.7）Sr_（0.3）CoO_（3-δ）（SSCO） regarding the special requirements for carbon capture and storage（CCS） application were *** CO_ was used as the sweep gas at 900 °C,leading to that the oxygen permeation flux decreases by about 34 %.Several cycles of changing the sweep gas between helium and CO_2 indicate the good reversibility of this *** carbonate formation and adsorption of CO_2 on the membrane surface are responsible for the degradation of the membrane *** better CO_2 resistance results from the substitution of Sm for Sr due to the higher acidity of Sm_2O_3（1.278） than that of Sr O（0.978） and a discontinuous layer of carbonate.

关键词： Sm0.7Sr0.3CoO3-δ Oxygen permeation CO2 Carbonate Perovskite

c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 30-37页

作者： Rong-Rong Wang cheng-Fang Li De-Zu Wang cheng-wu zhang Gui-Xiang Liu Qingdao University Department of Ophthalmology Jimo Traditional Chinese Medicine Hospital Department of Ophthalmology Affiliated Qingdao Hiser Hospital of Qingdao University Institute of Advanced Materials Nanjing Tech University Department of Ophthalmology Affiliated Hospital of the Medical College of Qingdao University

AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells(RGCs) by double-immunofluorescent staining. Then we created optic nerve axotomy model in wild type as well as JNK1, JNK2, JNK3, isoform specific gene deficiency mice. With that, we checked the protein expression profile of JNKs and its active form, and quantified the survival RGCs number by immunofluorescence staining. We further explored the molecules underlying isoform specific protective effect by real-time polymerase chain reaction(PCR) and Western blotting assay. RESULTS: We found that all the three isoforms of JNKs were expressed in the RGCs. Deficiency of JNK3, but not JNK1 or JNK2, significantly alleviated optic nerve axotomyinduced RGCs apoptosis. We further established that expression of Noxa, a pro-apoptotic member of BH3 family, was significantly suppressed only in JNK3 gene deficiency mice. But tumor necrosis factor receptor 1(TNFR1) and Fas, two key modulators of death receptor mediated apoptosis pathway, did not display obvious change in the expression. CONCLUSION: It is suggested that mitochondria mediated apoptosis, but not death receptor mediated apoptosis got involved in the JNK3 gene deficiency induced RGCs protection. Our study provides a novel insight into the isoform-specific role of JNKs in neurotrauma and indicates some cues for its therapeutics.

关键词： retinal ganglion cells c-Jun N-terminal kinases optic nerve mitochondria Noxa neurotrauma

Laparoscope resection of retroperitoneal ectopic insulinoma: A rare case

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World Journal of Gastroenterology 2015年第14期21卷 4413-4418页

作者： Jie Liu cheng-wu zhang De-Fei Hong Jia wu Hong-Guo Yang Yuan Chen Da-Jian Zhao Yu-Hua zhang Department of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s Hospital Department of General Surgery Haining Branch of Zhejiang Provincial People’s Hospital Department of Pathology Zhejiang Provincial People’s Hospital

Ectopic insulinoma is a very rare and dormant *** we report the case of a 79-year-old female who presented with repeated episodes of hypoglycemia and was diagnosed with insulinoma based on laboratory and imaging *** tomography and positron emission tomography revealed a tumor in the retroperitoneum under and left of the hepatoduodenal ligament, which was resected successfully using a laparoscopic *** results revealed an ectopic insulinoma, which was confirmed *** insulinomas are accompanied by hypoglycemia that can be misdiagnosed as drug- or *** tumors are difficult to diagnose and locate, particularly in atypical cases or for very small *** or targeted examinations, including low blood glucose, elevated insulin, proinsulin, and C-peptide levels, 48-h fasting tests, and relevant imaging methods should be considered for suspected cases of *** is the treatment of choice for patients with insulinoma, and laparoscopic resection is a feasible and effective method for select ectopic insulinoma cases.

关键词： Diagnosis Ectopic insulinoma Hypoglycemia Laparosc

Rare cause of upper gastrointestinal bleeding owing to hepatic cancer invasion:A case report

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World Journal of Gastroenterology 2014年第35期20卷 12704-12708页

作者： Wei-Ding wu Jia wu Hong-Guo Yang Yuan Chen cheng-wu zhang Da-Jian Zhao Zhi-Ming Hu Department of Hepatopancreatobiliary surgery and Minimally invasive surgery Zhejiang Provincial People’s Hospital Department of General Surgery Haining branch of Zhejiang Provincial People’s Hospital Department of Pathology Zhejiang Provincial People’s Hospital

Upper gastrointestinal bleeding refers to bleeding that arises from the gastrointestinal tract proximal to the ligament of *** primary reason for gastrointestinal bleeding associated with hepatocellular carcinoma is rupture of a varicose vein owing to pericardial *** report a rare case of gastrointestinal bleeding with hepatocellular carcinoma in a patient who presented with recurrent gastrointestinal *** initial diagnosis was gastric cancer with metastasis to the multiple lymph nodes of the lesser *** patient underwent exploratory laparotomy,which identified two lesions in the gastric *** gastrectomy and hepatic local excision was then *** results indicated that the hepatocellular carcinoma had invaded the stomach directly,which was confirmed *** patient is alive with a disease-free survival of 1 year since the *** carcinoma with gastric invasion should be considered as a rare cause of upper gastrointestinal bleeding in hepatocellular carcinoma patients,especially with lesions located in the left lateral hepatic *** is the best solution.

关键词： Bleeding Cancer Gastrointestinal tract Liver Neoplasm invasion

Malignant acanthosis nigricans with Leser–Trélat sign and tripe palms:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5632-5638页

作者： Ning Wang Peng-Jie Yu Zhi-Lin Liu Sheng-Mao Zhu cheng-wu zhang Graduate School Qinghai UniversityXining 810016Qinghai ProvinceChina Department of Gastrointestinal Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND Acanthosis nigricans(AN),Leser–Trélat sign,and tripe palm are all skin *** date,reports of these appearing as a paraneoplastic syndrome in a gastric cancer patient are quite *** SUMMARY We report the case of a 61-year-old man with darkened skin color in the face and torso with no obvious inducement after 1 year of treatment for Riehl’s *** had 40 brown maculopapular eruptions on his face and the top of his head with obvious *** wart-like hyperkeratosis with dark brown pigmentation was also observed on both sides of the *** had papillomalike lesions on the face,around the orbit,and on the *** bilateral palms had small,smooth,papillary projections with millet-like *** examination of the skin showed that the patient was suffering from AN,tripe palms,and Leser–Trélat *** showed the patient’s cardia was affected,and pathological biopsy revealed that he had moderate-to-poorly differentiated *** tomography test results showed that his cardia wall had *** on these histological and skin characteristics,the patient was diagnosed with gastric cancer with AN,tripe palms,and Leser–Trélat *** Researchers should follow up on patients with malignant AN,Leser–Trélat sign,and tripe palms.

关键词： Acanthosis nigricans Leser-Trélat sign Tripe palms Paraneoplastic syndrome Gastric cancer Case report