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Synthesis and magnetic properties of one-dimensional Mn(Ⅱ)complexes linked by dithiooxalato

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Chinese Science Bulletin 2003年第9期48卷 859-861页

作者： CUI Jianzhong, SHI wei, cheng Peng, chen Xufang, LIAO Daizheng, YAN Shiping, JIANG Zonghui & WANG GenglinDepartment of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to cheng Peng (e-mail: pcheng@ ***) 1. Department of Chemistry Nankai University Tianjin 300071 China

Three dithiooxalato (Dto) bridging one-dimensional Mn(Ⅱ) complexes [Mn(L)Dto](L = Phen (1), Bpy (2) and en (3)) were synthesized. All of the complexes have the similar one-dimensional structure through Dto bridge. The measurement of the variable temperature magnetic susceptibility of complex 1 showed that there are weak antiferromag- netic interactions between the Mn(Ⅱ) ions.

关键词：一维结构锰配合物合成反铁磁性 Dto 二硫代草酰胺

黄河兰州段河岸带土壤中微生物与耐药基因的赋存特征

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环境科学 2024年第5期45卷 2686-2693页

作者：韦程宸魏枫沂夏慧黄魁兰州交通大学环境与市政工程学院兰州730070 甘肃省黄河重点实验室兰州730070

河岸带土壤是流域的重要组成部分,生物污染物赋存特性影响了流域水环境的污染治理.以农田、周山和工业用地为代表性土壤,探究黄河兰州段河岸带土壤中微生物群落结构、抗生素抗性基因(ARGs)及其遗传原件(MGEs)的赋存特征.结果表明,变形... 详细信息

河岸带土壤是流域的重要组成部分,生物污染物赋存特性影响了流域水环境的污染治理.以农田、周山和工业用地为代表性土壤,探究黄河兰州段河岸带土壤中微生物群落结构、抗生素抗性基因(ARGs)及其遗传原件(MGEs)的赋存特征.结果表明,变形菌门、拟杆菌门和放线菌门为黄河兰州段河岸带土壤的优势菌门.河岸带土壤的微生物种群结构与土地利用类型存在相关性(P周山>工业.定量PCR结果表明,磺胺类ARGs为黄河流域兰州段土壤中的优势基因,其中sul1丰度最高,为其它检测ARGs的20~36000倍.工业类型土壤的ARGs中的总绝对丰度最高.主坐标分析(PCoA)显示ARGs的赋存特性与土地类型也有显著性关联(P<0.05),并且intl1与tnpA⁃04分别对磺胺类ARGs和四环素类ARGs的传播具有驱动效果.冗余分析(RDA)表明,黄河兰州段河岸带土壤中的无机盐离子和总磷的含量是改变微生物结构的主要理化因子,盐杆菌门和酸杆菌门是驱动ARGs结构变化的主要微生物菌群.

关键词：河岸带抗生素抗性基因(ARGs) 流域微生物群落土地利用类型

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali chen Yiyong wei Jin Liu Tao Zhu cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study

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World Journal of Gastroenterology 2015年第2期21卷 653-660页

作者： Er-Li Gu Yi-Qi Yu Jia-Li Wang Yan-Yan Ji Xiu-Yun Ma Qing Xie Hong-Ying Pan Shan-Min Wu Jun Li cheng-wei chen Xiao-wei Xu Yue-Er Wang Guang-Bi Yao Hong Wang Wen-Hong Zhang Department of Gastroenterology and Hepatology Jing’an District Central Hospital Jing’an Branch of Huashan Hospital Fudan University Department of Infectious Diseases Huashan HospitalFudan University Department of Infectious Diseases Ditan Hospital Department of Hepatology Department of Infectious DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong University Department of Infectious Diseases The 6th People’s Hospital of Hangzhou Shanghai Public Health Clincal Center Department of Infectious Diseases Jiangsu Provincial Hospital Department of Hepatology Shanghai Liver Disease Research Center of Nanjing Military Area Department of Infectious Diseases The 1st Affiliated Hospital of Zhejiang University MOH and MOE Key Laboratory of Medical Molecular Virology Shanghai Medical CollegeFudan University Institutes of Biomedical Sciences Fudan University

AIM: To observe the effect of response-guided add-on therapy with adefovir(ADV) and lamivudine(LAM) in cirrhotic hepatitis B(CHB) ***: A total of 100 patients with CHB and cirrhosis were divided into three arms according to hepatitis B virus(HBV) DNA level after 24 wk LAM monotherapy: Arm A(complete response, HBV DNA ≤ 60 IU/m L, n = 49), Arm B(partial response, HBV DNA: 60-2000 IU/m L, n = 31) and Arm C(inadequate response, HBV DNA > 2000 IU/m L, n = 20). ADV was added to LAM at week 48 in Arms A and B, but at week 24 in Arm C. Virological response, YMDD mutations, biochemical response, and liver function were ***: Comparison of the three arms demonstrated that early complete virologic response at week 24was associated with maintained viral suppression(undetectable rate of HBV DNA at week 144 was 95.96%, 66.67% and 35.29%, respectively, P = 0.000) and reduced YMDD mutations(mutation rate at week 144 was 0%, 3.23% and 15%, respectively, P = 0.015) after 144 wk treatment. For patients who failed to achieve complete virological response at week 24, switching to combination therapy further decreased HBV DNA level by 1 log10 IU/m L. All three arms obtained biochemical benefits including decline of alanine aminotransferase and elevation of albumin. In patients who developed HBV DNA breakthrough for YMDD mutations, ADV add-on therapy did not induce further multiple drug resistance to LAM or ***: Optimized response-guided add-on therapy of ADV and LAM maintains long-term suppression of HBV DNA and improves liver function in CHB patients with compensated liver cirrhosis.

关键词： Hepatitis B Cirrhosis Adefovir dipivoxil Lamivudin

The Denver Tube Combined with Antiviral Drugs In the Treatment of HBV-related Cirrhosis with Refractory Ascites: A Report of Three Cases

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国际感染病学（电子版） 2014年第1期3卷 42-45页

作者： Xiao-jin Wang Li-qin Shi Qing-chun Fu Liu-da Ni Feng Zhou Jin-wei chen cheng-wei chen Shanghai Liver Disease Research Center Nanjing Military Command

Treatment of nucleos(t)ide antiviral drugs for decompensated HBV-related cirrhosis can significantly improve the prognosis. But those patients with refractory ascites possibly deteriorate due to the complications of ascites before any benefit from anti-viral drugs could be observed. Therefore, it is important to find a way to help the patients with HBV-related cirrhosis and refractory ascites to receive the full benefits from antiviral therapy. Peritoneovenous shunt(PVS) using Denver tube enables ascites to continuously bypass into systemic circulation, thereby reducing ascites and albumin input and improving quality of life. We report herein 3 cases of decompensated HBV-related cirrhosis with refractory ascites, PVS using Denver tube was combined with lamivudine for antiviral treatment before and after. Then, ascites was alleviated significantly or disapeared and viral responsed well. All patients achieved a satisfactory long-term survival from 6.7 to 14.7 years. It was suggested that the Denver shunt could be used as an adjuvant method to antiviral drugs for decompensated HBV-related cirrhosis with refractory ascites to help the patients reap the full benefits and maximize efficacy of antiviral treatment.

关键词： Cirrhosis,decompensation Ascites Denver tube Nucleos(t)ide analogue

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带双参数五次广义Ball曲线的扩展

北京服装学院学报（自然科学版） 2016年第2期36卷 71-78页

作者：王成伟陈辉北京服装学院基础教学部北京100029

为了明确形状参数对五次Ball曲线形状的影响,给出一个含有参数α和β的五次多项式基函数,分析了此基函数的性质.同时定义基于该组基函数带有形状参数的多项式曲线,讨论了两段曲线连续拼接的条件.在保持控制多边形不变的情况下,可以通过... 详细信息

为了明确形状参数对五次Ball曲线形状的影响,给出一个含有参数α和β的五次多项式基函数,分析了此基函数的性质.同时定义基于该组基函数带有形状参数的多项式曲线,讨论了两段曲线连续拼接的条件.在保持控制多边形不变的情况下,可以通过改变形状参数来调整曲线形状,使得曲线具有更强的表达能力.曲线不仅具有五次Ball曲线的特性,而且具有形状的可调性和更好的逼近性.计算实例表明,该方法是有效的,可以广泛地应用于计算机辅助设计中对曲线形状的调整.

关键词：广义Ball曲线形状参数曲线设计连续性

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing chen Shuyuan Bai Qiong Wu Yushan chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

The Effect and Mechanism of Gegenqinlian Decoction to Myocardial Ischemia Reperfusionlnduced Arrhythmia

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The Effect and Mechanism of Gegenqinlian Decoction to Myocar...

Processed Research about Gegen Qinlian Decoction to Vascular Protection of Arrhythmias in Rats

安徽省药理学会2012年学术年会

作者： Jie Yang Zi-jiang Long Lei Mu Ming chen cheng-chen wei Bo-chun Ding Pharmacology school Anhui University of Traditional Chinese Medicine

Objective To Study the effect and mechanism of Gegenqinlian decoction to myocardial ischemia reperfusion induced arrhythmia model role of rats,to provide experimental evidence for clinical *** To divided the health SD rats into six groups,there were 10 rats in each group,Sham operation group(equal capacity distilled water),Model group(equal capacity distilled water),The Wenxinkeli group(2.43g·kg-1),Gegenqinlian decoction high dose(8.64g crude drug·kg-1),medium dose(4.32g crude drug·kg-1),low dose(2.16g crude drug·kg-1) *** the Sham operation group,the other groups were performed by liquating anterior interventricular branch of the left desending coronary artery rat to establish myocardial ischemia reperfusion induced arrhythmia model role of rats,after the administration of continuous 7 days, electrocardiogram of leadⅡwas examined on the myocardial ischemia-reperfusion model. Postoperative were determined by spectrophotometry myocardial tissue of Na+-K+-ATP enzyme (Na+-K+-ATPase),Ca2+-ATP enzyme(Ca2+-ATPase)activity and serum superoxide dismutase (SOD),malondialdehyde(MDA) *** Gegenqinlian decoction can significantly reduce the incidence of arrhythmia,serum MDA and increase serum SOD,also can significantly increase Na+-K+-ATPase,Ca2+-ATPase activity(P<0.01 or P<0.05).Conclusion Gegenqinlian decoction has good resistance to laboratory arrhythmia role in the way of increasing enzymes activity and removing oxygen free radicals,to improve arrhythmia role and protect the ischemic myocardium

关键词： Gegenqinlian decoction the anti-arrythmic myocardial ischemia reperfusion

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Processed Research about Gegen Qinlian Decoction to Vascular...